Article Per Year (5 Year)
p-Index From 2021 - 2026
2.775
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Pharmascience Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Science Midwifery Jurnal Impresi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sciences of Pharmacy Jurnal Farmasi Indonesia International Journal Multidisciplinary Jurnal Medika Farmaka Jurnal Kesehatan Bakti Tunas Husada Indonesian Journal of Community Development Jurnal Farmasi Galenika International Journal of Health, Medicine, and Sports Kimia Padjadjaran
Marita Kaniawati
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
Efek Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Daun Pegagan (Centella asiatica (L.) Urb) terhadap Ekspresi Gen eNOS pada Jaringan Hati Tikus Obes Sulaeman, Agus; Agustian, Salim; Susilawati, Elis; Muhsinin, Soni; Kaniawati, Marita; Feliana, Marita
Jurnal Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23813

Abstract

Obesitas adalah kondisi patologis akibat akumulasi lemak berlebih yang meningkatkan risiko gangguan metabolik, termasuk disfungsi endotel yang ditandai oleh penurunan produksi Nitric Oxide (NO) sintesis oleh enzim Endothelial Nitric Oxide Synthase (eNOS). Penelitian ini bertujuan mengevaluasi efek kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan daun pegagan (Centella asiatica (L.) Urb) terhadap kadar NO serum dan ekspresi gen eNOS pada jaringan hati tikus obesitas. Penelitian eksperimental ini menggunakan tikus jantan yang diinduksi obesitas dengan pakan tinggi lemak dan karbohidrat selama 60 hari. Tikus dibagi enam kelompok: normal (kontrol negative), obesitas (kontrol positif), pembanding orlistat 10,8 mg/kgBB, ekstrak kunyit 200 mg/kgBB, ekstrak pegagan 20 mg/kgBB, dan kombinasi kunyit-pegagan 200:100 mg/kgBB. Parameter yang diukur meliputi berat badan, kadar NO serum (metode Griess), ekspresi gen eNOS (qPCR), kadar SGOT dan  SGPT. Hasil menunjukkan kombinasi ekstrak secara signifikan menurunkan berat badan dan meningkatkan kadar NO dibandingkan kelompok obesitas (p < 0,05), meningkatkan ekspresi gen eNOS serta secara (p< 0,05) signifikan menurunkan kadar SGOT dan SGPT . Penelitian ini mengindikasikan potensi kombinasi ekstrak kunyit dan pegagan sebagai agen preventif disfungsi endotel pada obesitas melalui peningkatan produksi NO dan regulasi ekspresi gen eNOS serta berperan sebagai hepatoprotektor. Kata Kunci: Ekstrak Kunyit, Ekstrak Pegagan, Ekspresi Gen eNOS, Jaringan Hati, Obesitas  Obesity is a pathological condition caused by excessive fat accumulation that increases the risk of metabolic disorders, including endothelial dysfunction characterized by decreased Nitric Oxide (NO) synthesis by the enzyme Endothelial Nitric Oxide Synthase (eNOS). This study aims to evaluate the effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa L.) and gotu kola leaves (Centella asiatica (L.) Urb) on serum NO levels and eNOS gene expression in the liver tissue of obese rats. This experimental study used male rats induced to become obese with a high-fat and high-carbohydrate diet for 60 days. The rats were divided into six groups: normal (negative control), obese (positive control), orlistat 10.8 mg/kgBW, turmeric extract 200 mg/kgBW, gotu kola extract 20 mg/kgBW, and turmeric-gotu kola combination 200:100 mg/kgBW. The measured parameters included body weight, serum NO levels (Griess method), eNOS gene expression (qPCR), SGOT and SGPT levels. The results showed that the combination of extracts significantly reduced body weight and increased NO levels compared to the obesity group (p < 0.05), increased eNOS gene expression, and significantly (p < 0.05) decreased SGOT and SGPT levels. This study indicates the potential of the combination of turmeric and pegagan extracts as a preventive agent for endothelial dysfunction in obesity through the enhancement of NO production and regulation of eNOS gene expression as well as acting as a hepatoprotector.
Article review: The role of probiotics in maintaining balance intestinal microbiota on diarrhea infection therapy Solihah, Nurlaella; Mulyani, Yani; Kaniawati, Marita
Science Midwifery Vol 13 No 5 (2025): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2165

