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All Journal The Indonesian Biomedical Journal Jurnal Pendidikan Matematika (Kudus) JKM (Jurnal Kebidanan Malahayati) Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan G-Couns: Jurnal Bimbingan dan Konseling Journal of Educational Learning and Innovation (ELIa) Jurnal Studi Islam dan Kemuhammadiyahan (JASIKA) Jurnal Mebang AL HAZIQ: Journal of Community Service Jurnal Kesehatan Metro Sai Wawai
Sri Lestariningsih
Program Studi Kebidanan Metro Poltekkes Kemenkes Tanjungkarang
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Profil Berpikir Matematis Siswa Tunagrahita Sa’ady, Ma’rufatin Nurus; Lestariningsih, Sri
Jurnal Pendidikan Matematika Vol 2, No 2 (2019): Jurnal Pendidikan Matematika (Kudus)
Publisher : Universitas Islam Negeri Sunan Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21043/jpm.v2i2.6362

Abstract

Penelitian ini bertujuan untuk mendeskripsikan profil berpikir matematis siswa tunagrahita di kelas II SLBN Kaliwungu Kudus. Penelitian ini bersifat deskriptif kualitatif. Teknik pengumpulan data meliputi observasi, wawancara, dan dokumentasi. Hasilnya siswa tunagrahita kelas II SLBN Kaliwungu merupakan siswa yang mampu mengenal angka 1-11, mampu berhitung 1-20, mau belajar dan tanggap, namun guru harus mampu membimbing. lebih eksklusif. Peran orang tua juga mempengaruhi perkembangan siswa, orang tua harus selalu memperhatikan tumbuh kembang anak, serta terus mendukung dan memotivasi. This research aims to describe the profile of mathematical thinking of mentally retarded students in class II of SLBN Kaliwungu Kudus. This research is a descriptive qualitative. Data collection techniques include observation, interviews, and documentation. The result that the mentally retarded students of the second grade of SLBN Kaliwungu were students who were able to recognize numbers 1-11, were able to count 1-20, willing to learn and be responsive, but the teacher had to be able to guide more exclusively. The role of parents is also influence student development, parents must always pay attention to the child's growth and development, and continue to support and motivate.
Co-Authors Aminati, Wahyu Anggraini, Yetti Azam Syukur Rahmatullah, Azam Syukur Bambang Purwanto Brahmana, Ivanna Beru Brian Wasita Eka Tri Wulandari, Eka Tri Eti Poncorini Pamungkasari Fatonah, Anna Khabibah, Febriyanti Umi Lestari, Gangsar Indah Maksum, Yusro Hadi MULYOTO PANGESTU Oktaviani, Danissa Dyah Purnomo, Halim Rita Cempaka Rofana Aghniya Sa’ady, Ma’rufatin Nurus Sa’ady, Ma’rufatin Nurus Siti Khoiriyah Siti Maesaroh Soetrisno Soetrisno Uki Retno Budihastuti Wahyu Nanda Eka Saputra, Wahyu Nanda Eka Widiyanti, Septi Wijayanti, Yoga Tri Yuliawati Yustiza, Non Rachmani