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All Journal e-Journal Pustaka Kesehatan Althea Medical Journal Jurnal Kesehatan Andalas Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Majalah Kedokteran Andalas Jurnal Respirasi (JR) Jurnal Kesmas Untika Luwuk: Public Health Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Jember Medical Journal (JMJ) Folia Medica Indonesiana
Cholis Abrori, Cholis
Department Of Pharmacology, Faculty Of Medicine, University Of Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Althea Medical Journal

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Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Co-Authors Adji, Novan Krisno Afifatun Hasanah Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Arifa Mustika Athoillah, Nabil Atina Robbiatul Azizah Azham Purwandhono Bagus Hermansyah Chikita R Hanifati Cicih Komariah Desie Dwi Wisudanti Deti Rosalina Diana Chusna Mufida Dimas Zabirrurohman Putra Dina Helianti Dini Agustina Dion Krismashogi Dharmawan Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erma Sulistyaningsih Farida Yan Pratiwi Kurnia Fath Arina Fahma Fauqi Amalia Habibi, Ali Hairrudin Hairrudin Heni Fatmawati Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Indi Kamilia Fitri Inke Kusumastuti Jasmine Fachrunnisa Justina Evy Tyaswati Khana Nurfadhila Komang Yunita Wiryaning Putri Laili, Elisa Fadia Laili, Nikmatul Laksmi Indreswari Lucky Tiya M. Ali Shodikin M. Ihwan Narwanto M.S. Irham Rozaq Maulana, Aditha Satria Mauliya Sri Sukmawati Wahyudi Miftakhul Huda Moh. Lutfi Hasbullah Muhamad Hasan Muhammad Hanif Ar Robbani Muhammad Hasan Munawaroh, Ayu Mushab Mushab Mushab, Mushab Natasha Amelia Nita, Surya Novan Krisno Adji Nurlaila Ayu Purwaningsih Nyoman Defriyana Suwandi Olyvia Yulyani Khaerul Putri Pipiet Wulandari Pralampita, Pulong Wijang Prayoga Adinawer Sirait Putri, Elvia Rahmi Marga Rahami, Nahla Ahmad Rena Normasari Rezza Putri Mahartika Rosita Dewi Rozaq, M.S. Irham Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Sheillavi Fauziah Alex Saddamiah Sumadi Supangat Supangat Supangat Tsintani Nur Aristiana Wibsono, Sony Wiwien Sugih Utami Yedi Murdanu Yovita Karina Pandan Putri Yudha Nurdian Yuli Hermansyah Yuli Hermansyah, Yuli Yunita Armiyanti Zahrah Febianti