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All Journal VALENSI Jurnal Ilmiah Farmasi CHEMISTRY PROGRESS Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Riset Industri Hasil Hutan Pharmascience Berkala Kedokteran Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Teknologi Agro-Industri Chemistry Indonesian Journal of Chemical Research Acta Biochimica Indonesiana Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Jejaring Matematika dan Sains Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Gunung Djati Conference Series Herbal Medicine Journal Jurnal AGRISEP: Kajian Masalah Sosial Ekonomi Pertanian dan Agribisnis Jurnal Natural Scientiae Juragan (Jurnal Agroteknologi)
Noer Komari
Jurusan Kimia FMIPA Universitas Lambung Mangkurat
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Kajian Molecular Docking Senyawa Karwinaphthol B dari Tanaman Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Inhibitor Enzim Glukokinase Puji Astuty; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.5412

Abstract

Karwinaphthol B is a compound of the naphthoquinone group. Karwinaphthol B is a chemical compound found in Bawang Dayak. Karwinaphthol B is one of the compounds considered to have antidiabetic effects. Diabetes Mellitus is a chronic disease that occurs when the body cannot produce enough insulin or cannot use insulin (insulin resistance) which causes blood glucose levels to rise (hyperglycaemia) under normal conditions. This study aims to see the potential of karwinaphthol B as a glucokinase inhibitor with parameters such as ∆G value and interaction of amino acid residues with molecular docking and pharmacophore studies using filter Lipinski, pkCSM, and SwissADME. The results of molecular docking showed that karwinaphthol B compound had potential as antidiabetic based on the ∆G value of -8.39 kcal/mole. Karwinaphthol B compound has an LD50 value of 2.168 mole/kg which is included in the non-toxic category; does not have hepatotoxicity, skin sensitization, and has a good bioavailability value. The interaction of Karwinaphthol B compounds with glucokinase enzymes at amino acid residues VAL62, ARG63, SER64,THR65, PRO66,  GLU67, GLY68, SER69, GLN98, MET210 , ILE211, TYR214, TYR215, CYS220, GLU221, MET235,  CYS252, LEU451, VAL452, and VAL455.
Pembuatan dan Karakterisasi Arang Aktif dari Kayu Alaban (Vitex Pinnata L.) Menggunakan Asam Asetat Marisa Shellyanti; Noer Komari
Jurnal Natural Scientiae Vol 3, No 2 (2023): November 2023
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v3i2.9892

Abstract

Kayu alaban merupakan pohon yang dapat tumbuh di berbagai jenis tanah. Jenis arang kayu alaban memiliki karakteristik yang unggul dibandingkan dengan jenis arang lainnya. Arang kayu alaban memiliki kandungan karbon yang tinggi, yaitu sekitar 90%, sehingga arang kayu alaban menjadi salah satu bahan bakar yang sangat efisien dan ramah lingkungan. Arang kayu alaban cukup tersedia di pasar dan warung serta toko kelontong dan biasanya dipakai untuk kegiatan di dapur. Salah satu kelemahan arang tersebut adalah belum diaktivasi. Penelitian ini untuk mengetahui kualitas arang aktif dari kayu alaban dengan asam asetat sebagai aktivator. Hasil penelitian menunjukkan bahwa arang tanpa aktivasi dan sesudah aktivasi memenuhi aturan yang mengacu SNI 06-3730-95 untuk kadar air (3,955% dan 3,345%) dan kadar abu (1,865% dan 2,895%). Arang setelah aktivasi memiliki daya serap iodium sebesar 761,58 mg/g telah memenuhi syarat SNI 06-3730-95.
Kajian Molecular Docking Senyawa Quercetin dari Buah Terong Pokak (Solanum torwum Swartz) sebagai Antiinflamasi pada Protein Tumor Necrosis Factor-α (TNF-α) Lusi Thenios; Noer Komari
Jurnal Natural Scientiae Vol 2, No 1 (2022): Mei 2022
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jns.v2i1.4462

