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All Journal Jurnal Kesehatan Lingkungan indonesia Poltekita : Jurnal Ilmu Kesehatan Medical Laboratory Analysis and Sciences Journal Jurnal teknologi Kesehatan Borneo MAHESA : Malahayati Health Student Journal Innovative: Journal Of Social Science Research Jurnal Laboratorium Khatulistiwa MEDICA (International Medical Scientific Journal) ELECTRON (Journal of Science and Technology)
Laila Kamilla
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Potensi Pare (Momordica Charantia Linn) Sebagai Antidiabetes nirnadia, nirnadia; Kamilla, Laila; Djohan, Herlinda
Jurnal Laboratorium Khatulistiwa Vol 4, No 1 (2020): November 2020
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v4i1.942

Abstract

Diabetes mellitus merupakan penyakit menahun degeneratif yang ditandai dengan adanya kenaikan kadar gula di dalam darah yang disebabkan oleh kerusakan kelenjar pankreas sebagai penghasil hormon insulin. Pengobatan tradisional untuk terapi diabetes mellitus dianggap lebih aman dan dapat meminimalkan efek samping terhadap tubuh. Pare (Momordica charantia) merupakan tanaman terna semusim yang memiliki aroma bau khas dan rasa yang pahit mengandung senyawa kimia berupa flavonoid, saponin, steroid, tritepenoid, alkaloid, vicine, polipeptida, momordin, charantin dan polipeptida yang dapat menurunkan kadar glukosa dalam darah.Tujuan kajian literatur ini adalah mengkaji potensi pare dan mekanismenya sebagai antidiabetes. Pare memiliki kemampuan untuk menurunkan kadar glukosa darah dengan cara memiliki fungsi sebagai antioksidan untuk menurunkan resistensi insulin, meningkatkan sensitivitas insulin, asupan glukosa jaringan, sintesis glikogen otot hati, oksidasi glukosa, menurunkan glukoneogenesis hati, dan menekan absorbsi glukosa pada usus. Jenis penelitian yang digunakan adalah kajian literatur. Sumber basis data yang digunakan adalah sumber data sekunder yang diperoleh dengan melakukan penelusuran sumber pustaka melalui database Google scholar, PubMed, freefullpdf dan Google Book.Berdasarkan hasil kajian literatur didapatkan 16 jurnal, 14 jurnal dengan subjek penelitian terhadap hewan coba dan 2 jurnal secara in-vitro yaitu 1 jurnal terhadap flavonoid dari ekstrak daun pare metode nellson somogyi dan 1 jurnal terhadap isolasi polipeptida k dan minyak dari ekstrak biji pare. Dari 16 jurnal tersebut, 1 jurnal menyatakan bahwa ekstrak etanol pare 2% terhadap hewan coba tikus pada dosis 50 mg/kgBB sudah mampu menurunkan kadar glukosa darah. Kesimpulan dari hasil kajian literatur didapatkan adanya potensi pare (Momordica charantia) sebagai antidiabetes.
Efektivitas Sediaan Sabun Wajah Cair Ekstrak Daun Katuk (Sauropus androgynus (L.) Merr.) terhadap Pertumbuhan Bakteri Staphylococcus aureus Metode Difusi Salim, Maulidiyah; Gestiwana, Oksa; Kamilla, Laila
Jurnal Laboratorium Khatulistiwa Vol 7, No 1 (2023): NOVEMBER 2023
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v7i1.1255

