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All Journal Jurnal Teknologi Dan Industri Pangan EKSAKTA: Journal of Sciences and Data Analysis JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Cancer Chemoprevention Eksergi: Chemical Engineering Journal Jurnal Rekayasa Sipil dan Desain Jurnal Kimia dan Kemasan agriTECH Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Majalah Obat Tradisional EduChemia: Jurnal Kimia dan Pendidikan Jurnal Kimia Riset Dental Journal (Majalah Kedokteran Gigi) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Titian Ilmu: Jurnal Ilmiah Multi Sciences ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan Berdikari: Jurnal Pengabdian Masyarakat Indonesia Indonesian Journal of Chemical Analysis (IJCA) Jurnal Ilmiah Cendekia Eksakta Stannum : Jurnal Sains dan Terapan Kimia IJCR (Indonesian Journal of Chemical Research) STATIKA: Jurnal Teknik Sipil Magistrorum et Scholarium: Jurnal Pengabdian Masyarakat Gunung Djati Conference Series AGRIC Rafflesia Journal of Natural and Applied Sciences (RJNAS) Biosaintifika: Journal of Biology & Biology Education Journal of Tropical Pharmacy and Chemistry
Yohanes Martono
Universitas Kristen Satya Wacana
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Leaf Extract Microencapsulation of Stevia rebaudiana Bert Using Inulin-Chitosan as Anti-Diabetes Diet Mutmainah Mutmainah; Yohanes Martono; Ika Puspitaningrum; Lia Kusmita
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.270

Abstract

Diabetes mellitus is a collection of symptoms that arise in someone who has increased blood glucose levels. The Stevia plant (Stevia rebaudiana Bert) contains a compound of diterpene glycosides as steviosida and rebaudiosida A. Purified extract of steviosida and rebaudiosida A is widely used as a sweetener for low calorie food and beverage products or as a sugar substitute for diabetics and has the effect of lowering blood sugar levels. This study aims to determine the antidiabetic effect of microencapsulated preparations of Stevia leaf extract (Stevia rebaudiana) with a combination of inulin chitosan encapsulation. Antidiabetic mellitus test was carried out in vivo using test animals of male white rats of Wistar strain. The inducing compound that can cause the condition of diabetes mellitus test animals is Aloxan with a dose of 150 mg / kg Body weight of rats. given intraperitoneally for one day, then the mice were allowed to stand for 3 days to reach a state of diabetes mellitus. Blood glucose levels of test animals were measured on days 1 (initial), 5 (induction) and 12 (treatment) to determine the initial blood glucose levels, after induction of alloxan and after administration of test compounds both CMC Na 0.5% , glibenclamide, and preparations microencapsulation of Stevia leaf extract at a dose of 100; 300; and 700 mg / kg body weight. The results were obtained after 7 days of treatment, it was seen that blood glucose levels in the CMC group remained high, while the Glibenclamid administration group, and the three dosages of microencapsulation preparations of Stevia leaf extract could reduce blood glucose levels. This can be seen from the statistical test that there is a significant difference (p
EFEKTIVITAS ASPAL EMULSI METODE CAMPURAN DINGIN PADA LAPISAN LASTON AC-BASE: EFEKTIVITAS ASPAL EMULSI METODE CAMPURAN DINGIN PADA LAPISAN LASTON AC-BASE Frederik Tambunan, Hermon; Martono, Yohanes; Catur Marina, Bernaditha; Dwiky Iswara, Kerri; Abi Berkah Nadi, Muhammad; Zhafira, Elian; Gunawan, Raden
STATIKA: Jurnal Teknik Sipil Vol. 10 No. 1 (2024): STATIKA JURNAL TEKNIK SIPIL
Publisher : Politeknik Raflesia Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53494/jts.v10i1.575

