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All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Pharmascience Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Science Midwifery Jurnal Impresi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Jurnal Farmasi Indonesia International Journal Multidisciplinary Jurnal Medika Farmaka Jurnal Kesehatan Bakti Tunas Husada Indonesian Journal of Community Development Jurnal Farmasi Galenika International Journal of Health, Medicine, and Sports Kimia Padjadjaran
Marita Kaniawati
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Efek Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Daun Pegagan (Centella asiatica (L.) Urb) terhadap Ekspresi Gen eNOS pada Jaringan Hati Tikus Obes Sulaeman, Agus; Agustian, Salim; Susilawati, Elis; Muhsinin, Soni; Kaniawati, Marita; Feliana, Marita
Journal of Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23813

Abstract

Obesitas adalah kondisi patologis akibat akumulasi lemak berlebih yang meningkatkan risiko gangguan metabolik, termasuk disfungsi endotel yang ditandai oleh penurunan produksi Nitric Oxide (NO) sintesis oleh enzim Endothelial Nitric Oxide Synthase (eNOS). Penelitian ini bertujuan mengevaluasi efek kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan daun pegagan (Centella asiatica (L.) Urb) terhadap kadar NO serum dan ekspresi gen eNOS pada jaringan hati tikus obesitas. Penelitian eksperimental ini menggunakan tikus jantan yang diinduksi obesitas dengan pakan tinggi lemak dan karbohidrat selama 60 hari. Tikus dibagi enam kelompok: normal (kontrol negative), obesitas (kontrol positif), pembanding orlistat 10,8 mg/kgBB, ekstrak kunyit 200 mg/kgBB, ekstrak pegagan 20 mg/kgBB, dan kombinasi kunyit-pegagan 200:100 mg/kgBB. Parameter yang diukur meliputi berat badan, kadar NO serum (metode Griess), ekspresi gen eNOS (qPCR), kadar SGOT dan  SGPT. Hasil menunjukkan kombinasi ekstrak secara signifikan menurunkan berat badan dan meningkatkan kadar NO dibandingkan kelompok obesitas (p < 0,05), meningkatkan ekspresi gen eNOS serta secara (p< 0,05) signifikan menurunkan kadar SGOT dan SGPT . Penelitian ini mengindikasikan potensi kombinasi ekstrak kunyit dan pegagan sebagai agen preventif disfungsi endotel pada obesitas melalui peningkatan produksi NO dan regulasi ekspresi gen eNOS serta berperan sebagai hepatoprotektor. Kata Kunci: Ekstrak Kunyit, Ekstrak Pegagan, Ekspresi Gen eNOS, Jaringan Hati, Obesitas  Obesity is a pathological condition caused by excessive fat accumulation that increases the risk of metabolic disorders, including endothelial dysfunction characterized by decreased Nitric Oxide (NO) synthesis by the enzyme Endothelial Nitric Oxide Synthase (eNOS). This study aims to evaluate the effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa L.) and gotu kola leaves (Centella asiatica (L.) Urb) on serum NO levels and eNOS gene expression in the liver tissue of obese rats. This experimental study used male rats induced to become obese with a high-fat and high-carbohydrate diet for 60 days. The rats were divided into six groups: normal (negative control), obese (positive control), orlistat 10.8 mg/kgBW, turmeric extract 200 mg/kgBW, gotu kola extract 20 mg/kgBW, and turmeric-gotu kola combination 200:100 mg/kgBW. The measured parameters included body weight, serum NO levels (Griess method), eNOS gene expression (qPCR), SGOT and SGPT levels. The results showed that the combination of extracts significantly reduced body weight and increased NO levels compared to the obesity group (p < 0.05), increased eNOS gene expression, and significantly (p < 0.05) decreased SGOT and SGPT levels. This study indicates the potential of the combination of turmeric and pegagan extracts as a preventive agent for endothelial dysfunction in obesity through the enhancement of NO production and regulation of eNOS gene expression as well as acting as a hepatoprotector.
Article review: The role of probiotics in maintaining balance intestinal microbiota on diarrhea infection therapy Solihah, Nurlaella; Mulyani, Yani; Kaniawati, Marita
Science Midwifery Vol 13 No 5 (2025): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2165

