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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Majalah Obat Tradisional The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer Makara Journal of Health Research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Bioma : Jurnal Ilmiah Biologi

Ria Kodariah

Departemen Patologi Anatomi FKUI

Author-ID : 299194

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Centella asiatica ethanol extract increases hippocampal brain derived neurotrophic factor in male Wistar rats Handayani, Astri; Yolanda, Sophie; Kodariah, Ria
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.143-149

BackgroundSynaptic plasticity, which primarily takes place in the hippocampus, is the molecular basis of long- term memory formation. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays a significant role in synaptic plasticity and memory formation. When BDNF is released, it binds to its receptor and activates various intracellular signal transduction pathways leading to synaptic plasticity. Several methods to improve memory function in humans have been studied, one of which is the use of herbal compounds, such as Centella asiatica (CeA), an herbaceous plant that has been used for improving memory. This study aims to examine the effects of CeA ethanol extract on BDNF protein expression in the CA1 hippocampal region in adult male rats.MethodsA randomized experimental design was performed involving 18 adult male Wistar rats. The rats were randomized into three groups: one control/distilled water group and two groups treated with doses of CeA ethanol extract of 300 mg/kgBW (CeA300) and 600 mg/kgBW (CeA600), respectively. CeA ethanol extract was administered orally for 28 consecutive days with weekly weight-adjusted dose. After 28 days, the rats were decapitated, and the hippocampus was isolated from the brain. BDNF protein expression was assessed using immunohistochemistry. Data was analyzed using Kruskal-Wallis test and continued with post-hoc analysis. ResultsThere was a significant increase in BDNF protein expression in the CeA600 group compared to the control group (p<0.001). ConclusionAdministration of CeA ethanol extract increased BDNF protein expression in the CA1 hippocampal region of adult male rats.

Peran CD44 pada Progresivitas Non Alcoholic Steatohepatitis (NASH) Sarwanti; Marini Stephanie; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Non alcoholic Steatohepatitis (NASH) is part of a group of conditions called Non-Alcoholic Fatty Liver Diseases(NAFLD) where it is a chronic disease, which defined after elimination other causes of fatty liver, such as excessivealcohol consumption and other causes of chronic liver diseases. NASH is fatty liver disease which characterized byballooning of hepatocyte and lobular inflammation with or without fibrosis. Histopathology diagnose on NASH can bedefined by performing liver biopsy. The purpose of liver biopsy is to define level and degree of the disease. Cluster ofDifferentiation (CD) 44 is a transmembrane glycoprotein receptor which located on the surface of macrophage cells,lymphocytes and endothelial cells. In studies which conducted on mice and humans, showed that CD44 playsimportant role in the progression of NASH. CD44 regulates inflammation of adipose tissue and liver. CD44 ispresumed as a marker which increase macrophage infiltration and other inflammatory cells on liver. This processleads to ultimate increment on insulin resistance and fatty liver. Deficiency was discovered on mice which injectedwith methionine and choline deficiency diet (MCDD). CD44 is associated with preventive method to prevent livercomplication by reducing macrophage or monocyte and as well as neutrophil accumulation in liver which wasevaluated through reducing numbers of inflammatory focus, expression of inflammatory cytokines: tumor necrosisfactor α (TNFα), interleukin (IL) -1B and nitric oxide synthesis (iNOS), and pro-inflammatory types of macrophage. Inobese patients, number of CD44 is predicted to be increasing.

Ekspresi Programmed Death Ligand-1 (PD-L1) pada Seminoma Testis sebagai Potensi Faktor Prognostik Freciyana Boedijono; Budiana Tanurahardja; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs)and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expression seminoma indetermining overall survival (OS) and progression free survival (PFS).MethodsThis is a retrospective cohort study with survival analysis. Clinical data were obtained from medical record in RSUPN CiptoMangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological data were obtained fromAnatomical Pathology Department and PD-L1 immunohistochemical staining were performed.ResultsA significant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0.023) and PFS (p=0.002) in testicularseminoma was found. No significant correlation between PD-L1 expression in TILs with 2-year OS (p=0.235) and PFS (p=0.111).We also found significant correlations between PD-L1 expression of tumor cells and TILs with PFS (p=0.019). A significantcorrelation between stage with 2-year OS (p=0.010) and PFS (p=0.000) and lymph node metastases with 2-year OS (p=0.010) andPFS (p=0.000).ConclusionPD-L1 expression of testicular seminoma cells were significantly correlated with OS and PFS. There were no statistically significantassociations between PD-L1 expression in TILs with OS and PFS.