Abstract

Perancangan campuran aspal panas merupakan metode pencampuran umum yang diterpakan dalam pelaksanaan lapis perkerasan jalan. Tantangan suhu yang harus memenuhi spesifikasi teknis menjadi perhatian saat penghamparan. Penggunaan aspal emulsi untuk campuran spal dingin diharapkan mmpu menjadi solusi. Studi ini dilakukan untuk melihat efektifitas dari penggunaan aspal emulsi campuran dingin dibandingkan dengan aspal campuran panas pada jenis perkerasan Laston AC-Base. Hasil penelitian penelitian menunjukkan dengan campuran aspal emulsi sebesar KAE 7,3% memiliki nilai stabilitas mencapai 2.635 kg, namun memiliki angka flow sebesar 1,78 mm. Angka ini menunjukkan bahwa hasil campuran aspal dengan menggunakan aspal emulsi campuran dingin memiliki tingkat kelelehan plastis yang masih dibawah ambang batas minimal sebesar 3 mm.
Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity Kristiani, Elizabeth Betty Elok; Kasmiyati, Sri; Martono, Yohanes
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28002

Abstract

Currently, the public is interested in polyherbal-based foods and beverages as a source of natural antioxidants. The aim of the study is to evaluate the antioxidant properties and the phenolic and flavonoid compounds of formulations containing Z. officinale, C. citratus, and P. reticulatus (ZCP). Each sample was extracted using the maceration process in an ethanol solvent at room temperature for three 72-hour periods. There were fourteenth formulation of Z. officinale rhizome, C. citratus leaves, and P. reticulatus fruit which used Design of Expert (DoE). The DPPH method was used to determine the power of antioxidants. The flavonoid content of the extract was measured using the colorimetric method and AlCl3 reagent, while phenolics content using Folin-Ciocalteu. The formulations ZCP 1:0:0, 0:0:1, and 1:1:1 showed the antioxidant capacity in a strong categorization, with an IC50 value less than 50 µg/ml, while ZCP 0:1:0 was in a weak categorization (IC50 > 250 µg/ml). Another ZCP formulation was in a medium category. The ZCP 1:1:1 formulation was suggested as the best one for this investigation, which contains three plant samples. This formulation is interesting for further toxicity studies and in vivo testing so that it can be applied as an antioxidant-rich supplement product.
Extract Formulation of Zingiber officinale and Phylanthus reticulatus Induces Apoptosis of WiDr Colon Cancer Cells Kristiani, Elizabeth Betty Elok; Kasmiyati, Sri; Martono, Yohanes; Kachingwe, Baxter Hepburn
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 3 (2025): November 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i3.25776

Abstract

People use ginger (Zingiber officinale) extensively for health purposes. Our previous studies have shown that Phyllanthus reticulatus has strong antioxidant capabilities. This study investigates the anticancer potential of ethanolic extract of Z. officinale and P. reticulatus formulations (ZP), focusing on their cytotoxicity and mechanisms against cancer cells. Samples were extracted using the maceration method. The method for determining the cytotoxicity of cells is MTT, the cell cycle is flow cytometry, apoptotic cells are flow cytometry and double staining, and caspase-8 and caspase-9 expression using the immunocytochemistry method. The analysis of caspase-8 and caspase-9 expression using the immunocytochemistry method. Among the tested formulations, the ethanolic extract of ZP_1:0 showed the most promise against WiDr colon cancer cells (IC50 value of 102.1 µg/ml). The ZP_1:0 demonstrated dose-dependent apoptosis induction in WiDr cells, showing early and late apoptosis, with minimal necrosis. The extract activates extrinsic and intrinsic apoptotic pathways in inducing cancer cell death. Compared to doxorubicin, the ZP 1:0 formulation selectively promotes apoptosis with reduced necrotic damage, suggesting the potential for reduced systemic toxicity. The study supports the potential of Z. officinale as a source of safer, plant-based anticancer agents, particularly for colon cancer, while recommending further research to identify and enhance active compounds.
Synthesis and Characterization of Nano Activated Carbon Tea Waste (Camellia sinensis L.) Viewed from the Content and Ratio of Orthophosphoric Acid Wijaya, Daniel Ricky Putra; Martono, Yohanes; Riyanto, Cucun Alep
INDONESIAN JOURNAL OF CHEMICAL RESEARCH VOLUME 3, ISSUE 2, 2018
Publisher : Chemistry Department, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.07 KB) | DOI: 10.20885//ijcr.vol3.iss2.art2