Abstract

Sweet leaf bush are one of the vegetable plants that are rich in nutrients and secondary metabolites, so they are commonly used as vegetables and as herbal medicines. The results of the phytochemical screening of sweet leaf bush contain tannins, saponins, flavonoids and alkaloids, so that sweet leaf bush can be used as an antibacterial liquid facial soap preparation. This study aims to determine the effectiveness of liquid facial soap preparations of sweet leaf bush extract formula I with a concentration of 5%, formula II with a concentration of 10%, formula III with a concentration of 15% and formula IV with a concentration of 20% in inhibiting the growth of Staphylococcus aureus bacteria using the diffusion method.This research design uses Quasi Experiment. The population in this research is sweet leaf bush. The sample used was sweet leaf bush extract which was used to make antibacterial liquid facial soap preparations with formula I of 5% concentration, formula II with a concentration of 10%, formula III with a concentration of 15% and formula IV with a concentration of 20%. Antibacterial testing method using the Kirby-Bauer diffusion method.The results of the antibacterial study obtained an average diameter of the inhibition zone in formula I of 12,167 mm, formula II of 14,667 mm, formula III of 17,083 mm and formula IV of 18,667 mm. Based on the diameter of the inhibition zone formed in formulas I, II, III and IV it is categorized as a strong inhibition response.The results of the statistical analysis of the One Way Anova test obtained p value = 0.000 < α 0,05, which means that there is a difference between the average concentrations of the sweet leaf bush extract liquid face soap formula in inhibiting the growth of Staphylococcus aureus bacteria using the diffusion method.Sweet leaf bush are one of the vegetable plants that are rich in nutrients and secondary metabolites, so they are commonly used as vegetables and as herbal medicines. The results of the phytochemical screening of sweet leaf bush contain tannins, saponins, flavonoids and alkaloids, so that sweet leaf bush can be used as an antibacterial liquid facial soap preparation. This study aims to determine the effectiveness of liquid facial soap preparations of sweet leaf bush extract formula I with a concentration of 5%, formula II with a concentration of 10%, formula III with a concentration of 15% and formula IV with a concentration of 20% in inhibiting the growth of Staphylococcus aureus bacteria using the diffusion method.This research design uses Quasi Experiment. The population in this research is sweet leaf bush. The sample used was sweet leaf bush extract which was used to make antibacterial liquid facial soap preparations with formula I of 5% concentration, formula II with a concentration of 10%, formula III with a concentration of 15% and formula IV with a concentration of 20%. Antibacterial testing method using the Kirby-Bauer diffusion method.The results of the antibacterial study obtained an average diameter of the inhibition zone in formula I of 12,167 mm, formula II of 14,667 mm, formula III of 17,083 mm and formula IV of 18,667 mm. Based on the diameter of the inhibition zone formed in formulas I, II, III and IV it is categorized as a strong inhibition response.The results of the statistical analysis of the One Way Anova test obtained p value = 0.000 < α 0,05, which means that there is a difference between the average concentrations of the sweet leaf bush extract liquid face soap formula in inhibiting the growth of Staphylococcus aureus bacteria using the diffusion method.
POTENSI TEPUNG KULIT PISANG RAJA SEBAGAI MEDIA ALTERNATIF PERTUMBUHAN JAMUR Penicillium sp. Kamilla, Laila; Fadilla, Alda Nur; Nuswantoro, Ari; Tumpuk, Sri
Jurnal Laboratorium Khatulistiwa Vol 8, No 1 (2024): November 2024
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v8i1.1665

Abstract

Sumber karbohidrat yang mudah ditemukan dan belum banyak dimanfaatkan adalah tepung kulit pisang raja. Kulit pisang raja memiliki potensi untuk digunakan sebagai media alternatif karena memiliki kandungan zat seperti karbohidrat, protein, dan lemak. Tujuan penelitian ini untuk mengetahui potensi tepung kulit pisang raja sebagai media pertumbuhan jamur Penicillium sp. Penelitian ini menggunakan desain penelitian Quasi Experiment. Populasi dalam penelitian ini yaitu kulit pisang raja. Sampel yang digunakan adalah tepung kulit pisang raja yang dibuat dalam konsentrasi 10%, 20%, 30%, 40%, 50% dengan 5 kali pengulangan didapatkan jumlah sampel 25. Hasil penelitian yaitu konsentrasi 10% rata- rata 11,6 CFU, konsentrasi 20% rata-rata 12,8 CFU, konsentrasi 30% rata-rata 17,4 CFU, konsentrasi 40% rata-rata 21,8 CFU, konsentrasi 50% rata-rata 28 CFU dan media standar Sabouraud Dextrose Agar (SDA) koloni diperoleh rata-rata 152,6 CFU. Hasil uji Anova didapatkan nilai 0,000 < 0,05 yang menyatakan ada perbedaan pertumbuhan jumlah koloni pada tiap konsentrasi media alternatif dengan media standar Sabouraud Dextrose Agar (SDA) dapat disimpulkan media alternatif tepung kulit pisang raja berpotensi digunakan sebagai media pertumbuhan jamur Penicillium sp. namun tidak dapat menggantikan media standar Sabouraud Dextrose Agar (SDA).
The Effect of Kratom Leaf Alkaloid Extract on Blood Glucose Levels Using an In Vivo Method Dewi, Bastiana; Kamilla, Laila; Sutriswanto, Sutriswanto; Tumpuk, Sri; Triana, Linda
Jurnal Laboratorium Khatulistiwa Vol 8, No 2 (2025): Mei 2025
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v8i2.1851

