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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Kesehatan Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Promotion and Behavior Journal of Maternal and Child Health Narra J Journal of Multidisciplinary Applied Natural Science Journal of General Procedural Dermatology and Venereology Indonesia
Ambar Mudigdo
Medical School of Sebelas Maret University, Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Path Analysis on the Biopsychosocial Factors Affecting the Quality of Life in Patients with Breast Cancer Dewi, Rizka Amalia; Mudigdo, Ambar; Pamungkasari, Eti Poncorini
Journal of Epidemiology and Public Health Vol 5, No 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the most com­mon cancer among women, affecting 2.1 mil­lion women every year. Assessment of quality of life is con­sidered the most important and strong in­dicator for breast cancer outcomes. The purpose of this study was to analyze biopsychosocial factors that affect the quality of life of breast cancer patients.Subjects and Method: A cross-sectional study was conducted in the breast cancer community in Su­ra­karta, Central Java from December 2019 to January 2020. A sample of 200 breast cancer patients was selected by simple random sam­pling. The dependent variable was the quality of life of breast cancer patients. The independent var­i­ables were stadium, chemotherapy, length of diag­nosis, age, depression, coping strategies, social net­­­­works, level of knowledge, education level, income level, employment status, and marital sta­­­tus. Quality of life was measured by WHO-QOL-BREF. Other data were collected by question­naire. Data were analyzed by path ana­lysis using the Stata 13 application.Results: The quality of life of breast cancer pa­tients was directly increased by high family income (b=­ 3.27; 95% CI= 1.67 to 4.87; p<0.001), strong social network (b= 2.61; 95%CI= 0.96 to 4.26; p= 0.002), length of diagnosis ≥24 months (b= 2.68; 95% CI= 0.98 to 4.39; p= 0.002), good coping strategy (b= 1.65; 95% CI= 0.12 to 3.19; p= 0.034), and finish­ed chemotherapy (b=1.32; 95% CI = -0. 22 to 2.87; p= 0.093). The quality of life of breast can­­cer patients was directly decre­ased by depression (b= -2.78; 95% CI=-4.41 to -1.15; p= 0.001) and ad­van­ced stage (b=-2.43; 95% CI= -4.04 to 0.83; p=­ 0.­003). Quality of life was in­directly affected by cop­­ing strategy, marital status, chemotherapy, know­ledge, length of diag­nosis, age, employment, and education.Conclusion: The quality of life of breast cancer pa­tients is directly increased by high family in­come, strong social network, length of diagnosis ≥24 months, good coping strategy, and finish­ed chemotherapy. The quality of life of breast can­­cer patients is directly decre­ased by depression and ad­van­ced stage. Quality of life is in­directly affect­ed by cop­­ing strategy, marital status, chemothe­rapy, know­ledge, length of diag­nosis, age, employment, and education.Keywords: quality of life, breast cancer, path analysisCorrespondence: Rizka Amalia Dewi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. E­mail: drizkaez@gmail.com.  Mobile: +62823­13­12­1768.Journal of Epidemiology and Public Health (2020), 05(01): 119-131https://doi.org/10.26911/jepublichealth.2020.05.01.12
Lucio phenomenon in pregnancy: A histopathology review Fiqnasyani, Siti Efrida; Oktavriana,, Triasari; Rosmarwati, Ervina; Novriana, Dita Eka; Mudigdo, Ambar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Background: Lucio phenomenon (LP) is a reaction occurring in lepromatous, non-nodular, diffuse leprosypatients who have not received multidrug therapy (MDT). The diagnosis of LP are based on clinical features and supported by histopathological examination. This report was conducted to establish a diagnosis of LP byhistopathological examination, considering that cases of LP in pregnancy are quite rare so that clinicians can be more precise. Case: A 35-year-old pregnant woman complained of extensive ulcers on her hand and legs. Madarosis, saddle nose, and earlobes were found A slit skin smear examination showed a bacterial index of +4 and a morphological index of 20%. A skin biopsy from a leg ulcer with HE staining revealed thinning of the epidermis,foamy macrophages, inflammatory cell infiltrate in the dermis and subcutaneous layers, necrotizing vasculitis with thickening of blood vessel walls, and perivascular lymphohistiocytic infiltrate. Histopathological examination of auricular infiltrate showed basket weave type hyperkeratosis, grenz zone, lymphohistiocytic inflammatory cell infiltrates, foamy and touton cells. Histopathological examination by FF staining showed a heavy M. leprae invasion. Discussion: Histopathological characteristics of LP in this patient found flattened epidermis, subepidermal grenz zone, aggregates and sheets of foamy macrophages admixed with predominantly huge numbers of acid-fast bacilli, foamy macrophages and touton cells. The main microscopic features also found subcutis necrotizing vasculitis. Histopathological examinations are essential to diagnose LP. Conclusion: Histopatholgy of Lucio Phenomenon found grenz zone, inflammatory cell infiltrate and foamy cells. This histopatholgy will support the diagnosis and best treatment for LP patient.
Evaluating autologous peritoneum grafting for enhanced healing of bile duct injuries: A preliminary data from an animal study Nugroho, Anung N.; Mudigdo, Ambar; Soetrisno, Soetrisno; Yarso, Kristanto Y.; Nurwati, Ida; Indarto, Dono; Pamungkasari, Eti P.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1873