Abstract

Waste of tea is still limited in terms of utilization, potentially to be made into nanocarbon. In this research, nanocarbon synthesis from the waste of tea through carbonation method using furnace and purification with HNO3 with activator substance used is H3PO4. The specific objective of this study was to determine the optimal levels and ratios of ortho-phosphoric acid and to determine the properties and characteristics of nanocarbon from tea waste. Based on the FT-IR spectra, the best ortho-phosphate acid levels and ratios are 50% and 1:2 (w/w) H3PO4. The XRD analysis showed that the activated carbon dregs obtained were C graphite which was characterized by the diffraction peak at 2theta: 26.2°; 26.5°; 42.2°; 42.4°; and 44.3°. Based on the TEM image obtained shows that the activated carbon of the resulting tea waste has a particle size of 20-40 nm.
Studi Optimalisasi Perparkiran dan Pedestrian di Fakultas Teknik Jurusan Sipil Universitas Lampung Nawawi, Sherly Novita Sari; Sulistyorini, Rahayu; Martono, Yohanes
Jurnal Rekayasa Sipil dan Desain (JRSDD) Vol. 3 No. 1 (2015): Edisi Maret 2015
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jrsdd.v3i1.395

Abstract

Faculty of Civil Engineering Department as one of the majors at the University of Lampung whichhas the number of students, faculty and others are quite large, this has resulted in demand forparking at the Faculty of Engineering Department of Civil is a problem that can not be ignoredbecause of the Faculty of Civil Engineering Department as a center of community activityacademic need a good arrangement and the campus community college population continues toincrease each academic year. This study aims to investigate the characteristics of the motorvehicle users both motorcycles and cars in the Faculty of Engineering Department of Civil,knowing parking needs in the Faculty of Engineering Department of Civil, find out if parking andpedestrian facilities in the Faculty of Engineering Department of Civil been sufficient,, analyzeparking management solution and pedestrian in the Faculty of Civil Engineering Department.Characteristics of motor vehicle users both motorcycles and cars derived from a comparisonbetween the accumulation of the highest parking vehicles with the number of parking spacesavailable, vehicle car I is 14 pieces of land, land second car that is 20 pieces, motorcycle land I is20 pieces, motorcycles land II is 27 pieces, motorcycles III, 11 pieces of land and land motorcycleIV is 4 pieces. Based on a survey and analysis parking requirements for the Faculty ofEngineering Department of Civil to cars I and II land at 192% / day, for the motorcycle land I of11.2% / day, for the motorcycle land II, III and IV of 126% / day .Keywords: Transportation, Parking, Pedestrian
Analisis Kemacetan Lalu Lintas Sepanjang Jalan Z.A. Pagar Alam Dengan Metode Manual Kapasitas Jalan Indonesia (Studi kasus segmen Universitas Lampung sampai dengan Mall Boemi Kedaton) Novitasari, Shartyka; Martono, Yohanes; Putra, Sasana
Jurnal Rekayasa Sipil dan Desain (JRSDD) Vol. 7 No. 1 (2019): Edisi Maret 2019
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jrsdd.v7i1.1145

