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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) ALKIMIA : Jurnal Ilmu Kimia dan Terapan SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Farmasi dan Sains Indonesia (JFSI) JUKESHUM: Jurnal Pengabdian Masyarakat INDRA: Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Lentera Negeri Sinteza Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Teknologi Informasi untuk Masyarakat (Jurnal Teknokrat)
Muhlisun Azim
Universitas Hamzanwadi
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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ANTIBACTERIAL ACTIVITY TEST OF WATER APPLE LEAF EXTRACT Syzygium aqueum (Burm.f) Alston AGAINST Salmonella typhi BACTERIA USING ELISA READER Zulfiana, Salina; Azim, Muhlisun; Gemantari, Baiq Maylinda
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 6 No. 2 (2024): July - December 2024
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v6i2.10169

Abstract

The water apple plant Syzygium aqueum (Burm. f) Alston is one of the plants used as traditional medicine due to its secondary metabolites such as flavonoids, steroids, terpenoids, alkaloids, tannins, phenols, saponins which can be utilized as antibacterials, antioxidants and others. This research aims to determine the IC50 antibacterial activity of the water apple leaf extract against Salmonella typhi ATCC-14028 bacteria in inhibiting bacterial growth. Extraction was carried out using multi-step maceration using n-hexane, ethyl acetate, and methanol as solvents to obtain the concentrated extracts. Antibacterial activity test was conducted by using the microdilution method on Mueller Hinton Broth media by calculating optical density (OD) values at concentrations of 500 ppm, 250 ppm, 125 ppm, 62.50 ppm, 31.25 ppm, 15.63 ppm, 7.831 ppm, and 3.906 ppm. The optical density value was measured at a wavelength of 595 nm by Elisa microplate reader. Phytochemical contents were investigated and the presence of flavonoid, phenol, steroid, and terpenoid compounds in the extracts was indicated. Water apple leaf extracts have antibacterial activity in inhibiting the growth of Salmonella typhi ATCC-14028 bacteria showing an IC50 value of n-hexane, ethyl acetate, and methanol extracts of 155,607 ± 30,592 µg/mL, 56.492 ± 50.124 µg/mL, 107.96 ± 50.124 µg/mL which is categorized as weak, strong, and moderate respectively.
VALIDASI METODE ANALISIS SIBUTRAMIN HCL PADA SEDIAAN JAMU PELANGSING DENGAN SPEKTROFOTOMETER UV-VISIBLE Febriani, Yuyun; Izati Savitri, Nurul; Azim, Muhlisun
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p20-30

Abstract

Sibutramine HCl was known as one of the anti-obesity drugs known for its appetite-suppressing properties. The aims of this research were to analyze pharmaceutical chemicals content in slimming herbal remedies available in the East Lombok district market and to analyze the value and validation parameters for analyzing method of sibutramine HCl in these remedies using UV-Visible spectrofotometry. The method used qualitative analysis using thin-layer chromatography (TLC) and quantitative method used spectrophotometry UV-Visible. The method was validated to meet the specified requirements, including linearity, Limit of Detection (LoD), Limit of Quantification (LoQ), precision, and accuracy. The results of this research were, in qualitative analysis, 2 out of 5 samples were identified to contain sibutramine HCl with a value of Rf of 0.78. The selected wavelength for sibutramine HCl analysis was 224.40 nm, and the respective parameters of linearity, LoD, LoQ, precision, and accuracy were (r) 0.9991, 2,406 ppm, 7,291 ppm, 0.446% RSD, and 98.92% recovery. Based on the results above, showed that using the spectrofotometry UV-Visible method in this research complies with the established parameters.
The Influence of Socialization on Students' Knowledge Levels About Antibiotic Resistance in Selong District, East Lombok: Pengaruh Edukasi Terhadap Tingkat Pengetahuan Siswa Tentang Resistensi Antibiotik di Kecamatan Selong, Lombok Timur Risma Fatmayanti, Baiq; Ramadhan, Leny; Rafsanjani, Arief; Marlita, Jeli; Azim, Muhlisun; Febriani, Yuyun
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i2.1277