Abstract

Increased incidence of laparoscopic cholecystectomy-related bile duct injuries (BDIs), combined with its risk of serious complications and mortality, highlights the need for a more effective repair technique. Although the use of autologous graft in BDI repair has been promoted, the role of autologous parietal peritoneum remains underexplored. The aim of this study was to evaluate the effect of autologous parietal peritoneum grafts in rabbit models of partial BDI, emphasizing its effect on the expression of cluster of differentiation 68 (CD68) and transforming growth factor-β (TGF-β). An experimental post-test-only design was employed, using 27 male New Zealand rabbits (Oryctolagus cuniculus) aged 8–10 months. The rabbits were allocated into three groups: control (primary closure), autologous parietal peritoneum graft, and autologous gallbladder graft. Partial BDI measuring 15×5 mm were surgically created and repaired according to group assignments. The expression of CD68 and TGF-β were measured via enzyme-linked immunosorbent assay (ELISA), while the anastomosis was pathologically examined through hematoxylin and eosin (H&E) staining on days 3, 7, and 14 post-surgery. Statistical analysis was performed using analysis of variance (ANOVA) followed by Bonferroni post hoc tests. No statistically significant difference was observed in the expression of CD68 or TGF-β among the three treatment groups on days 3, 7, and 14 post-surgery, indicating that the effects of autologous parietal peritoneum graft were comparable to the control and the autologous gallbladder graft in promoting wound healing. Fibroblast density on day 3 was significantly lower in the parietal peritoneum group (p=0.040), reflecting delayed recruitment, but normalized by day 14, indicating successful integration and remodeling. The study highlights the potential role of autologous parietal peritoneum grafts for BDI.
Path Analysis on the Biopsychosocial Factors Affecting the Quality of Life in Patients with Breast Cancer Dewi, Rizka Amalia; Mudigdo, Ambar; Pamungkasari, Eti Poncorini
Journal of Epidemiology and Public Health Vol. 5 No. 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Breast cancer is the most com
Therapeutic Potential of Synbiotic Roselle Extract Yogurt in Modulating Inflammatory Markers and Oral Microbiota in a Rat Model of 5-Fluorouracil-Induced Oral Mucositis Sena, Anantha; Mudigdo, Ambar; Arief, Irma-Isnafia; Indarto, Dono
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.58-70

Abstract

Mucositis is a common complication in cancer patients undergoing 5-fluorouracil (5-FU) chemotherapy. Roselle (Hibiscus sabdariffa) extract in synbiotic yogurt could be a beneficial alternative because it might change the inflammatory response and oral microbiota. The study aimed to investigate the effects of synbiotic roselle extract yogurt on inflammatory responses and oral microbiota in oral mucositis caused by 5-FU. An experimental study with twenty-four Sprague-Dawley rats divided into four groups (n=6): healthy control (NC), disease control (PC), synbiotic roselle extract yogurt therapy (P1), and standard therapy (P2) groups. This study evaluated the number of bacterial colonies, expression of COX-2 and caspase-1, and levels of IL-1β and VEGF (days 4 and 7). The P1 group had a significantly increased beneficial lactic acid bacteria (6.91±0.87) and a decrease in pathogenic bacteria, including Staphylococcus aureus (3.89±0.05), Escherichia coli (0), and Enterobacter aerogenes (1.78±0.29), compared to the PC group. Additionally, there was a statistically significant increase in VEGF levels in the tissue (0.07±0.03 ng/mL), a decrease in serum IL-1β levels (48.02±10.29 pg/mL), and an expression of caspase-1 and COX-2 compared to the PC group (p<0.05). Synbiotic roselle extract yogurt shows promise as a therapeutic strategy for managing mucositis by restoring microbial balance and mitigating inflammation.
Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride Sahara, Nita; Mudigdo, Ambar; Wasita, Brian; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Cilmiaty, Risya
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.370

