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Cempedak leaf extract (Artocarpus champeden) as a novel ingredient in antibacterial peel-off gel face masks Putri, Faizah Alivia; Widia, Widia; Syarmila, Syarmila; Mahardika, Robby Gus
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4920

Abstract

Background: Phenolic compounds in plants act as natural antioxidants, with cempedak (Artocarpus champeden) leaf extract showing promise due to its high phenolic content and potential antibacterial properties against Propionibacterium acnes. Objective: This study explores the effectiveness of cempedak leaf extract as an active ingredient in peel-off gel face masks for antibacterial purposes. Methods: Cempedak leaf extract was analyzed for phenolic content and Fourier transform infrared (FTIR). Its antibacterial activity was tested against P. acnes using agar diffusion, comparing inhibition zones with positive control. A peel-off gel face mask was formulated with cempedak leaf extract, undergoing physical and an irritation test. Results: Cempedak leaf extract contained a total phenolic content of 342.35 mg EAG/g and exhibited significant antibacterial activity. The face mask formulation with cempedak leaf extract showed promising physical properties and did not irritate, meeting the peel-off gel face mask standards. Conclusion: Cempedak leaf extract has potent antibacterial properties, making it an effective ingredient in peel-off gel face masks for treating acne. Further research could explore its commercial potential in skincare products.
Aktivitas Antioksidan dan Fitokimia dari Ekstrak Etil Asetat Pucuk Idat (Cratoxylum glaucum) Mahardika, Robby Gus; Roanisca, Occa
Indonesian Journal of Chemical Research Vol 5 No 2 (2018): Edisi Bulan Januri (Edition For January)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2018.5-rob

Abstract

Neutralizing free radicals can use both synthetic and natural antioxidant compounds. Although synthetic antioxidant compounds are more active, but lately the use of synthetic antioxidants is being reduced because they are reported to have carcinogenic side effects. Natural antioxidant compounds found in plants are phenolic groups such as flavonoids, tannins, xanthones, and anthraquinones. This compound is widely found in the genus Cratoxylum where one of the species is pucuk idat (Cratoxylum glaucum). Pucuk idat are often used by people of Bangka as a flavoring dish and are believed to be traditional medicine to facilitate breastfeeding, tighten skin, treat fever, cough, and diarrhea. The increasing of antioxidants needs and lots efficacy of pucuk idat, hence this study aims to determine the antioxidant activity of ethyl acetate extract Cratoxylum glaucum. The antioxidant test in this study used the DPPH (Diphenylpicrylhydrazyl) method and vitamin C as a positive control. The results of this study indicate that the extract of ethyl acetate Cratoxylum glaucum has strong antioxidant activity with value IC50 32,213 μg / mL. Phytochemical content itself includes hydroquinone phenols (tannins), flavonoids, and steroids. This shows that ethyl acetate extract Cratoxylum glaucum can be used as natural antioxidant.
Potensi Antibakteri Ekstrak Daging Buah Kelubi (Eleiodoxa conferta) Bangka Belitung Menggunakan Microwave-Assisted Extraction (MAE) Surtina, Surtina; Sari, Ratih Puspita; Zulita, Zulita; Rani, Rani; Roanisca, Occa; Mahardika, Robby Gus
Indonesian Journal of Chemical Research Vol 7 No 2 (2020): Edisi Bulan Januari (Edition for January)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.7-sur

Abstract

Antibacterial tests were carried out using ethanol extract of kelubi meat (Eleidoxa conferta), extraction using the Microwave-Assisted Extraction method with a ratio of 2: 20 for 30 minutes at 60 °C. Antibacterial tests using diffusion methods with concentrations of 20%, 40%, 60%, 80%, and 100%; positive control of 0.005% amoxillin and DMSO negative control. Antibacterial test results showed that the inhibition zone of ethanol extract in E. coli bacteria with a concentration of 20% was in the moderate category, for a concentration of 40% including the strong category while the concentration of 60%, 80% and 100% was very strong. The inhibition zone of ethanol extract for the S. aureus bacterium with a concentration of 20% is included in the strong category while the concentration of 40%, 60%, 80%, and 100% is categorized as very strong. From these results it can be concluded that the inhibitory zone in Stapylococcus aureus bacteria is greater than that of E. coli bacteria.
Kapasitas Antioksidan Ekstrak Buah Rukam (Flacourtia rukam) Menggunakan Metode Microwave Assisted Extraction (MAE) Fadiyah, Inas; Lestari, Iin; Mahardika, Robby Gus
Indonesian Journal of Chemical Research Vol 7 No 2 (2020): Edisi Bulan Januari (Edition for January)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2020.7-ina

