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VALIDASI METODE ANALISIS SIBUTRAMIN HCL PADA SEDIAAN JAMU PELANGSING DENGAN SPEKTROFOTOMETER UV-VISIBLE Febriani, Yuyun; Izati Savitri, Nurul; Azim, Muhlisun
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p20-30

Sibutramine HCl was known as one of the anti-obesity drugs known for its appetite-suppressing properties. The aims of this research were to analyze pharmaceutical chemicals content in slimming herbal remedies available in the East Lombok district market and to analyze the value and validation parameters for analyzing method of sibutramine HCl in these remedies using UV-Visible spectrofotometry. The method used qualitative analysis using thin-layer chromatography (TLC) and quantitative method used spectrophotometry UV-Visible. The method was validated to meet the specified requirements, including linearity, Limit of Detection (LoD), Limit of Quantification (LoQ), precision, and accuracy. The results of this research were, in qualitative analysis, 2 out of 5 samples were identified to contain sibutramine HCl with a value of Rf of 0.78. The selected wavelength for sibutramine HCl analysis was 224.40 nm, and the respective parameters of linearity, LoD, LoQ, precision, and accuracy were (r) 0.9991, 2,406 ppm, 7,291 ppm, 0.446% RSD, and 98.92% recovery. Based on the results above, showed that using the spectrofotometry UV-Visible method in this research complies with the established parameters.

The Influence of Socialization on Students' Knowledge Levels About Antibiotic Resistance in Selong District, East Lombok: Pengaruh Edukasi Terhadap Tingkat Pengetahuan Siswa Tentang Resistensi Antibiotik di Kecamatan Selong, Lombok Timur Risma Fatmayanti, Baiq; Ramadhan, Leny; Rafsanjani, Arief; Marlita, Jeli; Azim, Muhlisun; Febriani, Yuyun
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i2.1277

Antibiotics are drugs used to treat bacterial infections. Irrational use of antibiotics without a doctor's prescription causes antibiotic resistance. West Nusa Tenggara province is ranked sixth with the largest number of antibiotic consumption without a doctor's prescription so the incidence of antibiotic resistance increases. This community service aims to provide antibiotic resistance education to high school students in Selong District. The community service method was carried out at SMAN 1 Selong and SMAN 2 Selong which started with pretest, socialization, and posttest activities to measure students' knowledge of antibiotic resistance before and after socialization. The significance test of changes in students' knowledge levels before and after socialization was conducted using a paired sample t-test. The socialization participants from SMAN 1 Selong and SMAN 2 Selong consisted of 141 high school students in grade XI with an average age of 16. The pretest and posttest data analysis showed that students' knowledge levels regarding antibiotic resistance increased from 41% to 59% at SMAN 1 Selong and 42% to 58% at SMAN 2 Selong after socialization. The average value of students' knowledge about antibiotic resistance increased from 10.04 points to 14.73 points for SMAN 1 Selong and 10.33 points to 14.16 points for SMAN 2 Selong after the socialization was given from a total of 17 maximum points that could be obtained. The results of data analysis using paired sample t-test showed a significant difference (p<0.05) in the average level of student knowledge before and after the socialization activity was carried out. Thus, the antibiotic resistance socialization activity has successfully increased student knowledge in Selong District, especially at SMAN 1 Selong and SMAN 2 Selong effectively.

Edukasi dan Pendampingan Pengelolaan Sampah Anorganik Berprinsip Zero Waste System di Desa Bagik Payung Selatan Kecamatan Suralaga Febriani, Yuyun; Azim, Muhlisun; Rafsanjani, Arief; Ramadhan, Leny; Risma Fatmayanti, Baiq
Jurnal Teknologi Informasi untuk Masyarakat Vol. 2 No. 1 (2024): Jurnal Teknologi Informasi untuk Masyarakat (Teknokrat)
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/jt.v2i1.26422

