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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmu Dasar AL KAUNIYAH Indonesian Journal of Cancer Chemoprevention UNEJ e-Proceeding Jurnal ORTOPEDAGOGIA BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal SOLMA Jurnal Biologi Tropis Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Mandala Pengabdian Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat EduInovasi: Journal of Basic Educational Studies Sasambo: Jurnal Abdimas (Journal of Community Service) Jurnal Kesehatan Masyarakat
Kiky Martha Ariesaka
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Reconciling Contradictory Findings: In Silico Evaluation of Annonacin’s Antimalarial Efficacy and Safety Tsaqif, Anindya Zerlina; Khodijah, Khodijah; Prayogi, Fahrizal Ryuzen; Nuryady, Moh Mirza; Ariesaka, Kiky Martha
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39412

Abstract

Introduction. With the increasing resistance to existing antimalarial therapies, the discovery of new drugs has become urgent. Annona muricata contains phenolic compounds with antioxidant potential and bioactive properties, including annonaceous acetogenins, which exhibit cytotoxicity, raising safety concerns. Conversely, other studies have shown significant antimalarial activity from A. muricata extracts without observed toxicity, suggesting its potential as a lead compound for malaria treatment. This inconsistency calls for further investigation, particularly through in silico analyses, to clarify the interactions between these compounds and key malaria targets. Aim. This study employs in silico methods to explore Annonacin’s binding affinity to malaria proteins, PfDHODH and PfLDH, and evaluates its toxicity and bioavailability. Methods. Molecular docking was conducted using Molegro Virtual Docker (MVD) version 6.0 to assess Annonacin’s binding interactions with PfDHODH and PfLDH. Toxicity was analyzed using ProTox-II, focusing on cytotoxicity and LD50 value. Pharmacokinetic properties, including gastrointestinal absorption and adherence to Lipinski’s rule of five, were evaluated using SwissADME. Results. Docking results revealed that Annonacin forms stable complexes with both proteins, suggesting strong inhibitory potential. However, toxicity analysis highlighted significant cytotoxic effects, with an LD50 of 400 mg/kg placing Annonacin in Toxicity Class IV, indicating ingestion risks. Pharmacokinetic analysis revealed challenges such as low gastrointestinal absorption and a violation of Lipinski’s rule due to high molecular weight. Conclusion. These findings suggest Annonacin has antimalarial potential, but its development is hindered by safety concerns and pharmacokinetic limitations. Further optimization is needed to balance efficacy with safety, providing a foundation for future research and development.
Transformasi Perilaku Hidup Bersih dan Sehat Melalui Model Edukasi Berbasis Komunitas di Pondok Pesantren Nurul Ulum Putri Malang Iftitahurroza, Hilma Tsurayya; Sishartami, Lintang Widya; Ariesaka, Kiky Martha; Weningtyas, Anditri; Kurniawati, Andini; Qurrataa'yun, Ahmad Al; Aulia, Sabrina; Auliarahma, Zhafirah; Manggolono, Lintang Nirmalasari Gemalochaya
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.21347

Abstract

Pendahuluan: Pondok pesantren memiliki peran strategis dalam membentuk karakter dan perilaku santri, namun kondisi kesehatan di lingkungan pesantren masih memerlukan perhatian, terutama terkait penerapan Perilaku Hidup Bersih dan Sehat (PHBS). Di Pondok Pesantren Nurul Ulum Putri Malang, masih ditemukan rendahnya pemahaman dan praktik PHBS di kalangan santri, sehingga diperlukan upaya edukasi yang kontekstual dan partisipatif. Metode: Ceramah interaktif, diskusi, demonstrasi praktik, dan pendampingan kader santri sehat. Hasil: Nilai rata-rata pretest sebesar 78,63 meningkat menjadi 87,87 pada postest, dengan nilai p = 1,0059 × 10⁻⁵ (p < 0,001), menunjukkan peningkatan signifikan pengetahuan santri setelah edukasi. Santri menunjukkan antusiasme tinggi dan mulai menerapkan perilaku sehat seperti menjaga kebersihan diri, lingkungan, dan sanitasi. Kesimpulan: Edukasi PHBS berbasis komunitas terbukti efektif meningkatkan pengetahuan dan sikap santri terhadap perilaku hidup bersih dan sehat di pesantren.
Pendampingan Pengolahan Produk Kreatif Resin Berbahan Anggrek sebagai Kerajinan Tangan Masyarakat Desa Dadaprejo, Kota Batu Nuryady, Mohammad Mirza; Permana, Tutut Indria; Fatmawati, Diani; Levina, Levina; Juliana, Imelda; Janufian, Fairus Athar; Ariesaka, Kiky Martha
Sasambo: Jurnal Abdimas (Journal of Community Service) Vol. 8 No. 2 (2026): Mei
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/4km80049