Abstract

Quercetin is a polyphenolic flavonoid with potential chemopreventive activity. Quercetin is a chemical compound found in Solanum torvum Sw fruit. Quercetin is one of the compounds that are considered to have anti-inflammatory effects. Inflammation is a localized protective response elicited by tissue damage caused by physical trauma, damaging chemicals, or microbiology. Tumor Necrosis Factor-α (TNF-α) is a proinflammatory cytokine that functions in mediating the innate immune response. Irregular production of cytokines can lead to various immunopathological conditions, including auto-inflammatory, autoimmune, and cancer-causing diseases. This study aims to determine the potential of quercetin compounds derived from turkey berry (Solanum torvum Sw.) which have the potential as anti-inflammatory drugs with parameters such as ∆G, the interaction of residues on TNF-α protein (PDB ID: 6X85) with molecular docking, and pharmacophore studies using Lipinski, pkCSM, and SwissADME filters. The molecular docking simulation results showed that the quercetin compound had a ∆G value of -8.55 kcal/mol and had amino acid residue interactions in the form of ILE155; TYR59; GLY121; TYR119; GLN61; TYR151; VAL123; LEU157; ILE58; GLY122; SER60; LEU120; LEU157. Quercetin has the potential as an anti-inflammatory drug on TNF- α protein with an LD50 value of 2.471; bioavailability value of 0.55; does not have hepatotoxicity and skin sensitization properties and has passed the Lipinski test.
Pemodelan Protein dengan Homology Modeling menggunakan SWISS-MODEL: Protein Modeling with Homology Modeling using SWISS-MODEL Komari, Noer; Hadi, Samsul; Suhartono, Eko
Jurnal Jejaring Matematika dan Sains Vol. 2 No. 2 (2020): Edisi Desember 2020
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2020.v2.i2.408

Abstract

The three-dimensional (3D) structure of proteins is necessary to understand the properties and functions of proteins. Determining protein structure by laboratory equipment is quite complicated and expensive. An alternative method to predict the 3D structure of proteins in the in silico method. One of the in silico methods is homology modeling. Homology modeling is done using the SWISS-MODEL server. Proteins that will be modeled in the 3D structure are proteins that do not yet have a structure in the RCSB PDB database. Protein sequences were obtained from the UniProt database with code A0A0B6VWS2. The results showed that there were two models selected, namely model-1 with the PDB code template 1q0e and model-2 with the PDB code template 3gtv. The results of sequence alignment and model visualization show that model-1 and model-2 are identical. The evaluation and assessment of model-1 on the Ramachandran Plot have a Favored area of ??97.36%, a MolProbity score of 0.79, and a QMEAN value is 1.13. Model-1 is a good 3D protein structure model.
PEMBUATAN HAND SANITIZER ALAMI DI DESA CEMPAKA BARU KOTA BANJARBARU Komari, Noer; Dwi Rasy Mujiyanti; Dewi Umaningrum; Dahlena Ariyani
Jurnal Pengabdian Kepada Masyarakat (MEDITEG) Vol. 6 No. 1 (2021): Jurnal Pengabdian Kepada Masyarakat (MEDITEG)
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat (P3M) Politeknik Negeri Tanah Laut (Politala)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/mediteg.v6i1.81

Abstract

The spread of Covid-19 was out of control and spread throughout Indonesia, including Banjarbaru which had a red zone. Desa Cempaka Baru Kota Banjarbaru is a transmigration settlement that is still safe against Covid-19. Even though it is safe, the community is quite at high risk of contracting it. People are required to comply with health protocols, especially cleaning their hands, including using a hand sanitizer. The demand for hand sanitizers in the market is increasing and the price is also rising, so an alternative is needed to make your own hand sanitizer. The aim of the activity is to educate village communities to make hand sanitizers by utilizing materials around their environment. The activity stages include socialization, implementation of making hand sanitizers, and evaluation. Assistance in the form of hand sanitizer products, hand washing stations, and banners advising the prevention of Covid-19 transmission were also provided to the public. The process of making hand sanitizers was demonstrated by students who helped with activities and involved 15 women who were members of the “Sasirangan Working Group”. The service product is a natural hand sanitizer made from lemongrass and betel leaves. The community was very enthusiastic about participating in this activity and promised to make their own later.
Potential of Chemical Compounds from Coloring Plants (Stenochlaena palutris) as Competitors for ALK Protein Damage Due To Pesticide Exposure: In Silico Study Sarmila, Sarmila; Nafisah, Nafisah; Habibah, Hanna; Saputri, Indah; Setiawati, Indah; Komari, Noer
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17415