Abstract

Kratom contains alkaloids, flavonoids, saponins, and tannins, which have traditionally been used to boost energy and treat various health conditions, including diabetes. This study aims to analyze the effect of kratom leaf alkaloid extract on blood glucose levels in vivo using a quasi-experimental design. The subjects were 27 male Swiss Webster mice (Mus musculus), divided into three treatment groups receiving kratom leaf alkaloid extract at doses of 0.147 mg/20gBW, 0.294 mg/20gBW, and 0.588 mg/20gBW. The alkaloid extract was obtained through fractionation. Each treatment group was replicated nine times using purposive sampling. An oral glucose tolerance test was conducted to measure blood glucose levels. The Simple Linear Regression test results showed a p-value of 0.000 (p < 0.05), indicating a significant effect of kratom leaf alkaloid extract on blood glucose levels in vivo.
Daya Hambat Sediaan Deodoran Spray Minyak Atsiri Kulit Jeruk Bali Terhadap Bakteri Staphylococcus aureus Suwandi, Edy; Saputra, Daniel Angkasa; Kamilla, Laila; Sari, Emilda
Jurnal Laboratorium Khatulistiwa Vol 8, No 2 (2025): Mei 2025
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v8i2.1832

Abstract

Deodoran spray adalah sediaan kosmetika yang digunakan untuk menyerap keringat dan menutupi bau badan. Bau badan merupakan masalah yang cukup penting, bau badan ini dapat ditimbulkan karena kurang menjaga kebersihan badan dan adanya aktivitas bakteri Staphylococcus aureus. Jeruk bali memiliki senyawa metabolit sekunder terpenoid. Senyawa metabolit sekunder tersebut dapat dimanfaatkan sebagai agen antibakteri pada sediaan deodoran spray. Tujuan penelitian ini untuk menganalisis perbedaan sediaan deodoran spray minyak atsiri kulit jeruk bali pada konsentrasi 3%, 6% dan 9% dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini berbentuk Quasi Experimental Design, populasi pada penelitian ini adalah sediaan deodoran spray minyak atsiri kulit jeruk bali dengan menggunakan teknik sampling purposive. Sampel yang digunakan adalah sediaan deodoran spray minyak atsiri kulit jeruk bali konsentrasi 3%, 6% dan 9% yang dibuat 9 kali pengulangan pada masing- masing perlakuan, sehingga total sampel yang digunakan untuk 3 kelompok perlakuan tersebut adalah 27 sediaan deodoran spray yang diuji kekuatan antibakterinya dalam menghambat pertumbuhan bakteri Staphylococcus aureus dengan menggunakan metode difusi cakram Kirby-Bauer. Hasil uji daya hambat sediaan deodoran spray minyak atsiri kulit jeruk bali terhadap bakteri Staphylococcus aureus didapatkan rata-rata zona hambat pada konsentrasi 3% sebesar 7,1 mm, konsentrasi 6% sebesar 7,9 mm dan konsentrasi 9% sebesar 8,7 mm. Dari hasil analisis data uji Friedman diperoleh p-value 0,000 < α 0,05. Sehingga terdapat perbedaan antara setiap konsentrasi sediaan deodoran spray minyak atsiri kulit jeruk bali terhadap pertumbuhan bakteri Staphylococcus aureus.
Analysis of monocyte and lymphocyte counts of TBDC patients taking anti-TBC drugs Susanti, Eka; Sugiono, Sugiono; Kamilla, Laila
ELECTRON (Journal of Science and Technology) Vol. 7 No. 1 (2025): ELECTRON (Journal of Science and Technology)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/electron.v7i1.514