Abstract

Benign prostatic hyperplasia (BPH) progression is critically influenced by the androgen receptor (AR), Fibroblast growth factor-2 (FGF-2), and transforming growth factor-β (TGF-β) signaling axis. Although finasteride (FIN) is the standard therapeutic agent, its use is limited by adverse effects. This study evaluated the efficacy of Cosmos caudatus (CC) extract, administered alone or in combination with FIN, in modulating the AR–FGF-2–TGF-β axis in a testosterone-induced BPH rat model. Rats were divided into five groups (n = 6): Normal (N), BPH control (KN), FIN (KP; 0.44 mg/kg), CC extract (P1; 250 mg/kg), and combination (P2; CC 250 mg/kg + FIN 0.44 mg/kg). Prostatic AR, FGF-2, and TGF-β expression was analyzed using immunohistochemistry (IHC) with H-score quantification. Both KP and P1 significantly reduced AR (KP: 112 ± 15; P1: 105 ± 12 vs KN: 195 ± 18, p < 0.05) and FGF-2 (KP: 98 ± 14; P1: 92 ± 11 vs KN: 180 ± 20, p < 0.05), approaching normal values (AR N: 90 ± 10; FGF-2 N: 85 ± 9). In contrast, combination therapy (P2) failed to suppress AR (188 ± 17, p = 0.936) and FGF-2 (175 ± 19, p = 0.870) and induced a significant increase in TGF-β (P2: 145 ± 16 vs KN: 110 ± 12, p < 0.05). All treatment groups showed reduced epithelial thickness and prostate index (p < 0.05). These findings indicate that CC extract alone exerts therapeutic effects comparable to FIN by modulating the AR–FGF-2 axis, whereas combining it with FIN disrupts pathway regulation and promotes a pro-fibrotic response. The study supports the potential of CC extract as an effective alternative for BPH management without pharmacologic complications.
Co-Authors -, Lusiatun -, Soemanto Abd. Rasyid Syamsuri Adang Muhammad Gugun, Adang Muhammad Adi Prayitno Andriani, Rita Benya Anggraini, Tiyan Arfailasufandi, Roiela Argyo Demartoto, Argyo Aris Sudiyanto Armadhani, Riska Bhisma Murti Brian Wasita Budhiastuti, Uki Retno Dewi, Rizka Amalia Didik Tamtomo, Didik Dita Eka Novriana Dono Indarto Eti Poncorini Pamungkasari Fadhilla, Hidayah Nur Falah Indriawati Barokah, Falah Indriawati Febry Istyanto Fiqnasyani, Siti Efrida Hastuti, Tri Ari Ida Nurwati Idulhaq, Mujaddid Ilmiyah, Desy Eka Irma Isnafia Arief Kusumawati, Lindha Sri Listyawardhani, Yana Luky Adrianto Maringga, Estin Gita Michael Tantoro Harnomo Ningtyas, Anindiya Nugroho, Anung N. Oktavriana,, Triasari Oyong Oyong Pamungkasari, Eti P. Paramasari Dirgahayu Paulus Kusnanto Pradani, Amalia Dinda Ayu Puspitasari Puspitasari Qadrijati, Isna Qadrijati, Isna Rahardjo, Setyo Sri Rahayuningsih, Tutik Ratna Diana Fransiska RB. Soemanto Risya Cilmiaty, Risya Rita Adriani Benya Adriani Rosmarwati, Ervina Sahara, Nita Saptowati, Dewi Sari, Heni Elmiani Sari, Nunik Ike Yunia Sena, Anantha Sentana, Okkie Mharga Soemanto, RB Soetrisno Soetrisno Sulistyo, Anita Sri Supriyadi Hari Respati Tonang Dwi Ardyanto Triyanta Yuli Pramana Uki Retno Budihastuti Utomo, Pamudji Wahyu Tri Sudaryanto Wardhani, Gesit Kusuma Warman, Fanny Indra Wati, Wayan Wildan Nur Winiarti, Dian Yarso, Kristanto Y. Yosin, Esti Pratiwi Yulia Fitriani, Yulia