Abstract

Rukam fruit (Flacourtia rukam) is one of the species spread in Indonesia, specifically Bangka Island. Rukam has a higher phenolic ratio than guava (Psidium guajava). Phenolic compounds have a major role as antioxidants, while antioxidants have the ability to fight free radicals. Therefore a study was conducted to examine the application of secondary metabolites and antioxidant bioactivity of the Flacourtia rukam species using the Microwave Assisted Extraction method. Rukam fruit extract is obtained by using the Microwave Assisted Extraction (MAE) method. While for the antioxidant test using the DPPH method. The test results of antioxidant activity of rukam fruit extract with ethanol solvent were obtained with IC50 value 47.7022 ppm and in rukam fruit extract with acetone solvent IC50 33.1702 ppm obtained using this antioxidant antioxidant powder was very strong.
Potency of Bentonite and Pelawan Wood Active Charcoal as Virgin Coconut Oil (VCO) Purity Improvements Through Free Fatty Acid Binding Utami, Sri Risky; Lidya, Lidya; Afrilia, Mega; Mahardika, Robby Gus
Indonesian Journal of Chemical Research Vol 9 No 3 (2022): Edition for January 2022
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2022.9-mah

Abstract

Virgin Coconut Oil (VCO) is pure coconut oil produced from fresh coconuts and does not contain additional chemicals. VCO has a high lauric acid content which acts as an antibiotic, namely antiviral, antibacterial and antiprotozoal so that VCO can increase the human body's resistance to disease or viruses. Free fatty acid (FFA) levels will significantly affect the quality of VCO. The requirement for maximum fatty acid content in VCO to be suitable for consumption is 0.2%. One of the efforts to reduce the free fatty acid levels of VCO is to use adsorbents such as activated charcoal and bentonite. This study aims to determine the effect of bentonite and activated charcoal of pelawan wood (Tristaniopsis merguensis) enhancers of VCO purity. The results showed that the best reduction in free fatty acids was using bentonite and activated charcoal of wood-furnaced pelawan, which was 0.265, while the best turbidity test result was 0.193.
Antioxidant Capacity Fraction of the Pelawan Stems (Tristaniopsis merguensis Griff) Mahardika, Robby Gus; Fajri, Khairul; Henri, Henri
Indonesian Journal of Chemical Research Vol 10 No 3 (2023): Edition for January 2023
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.10-mah

Abstract

The impact of reactions free radical compounds can cause various health problems such as inflammation, aging, and cancer. Therefore, to avoid damage caused by free radicals, the body needs an important substance, antioxidants. Natural antioxidants are more recommended than synthetic antioxidants because synthetic antioxidants must be in accordance with the prescribed dose because they can cause side effects that are harmful to the body. This study aimed to determine the antioxidant activity of the extract and fraction of the Pelawan (Tristaniopsis merguensis Grifft.) stem extract. Antioxidant testing was carried out using the DPPH method on extracts and fractions of Pelawan stem extract (T. merguensis Grifft.). In addition, qualitative phytochemical testing was also carried out on extracts of the stems of Pelawan (T. merguensis). The results of the three solvent fractions, n-hexane, ethyl acetate, and methanol, were positive for flavonoid and phenolic secondary metabolites. Meanwhile, the antioxidant activity in reducing DPPH radicals in the methanol extract fraction of pelawan stems had a very strong activity with an IC50 value of 36.33 g/mL, while the ethyl acetate and n-hexane extract fractions had a very weak antioxidant activity with an IC50 value of 387.43 μg/mL dan 759.88 μg/mL.
PENGARUH SALINITAS TERHADAP PERTUMBUHAN SEL, KONSENTRASI FENOLIK DAN FLAVONOID SPIRULINA PADA MEDIA KULTUR MODIFIKASI WALNE DAN AIR LIMBAH BUDIDAYA IKAN Anggraeni, Anggraeni; Gus Mahardika, Robby; Utami, Eva
Jurnal Harpodon Borneo VOLUME 17 NO.1 APRIL 2024
Publisher : Fakultas Perikanan Dan Ilmu Kelautan Universitas Borneo Tarakan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35334/harpodon.v17i1.5551

Abstract

Spirulina merupakan mikroalga potensial untuk dikultur karena mengandung bahan aktif pada pangan fungsional, seperti pigmen fikosianin, fenolik dan senyawa flavonoid. Pertumbuhan dan produksi senyawa aktif Spirulina optimal apabila dikultur pada media yang mengandung nutrisi yang cukup, terutama nitrogen. Penyerapan nitrogen dipengaruhi oleh salinitas. Penelitian ini bertujuan untuk menganalisis salinitas optimum yang mampu meningkatkan pertumbuhan sel dan senyawa aktif Spirulina. Penelitian dilakukan secara eksperimental laboratoris. Perlakuan salinitas digunakan 6 taraf konsentrasi, yaitu 0, 10, 15, 20, 25, dan 30 ppt. Media kultur dimodifikasi dengan penambahan nutrisi walne dan air limbah budidaya ikan dengan perbandingan 1:1. Parameter yang diamati berupa laju pertumbuhan sel, konsentrasi senyawa fenolik dan flavonoid secara kuantitatif. Hasil penelitian menunjukkan bahwa perlakuan salinitas yang berbeda berpengaruh terhadap laju pertumbuhan, sintesis senyawa fenolik dan flavonoid. Salinitas 30 ppt menghasilkan pertumbuhan sel Spirulina tertinggi dengan jumlah 34.575 unit/mL. Konsentrasi fenolik dan flavonoid yang diberi perlakuan salinitas memiliki konsentrasi yang lebih tinggi dibandingkan tanpa perlakuan salinitas. Peningkatan salinitas memberikan reaksi positif terhadap peningkatan kadar flavonoid, namun menunjukkan reaksi negatif pada kadar fenolik.
Nanoencapsulation of Pelawan Stem Extract (Tristaniopsis merguensis Grifft.) Using Polycaprolactone (PCL) Mahardika, Robby Gus; Shakila, Shania; Budi Kurniawan, Widodo; Amelia, Ririn
ALKIMIA Vol 7 No 1 (2023): ALKIMIA
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/wr4fqj14