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that attacks the lungs and spreads through the air. Monocytes and lymphocytes play an important role in the immune response to TB. Changes in their numbers can reflect the immune response and treatment effectiveness. Monitoring patients during treatment provides insight into disease progression and therapy response. This study aims to analyze the number of monocytes and lymphocytes in TB patients taking anti-tuberculosis drugs at Puskesmas Ledo, Bengkayang Regency. The study was descriptive quantitative to describe the number of monocytes and lymphocytes. The population was all TB patients undergoing treatment in the working area of Puskesmas Ledo, with total sampling technique and the number of respondents as many as 30 people. From the results of the study, 21 respondents had high monocyte counts: 8 in the early phase of treatment and 13 in the advanced phase. Meanwhile, 9 respondents had non-high monocyte counts, consisting of 4 in the initial phase and 5 in the continuation phase. Of the total respondents, 3 people had high lymphocyte counts, namely 2 in the initial phase and 1 in the continuation phase, while 27 had non-high lymphocyte counts, consisting of 10 in the initial phase and 17 in the continuation phase. In conclusion, high monocyte counts were more common in the continuation phase (61.9%), while high lymphocyte counts were more common in the early phase (66.7%).
Evaluation of the accuracy and precision of the microlab 300 device for total cholesterol test on the CHOD-PAP method Ananda, Fanny Rizki; Sungkawa, Hendra Budi; Kamilla, Laila; Fatayati, Imma
ELECTRON (Journal of Science and Technology) Vol. 7 No. 1 (2025): ELECTRON (Journal of Science and Technology)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/electron.v7i1.516

Abstract

Internal quality assurance (PMI) is a routine preventive and monitoring activity in the laboratory to minimize errors and produce accurate tests. Quality accuracy and precision are important indicators in assessing PMI. Accuracy indicates the closeness of the test results to the true value, while precision describes the closeness of the results of repeated tests on the same sample. Total cholesterol examination using a spectrophotometer, especially the CHOD-PAP method, is often carried out at the Clinical Laboratory of the Poltekkes Kemenkes Pontianak due to its stability. This observational study aims to evaluate the accuracy and precision of the Microlab 300 tool for total cholesterol examination using the CHOD-PAP method at the Integrated Laboratory of the Poltekkes Kemenkes Pontianak. The study population was the assayed control serum solution, with samples in the form of normal control serum solution dialab which was divided into 100 vials containing 50 µL. A total of 30 vials were used for the preliminary period and 30 vials for the control period. The parameter examined was total cholesterol by CHOD-PAP method. The results showed the average accuracy of the Microlab 300 tool was 96.08% and precision was 99.21%. The daily graph using Westgard's rule shows that the control material is within the control limits. Thus, it can be concluded that the Microlab 300 tool shows good accuracy and precision in the examination of total cholesterol CHOD-PAP method in the laboratory
Relationship of preeclampsia in pregnant mothers with ureum and creatinin levels Nurhadiah, Nurhadiah; Kamilla, Laila; Triana, Linda; Maretalinia, Maretalinia
ELECTRON (Journal of Science and Technology) Vol. 7 No. 2 (2025): ELECTRON (Journal of Science and Technology)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/electron.v7i2.520

Abstract

Preeclampsia is a complication of pregnancy due to increased blood pressure, accompanied by proteinuria and odema. Risk factors include primigravida, multiple pregnancy, extreme age at pregnancy, previous history of preeclampsia, family history, and diseases such as kidney, diabetes mellitus, and hypertension. The purpose of this study was to determine the relationship of preeclampsia with ureum and creatinine levels in pregnant women at RSUD Dr. Rubini Mempawah. This research is descriptive analytic with cross sectional approach. The population was all pregnant women who visited in May-July 2024 at RSUD Dr. Rubini Mempawah, with purposive sampling technique. Examination of ureum using Enzym Method and creatinine with IFCC Method. Of the 65 respondents, high ureum levels were found in 20 people (30.8%), with 7 people having preeclampsia and 13 people not. High creatinine levels were found in 21 people (32.3%), consisting of 11 people with preeclampsia and 10 without preeclampsia. Chi-Square test showed a p value = 0.438 (> 0.05) for ureum, indicating no relationship, so Ha was rejected. While p = 0.003 (<0.05) for creatinine, indicating there is an association, so Ha is accepted. In conclusion, there is no relationship between preeclampsia and ureum levels and there is a relationship between preeclampsia and creatinine levels in pregnant women at RSUD Dr. Rubini Mempawah
Analysis of Potassium Levels in Patients with Pulmonary Tuberculosis Who Take Anti Tuberculosis Drugs Laila Kamilla; Qorina Miranti; Linda Triana; Sri Tumpuk
Jurnal teknologi Kesehatan Borneo Vol 4 No 2 (2023): Jurnal teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v4i2.265