Abstract

Diarrhea infections are a significant global health problem, especially in developing countries and can be caused by bacterial, viral or parasitic infections. Antibiotics are often given times ineffective in long-term use and risk disrupting the balance of intestinal microbiota. So that probiotics are needed that come from living microorganisms that provide health benefits if consumed in sufficient quantities. Review This article aims to review the role of probiotics in maintaining the balance of intestinal microbiota and their effectiveness in diarrheal infection therapy. Through literature analysis, several probiotic strains such as Lactobacillus and Bifidobacterium have shown their ability to inhibit the growth of pathogens, such as Escherichia coli and Clostridium difficile, through nutrient competition, production of antimicrobial substances, and immune modulation. This article concludes that probiotics have great potential as an additional therapy that is safe, effective and has minimal side effects in treating diarrheal infections. However, further studies are needed to determine the optimal dose, duration of use, and effectiveness of probiotics in various populations and types of diarrhea.
Comparative Glycemic Effectiveness of Long- and Rapid-Acting Insulin in Patients with Type 2 Diabetes Mellitus Sutrisno, Entris; Kaniawati, Marita; Maharani, Ilmi Intan; Sodik, Jajang Japar
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404502

Abstract

Insulin therapy is essential for managing type 2 diabetes mellitus (T2DM), particularly in patients who fail to achieve glycemic targets with oral antidiabetic agents. Long-acting insulin is primarily used to control basal glucose levels, while rapid-acting insulin targets postprandial hyperglycemia. However, comparative real-world evidence regarding their effectiveness on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) remains limited. This study aimed to evaluate and compare the effectiveness of long-acting and rapid-acting insulin in improving HbA1c and FBG levels among patients with T2DM. A retrospective before–and–after observational study was conducted involving 122 T2DM patients treated at the outpatient unit of Majalaya Regional General Hospital between January and December 2024. Patients received either long-acting insulin (e.g., insulin glargine) or rapid-acting insulin (e.g., insulin lispro and insulin aspart) as monotherapy. Changes in HbA1c and FBG before and after therapy were analyzed using paired t-tests or Wilcoxon signed-rank tests. Clinical effectiveness was defined according to American Diabetes Association criteria as a reduction of ≥1% in HbA1c or ≥30 mg/dL in FBG. Insulin therapy significantly reduced HbA1c (−7.77 ± 3.09, p < 0.001) and FBG levels (Z = −5.53, p < 0.001). Based on ADA criteria, 90.3% of patients achieved an effective reduction in HbA1c, while 43.5% achieved an effective reduction in FBG. Insulin lispro and insulin glargine showed the highest HbA1c-based effectiveness (100%), whereas FBG-based effectiveness varied across formulations. Insulin therapy significantly improves long-term and short-term glycemic control in T2DM patients, with insulin lispro and insulin glargine demonstrating the most consistent effectiveness.
Co-Authors Agus Sulaeman agustian, dudy Agustian, Salim Agustina Aligita, Widhya Amelia, Ferda Anwar Santoso Auliyaa, Millata Azzah Wulandari, Yulinda Cintiya Dewi , Silvy Dimas Alamanda, Vidiana Dodit Rinaldi, Muhammad Dwi Fatma, Ira Efraim Lian, Kevin Fajeri, Nur Iman Feliana, Marita Gabriela Da Costa Soares, Fidelia s Herliana, Lani Idar, Idar Irawan Yusuf Irene Welmince Bokotei, Martini Irviansyah, Cepy Okta Jefry Jefry Kambu, Jenita Kartadarma, Supriyatni Kartawinata, Tutus Gusdinar Kasihtheisya, Naida Kusmiati, Meti Languwila, Indrawati Maharani, Ilmi Intan Maia de Fatima Freitas, Floriana Manik, Theresia Nandah Marliani, Lia Mia N. A. Fatin Muthmainah, Siti Saidah Nugraha, Eka Rahmat Nurfazri, Aulia Priana, Eka Rofiasari, Linda Safari, Alit Rian Reladi Yanuar Saputra, Erwin Yuliana Septri Rahmawati, Nabila Sodik, Jajang Japar Solihah, Nurlaella Soni Muhsinin Subakti, Nanda Sukmawati, ika kurnia Susilawati, Elis Sutrisno, Entris Syakib Bakri Syihabbudin, Nazar Taofiq Putra Pratama, Muhamad Valiani, Cici Yani Mulyani Yusita, Intan Zinan, Daula Zahra