Abstract

Pesticide active ingredients have widespread toxicity effects on target and non-target organisms. Continuous exposure to pesticides causes cancer. Kelakai is thought to have potential cytotoxic activity against the growth of cancer cells. The aim of this research is to examine the potential activity of chemical compounds on Anaplastic Lymphoma Kinase (ALK) proteins exposed to organophosphate pesticides in silico. Protein and ligand preparation with the Chimera program, Docking using SwissDock, as well as virtual screening using the pkCSM web and ProTox. Ethion and neophytadiene have the most negative ∆G values of -8.62 kcal/mol and -8.39 kcal/mol, respectively. The binding site for ethion and neophytadiene compounds with the ALK protein is right at the active site of the ALK protein. Ethion is the most toxic organophosphate pesticide and has the potential to be cytogenic. Neophytadiene from kelakai compounds has the potential to act as a competitor in inhibiting the ALK protein. The similarity in the type and number of binding residues in ethion and neophytadiene in the ALK protein indicates competition between ethion and neophytadiene.
Structural and Molecular Dynamics Investigation of Bacterial and Fungal Xylanases Komari, Noer; Sanjaya, Rahmat Eko; Putra, Andifa Anugerah; Putri, Amaris Nathania Hanindia; Febriyanti, Nur Fatma
Indonesian Journal of Chemical Research Vol 12 No 1 (2024): Edition for May 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.12-kom

Abstract

Xylanase is a type of enzyme that hydrolyzed of β-1,4 glycosidic bonds in xylan, breaking it down into its constituent monomers. Xylanolytic enzymes are pivotal in processes such as bio-bleaching of pulp, textile manufacturing, and the recycling of waste paper. Successful bioconversion of xylan or lignocellulose relies on the collaborative action of various xylanolytic enzymes, including endo-xylanase, β-xylosidase, and other accessory enzymes. Docking simulations using Auto Dock 4.2 were conducted to analyze the interaction between ligands and xylanase, utilizing PDB 1B3V and 1FCE. Ligand interaction with xylanase was further investigated through molecular dynamics. The xylanase from Penicillium simplicissimum (PDB 1B3V) exhibited comparable affinities for α-D-xylopyranose and β-D-xylopyranose. In contrast, the xylanase from Clostridium cellulolyticum (PDB 1FCE) demonstrated a stronger affinity for β-D-glucopyranose than for 4-thiouridine. Molecular dynamic investigations indicated the stability of both structures against the tested ligands. These findings provide a foundation for potential experimental validations and the application of molecular mechanics techniques. Such approaches could unveil the detailed catalytic mechanism and bolster the industrial efficacy of the enzyme.
Determination of Protein Content Protein from various growing places of Pineapple (Ananas comosus Merr.) komari, Noer; Rahmadi, Adi; Samsul Hadi
JURAGAN - Jurnal Agroteknologi Vol. 2 No. 1 (2024)
Publisher : Yayasan Rahmatan Fiddunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/juragan.v2i1.828

Abstract

Pineapple is a special plant that has a sweet and sour taste and has various benefits. Based on where the pineapple grows, the taste will vary. The aim of this research is to determine the protein content of pineapple based on where it grows. This research method is to determine Lowry protein levels using spectrophotometry. The results of this research were measurements of protein levels in peat areas, the protein concentration was 48.14 µg/mL. After conversion by dilution, the volume used resulted in a sample weight of 0.019 grams. When converted to a sampling weight of 80 grams, the sample weight in percent is 0.024%. Meanwhile, when measuring in a mountainous environment, a level of 40.99 µg/mL was obtained, this is equivalent to a sample weight of 0.016 grams, when divided by the sampling weight of 80 grams, a level of 0.021% w/w was obtained. When sampling was carried out in the lowlands, the protein level obtained was 45.39 µg/mL. So the protein obtained is 0.018 grams, when you calculate the % weight per weight you get a level of 0.022%. The conclusion of this research is that the highest protein content is pineapple that grows in a peat environment.
Potensi Senyawa Kimia Ekstrak Etanol Kelakai (Stenochlaena palustris) sebagai Antitrombotik Saputri, Indah; Setiawati, Indah; Mukarramah, Mukarramah; An’nisa, Windy Sidratul; Afdella, Nor Afni; Komari, Noer
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.129

Abstract

Damage to blood vessels begins with the formation of platelet aggregation which then forms a thrombus in the artery, resulting in disruption of blood flow. Many efforts have been made to prevent platelet aggregation using herbal medicines. Kelakai is a typical Kalimantan plant thought to have antithrombotic potential. The aim of this research is to identify the potential of kelakai ethanol extract compounds as antithrombotics through in silico studies using virtual screening and molecular docking. The kelakai compound was obtained from GC-MS data taken from the ethanol extract of kelakai. The virtual screening results showed that the results of GC-MS analysis of ethanol extract found five compounds that had the potential to be antithrombotic. Molecular docking simulations with the antithrombin receptor protein (PDB ID: 1E04) show that the n-Hexadecanoic acid compound from kelakai ethanol extract has the lowest ∆G value of -8.72 kcal/mol. The n-Hexadecanoic acid compound from kelakai has potential as an antithrombotic.
FARMERS' KNOWLEDGE ON REASONS NOT TO USE RICE STRAW IN PADDY FIELDS (CASE IN MANDIKAPAU BARAT VILLAGE, BANJAR REGENCY, SOUTH KALIMANTAN) Kadarsah, Anang; Komari, Noer; Prahatama Putra, Aminuddin; Sunardi; Eko Suhartono
Jurnal AGRISEP JURNAL AGRISEP VOL 22 NO 01 2023 (MARCH)
Publisher : Badan Penerbitan Fakultas Pertanian, Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.927 KB) | DOI: 10.31186/jagrisep.22.01.1-14