Abstract

Formulation of nanoencapsulation using variations in the mass of Pelawan stem extract at (A) 0.15; (B) 0.25; and (C) 0.35 g combined with the addition of 0.5% PCL (Polycaprolactone) and Tween 80. Based on the analysis, the resulting nanocapsule sizes were 559.2, 447.2, and 297.0 nm, respectively, indicating that the nanoencapsulation of Pelawan stem extract has achieved nanoscale dimensions. The polydispersity index (PI) values for Pelawan stem extract formulas A, B, and C were 0.645, 0.687, and 0.476, respectively. Formula C has a PI value of less than 0.5, indicating that nanocapsules in formula C are more uniform. Formula C was the best formulation, with the smallest size and lowest PI. The Pelawan stem extract, rich in phenolic compounds, packaged in nanocapsule form through a simple nanoencapsulation process, holds potential as a future nutraceutical product.
PENGEMBANGAAN KUBE BERKAH MANDIRI DESA SEMPAN MELALUI PEROLEHAN PERIZINAN PRODUK DAN PEMASARAN BERBASIS DIGITAL Adisyahputra, Adisyahputra; Roanisca, Occa; Gus Mahardika, Robby; Yulia, Yulia
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 8, No 5 (2025): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v8i5.2110-2115

Abstract

Desa Sempan memiliki potensi komoditas pertanian yang sangat tinggi, keadaan ini dimanfaatkan oleh sekelompok Ibu Rumah Tangga (IRT) untuk mengolahnya menjadi produk yang bernilai ekonomi tinggi. Untuk mewadahi kegiatan produksi produk UMKM, ibu-ibu di Desa Sempan membentuk KUBE Berkah Mandiri. Produk UMKM yang terdapat di dalam KUBE tersebut belum memiliki perizinan produk. Oleh karena itu, melalui kegiatan pengabdian ini, tim pengabdi memfasilitasi perizinan produk, dan pemasaran berbasis digital untuk menjangkau pasar yang lebih luas. Metode yang digunakan dalam kegiatan pengabdian masyarakat ini adalah sosialisasi dan pendampingan langsung kepada anggota KUBE Berkah Mandiri. Hasil dari kegiatan pengabdian ini, seluruh anggota KUBE Berkah Mandiri telah mendapatkan Sertifikat PKP, Sertifikat SPP-IRT, label stiker produk, dan telah memiliki akun di E-Commerce Shopee dalam rangka perluasan jaringan pemasaran berbasis digital.
PENDAMPINGAN PEMBUATAN MASKER PEEL OFF PUCUK KAYU LUBANG Timonius flavescens (Jacq.) Baker MENJADI PRODUK UNGGULAN DESA AIK ABIK Gus Mahardika, Robby; Roanisca, Occa; Henri, Henri; Aprilia, Selvy
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 1 (2024): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i1.161-165

Abstract

Dusun Aik Abik memiliki potensi tumbuhan obat yang sangat tinggi. Masyarakat masih sering memanfaatkan tumbuhan obat sebagai terapi pengobatan. Tumbuhan kayu lubang (Timonius flavescens (Jacq.) Baker) sering digunakan masyarakat setempat untuk perawatan wajah dan mengobati jerawat. Tumbuhan tersebut dapat dikembangkan menjadi produk turunan masker peel off yang dapat dijadikan sebagai produk unggulan desa. Oleh karena itu, melalui kegiatan pengabdian kepada masyarakat ini tim pengabdi mentransfer inovasi pengolahan pucuk kayu lubang sebagai masker peel off untuk mendukung pemanfatan tumbuhan lokal menjadi produk yang bernilai ekonomi tinggi. Metode yang digunakan pada kegiatan ini berupa sosialisasi dan pendampingan secara langsung kepada mitra sasaran perangkat lembaga adat Dusun Aik Abik dan masyarakat.  Hasil kegiatan pengabdian kepada masyarakat ini adalah mitra sasaran memahami cara formulasi masker peel off berbahan pucuk kayu lubang dan menerima desain kemasan yang telah dicetak oleh tim pengabdi. Komitmen mitra sasaran akan melanjutkan pengembangan masker peel off menjadi produk unggulan Dusun Aik Abik.