Abstract

Road facilities aim to accomodate existing traffic volumes the designing is also adjusted to traffic characteristic. However, in fact, the comfort level has not meet the requirements of the guide book. This problem is indicated by the slowing down of passing vehicles, the long traffic jam that makes road density this research, simulated to compare vehicles volume and the road capacity along the research road, analysis the level of service catagory based on the road density, predicted the time traveled of the traffic and accomodated by types of road, degree of saturation and speed allowed.  Based on the date analysis the highest traffic jam for traffic volume is in Purnawirawan, then after the analysis of capacity, the highess road density is in University of Lampung, the underpass project for the degree of saturation the analysis is compared with the on the spot real time date. And the result is the highest traffic jam is in underpass project in University of Lampung wich is the real time distance traveled is more density than the distance allowed.  In conclusion, we need to review the geometric design of road, because the geometric design of road is really affect traffic jam. And we have to re-announced about public transportation, so the vehicles volume will decrease. Keywords: traffic volumes. Degree of saturation, speed, road capacity..
THE EFFECT OF TEMPE FERMENTATION TIME ON THE TOTAL PHENOLIC AND ISOFLAVONE GENISTEIN CONTENTS Suharto, Kiki Fransiska; Soetjipto, Hartati; Martono, Yohanes
ALCHEMY Jurnal Penelitian Kimia Vol 13, No 2 (2017): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.13.2.5094.228-238

Abstract

The objective of this study was to evaluate total phenolic compounds and isoflavone genistein contents during 0 - 9 days of fermentation time. Isoflavone extract were obtained by maceration and fractionation. Total phenolic compounds were measured by Folin ciocalteau method, meanwhile, the isoflavone genistein contents were analyzed by a High Performance Liquid Chromatography. The yield of isoflavone extract and the total phenolic compounds were analyzed using a randomized completely block design and the mean between treatments was compared by the Honestly Significant Difference (HSD) test using significance level of 5 %. The highest amount of total phenolic compounds during the incubation time was obtained on 4 days of fermentation time, i.e., 232.05n ± 7.71 μg/g, while the highest content of isoflavone genistein was obtained on 5 days of fermentation time, i.e., 100.48 μg/g. This research confirms that the fermentation process of tempe induces the total phenolic contents and the production of isoflavone genistein is fluctuating.
Kinerja Karbon Aktif Daun Eceng Gondok pada Penurunan Kadar Fosfat Artifisial dan Surfaktan dalam Limbah Detergen Wulandari, Resa; Riyanto, Cucun Alep; Martono, Yohanes
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.65626.149-161