Bagik Payung Selatan Village is one of the villages in Suralaga District, East Lombok Regency with a dense population of over 1.2 million people spread across 10 hamlets. The high population in Bagik Payung Selatan Village causes quite high amounts of waste production which can be seen from the large amount of rubbish piled up on the side of the road and environmental cleanliness still neglected. The community in Bagik Payung Selatan Village has a low level of awareness and knowledge regarding inorganic waste management. Most of the inorganic waste is plastic waste produced daily from household waste. This community service activity aims to provide education on inorganic waste management using ecobrick techniques with zero waste system principles in Bagik Payung Selatan Village so that the local community can manage inorganic waste well. The method of educating the community is carried out by providing outreach and training in skills to make handicraft products from inorganic waste which has previously been prepared using the ecobrick technique. The results of this community service activity include public knowledge and awareness regarding ecobrick techniques, the zero waste system principles, and community creativity in managing inorganic waste increased. The community is very enthusiastic about turning household waste into multiple useful handcraft products that can be reused and sold since they have high economic value to help the local community's economy.

FRAP REDUCING ACTIVITY OF PROTIUM JAVANICUM BURM.FIL LEAVES: A SCREENING ANTIOXIDANT POTENCY OF NATURAL COSMETIC INGREDIENT Sulastri, Novi; Gemantari, Baiq Maylinda; Hayaza, Azzam Hafid; Azim, Muhlisun; Hariadi, Puspawan; Pratiwi, Puspa Dwi
Indonesian Journal of Cosmetics Vol. 3 No. 2 (2025): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v3i2.2373

Tenggulun (Protium javanicum Burm.fil) has been traditionally used to treat various ailments such as cough, stomachache, diarrhea, inflammation and headache. The leaves have therapeutic roles in the treatment and prevention of illnesses acting as antibacterial, antidiabetic and antiinflammation agents. It is also reported that tenggulun leaves can be used for insecticides, cosmetics and food additives. This research aimed to determine antioxidant activity by reducing FRAP of the tenggulun leaves methanol extract using Trolox as the standard solution. The result showed that the tenggulun leaves extract contained secondary metabolites of flavonoid and polyphenolic. The extract showed the FRAP reducing activity at 0,008634±0.00043 μmol TE/g DW. These results indicated the ability of tenggulun methanolic extract to reduce Fe (III) into Fe (II) equivalent to Trolox by the presence of secondary metabolites confirmed.

2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Analysis and Antibacterial Activities of Renggak Seed (Amomum Dealbatum Roxb) Muhlisun Azim; Puspawan Hariadi; Baiq Risma Fatmayanti; Yuyun Febriani; Annisa Rizqita Wazni; Virta Dwi Anggraini
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.28683

Natural sources have complex interaction mechanisms in providing inhibitory effects against various radical reactions and multi-drug resistance (MDR). Amomum dealbatum (Renggak in Lombok) seed phytochemistry and bioactivities have the potential to be investigated. This study aims to explore the bioactivity of extracts and fractions of renggak seeds in reducing reactive oxygen species and inhibiting bacterial growth to overcome MDR. The methods used to determine the level of free radical scavenging and antibacterial activity in this study were the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar diffusion methods. The results of the phytochemical tests of the ethanolic extract of Renggak seeds contain triterpenoids, alkaloids, saponins, and phenolics. Meanwhile, in the hexane fraction were found alkaloids, saponins, and phenolics. The results of antibacterial tests on Staphylococcus aureus using the agar diffusion method for ethanol and hexane extracts at concentrations of 20, 40 and 60% were 12.50±1.00, 19.00±0.00, and 21.8±0.76 for ethanol extracts, respectively. The hexane fraction was 5.33±0.57, 10.83±0.57, and 14.33±0.28 mm. For Salmonella sp bacteria, it was 9.00±1.00, 14.16±0.29, and 18.16±1.04 mm for ethanol extracts than was 7.50±0.50, 12.67±0.76, and 15.67±0.76 mm for hexane fractions. Moreover, the ethyl acetate fraction contains triterpenoids, alkaloids, saponins and phenolics which are responsible for giving antioxidant effects with an IC50 value of 66.515±2.37 ppm and is classified as a strong antioxidant to scavenging free radicals of DPPH. The higher the concentration of the fraction, the higher the inhibition of the growth of Salmonella sp and Staphylococcus aureus bacteria. The ability of the extract and fraction to inhibit bacterial growth and reduce free radicals makes renggak seeds very potential for further investigation.