Abstract

Diarrhea infections are a significant global health problem, especially in developing countries and can be caused by bacterial, viral or parasitic infections. Antibiotics are often given times ineffective in long-term use and risk disrupting the balance of intestinal microbiota. So that probiotics are needed that come from living microorganisms that provide health benefits if consumed in sufficient quantities. Review This article aims to review the role of probiotics in maintaining the balance of intestinal microbiota and their effectiveness in diarrheal infection therapy. Through literature analysis, several probiotic strains such as Lactobacillus and Bifidobacterium have shown their ability to inhibit the growth of pathogens, such as Escherichia coli and Clostridium difficile, through nutrient competition, production of antimicrobial substances, and immune modulation. This article concludes that probiotics have great potential as an additional therapy that is safe, effective and has minimal side effects in treating diarrheal infections. However, further studies are needed to determine the optimal dose, duration of use, and effectiveness of probiotics in various populations and types of diarrhea.
Comparative Glycemic Effectiveness of Long- and Rapid-Acting Insulin in Patients with Type 2 Diabetes Mellitus Sutrisno, Entris; Kaniawati, Marita; Maharani, Ilmi Intan; Sodik, Jajang Japar
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404502

Abstract

Insulin therapy is essential for managing type 2 diabetes mellitus (T2DM), particularly in patients who fail to achieve glycemic targets with oral antidiabetic agents. Long-acting insulin is primarily used to control basal glucose levels, while rapid-acting insulin targets postprandial hyperglycemia. However, comparative real-world evidence regarding their effectiveness on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) remains limited. This study aimed to evaluate and compare the effectiveness of long-acting and rapid-acting insulin in improving HbA1c and FBG levels among patients with T2DM. A retrospective before–and–after observational study was conducted involving 122 T2DM patients treated at the outpatient unit of Majalaya Regional General Hospital between January and December 2024. Patients received either long-acting insulin (e.g., insulin glargine) or rapid-acting insulin (e.g., insulin lispro and insulin aspart) as monotherapy. Changes in HbA1c and FBG before and after therapy were analyzed using paired t-tests or Wilcoxon signed-rank tests. Clinical effectiveness was defined according to American Diabetes Association criteria as a reduction of ≥1% in HbA1c or ≥30 mg/dL in FBG. Insulin therapy significantly reduced HbA1c (−7.77 ± 3.09, p < 0.001) and FBG levels (Z = −5.53, p < 0.001). Based on ADA criteria, 90.3% of patients achieved an effective reduction in HbA1c, while 43.5% achieved an effective reduction in FBG. Insulin lispro and insulin glargine showed the highest HbA1c-based effectiveness (100%), whereas FBG-based effectiveness varied across formulations. Insulin therapy significantly improves long-term and short-term glycemic control in T2DM patients, with insulin lispro and insulin glargine demonstrating the most consistent effectiveness.
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Kaniawati, Marita; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Efraim Lian, Kevin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Farihah, Ai Siti; Ramadhan, Dika Azhar; Kaniawati, Marita; Sulaeman, Agus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
Co-Authors Agus Sulaeman agustian, dudy Agustian, Salim Agustina Aligita, Widhya Amelia, Ferda Anwar Santoso Auliyaa, Millata Azzah Wulandari, Yulinda Cintiya Dewi , Silvy Dimas Alamanda, Vidiana Dodit Rinaldi, Muhammad Dwi Fatma, Ira Efraim Lian, Kevin Fajeri, Nur Iman Farihah, Ai Siti Feliana, Marita Gabriela Da Costa Soares, Fidelia s Herliana, Lani Idar, Idar Irawan Yusuf Irene Welmince Bokotei, Martini Irviansyah, Cepy Okta Istiqomah, Aulia Nurfazri Jajang Japar Sodik Jefry Jefry Kambu, Jenita Kartadarma, Supriyatni Kartawinata, Tutus Gusdinar Kasihtheisya, Naida Kusmiati, Meti Languwila, Indrawati Lestari, Kharina Septi Maharani, Ilmi Intan Maia de Fatima Freitas, Floriana Manik, Theresia Nandah Marliani, Lia Mia N. A. Fatin Muthmainah, Siti Saidah Nugraha, Eka Rahmat Nurfazri Istiqomah, Aulia Nurfazri, Aulia Priana, Eka Ramadhan, Dika Azhar Rofiasari, Linda Safari, Alit Rian Reladi Yanuar Saputra, Erwin Yuliana Septri Rahmawati, Nabila Solihah, Nurlaella Soni Muhsinin Subakti, Nanda Sukmawati, ika kurnia Susilawati, Elis Sutrisno, Entris Syakib Bakri Syihabbudin, Nazar Taofiq Putra Pratama, Muhamad Valiani, Cici Yani Mulyani Yusita, Intan Zinan, Daula Zahra