Abstract

Pandemi Covid-19 memberikan dampak yang luar biasa terhadap kehidupan sosial bermasyarakat utamanya di sektor ekonomi. Industri Ekonomi kreatif memiliki peran yang sangat besar dalam roda perekonomian, oleh karena itu dibutuhkan upaya untuk mendukung ekonomi kreatif warga. Desa wisata anggrek Dadaprejo terkenal dengan tumbuhan anggreknya, umumnya bunga anggrek akan gugur dan menjadi limbah dalam beberapa minggu. Hal ini menjadi peluang agar bunga anggrek tetap dapat memiliki nilai ekonomis dengan dijadikan kerjainan tangan berupa resin anggrek. Kegiatan ini bertujuan untuk melatih warga agar dapat memanfaatkan bunga anggrek sebelum menjadi limbah untuk dimanfaatkan menjadi produk kerajinan tangan yang dapat membantu perekonomian warga. Target dari kegiatan ini adalah pertama masyarakat di sekitar wisata anggrek dapat memanfaatkan sumber daya yang ada untuk dijadikan produk kerajinan kreatif untuk meningkatkan ekonomi serta dengan adanya kerajinan tangan tersebut dapat semakin mendukung wisata desa anggrek. Hasil kegiatan ini terdapat kelompok masyarakat yang berhasil menjadikan resin anggrek ini sebagai usaha yang berkelanjutan dengan penjualan di bulan pertama mencapai dua kali lipat modal awal. Selain itu pemahaman masyarakat tentang industry kreatif serta pengetahuan tentang pengolahan resin sebagai kerajinan tangan menunjukkan adanya peningkatan pemahaman. Assistance in Processing Creative Orchid Resin Products as Handicrafts for the Dadaprejo Village Community, Batu City The Covid-19 pandemic has had a tremendous impact on social life, especially in the economic sector. The creative economy industry has a very large role in the economy; therefore, efforts are needed to support the citizens' creative economy. The Dadaprejo Orchid Tourism Village is famous for its orchid plants, mostly orchids fall and become waste within a few weeks. This is an opportunity so that orchids can still have economic value by being made into hands in the form of orchid resin. This activity aims to train residents to be able to use orchids before they become waste to be used as handicraft products that can help the local economy. The target of this activity is first that the community around orchid tourism can take advantage of existing resources to be used as creative craft products to improve the economy and with these handicrafts they can support orchid village tourism. As a result of this activity, there were community groups who succeeded in making this orchid resin a sustainable business with sales in the first month reaching double the initial capital. In addition, the public's understanding of the creative industry as well as about resin processing as a handicraft shows an increase in understanding.
Co-Authors Agil Wahyu Wicaksono Agung Kurniawan Ain Yuanita Insani Ain Yuanita Insani Al Munawir Aldina, Siti Nur Anditri Weningtyas Andreas Budi Wijaya Ardhanu Kusumanto Arif Ladika Aulia, Sabrina Auliarahama, Zhafirah Auliarahma, Zhafirah Azka Darajat Bakhtiar, Fannia Yosa Brilliant Givya Ariansari Brilliant Givya Ariansari Devi, Athaayaa Nastiti Ulayya Diani Fatmawati Editya Fukata Elly Purwanti Erfan Efendi Fanani, Erianto Fannia Yosa Bakhtiar Faridatus Solikha Fatmawati, Diani Fuad Adi Prasetyo Fuad Adi Prasetyo Fuad Jaya Miharja Fulviansyah, Zaidhan Lucano Ganes, Tegar Gelaner, Nauval Akhmadian Haryono, Putri Dwinita Hilda Khairinnisa Hilma Tsurayya Iftitahurroza Iftitahurroza, Hilma Tsurayya Ika Agus Rini, Ika Agus Ika Rahmawati Sutejo Ika Wahyuni Inggita Utami Ismaya, Matius Dimas Reza Dana Janufian, Fairus Athar Juliana, Imelda Juliana, Levina Imelda Khodijah Khodijah Khoiriyah, Zakiyatul Khoiro, Aisha Azaria Nisa’ul KURNIAWATI, ANDINI Levina Levina, Levina Lintang Widya Sishartami Lintang Widya Sishartami Maliza, Rita Manggolono, Lintang Nirmalasari Gemalochaya Mochammad Yunus, Mochammad Moh Mirza Nuryady, Moh Mirza Moh. Mirza Nuryady Mudzakir Taufiqurrahman Mudzakkir Taufiqurrahman Mudzakkir Taufiqurrqhman Nanang Tri Wahyudi Nazila, Farah Nungki Anggorowati Prasetya, Ahmada Viosepta Prayogi, Fahrizal Ryuzen Purwanti, Elly Putra, Alvino Ramadhany Putri, Adhiena Liany Anastasia Putri, Angelica Igsanti Qurrataa'ayun, Ahmad Al Qurrataa'yun, Ahmad Al Siti Nur Aldina Sri Wahyuni Sri Wahyuni Suhartanti, Ajeng Sri Susetyarini, Rr Eko Tsaqif, Anindya Zerlina Tutut Indria Permana Ulfa, Darlah Immaria Wahyu Dian Puspita Wahyuni, Sri Wibisono, Taurisma Aulia Nanda Widya Sishartami, Lintang Wiratama, Arif Ladika Zakiyatul Khoiriyah Zucha, Muhammad Ary