Pengetahuan masyarakat dan pemanfaatan tanaman obat keluarga di desa toya aikmel utara Muhlisun Azim; Arief Rafsanjani; Tripuspita Yuliana; Puspawan Hariadi
Lentera Negeri Vol. 2 No. 1 (2021): Lentera Negeri
Publisher : Indonesian Institute For Counseling, Education and Therapy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/99330

Family Medicinal Plants (TOGA) is an alternative in achieving GERMAS (Healthy Living Community Movement) as an effort to achieve traditional independent health. The success of the use of TOGA is strongly influenced by the level of public knowledge about the benefits of the type of medicinal plants which has been empirically investigated. The data obtained is qualitative data with descriptive approach analysis method. Data collection was carried out by conducting observations, interviews and technical training to the community in an effort to provide knowledge about TOGA and the creation of a TOGA demonstration plot. The results obtained from this activity are the emergence of public awareness of the use of home yard land for the manufacture of living pharmacies as an effort to achieve independent health and the emergence of public interest in the use of TOGA as a UMKM product in the form of packaged drink sachets as a pilot. The importance of public knowledge about TOGA is needed in supporting the success of achieving independent health and efforts to utilize local biological resources in initiating the manufacture of herbal plant-based UMKM products.

Promosi Pangan Beragam, Bergizi, Seimbang danFungsional Untuk Pencegahan dan Penanganan Stunting di Desa Masbagik Timur Baiq Risma Fatmayanti; Leny Ramadhan; Muhlisun Azim; Arief Rafsanjani; Yuyun Febriani; Jeli Marlita
Jurnal Mandala Pengabdian Masyarakat Vol. 7 No. 1 (2026): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v7i1.836

Kegiatan pengabdian masyarakat ini dilaksanakan di Desa Masbagik Timur, Lombok Timur, yang memiliki prevalensi stunting cukup tinggi. Kegiatan promosi pangan beragam, bergizi, seimbang dan fungsional (B2SF) sebelumnya telah dilakukan, namun untuk bisa menjaga pengetahuan masyarakat, maka perlu dilakukan kegiatan peningkatan pengetahuan secara berkala. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat mengenai pangan B2SF dalam menurunkan risiko stunting. Metode kegiatan meliputi observasi awal, koordinasi dengan pemerintah desa, penyusunan materi edukasi, pelaksanaan sosialisasi yang disertai pretest dan posttest, serta pemberian makanan tambahan (PMT) seperti susu, telur, dan camilan berbahan lokal (tepung mokaf, jagung, dan lebui). Kegiatan promosi dilakukan terhadap masyarakat usia produktif dengan mayoritas pekerjaan sebagai ibu rumah tangga. Data dianalisis menggunakan uji Wilcoxon dengan bantuan SPSS. Hasil menunjukkan bahwa sebagian besar masyarakat sudah memiliki pengetahuan baik mengenai stunting (86%), pentingnya ASI eksklusif (94%), dan ciri-ciri anak stunting (85%). Nilai rata-rata pretest dan posttest masing-masing 9,43 dan 9,44 berturut-turut. Nilai signifikansi terkait perbedaan nilai pretest dan posttest menunjukkan hasil yang tidak berbeda signifikan (p=0,802). Hal tersebut menandakan bahwa pengetahuan masyarakat sudah tinggi baik sebelum dan setelah kegiatan promosi dilakukan. Kesimpulannya, promosi pangan B2SF telah berhasil dilaksanakan di Desa Masbagik Timur. Selanjutnya, disarankan pembentukan kelompok belajar masyarakat melalui kader posyandu untuk memperkuat pemahaman dan penerapan pangan B2SF untuk mencegah stunting dapat terjaga secara berkelanjutan.