Abstract

This study aims to determine the reasons for not using rice straw in the rice field landscape of Mandikapau Barat Village, Banjar Regency. Landscape ecology data extracted from Google Maps. Types, rice production, farmer profiles, and knowledge of rice straw utilization were identified through interviews. The relationship between profile and reasons for not using rice straw was determined by bivariate analysis. Results showed that fragments’ shape is generally elongated (70%) and others hexagonal (30%). The corridor in dry rice fields is 40-50 cm narrow, while in wet rice fields, the embankment width is about 60-80 cm. The average ownership of rainfed rice fields was about ±3,917.6 m2. From nine rice field fragments observed, the average area was ±14,788.4 m2. The most widely grown local rice varieties are Siam Pandak Laut and Siam Cantik. The local rice production rate reached ±2.6 Ton Ha-1, while rice straw production was ±3.6 Ton Ha-1. Most respondents are women (76%), smallholders (80%), and aged 40-50 years (48%). Most respondents (84%) stated rice straw could not be used and had been passed down from generation to generation (64%). There was a relationship between gender and knowledge of straw utilization (p=0.036<0.050) and reasons for not using rice straw (p=0.021<0.050).
Co-Authors A.A. Ketut Agung Cahyawan W Abdullah Abdullah Adi Rahmadi Afdella, Nor Afni Ahmad Budi Junaidi Akmal Rizky Harun Amalia Khairunnisa Aminuddin Prahatama Putra Anang Kadarsah Anang Kadarsah, Anang Anjang Yudistri Annisa Rizqi Dwi Oktaviani An’nisa, Windy Sidratul Awin Fauzi Azidi Irwan Bambang Setiawan Dahlena Ariyani Desiya Ramayanti Azhara Dewi Umaningrum Diah Aulia Rosanti Dona Marisa, Dona Dwi Rasy Mujiyanti Dwi Rasy Mujiyanti Dwi Rasy Mujiyanti Eko Suhartono Eko Suhartono Erfanur Adlhani Etty Novita Febriyanti, Nur Fatma Fitri Hady Amrullah Habibah, Hanna HANNA HABIBAH Hanna Habibah Ina Risnawati INDAH SAPUTRI Indah Saputri INDAH SETIAWATI Indah Setiawati Kamilia Mustikasari Karlina Karlina Khoerul Anwar Kholifatu Rosyidah Laksono Trisnantoro Lisda Hayatie, Lisda Lusi Thenios Mardi Santoso Maria Dewi Astuti Marisa Shellyanti Megayulia Nooryaneti Melina Arini Sylvia Dewi Mirza Maulana Ahmad Mukarramah Mukarramah, Mukarramah Nadia Sasanti NAFISAH Nafisah Nafisah Nafisah Nafisah Ningtyas Indah Sari Noor Malinda Nurhidayati Pratiwi Prahatama Putra, Aminuddin Puji Astuty Putra, Andifa Anugerah Putri, Amaris Nathania Hanindia Rabiatul Adawiyah Rahmat Eko Sanjaya Rahmi Hardini Retno Agnestisia ROBIATUL ADAWIYAH Rusdiana Rusdiana Rusdiana Rusdiana Salmon Charles Pardomuan Tua Siahaan Samsul Hadi Samsul Hadi Samsul Hadi Saputri, Indah SARMILA Sarmila Sarmila Sarmila, Sarmila Siti Juliati Siti Ratna Jinan F Sri Hendriani Sujatmiko Sujatmiko Sujatmiko Sujatmiko Sunardi Sunardi Sunardi sunardi sunardi Sunardi, Ph.D., Sunardi Taslim Ersam Tri Ayu Novelena Umi Baroroh Lili Utami Utami Irawati Veronica Shania Aprillia Widiyanto, Gregorius Yenny Era Nova