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All Journal Jurnal Teknologi Dan Industri Pangan Microbiology Indonesia Alchemy : Journal of Chemistry Agrointek Journal of Food and Life Sciences Jurnal Pangan dan Agroindustri Jurnal Teknologi Pertanian Natural B Indonesian Journal of Human Nutrition agriTECH Majalah Kedokteran Sriwijaya BIOMA : Jurnal Biologi Makassar BIOEDUSCIENCE TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian Indonesian Journal of Halal Research Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) ZOOTEC Jurnal Ilmiah Pengabdian Kepada Masyarakat Journal of Research on Community Engagement
Joni Kusnadi
Fakultas Teknologi Pertanian, Universitas Brawijaya, Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Alchemy : Journal of Chemistry

 1 
Pengaruh Ekstrak Etanol 90% terhadap Kadar Malondialdehid (MDA) dan Superoksida Dismutase (SOD) Mencit Tikus yang Dipapar Asap Rokok Sutrisno Adi Prayitno; Joni Kusnadi; Erni Sofia Muritni
ALCHEMY:Journal of Chemistry Vol 6, No 1 (2018): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (743.954 KB) | DOI: 10.18860/al.v6i1.5018

Abstract

Cigarette smoke is a source of free radicals which cause human body organs damage when it is exposed. Cigarette smoke as a medium that causes oxidative stress that has the potential to cause oxidative damage. In addition, cigarette smoke also has potency to reduce SOD (Superoxide dismutase) levels and increase MDA (Malondialdehyde) levels especially in lung tissue. To control or prevent the presence of free radicals in the body, antioxidant compounds are needed by the body. The purpose of this research is to know the effect of the extract of red betle on SOD and MDA content of mice exposed to cigarette smoke. Red betle was extracted by maceration using ethanol. The exposed mice were treated with red betle extract for 14 days. Lung tissue of the mice was analyzed SOD and MDA conentrations. The results showed that SOD levels tend to increase and decrease MDA levels in mice test animals exposed to cigarette smoke. The optimal dose to decrease MDA levels and increase SOD is 230.4 mg/g weight/day. Histopatology result showed there is different figure of lung tissue (alveoli) before and after red betle extract treatment. Asap rokok adalah sumber radikal bebas yang dapat mengakibatkan rusaknya organ dalam tubuh manusia apabila terpapar. Asap rokok sebagai media penyebab terjadinya stress oksidatif yang berpotensi menyebabkan kerusakan oksidatif. Selain itu, asap rokok juga berpotensi dalam menurukan kadar SOD  (Superoksida Dismutase) dan meningkatkan kadar MDA (Malondialdehida) terutama pada jaringan paru. Untuk mengendalikan atau mencegah adanya radikal bebas ke dalam tubuh maka senyawa antioksidan dibutuhkan oleh tubuh. Tujuan penelitian adalah adalah mengetahui pengaruh ekstrak etanol daun sirih merah terhadap kadar SOD dan MDA mencit yang dipapar asap rokok. Daun sirih merah diekstrak menggunakan metode maserasi. Mencit yang telah dipapar asap rokok diberi perlakuan ekstrak selama 14 hari. Jaringan paru-paru dianalisis kadar MDA dan SOD. Hasil penelitian menunjukan kadar SOD cenderung mengalami peningkatan dan kadar MDA mengalami penurunan pada hewan uji mencit yang dipapar asap rokok. Dosis yang paling optimal untuk menurunkan kadar MDA dan menaikan SOD adalah dosis 230,4 mg/g bb/hari. Hasil histopatologi menunjukkan terdapat perbedaan gambaran jaringan paru-paru (alveoli) sebelum dan setelah perlakuan ekstrak. 