Abstract

Antibiotics are drugs used to treat bacterial infections. Irrational use of antibiotics without a doctor's prescription causes antibiotic resistance. West Nusa Tenggara province is ranked sixth with the largest number of antibiotic consumption without a doctor's prescription so the incidence of antibiotic resistance increases. This community service aims to provide antibiotic resistance education to high school students in Selong District. The community service method was carried out at SMAN 1 Selong and SMAN 2 Selong which started with pretest, socialization, and posttest activities to measure students' knowledge of antibiotic resistance before and after socialization. The significance test of changes in students' knowledge levels before and after socialization was conducted using a paired sample t-test. The socialization participants from SMAN 1 Selong and SMAN 2 Selong consisted of 141 high school students in grade XI with an average age of 16. The pretest and posttest data analysis showed that students' knowledge levels regarding antibiotic resistance increased from 41% to 59% at SMAN 1 Selong and 42% to 58% at SMAN 2 Selong after socialization. The average value of students' knowledge about antibiotic resistance increased from 10.04 points to 14.73 points for SMAN 1 Selong and 10.33 points to 14.16 points for SMAN 2 Selong after the socialization was given from a total of 17 maximum points that could be obtained. The results of data analysis using paired sample t-test showed a significant difference (p<0.05) in the average level of student knowledge before and after the socialization activity was carried out. Thus, the antibiotic resistance socialization activity has successfully increased student knowledge in Selong District, especially at SMAN 1 Selong and SMAN 2 Selong effectively.
Edukasi dan Pendampingan Pengelolaan Sampah Anorganik Berprinsip Zero Waste System di Desa Bagik Payung Selatan Kecamatan Suralaga Febriani, Yuyun; Azim, Muhlisun; Rafsanjani, Arief; Ramadhan, Leny; Risma Fatmayanti, Baiq
Jurnal Teknologi Informasi untuk Masyarakat Vol. 2 No. 1 (2024): Jurnal Teknologi Informasi untuk Masyarakat (Teknokrat)
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/jt.v2i1.26422

Abstract

Bagik Payung Selatan Village is one of the villages in Suralaga District, East Lombok Regency with a dense population of over 1.2 million people spread across 10 hamlets. The high population in Bagik Payung Selatan Village causes quite high amounts of waste production which can be seen from the large amount of rubbish piled up on the side of the road and environmental cleanliness still neglected. The community in Bagik Payung Selatan Village has a low level of awareness and knowledge regarding inorganic waste management. Most of the inorganic waste is plastic waste produced daily from household waste. This community service activity aims to provide education on inorganic waste management using ecobrick techniques with zero waste system principles in Bagik Payung Selatan Village so that the local community can manage inorganic waste well. The method of educating the community is carried out by providing outreach and training in skills to make handicraft products from inorganic waste which has previously been prepared using the ecobrick technique. The results of this community service activity include public knowledge and awareness regarding ecobrick techniques, the zero waste system principles, and community creativity in managing inorganic waste increased. The community is very enthusiastic about turning household waste into multiple useful handcraft products that can be reused and sold since they have high economic value to help the local community's economy.
Analisis Kualitatif dan Kuantitatif Natrium Diklofenak pada Jamu Pegal Linu yang Beredar di Kecamatan Keruak Wahyuningsih, Dahriah Fitri; Yuliana, Tri Puspita; Azim, Muhlisun
Sinteza Vol. 1 No. 2 (2021): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v1i2.5268

Abstract

Jamu tidak boleh mengandung bahan Kimia Obat (BKO) sebab bila ditambahkan akan membahayakan konsumen karena dosis yang berlebih serta bisa mengakibatkan keracunan hingga kematian. Tujuan penelitian ini yaitu untuk mengetahui keberadaan bahan kimia obat (BKO) pada jamu untuk pegal linu yang beredar di kecamatan keruak perlu dilakukan penelitian. Pengambilan sampel di lakukan dengan cara random di kecamatan Keruak, Lombok Timur. Analisis natrium diklofenak pada jamu untuk pegal linu dilakukan dengan metode analisis kualitatif serta analisis kuantitatif menggunakan spektrofotometri Uv-Vis. Analisis Kromatografi Lapis Tipis menggunakan plat silica GF 254 menggunakan fase gerak untuk natrium diklofenak kombinasi antara etil asetat : n-heksane dengan perbandingan (7ml : 3ml) yaitu 7 ml etil asetat dan 3 ml nheksane. Hasil analisis kualitatif terdapat 3 sampel yang teridentifikasi positif mengandung natrium diklofenak karena menunjukkan kesamaan nilai Rf sampel jamu dengan standar yaitu 0,4. Hasil analisis kuantitatif menggunakan Spektrofotometri Uv-Vis natrium diklofenak didapat panjang gelombang maksimum 275 nm dengan absorbansi yaitu 0,834. Kadar natrium diklofenak yang diperoleh pada sampel B 53,8% dan sampel C 49,2%. Persamaan linear nilai r = 0,982 yaitu y=0,0132x-0,1235 untuk natrium diklofenak. Hasil uji identifikasi menunjukkan dari 4 sampel 2 diantaranya mengandung natrium diklofenak.
Pengaruh Ekstrak Daun Beluntas (Pluchea indica L.) dalam Menghambat Pertumbuhan Bakteri Staphylococus epidermidis Penyebab Bau Badan Hariani, Dia Isma; Hariadi, Puspawan; Azim, Muhlisun
Sinteza Vol. 1 No. 2 (2021): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v1i2.5270