Abstract

Limbah detergen masuk ke dalam kategori limbah domestik karena limbah ini memiliki potensi membentuk film pada permukaan air dan menurunkan tingkat transfer oksigen ke dalam air. Oleh karena itu, penanganan limbah detergen diperlukan untuk meningkatkan kualitas air. Pada penelitian ini dilakukan sintesis karbon aktif dari Daun Eceng Gondok (DEG) sebagai adsorben fosfat dalam limbah fosfat artifisial dan surfaktan dalam limbah detergen. Tingginya kandungan selulosa dalam daun eceng gondok membuat tanaman tersebut memiliki potensi untuk diolah menjadi bahan dasar alternatif untuk karbon aktif. Sintesis karbon aktif DEG dilakukan melalui proses karbonisasi pada suhu 400 ℃ selama 60 menit dilanjutkan proses aktivasi dengan rasio karbon: H3PO4 30% yaitu 1:4 (b/b). Selanjutnya, pemanasan dilakukan menggunakan furnace pada suhu 600 ℃ selama 60 menit. Hasil penelitian menunjukkan bahwa karbon aktif DEG memiliki gugus fungsional O‒H, C‒H, C=C, C≡C, dan C‒O serta karakter mikropori (d = 1,10 nm) dan luas permukaan sebesar 726,49 m2/g. Pada kajian kinetika dan isoterm adsorpsi, penjerapan karbon aktif DEG terhadap fosfat dan surfaktan mengikuti pemodelan kinetika Elovich dengan kapasitas adsorpsi masing-masing adalah 11,67 mg/g dan 4,19 mg/g. Efektivitas karbon aktif DEG dalam adsorpsi fosfat dan surfaktan berturut-turut mencapai 78,35% dan 52,99%.Performance of Activated Carbon from Water Hyacinth Leaves (WHL) for Reducing Artificial Phosphate and Surfactant Levels in Detergent Waste. Detergent waste is classified into the domestic waste category because it forms a film on the water surface and reduce the oxygen level in the water. Therefore, handling detergent waste is necessary to improve water quality. In this research, activated carbon was synthesized from water hyacinth leaves (WHL) as an adsorbent for phosphate in artificial phosphate waste and surfactant in detergent waste. The high cellulose content in water hyacinth leaves gives this plant the potential to be processed into an alternative base material for activated carbon. The synthesis of activated carbon from WHL (ACWHL) was carried out through a carbonization process at 400 ℃ for 60 min followed by an activation process using a weight ratio of carbon: H3PO4 30% = 1:4 (w/w) followed by heating at 600 ℃ for 60 min. The research results show that ACWHL has the functional groups O‒H, C‒H, C=C, C≡C, and C‒O as well as microporous character (d = 1.10 nm) and a surface area of 726.49 m2/g. In the study of kinetics and adsorption isotherms, the adsorption of ACWHL on phosphate and surfactants followed Elovich kinetic modeling with adsorption capacities of 11.67 mg/g and 4.19 mg/g, respectively. The effectiveness of ACWHL in adsorption of phosphate and surfactant reached 78.35% and 52.99%, respectively.
Co-Authors A. Rindang Anggit Laksono Abdul Rohman Abi Berkah Nadi, Muhammad Agung Rimayanto Gintu Agung Rimayanto Gintu Agung Rimayanto Gintu Agung Rimayanto Gintu Agung Rimayanto Gintu Andreas Setiawan Andriyani Rosita Sari Anggelia Essi Christian Ari Hasna Widyapuspa Bereka Meidelivia Raharjianti Bernaditha Catur Marina Betsy Felita Betsy Felita Cucun Alep Riyanto Devina Intan Sari Devinta Lestari Dewi Kurnianingsih Arum Kusumahastuti Diyonisio Kevin Elisando Dwiky Iswara, Kerri Eliana Prabalaras Elisabeth Betty Elok Kristiani Elizabeth Betty E. Kristiani Elizabeth Betty Elok Kristiani Erlien Giovani Soeroso Fahmi Puteri Perdani Ferdy Semuel Rondonuwu Fidelia Novitasari Fransiskus Tri Wahyu Hananto Franyoto, Yuvianti Dwi Gunawan, Raden Harry Setiawan Hartati Soetjipto Hartati Soetjipto Hindra, Ronal Febria Ida Suskawati Ika Puspitaningrum Ika Puspitaningrum Ira Tyas Kurniasari Kachingwe, Baxter Hepburn Kusmita Kusmita Lia Kusmita Lucia Devi Danriani Lydia Ninan Lestario Maria Endah Retno Palupi Muhamad Syaiful Ampri Mutmainah Mutmainah Mutmainah Mutmainah Mutmainah Mutmainah Nawawi, Sherly Novita Sari November Rianto Aminu Noviana Gunawan Novitasari, Shartyka Nur Ayu Hidayati Rahayu Sulistyorini Rahayu Sulistyorini Rema Fitriyani Salsabila Eka Ghina Rana Sandra Ayu Apriliyani Sasana Putra, Sasana Sekar Nurani Saptaningtyas Sherly Novita Sari Nawawi Slamet Widodo Sri Hartini Sri Hartini Sri Kasmiyati Sudibyo Martono Sudibyo Martono Sugeng Riyanto Suharto, Kiki Fransiska Suryasatriya Trihandaru Susanti Pudji Hastuti Tambunan, Hermon Frederik Tiffany Febetania Widodo Tonia Nur Fitria Widhi Nugroho Meindra Wijaya, Daniel Ricky Putra Wulandari, Resa Yayi Suryo Prabandari Yoko Putra Nusantara Yuniarti, Zulfa Zhafira, Elian Zulfa Yuniarti