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All Journal Dentika Dental Journal Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) MDJ (Makassar Dental Journal) Eureka Herba Indonesia Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal of Syiah Kuala Dentistry Society
Olivia Avriyanti Hanafiah
Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry, Universitas Sumatera Utara Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Investigation of 3% Binahong (Anredera cordifolia) Leaf Extract Nanogel on the Alveolar Bone Healing: BMP-2 Modulation in Rat Models Bernard, Bernard; Syafruddin Ilyas; Olivia Avriyanti Hanafiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1020

Abstract

Background: Alveolar bone healing relies on osteoblasts activity and differentiation, with bone morphogenetic protein-2 (BMP-2) playing a crucial regulatory role. Binahong leaf extract (BLE) has demonstrated efficacy in bone healing due to its rich phytochemical composition. Nanogel offers enhanced bioavailability and targeted release to effectively deliver therapeutic agents. This study aims to assess the impact of 3% BLE nanogel on BMP-2 expression in tooth extraction socket healing. Methods: Thirty male Wistar rat underwent anaesthesia for the extraction of their lower incisors to induce alveolar bone healing. Subjects were randomly assigned into treatment (BLE nanogel) and control (base nanogel) group. Five rats from each group were respectively sacrificed at 7, 14, and 28 days after procedures. BMP-2 expression was assessed by performing immunohistochemistry analysis using BMP antibody reagent. Data were analysed using chi-square. Results: The analysis of BMP-2 expression showed no significant difference between treatment and control groups on days 7, 14, and 28 (p>0,05). However, a subtle increase was observed in the treatment group throughout observation period. Conclusion: Application of 3% BLE nanogel may enhance the expression of BMP-2, even though it was not significantly increase. The findings underscore the complex interplay between Binahong leaf extract, nanogel and BMP-2 expression.
The Effect of Snakehead Fish (Channa striata) Extract on Dry Socket Wound Healing: TGF-β1 Expression in Rats Model HG, Afifah Ayuni; Syafruddin Ilyas; Olivia Avriyanti Hanafiah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1035

Abstract

Background: Dry socket or alveolar osteitis is a condition characterized by the breakdown of blood clots due to excessive fibrinolysis activity, which disrupts the wound healing process. Consumption of nutrition-rich foods such as snakehead fish (Channa striata) rich in albumin, omega-3 fatty acids, vitamins, minerals, and striatin may accelerate delayed wound healing. This study aimed to analyze the role of snakehead fish extract on the expression of TGF-β1 in the healing of dry socket wounds after tooth extraction in Wistar rats. Methods: This study was an in vivo study with a posttest-only control group design. Forty-five Wistar rats were divided into five groups: snakehead fish extract groups with doses of 1/2, 1, 2, 4 times human dose, and a negative control. The lower left incisor teeth of the rats were extracted, then dry socket was induced with adrenaline using a paper point. On days 3, 7, and 14, TGF-β1 expression was assessed using immunohistochemical staining. Results: This study showed significant difference in TGF-β1 expression on days 3, 7, and 14. TGF-β1 expression was higher in the treatment groups than the control (p<0.05). Conclusion: Administration of snakehead fish extract increased TGF-β1 expression. These findings underline the complex interaction between snakehead fish extract and TGF-β1 expression.
Detecting Periodontal Destruction with Saliva Biomarkers in Aging: Systematic Review Pitu Wulandari; Syarida Hasnur binti Syafii; Julia Maharani; Olivia Avriyanti Hanafiah; Irma Ervina; Mutia Amalia Nasution
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.19739

Abstract

Immuno-inflammatory responses to bacteria in dental biofilms can lead to periodontal destruction, which can be indicated by inflammatory markers in saliva. This review highlights salivary biomarkers for detecting periodontal damage as elderly.Two independent reviewers conducted a systematic literature search on PubMed for English publications from 1961 to 2024 using keywords like “aging,” “saliva,” “biomarkers,” and “periodontitis.” The search included only randomized controlled trials that examined salivary biomarkers in aging populations. Out of 160,647 publications, four high-quality studies were included—two from Europe (Switzerland and Slovakia), one from the United States, and one from South Korea. The identified salivary biomarkers included Interleukin-1β, Interleukin-6, matrix metalloproteinases (MMP-3, MMP-8, MMP-9), advanced glycation end products (AGEs), advanced oxidation protein products (AOPP), and total antioxidant capacity (TAC). Based on the published studies, saliva biomarkers are valuable indicators of periodontal disease during aging.
Antibacterial Effectiveness of Mackerel (Rastrelliger sp) Fish Oil Emulgel against Staphylococcus aureus Bacteria Using Disk-Diffusion Method. Isnandar; Olivia Avriyanti Hanafiah; Indra Basar Siregar; Salsabila
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.22238

Abstract

Oral health is a major concern in Indonesia, which is caused by bacteria infections in oral cavity.¹ Bacteria such as Staphylococcus play a crucial role in the development of dental diseases, showing the need for improving oral hygiene to prevent infections.² Therefore, this research aimed to evaluate the effectiveness of mackerel fish oil (Rastrelliger sp.) emulgel against Staphylococcus aureus using the disk diffusion method in an in vitro. The investigation was carried out using an experimental laboratory design with a post-test only control group through the Kirby-Bauer disk diffusion method. The samples consisted of various concentrations of mackerel fish oil emulgel (10, 5, 2.5, 1.25, 0.62, and 0.31%). Clinium® gel 1% was used as a positive control, while gel base was served as a negative control. The formation of inhibition zone diameter after 24 hours of incubation was measured in millimeters (mm) using a vernier caliper. The results showed that mackerel fish oil (Rastrelliger sp.) emulgel had antibacterial activity against Staphylococcus aureus. The mean inhibition zone diameters observed at concentrations 10, 5, 2.5, 1.25, 0.62, and 0.31% were 16.99 mm, 13.23 mm, 10.32 mm, 7.18 mm, and 6.23 mm. Mackerel fish oil (Rastrelliger sp.) emulgel showed effective antibacterial activity against Staphylococcus aureus in an in vitro setting.
Co-Authors Abdullah Oes Adzimatinur Pratiwi Arin Pratiwi Nasution Avi Syafitri Ayuni HG, Afifah Bernard Bernard, Bernard Br Ginting, Rachel Adinda Yule Denny Satria Denny Satria, Denny Dewi Wulandari Dhian Jun Frihatin Situmorang Dhian Jun Frihatin Situmorang Diana Sofia Hanafiah Dohude, Gostry Aldica Dora Channel Dora Channel Dorinda Faradilla, Chintya Firman, Mantra Gema Nazri Yanti Hak, Muhammad Syafrudin Harahap, Nurul Izzatunna Jhirah Hendry Rusdy Hendry Rusdy HG, Afifah Ayuni Indra Basar Siregar Irma Ervina Isnandar Isnandar Julia Maharani Juliana Irmayanti Saragih Kasman Manullang Lestari, Chandra Lubis, Lokot Donna Muhammad Fauzan Lubis mutia amalia nasution Pitu Wulandari Preetypal Kaur JOHAL Putri Welda Utami Ritonga Putri, Maharani Syahnia Rahmi Syaflida Ratnaningtyas, Jemima Ridho, Muhammad Fathur Rusdy, Hendry Salsabila Stanlee, Elwin Syaflida, Rahmi Syafruddin Ilyas Syafruddin Ilyas Syarida Hasnur binti Syafii Tanandika, Janesia Wirsa, Dinda Andaru Yeheskiel Satria Yoga Erlangga