Abstract

Pulmonary Tuberculosis is an infectious disease caused by the bacteria Mycobacterium tuberculosis. Pulmonary Tuberculosis is treated with antituberculosis drugs, but these drugs can be toxic to the body and have side effects such as diarrhea, nausea, and vomiting. These side effects can disrupt the body's fluid balance with the loss of potassium. The purpose of this study was to analyze the side effects of taking anti-tuberculosis drugs (OAT) on potassium (K) electrolyte levels in Pulmonary Tuberculosis patients at UPT Puskesmas Perumnas 1. This study used a descriptive design with a cross sectional approach to describe or give an overview of electrolyte levels in Pulmonary Tuberculosis patients who took anti-tuberculosis drugs. The population in this study were 37 Pulmonary Tuberculosis patients, and the samples in this study were 26 Pulmonary Tuberculosis patients who were still on OAT treatment at UPT Puskesmas Perumnas 1. The potassium electrolyte examination method used in this study was the sodium tetraphenylboron method. From the results of the study, it was found that Lung Tuberculosis patients with normal potassium levels amounted to 8 people (30.8%) and Lung Tuberculosis patients who experienced hypokalemia amounted to 18 people (69.2%). The side effects felt from taking OAT were digestive disorders, namely diarrhea totaling 7 people (26.9%), nausea totaling 4 people (15.4%), and vomiting totaling 7 people (26.9%).
The Relationship Between NS1 Examination and the Examination of Hemoglobin, Hematocrit, Leukocytes, Platelets, and Erythrocytes in Dengue Fever Patients in The Pediatric Ward Ratulangi, Agus Dimas; Djohan, Herlinda; Kamilla, Laila
MEDICA (International Medical Scientific Journal) Vol. 7 No. 1 (2025): MEDICA (Internasional Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v7i1.486

Abstract

The NS1 antigen test is developed to detect dengue virus infection during the acute phase, a stage marked by various hematological abnormalities. An increase in hemoglobin levels greater than 20% can support the diagnosis of Dengue Hemorrhagic Fever (DHF), often caused by hemoconcentration due to plasma leakage, which also raises erythrocyte levels in the bloodstream. This study aimed to examine the relationship between NS1 test results and hemoglobin, hematocrit, leukocyte, platelet, and erythrocyte levels in pediatric DHF patients at Dr. Soedarso Regional Hospital. Using a cross-sectional design with total sampling, 203 samples were collected from suspected pediatric DHF patients between May and July 2023. Data included NS1 results and hematology parameters. The analysis showed a significant association between positive NS1 results and hemoglobin levels (p = 0.025) as well as platelet counts (p = 0.035), but no significant relationship with hematocrit (p = 0.872), leukocytes (p = 0.269), or erythrocytes (p = 0.060). In conclusion, NS1 positivity is significantly associated with hemoglobin levels and platelet count, but not with hematocrit, leukocytes, or erythrocytes in pediatric DHF patients.
Co-Authors Ananda, Fanny Rizki Anisa Fitri Midani Aprilia, Dinasti Ari Nuswantoro Dewi, Bastiana Djohan, Herlinda Eka Susanti Fadilla, Alda Nur Fidelia Putri, Angelyna Franciska, Maria Gestiwana, Oksa Hanif, Muhammad Ifham Hendra Budi Sungkawa, Hendra Budi Hermantika, David Deovia Triputra Ihsan, Bagus Muhammad Imma Fatayati Indah Purwaningsih Jajar Pramata Syari Khayan Khayan Lestari, cik Verra Budi Linda Triana Maretalinia, Maretalinia Maulidiyah Salim mawaddah, mutia putri nirnadia, nirnadia Novi Wahyuni Nur Endah Wahyuningsih Nurhadiah, Nurhadiah Nurhayati, Etiek Pusaka, Semerdanta Qorina Miranti Rahmatika, Tantri Ramadhanty, Khairida Ratulangi, Agus Dimas Sabrina Azani, Aulia Saputra, Daniel Angkasa Sari, Emilda Sen, Sharen Sri Tumpuk Sugiono Sugiono Sutriswanto, Sutriswanto Suwandi, Edy Syari, Jajar Trifani, Paula Jaenne Tumpuk, Sri Wahdaniah Wahyudi YANTI, RAHMI