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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmu Dasar AL KAUNIYAH Indonesian Journal of Cancer Chemoprevention UNEJ e-Proceeding Jurnal ORTOPEDAGOGIA BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) NurseLine Journal Jurnal SOLMA Jurnal Biologi Tropis Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Mandala Pengabdian Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Livestock and Animal Research EduInovasi: Journal of Basic Educational Studies Jurnal Kesehatan Masyarakat
Kiky Martha Ariesaka
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulation and Characterization Profile of Sugarcane (Saccharum officinarum L.) Leaf Extract Emulsion Sishartami, Lintang Widya; Weningtyas, Anditri; Ariesaka, Kiky Martha; Wiratama, Arif Ladika; Wibisono, Taurisma Aulia Nanda
Jurnal Biologi Tropis Vol. 25 No. 4b (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4b.10932

Abstract

Sugarcane (Saccharum officinarum L.) leaves contain various bioactive compounds, which exhibit antioxidant and pharmacological potential. However, their application in pharmaceutical preparations faces challenges due to low solubility, stability, and bioavailability. Therefore, the development of an emulsion formulation is needed to improve its stability and absorption. This study aims to determine the phytochemical content of sugarcane leaf extract and to evaluate the physical stability of its emulsion formulation. The extraction was obtained through maceration using 96% ethanol, followed by phytochemical screening. Emulsions were prepared using sugarcane leaf extract as the active ingredient, Virgin Coconut Oil (VCO) as the oil phase, Tween 80 as a surfactant, and PEG 400 as a co-surfactant. The formulations were tested for organoleptic properties, emulsion type, percent transmittance, pH, particle size, polydispersity index, zeta potential, centrifugation, and cycling stability. The results showed that sugarcane leaf extract contained flavonoids, alkaloids, tannins, phenols, triterpenoids, and saponins. Among the four tested formulas, F1 and F2 showed the best stability, with pH 6–7, high percent transmittance, uniform particle size with polydispersity index <0.3, and absence of phase separation. These findings suggest that F1 and F2 represent optimal emulsion formulations for further pharmaceutical development.
SANTERA (Santri Sehat Terawat): Edukasi Penyakit Menular Berbasis Lingkungan dan Gaya Hidup Sehat bagi Santri Ariesaka, Kiky Martha; Sishartami, Lintang Widya; Weningtyas, Anditri; Iftitahurroza, Hilma Tsurayya; Ismaya, Matius Dimas Reza Dana; Wiratama, arif Ladika; Wibisono, Taurisma Aulia Nanda; Bakhtiar, Fannia Yosa
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.672

Abstract

Lingkungan pesantren yang padat dan komunal menyebabkan santri rentan terhadap penyakit menular serta gaya hidup tidak sehat. Berdasarkan hasil wawancara dengan guru, ditemukan masalah kesehatan yang dominan seperti skabies, diare, serta kelelahan akibat kebiasaan menahan buang air besar dan melewatkan sarapan. Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan kesadaran santri mengenai pentingnya kebersihan diri dan gaya hidup sehat melalui edukasi kesehatan kontekstual. Kegiatan dilaksanakan dalam tiga tahap kunjungan dan menggunakan pendekatan model ADDIE yang mencakup analisis kebutuhan, perancangan materi, pengembangan media edukatif berupa presentasi dan flyer, pelaksanaan edukasi secara interaktif kepada santri, serta evaluasi menggunakan kuesioner kepuasan. Hasil menunjukkan bahwa seluruh indikator kepuasan memperoleh skor rerata tinggi, berkisar antara 76,5% hingga 83%, dengan kategori sangat baik. Selain itu, peserta menunjukkan antusiasme dan partisipasi aktif selama sesi edukasi, serta adanya niat untuk menerapkan dan menyebarluaskan informasi yang diperoleh. Tim pengabdian juga memberikan dukungan fasilitas kesehatan berupa alat kebersihan, alat pemeriksaan sederhana, dan obat-obatan umum yang dibutuhkan oleh Unit Kesehatan Pesantren. Kegiatan ini memberikan dampak positif jangka pendek dalam hal peningkatan pengetahuan dan kesadaran, serta memperkuat kapasitas kelembagaan dalam menjaga kesehatan santri. Oleh karena itu, program ini dinilai berhasil mencapai tujuannya dan berpotensi untuk direplikasi di lingkungan pesantren lainnya dengan penyesuaian konteks lokal.
Reconciling Contradictory Findings: In Silico Evaluation of Annonacin’s Antimalarial Efficacy and Safety Tsaqif, Anindya Zerlina; Khodijah, Khodijah; Prayogi, Fahrizal Ryuzen; Nuryady, Moh Mirza; Ariesaka, Kiky Martha
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39412

