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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmu Dasar AL KAUNIYAH Indonesian Journal of Cancer Chemoprevention UNEJ e-Proceeding Jurnal ORTOPEDAGOGIA BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) NurseLine Journal Jurnal SOLMA Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Buletin Ilmiah Nagari Membangun INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Livestock and Animal Research EduInovasi: Journal of Basic Educational Studies Jurnal Kesehatan Masyarakat
Kiky Martha Ariesaka
Universitas Negeri Malang
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Bioinformatics study of the A222V substitution in SARS-CoV-2 Spike Protein Ariesaka, Kiky Martha; Nuryady, Moh Mirza; Rini, Ika Agus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39242

Abstract

COVID-19, caused by SARS-CoV-2, has infected over 200 million people and caused 4.3 million deaths globally, with over 3.7 million cases and 110,000 deaths in Indonesia. SARS-CoV-2, a single-stranded RNA virus, has a genome encoding proteins such as Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). The S protein, comprising S1 and S2 domains, facilitates ACE2 receptor binding and membrane fusion. This study examines the phylogenetic relationship of the A222V substitution in the S protein with various global isolates. We collected 25 complete SARS-CoV-2 sequences from the GISAID database, performed multiple sequence alignments using Clustal W in MEGA-X software, and constructed phylogenetic trees using the neighbor-joining method. The urgency of this paper lies in understanding the impact of the A222V mutation on the virus's infectivity and spread, which is crucial for developing targeted treatments and vaccines. The A222V variant, first identified in Spain in summer 2020, has spread rapidly across Europe, raising concerns about its potential to increase transmissibility or affect vaccine efficacy. The A222V variant likely affects protein conformation or stability rather than receptor binding or membrane fusion. Understanding these changes is essential as it can influence the virus's behavior and efficacy of public health interventions. The study found high mutation rates in the S gene with diverse point mutations. Phylogenetic analysis revealed that A222V isolates clustered closely with D614G variants. In conclusion, not all mutations result in amino acid changes, and A222V has minimal impact on ACE2 binding but may influence protein stability.
Co-Authors Agil Wahyu Wicaksono Agung Kurniawan Ain Yuanita Insani Ain Yuanita Insani Al Munawir Aldina, Siti Nur Anditri Weningtyas Andreas Budi Wijaya Ardhanu Kusumanto Arif Ladika Aulia, Sabrina Auliarahama, Zhafirah Auliarahma, Zhafirah Azka Darajat Bakhtiar, Fannia Yosa Brilliant Givya Ariansari Brilliant Givya Ariansari Devi, Athaayaa Nastiti Ulayya Diani Fatmawati Editya Fukata Elly Purwanti Erfan Efendi Fanani, Erianto Fannia Yosa Bakhtiar Faridatus Solikha Fatmawati, Diani Fuad Adi Prasetyo Fuad Adi Prasetyo Fuad Jaya Miharja Fulviansyah, Zaidhan Lucano Ganes, Tegar Gelaner, Nauval Akhmadian Haryono, Putri Dwinita Hilda Khairinnisa Hilma Tsurayya Iftitahurroza Iftitahurroza, Hilma Tsurayya Iftitahurroza, Iftitahurroza Ika Agus Rini, Ika Agus Ika Rahmawati Sutejo Ika Wahyuni Inggita Utami Juliana, Levina Imelda Khodijah Khodijah Khoiriyah, Zakiyatul Khoiro, Aisha Azaria Nisa’ul KURNIAWATI, ANDINI Ladika, Arif Lintang Widya Sishartami Lintang Widya Sishartami Maliza, Rita Manggolono, Lintang Nirmalasari Gemalochaya Mochammad Yunus, Mochammad Moh Mirza Nuryady, Moh Mirza Moh. Mirza Nuryady Mudzakir Taufiqurrahman Mudzakkir Taufiqurrahman Mudzakkir Taufiqurrqhman Nanang Tri Wahyudi Nazila, Farah Nungki Anggorowati Prasetya, Ahmada Viosepta Purwanti, Elly Putra, Alvino Ramadhany Putri, Adhiena Liany Anastasia Putri, Angelica Igsanti Qurrataa'ayun, Ahmad Al Siti Nur Aldina Sri Wahyuni Sri Wahyuni Suhartanti, Ajeng Sri Susetyarini, Rr Eko Tsurayya, Hilma Tutut Indria Permana Ulfa, Darlah Immaria Wahyu Dian Puspita Wahyuni, Sri Widya Sishartami, Lintang Wiratama, Arif Ladika Zakiyatul Khoiriyah Zucha, Muhammad Ary