The effect of dadih in BALB/c mice on pro-inflammatory and anti-inflammatory cytokine productions Ria Kodariah; Hadits Lissentiya Armal; Heri Wibowo; Andi Yasmon
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The normal microflora formed as commensal bacteria have roles in maintaining homeostasis in the intestine tract. The reduction in the amount and on the diversity of the commensal bacteria lead to gastrointestinal dysbiosis which increase number of pathogens, induce inflammatory and can drive to colorectal cancer. Probiotics can be used to prevent, regulate, and modulate immune response by triggering the development of pathogen-specific memory. Currently, many foreign probiotic products are available in the market that cause the domestic products are less well known. Dadih is an original probiotic’s products originally from West Sumatra, Indonesia. It is made from fermented buffalo milk containing lactic acid bacteria (LAB). The objective of the study was to investigate the effect of dadih pro-inflammatory and anti-inflammatory cytokine production. The study was conducted using male BALB/c mice aged 6-8 weeks with body weight (BW) 20-30 g. Mice were given dadih at doses of 112 mg/20g BW for eight weeks. The results indicated that LAB bacteria in dadih are coccus, Gram-positive bacteria with 3x107 colony-forming units (CFU) and dominated by Lactococcus lactis subsp. lactis. In addition, the increase of both the anti-inflammatory cytokines (IL-10) and pro-inflammatory cytokines (TNF-α and IL-1β) was observed. In conclusion, the dadih can be used to maintain the immune system of mice.

Peranan Gen HOXA10 terhadap Infertilitas Terkait Endometriosis Salinah Salinah; Ria Kodariah; Puspita Eka Wuyung
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Endometriosis merupakan penyakit yang bersifat progresif, kronik, rekuren dan hingga saat ini etiologi pastinya belum diketahui. Gejala yang ditimbulkan endometriosis bervariasi mulai dari asimptomatik, nyeri pelvis hingga infertilitas. Beberapa studi terakhir di bidang biologi molekular menunjukkan adanya kemungkinan endometriosis sebagai penyakit epigenetik dan salah satu gen yang diketahui mengalami perubahan epigenetik adalah gen HOXA10. Gen HOXA10 berperan mengatur reseptivitas endometrium selama proses implantasi. Keberhasilan proses implantasi merupakan salah satu faktor yang berperan pada fertilitas wanita dan Gen HOXA10 memiliki peranan penting dalam proses implantasi tersebut. Metilasi gen HOXA10 mengalami peningkatan yang signifikan pada endometrium eutopik wanita yang mengalami endometriosis. Pada endometrium wanita yang mengalami endometriosis terdapat penurunan ekspresi HOXA10 yang signifikan dan hal tersebut mengindikasikan adanya gangguan pada reseptivitas uterus yang dapat berperan dalam menurunnya tingkat kesuburan.

The Effect of Pegagan (Centella Asiatica (L.) Urban) Ethanol Extracts on Hippocampal PSD-95 Protein Expression in Male Wistar Rats Adibah Ferhad; Auliyani Andam Suri; Astri Handayani; Sri Redjeki; Ria Kodariah
Majalah Obat Tradisional Vol 23, No 3 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

One effort to overcome the decline in memory function is through herbal medicine. Pegagan (Centella asiatica (L.) Urban) contain the active components of triterpenoid and flavonoids, has been known to be able to improve memory function. Synaptic plasticity is the basis of memory formation which is strongly influenced by synapse proteins such as PSD-95. Loss of PSD-95 protein can cause memory function decline. This study aims to determine the effect of 70% ethanol extract of pegagan toward PSD-95 protein expression on hippocampus of male Wistar rat. Eighteen male Wistar rats were randomly divided into 3 groups, 6 rats/group: group (1) given ethanol extract of pegagan with dose 300 mg / kgBW / day (CA300), (2) given ethanol extract of pegagan with dose 600 mg / kgBW / day (CA600), and (3) control group (K), given daily aquadest. All three groups were treated for 28 consecutive days. At the end of the treatment period, rats were decapitated and the hippocampus was isolated from the brain. Analysis of protein was done by immunohistochemical method. Statistical analysis was performed by One Way ANOVA parametric test followed by Post-Hoc Bonferroni. The results showed that there was no significant difference between group K and group CA300 (P = 0.123), whereas there were significant differences between CA600 group and K group and CA300 group (P = 0.000). From this research, it can be concluded that 70% ethanol extract of pegagan with dose 600mg / kgBW / day can increase expression of PSD-95 protein on hippocampus of male Wistar rat.