Co-Authors A'rasyiJ Imaduddin A.A. Ketut Agung Cahyawan W Adistia Ritri Prihandini Adistia Ritri Prihandini, Adistia Ritri Afifah Puji Hastuti Afifah Puji Hastuti, Afifah Puji Afla Tazakka Aj-juwita Afla Tazakka Aj-juwita Afriliana, Asmak AGUSTIN KRISNA WARDANI Agustin Mardiana, Nur Ahmad Zakiyul Wafi Ainina Ahmad Santoso Ali Masykur Ali Masykur Andayani, Dian Wuri Anik Ardianti Anik Ardianti Atmiral Ernes Ayu Fitriana Wulandari Baiq Dina Mariana Benediktus Hendra Perkasa Citra Firdhausi Citra Firdhausi Daimon Syukri Dedi Dedi Denta, Anggeria Oktavisa Dian Widya Ningtyas Dila Rahmawati Dr.Ir. Yunianta, DEA Dwi Esti Prayanti Dwi Ratnaningsih DWI SURYANTO Edi Priyo Utomo Elke Galuh Primurdia Elke Galuh Primurdia Elok Zubaedah Elok Zubaidah Endrika Widyastuti Endrika Widyastuti Eni Purwanti Eni Purwanti, Eni Erni Sofia Muritni Erni Sofia Murtini Erryana Martati Estri Laras Arumingtyas Estri Laras Arumingtyas Eunike Debora Purba Fadri, Rince Alfia Faiqotur Rohmania Feronika Heppy Sriherfyna Fitri Nurzanah Fitriyana, Nurul Isnaini Freini Dessi Efendi Hakiki, Hilda Maghfirotu Hamidin Rasulu Hana Susanti Maleta Hannes Dwi Novia Hariry, Amelia Hasria Alang Herlambang, Dwi Hernandi, Kevin Hohn Hilda Maghfirotu Hakiki Ima Andriastuti IS HELIANTI Ito, Nobutaka Jamhari Jamhari Jaya Mahar Maligan Kartika Cahyania Pratiwi Kevin Hohn Hernandi Khairul Ambri Khotibul Umam Al-Awwaly Khotibul Umam Al-Awwaly Khusnul Khotimah Khusnul Khotimah KIKI FIBRIANTO Lenny Yudha Febriyanti Lenny Yudha Febriyanti Lia Ratnawati Lilis Karlina Malsa Fian Yana Malsa Fian Yana Mega Kristanti Ayuratri Muhammad Reza Ramadhana Muhammad Reza Ramadhana, Muhammad Reza Nazir, N Nenu Maria Ovy Sonia Nenu Maria Ovy Sonia Nisa Harmia Yuliasih Noor Hidayat, Noor Novi Vensia Magdalena Novi Vensia Magdalena Novita Wijayanti Nur Istianah Nur Istianah Nur Kusmiyati Pamulanti, Anjar Pebiningrum, Arlinda Pendik Setiawan Pratiwi Anggun Retnowati Pratiwi Anggun Retnowati Putri, Annisyia Zarina Raida Amelia Ifadah Raida Amelia Ifadah Rif'ah, Hamidah Itha'atur RIMA AZARA Rinelda Ayu Sintasari Rinelda Ayu Sintasari Rukmi, Widya Dwi Septi, Nur Diana Shanty Karinawatie Sudarma Dita Wijayanti Sudarma Dita Wijayanti Sudarminto Setyo Yuwono Suharjono Suharjono Suharjono Suharjono, Suharjono Sutik Rahayu Endah Sutrisno Adi Prayitno Suwasono, Sony Tabitha Larasati Tabitha Larasati Tanti Untari Tanti Untari Teti Estiasih Titis Sari Kusuma Tri Ardyati Tri Ardyati Try Ardyati Tutik Murniasih Tuty Anggraini Vivi Retno Sari Vivi Retno Sari Widya Dwi Rukmi Putri Yan Abdi Nugroho Yan Abdi Nugroho Yohana Lydia Rissa Tanjung Yohana Lydia Rissa Tanjung Zuliyaningsih Zuliyaningsih