Abstract

Bau badan merupakan masalah yang dapat mengganggu aktivitas sehari-hari, salah satu penyebabnya adalah bakteri Staphylococus epidermidis. Salah satu tanaman yang diduga dapat mencegah bau badan adalah tanaman daun beluntas. Tujuan dari penelitian ini adalah untuk menguji skrining fitokimia ekstrak daun beluntas dengan uji flavonoid, terpenoid, dan fenolik serta uji antibakteri terhadap bakteri Staphylococus epidermidis. Uji antibakteri menggunakan metode difusi agar tehnik sumuran menggunakan konsentrasi 40%, 80%, dan 100% dengan kontrol positif ciprofloxasin 50µg/ml dan kontrol negatif DMSO 10%. Hasil skrining menunjukkan ekstrak daun beluntas mengandung flavonoid, tanin, steroid, dan fenolik. Uji antibakteri menghasilkan diameter zona hambat yang terbentuk pada kelompok konsentrasi 40%, 80%, dan 100%, secara berurutan adalah 8,84 mm, 10,52 mm, dan 12,77 mm. Hasil uji statistik menggunakan uji One Way Annova didapatkan nilai signifikan p=0,000. Kesimpulan dari penelitian ini adalah ekstrak daun beluntas mampu menghambat bakteri Staphylococus epidermidis dengan konsentrasi paling efektif yaitu konsentrasi 80% dan 100%.
Aktivitas Antioksidan Buah Sawo Manila (Manilkara zapota L) Sebagai Kandidat Produk Perawatan Kulit Azim, Muhlisun; Saputra, Dani; Hariadi, Puspawan
Sinteza Vol. 2 No. 2 (2022): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.594 KB) | DOI: 10.29408/sinteza.v2i2.7662

Abstract

Antioksidan merupakan senyawa-senyawa yang dapat mencegah terbentuknya radikal bebas yang akan menyerang dinding sel. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan pada buah sawo manila (Manilkara zapota L). Senyawa antioksidan yang ditemukan pada buah sawo manila adalah senyawa alkaloid, flavonoid, tanin, dan saponin. Desain penelitian ini menggunakan desain eksperimental di laboratorium farmasi Universitas Hamzanwadi. Sampel diekstraksi dengan etanol 96%, dilanjutkan dengan proses fraksinasi menggunakan kolom kromatografi. Eluen yang digunakan pada proses fraksinasi yaitu etil asetat, etil asetat-metanol, dan metanol. Pengujian aktivitas antioksidan dilakukan secara kualitatif dan kuantitatif. Hasil pengujian  secara kualitatif menunjukkan semua sampel mengandung antioksidan karena terlihat warna kuning ketika disemprotkan DPPH pada plat KLT. Sedangkan hasil pengujian secara kuantitatif menunjukkan bahwa nilai IC50 fraksi I 46 ppm dengan kategori sangat kuat, nilai IC50 fraksi II 97 ppm dengan kategori kuat, nilai IC50 fraksi III 149 ppm dengan kategori sedang, dan nilai IC50 vitamin C 29 ppm dengan kategori sangat kuat. Kesimpulannya yaitu fraksi buah sawo manila (Manilkara zapota L) memiliki aktivitas antioksidan dengan kategori sangat kuat, kuat dan sedang.
Fraksinasi Sari Kulit Buah Pisang Kepok (Musa acuminata) Mentah Tua dan Evaluasi Aktivitas Antibakteri terhadap Pertumbuhan Bakteri Propionibacterium acnes Azhari, Yusron; Azim, Muhlisun; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.11953