Environmental Enrichment and Aerobic Exercise Enhances Spatial Memory and Synaptophysin Expression in Rats Diah Ayu Aguspa Dita; Nurul Paramita; Ria Kodariah; Neng Tine Kartinah
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.945

BACKGROUND: Exposure to environmental enrichment has a positive effect on brain function, including improved cognition. Environmental enrichment has many aspects, including social interactions, object stimulations, and physical activities. Exercise and environmental enrichment can be considered to improve cognitive function with different underlying mechanisms. This study aims to compare the effects of environmental enrichment and aerobic exercise at both synaptic and whole-organism levels using synapyophysin as a measure of synaptic physiology and spatial memory as a measure of cognitive function.METHODS: A six-week in vivo experimental study on 15, 6-month old male Wistar rats randomly divided into three groups (n=5): aerobic group (A), enriched environment group (EE), and enriched with an aerobic or combined group (EEA). All rats were tested four times in the Water-E maze (WEM) task at weeks 0, 2, 4, and 6 of the study. We used immunohistochemistry to determine the synaptophysin expression in hippocampal CA1 region.RESULTS: Based on synaptophysin immunostaining, there were higher optical density scores for synaptophysin in hippocampal CA1 region following EEA, but there were no statistically significant differences between groups (ANOVA test, p>0.05). The spatial memory test showed there were significantly reduced travel time and total errors from the 2nd and 4th weeks in the EEA group, respectively (p<0.05).CONCLUSION: The combination of enriched environment and aerobic exercise seems to rapidly improve spatial memory and enhances the presynaptic protein, synaptophysin in hippocampal CA1 region.KEYWORDS: aerobic exercise, environmental enrichment, spatial memory, synaptophysin, Water-E maze

PENGARUH EKSTRAK METANOL DAUN SIRSAK (Annona muricata Linn.) TERHADAP VIABILITAS GALUR SEL KANKER PROSTAT Retno Yulianti; Ria Kodariah; Puspita Ekawuyung
Majalah Kedokteran Andalas Vol 37, No 3 (2014): Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakDaun sirsak mengandung senyawa aktif annonaceous acetogenins yang memiliki efek sitotoksik pada sel kanker. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun sirsak terhadap viabilitas dan peningkatan daya hambat terhadap galur sel kanker prostat PC3. Desain penelitian adalah eksperimental in vitro. Subyek penelitian adalah cell line PC3 yang terbagi 5 kelompok yaitu kelompok kontrol sel, kelompok perlakuan dengan ekstrak metanol daun sirsak (EMDS) dengan konsentrasi 6,25; 12,5 dan 25 mg/mL dan kelompok doksorubisin. Kelompok perlakuan diuji viabilitas sel dengan MTT assay pada inkubasi 0 dan 24 jam dan dilakukan pengamatan morfologi sel. Data dianalisis dengan uji statistik ANOVA. Hasil penelitian menunjukkan penurunan nilai OD pada kelompok EMDS 6,25 dan 12,5 ug/mL, namun uji statistik tidak berbeda bermakna dan kemampuan menghambat viabilitas sel paling besar ada pada kelompok EMDS 12,5 ug/mL (nilai OD 0,94). Pengamatan morfologi sel menunjukkan efek sitotoksik. Kesimpulan: Ekstrak metanol daun sirsak memiliki peran potensial sebagai antikanker terhadap galur sel kanker prostat PC3 meskipun sangat kecil efek penghambatannya.AbstractSoursop leaves contain annonaceous acetogenins active compounds that have a cytotoxic effect on cancer cells. The aim of this study is to determine the effect of soursop leaf extract on the viability and inhibitory rate on the prostate cancer cell line PC3. The study was an experimental in vitro study. Subjects were 5 groups of PC3 cell line: cell control group, the group treated with methanol extract of soursop leaves (EMDS) with the concentrations of 6.25; 12.5 and 25 mg/mL and the doxorubicin group. The groups were tested using the MTT cell viability assay at 0 and 24 hours of incubation followed by PC3 cell morphology examination. Data were analyzed by ANOVA test. The results showed a decrease in the OD value of 6.25 and 12.5 ug/mL EMDS group, but statistical tests did not differ significantly and the EMDS 12.5 mg/mL group showed the highest ability in inhibiting cell viability (OD 0.94). Observation of cell morphology showed cytotoxic effects. Conclusion: The methanol extract of soursop leaf has a potential as an anticancer against prostate cancer cell lines despite the very small inhibitory effect.

ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1) SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT Feriandri Utomo; Nurjati Chairani Siregar; Ria Kodariah
Majalah Kedokteran Andalas Vol 39, No 1 (2016): Published in April 2016
Publisher : Faculty of Medicine, Universitas Andalas

Penurunan kadar Zink (Zn) berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat, dan rendahnya Caspase-3 (eksekutor apoptosis). Ekspresi ZIP-1 (importer Zn) turun pada adenokarsinoma prostat. Korelasi ZnT-1 (eksporter Zn), ZIP-1 dan Caspase-3 diduga berpotensi menjadi faktor prognosis adenokarsinoma prostat. Penelitian ini bertujuan menganalisis korelasi ekspresi ZnT-1, ZIP-1, Caspase-3 dan skor Gleason adenokarsinoma prostat. Studi retrospektif analitik potong lintang dilakukan pada 14 kasus adenokarsinoma prostat skor Gleason ≤7 dan 16 kasus dengan skor Gleason >7. Ekspresi ZnT-1 dinilai dengan metode imunohistokimia. Analisis tambahan dilakukan untuk melihat korelasi ZnT-1, ZIP-1 dan Caspase-3. Hasil penelitian didapatkan ZnT-1 pada skor Gleason >7 lebih rendah daripada skor Gleason ≤7. ZnT-1 berkorelasi dengan skor Gleason. ZnT-1 berkorelasi dengan ZIP-1 pada skor Gleason >7. ZIP-1 berkorelasi dengan Caspase-3 pada skor Gleason ≤7. ZIP-1 berkorelasi kuat dengan Caspase-3 pada skor Gleason 8. Penelitian ini menyimpulkan rendahnya ekspresi ZnT-1 dan ZIP-1 berpotensi menjadi faktor prognosis adenokarsinoma prostat.

Analysis Expression of ZIP1 and Caspase-3 Protein in Adenocarsinoma of the Prostate Septiawan, Aditya D; Kodariah, Ria; Saraswati, Meilania
Makara Journal of Health Research Vol. 20, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells. Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyse the correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason Score. This was a cross-sectional, retrospective analytical study on 31 Formalin-fixed, paraffin-embedded tissue that meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3. Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from the cases' reports. The correlation of their expression with respect to Gleason score was analysed with Pearson's correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were 35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression (r = 0.379; p = 0.018). However, their correlation was stronger in intermediate-grade group (r = 0.73; p = 0.01) and the correlation was much weaker in high-grade group (r = 0.04; p = 0.48). Conclusions: There was a positive correlation between ZIP1 and Caspase-3 expression in prostate adenocarcinoma.

Co-Authors A. N. Kurniawan Adibah Ferhad Aditya D Septiawan Andi Yasmon Angeline Maranata Antonius N. Kurniawan Astri Handayani Auliyani Andam Suri Averdi Roezin Benedikta D. Saraswati Budiana Tanurahardja Desak Gede Budi Krisnamurti Desak Gede Budi Krisnamurti Dewi Sukmawati Dewi Sukmawati Diah Ayu Aguspa Dita Diah Rini Handjari Dwi A. Suryandari Dwi Anita Suryandari DWIKARJANTI, INDRANITA Endang S.R. Hardjolukito Ening Krisnuhoni Evelina Evelina Fanny Oktorina Feriandri Utomo Firda Asma'ul Husna Flora Dameria Freciyana Boedijono Handayani, Astri Hellyanti, Tantri Hening Pujasari Heri Wibowo Indranita Dwikarjanti Irwina Eka Deraya Katsuyuki Aozasa Kusumastuti, Sanindita Liem, Isabella Kurnia Luluk Yunaini Maria F. Ham Marini Stephanie Marini Stephanie Meilania Saraswati Meryanne Elisabeth Neng Tine Kartinah Almuktabar Nur Rahadiani Nurjati Chairani Siregar Nurul Paramita Primariadewi Rustamadji Puji Sari Puspita Eka Wuyung Puspita Eka Wuyung Puspita Eka Wuyung Puspita Eka Wuyung Puspita Ekawuyung Radietya Alvarabie Reni Oktavina Retno Yulianti Salinah Salinah Salinah Sarwanti Septiawan, Aditya D Shin-Ichi Nakatsuka Soehartati Gondhowiardjo Sophie Yolanda Sri Redjeki Tantri Hellyanti Wen-Juan Luo Yayi Dwina Yordana, William Yuda Nabella Prameswari Zakiyah Zakiyah

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