Abstract

Introduction. With the increasing resistance to existing antimalarial therapies, the discovery of new drugs has become urgent. Annona muricata contains phenolic compounds with antioxidant potential and bioactive properties, including annonaceous acetogenins, which exhibit cytotoxicity, raising safety concerns. Conversely, other studies have shown significant antimalarial activity from A. muricata extracts without observed toxicity, suggesting its potential as a lead compound for malaria treatment. This inconsistency calls for further investigation, particularly through in silico analyses, to clarify the interactions between these compounds and key malaria targets. Aim. This study employs in silico methods to explore Annonacin’s binding affinity to malaria proteins, PfDHODH and PfLDH, and evaluates its toxicity and bioavailability. Methods. Molecular docking was conducted using Molegro Virtual Docker (MVD) version 6.0 to assess Annonacin’s binding interactions with PfDHODH and PfLDH. Toxicity was analyzed using ProTox-II, focusing on cytotoxicity and LD50 value. Pharmacokinetic properties, including gastrointestinal absorption and adherence to Lipinski’s rule of five, were evaluated using SwissADME. Results. Docking results revealed that Annonacin forms stable complexes with both proteins, suggesting strong inhibitory potential. However, toxicity analysis highlighted significant cytotoxic effects, with an LD50 of 400 mg/kg placing Annonacin in Toxicity Class IV, indicating ingestion risks. Pharmacokinetic analysis revealed challenges such as low gastrointestinal absorption and a violation of Lipinski’s rule due to high molecular weight. Conclusion. These findings suggest Annonacin has antimalarial potential, but its development is hindered by safety concerns and pharmacokinetic limitations. Further optimization is needed to balance efficacy with safety, providing a foundation for future research and development.
Co-Authors Agil Wahyu Wicaksono Agung Kurniawan Ain Yuanita Insani Ain Yuanita Insani Al Munawir Aldina, Siti Nur Anditri Weningtyas Andreas Budi Wijaya Ardhanu Kusumanto Arif Ladika Aulia, Sabrina Auliarahama, Zhafirah Auliarahma, Zhafirah Azka Darajat Bakhtiar, Fannia Yosa Brilliant Givya Ariansari Brilliant Givya Ariansari Devi, Athaayaa Nastiti Ulayya Diani Fatmawati Editya Fukata Elly Purwanti Erfan Efendi Fanani, Erianto Fannia Yosa Bakhtiar Faridatus Solikha Fatmawati, Diani Fuad Adi Prasetyo Fuad Adi Prasetyo Fuad Jaya Miharja Fulviansyah, Zaidhan Lucano Ganes, Tegar Gelaner, Nauval Akhmadian Haryono, Putri Dwinita Hilda Khairinnisa Hilma Tsurayya Iftitahurroza Iftitahurroza, Hilma Tsurayya Ika Agus Rini, Ika Agus Ika Rahmawati Sutejo Ika Wahyuni Inggita Utami Ismaya, Matius Dimas Reza Dana Juliana, Levina Imelda Khodijah Khodijah Khoiriyah, Zakiyatul Khoiro, Aisha Azaria Nisa’ul KURNIAWATI, ANDINI Lintang Widya Sishartami Lintang Widya Sishartami Maliza, Rita Manggolono, Lintang Nirmalasari Gemalochaya Mochammad Yunus, Mochammad Moh Mirza Nuryady, Moh Mirza Moh. Mirza Nuryady Mudzakir Taufiqurrahman Mudzakkir Taufiqurrahman Mudzakkir Taufiqurrqhman Nanang Tri Wahyudi Nazila, Farah Nungki Anggorowati Prasetya, Ahmada Viosepta Prayogi, Fahrizal Ryuzen Purwanti, Elly Putra, Alvino Ramadhany Putri, Adhiena Liany Anastasia Putri, Angelica Igsanti Qurrataa'ayun, Ahmad Al Siti Nur Aldina Sri Wahyuni Sri Wahyuni Suhartanti, Ajeng Sri Susetyarini, Rr Eko Tsaqif, Anindya Zerlina Tutut Indria Permana Ulfa, Darlah Immaria Wahyu Dian Puspita Wahyuni, Sri Wibisono, Taurisma Aulia Nanda Widya Sishartami, Lintang Wiratama, Arif Ladika Zakiyatul Khoiriyah Zucha, Muhammad Ary