Abstract

Acne vulgaris is a skin condition performed the acne due to bacterial activity that infects the skin. Acne problems are often the cause of a person that decrease in self-confidence. One of the most common acne-causing bacteria is Propionibacterium acnes. P.acnes is a gram-positive bacterium with its morphological, shape, properties and composition classified in the group of corynebacteria, but this type of bacteria is not toxigenic or bacteria that does not produce toxic substances (toxic). One of the materials that can be used for acne medication is banana peel. Banana peels are residual waste products from domestic industrial production. The waste of Banana peels have potential as an antibacterial. They contain secondary metabolites such as phenolics, quinones and flavonoids which can act as antibacterials. The purpose of this study was to examine the antibacterial activity of raw kepok banana (Musa acuminata) peel extract against Propionibacterium acne bacteria as a cause of acne. Antibacterial activity test in this study was carried out using the well diffusion method to see how the antibacterial effect of raw kepok banana peel (Musa acuminata) had on the growth of Propionibacterium acnes bacteria. Kepok banana peel extracts were fractionated with hexane, ethyl acetate and water. The results of the antibacterial activity test for the three fractions showed that the water fraction of kepok banana peel extract represented the best inhibition zone of 10.02 ± 0.05 mm, 11.28 ± 0.13 mm, 12.38 ± 0.02 mm and 16.97 ± 0.36 with a strong category at successive concentrations of 20%, 40%, 60% and 80%.
2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Analysis and Antibacterial Activities of Renggak Seed (Amomum Dealbatum Roxb) Azim, Muhlisun; Hariadi, Puspawan; Fatmayanti, Baiq Risma; Febriani, Yuyun; Wazni, Annisa Rizqita; Anggraini, Virta Dwi
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.28683

Abstract

Natural sources have complex interaction mechanisms in providing inhibitory effects against various radical reactions and multi-drug resistance (MDR). Amomum dealbatum (Renggak in Lombok) seed phytochemistry and bioactivities have the potential to be investigated. This study aims to explore the bioactivity of extracts and fractions of renggak seeds in reducing reactive oxygen species and inhibiting bacterial growth to overcome MDR. The methods used to determine the level of free radical scavenging and antibacterial activity in this study were the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar diffusion methods. The results of the phytochemical tests of the ethanolic extract of Renggak seeds contain triterpenoids, alkaloids, saponins, and phenolics. Meanwhile, in the hexane fraction were found alkaloids, saponins, and phenolics. The results of antibacterial tests on Staphylococcus aureus using the agar diffusion method for ethanol and hexane extracts at concentrations of 20, 40 and 60% were 12.50±1.00, 19.00±0.00, and 21.8±0.76 for ethanol extracts, respectively. The hexane fraction was 5.33±0.57, 10.83±0.57, and 14.33±0.28 mm. For Salmonella sp bacteria, it was 9.00±1.00, 14.16±0.29, and 18.16±1.04 mm for ethanol extracts than was 7.50±0.50, 12.67±0.76, and 15.67±0.76 mm for hexane fractions. Moreover, the ethyl acetate fraction contains triterpenoids, alkaloids, saponins and phenolics which are responsible for giving antioxidant effects with an IC50 value of 66.515±2.37 ppm and is classified as a strong antioxidant to scavenging free radicals of DPPH. The higher the concentration of the fraction, the higher the inhibition of the growth of Salmonella sp and Staphylococcus aureus bacteria. The ability of the extract and fraction to inhibit bacterial growth and reduce free radicals makes renggak seeds very potential for further investigation.
Co-Authors Abdul Rahim Anggraini, Virta Dwi Arief Rafsanjani Azhari, Yusron Baiq Maylinda Gemantari Baiq Risma Fatmayanti Erma Ewisa Oktresia Hariani, Dia Isma Izati Savitri, Nurul Jeli Marlita Leny Ramadhan Nanang Rudianto Ariefta Novasari, Novasari Nur Rezky Khairun Nisaa P. Hariadi Puspawan Hariadi Risma Hayatun Nufus Saputra, Dani T. Yuliana Tri Puspita Yuliana Wahyuningsih, Dahriah Fitri Wazni, Annisa Rizqita Yoshihito Shiono Yuyun Febriani Zulfiana, Salina