Sosialisasi Pemilihan Dan Penggunaan Kosmetik di Kalangan Siswi MA Mu’alimat Pancor, Lombok Timur Leny Ramadhan; Baiq Risma Fatmayanti; Yuyun Febriani; Arief Rafsanjani; Muhlisun Azim
Jurnal Mandala Pengabdian Masyarakat Vol. 7 No. 1 (2026): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v7i1.904

Kegiatan Pengabdian kepada Masyarakat yang dilaksanakan di MA Mu’alimat Pancor, Lombok Timur. Tujuannya untuk meningkatkan pengetahuan kesadaran Siswi MA Mu’alimat mengenai pemilihan dan penggunaan kosmetik yang aman. Fenomena meningkatnya penggunaan kosmetik dikalangan remaja putri seringkali tidak diimbagi dengan pemahamanan terhadap keamanan produk dan tampak pengunaan bahan berbahaya. Kegiatan sosialisasi dilaksanakan melalui metode penyuluhan interaktif meliputi, observasi awal, diskusi, penyusunan materi dan kuesioner, koordinasi dan perizinan dengan pihak sekolah serta pelaksanaan kegiatan disertai pretest dan posttest dan selanjutnya data di analisis dengan SPSS (Uji Wilcoxon). Hasil analisis menunjukkan adanya peningkatan pengetahuan siswi setelah diberikan edukasi. Pada aspek pemilihan kosmetik diperoleh nilai signifikansi sebesar 0,005 (p<0,05), sedangkan pada aspek penggunaan kosmetik diperoleh nilai signifikansi sebesar 0,039 (p<0,05). Hasil tersebut menunjukkan bahwa sosialisasi yang diberikan efektif dalam meningkatkan pengetahuan siswi terkait pemilihan dan penggunaan kosmetik yang aman. Kesimpulannya, kegiatan sosialisasi memberikan pengaruh terhadap peningkatan pengetahuan siswi MA Mu’alimat Pancor mengenai kosmetik aman.. Edukasi yang diberikan diharapkan dapat membantu remaja lebih bijak dalam memilih dan menggunakan produk kosmetik sehingga terhindar dari penggunaan produk yang berisiko bagi kesehatan.

ANALISIS DAN VALIDASI KANDUNGAN IODIUM PADA GARAM RAKYAT DENGAN METODE TITRASI IODOMETRI Baiq Mina Ahlul Taqwa; Yuyun Febriani; Muhlisun Azim
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.21966

Garam beriodium yang digunakan sebagai garam konsumsi harus memenuhi standar Nasional Indonesia (SNI No.01-3556-2010) yang mengandung iodium sebesar 30-80ppm. Proses validitas hasil data suatu metode menjadi penting sebelum melakukan suatu analisis karena dengan melakukannya diharapkan menghasilkan data yang baik dan akurat. Penelitian ini bertujuan untuk mengetahui kadar garam dan validitas metode iodometri yang digunakan dan data validasi dikumpulkan dengan mengamati beberapa parameter yaitu presisi, akurasi, kekuatan dan spesifisitas. Sampel yang digunakan adalah 3 sampel yang beredar di wilayah Lombok timur terutama bagian selatan yang di ambil dari 3 wilayah. Penelitian ini bersifat eksperimental berskala laboratorium. Hasil penelitian menggunakan metode titrasi iodometri, dalam 3 sampel yang dititrasi langsung sudah memenuhi kadar iodium menurut SNI (30-80ppm) namun garam yang diberikan perlakuan yang berbeda dari segi suhu mengalami penurunan kadar akan tetapi masih dapat memenuhi kadar iodium menurut SNI (30-80) namun 2 sampel yang disimpan pada kantong pelastik diluar ruangan tidak memenuhi kadar iodium menurut SNI (30-80). Karna sampel 1 dengan konsentrasi 20 ppm kadarnya 28,52ppm dan sampel 2 dengan konsentrasi 20ppm,30ppm,40ppm yang berada pada rentan 26,14-28,52ppm. Sedangkan hasil dari validasi metode iodometri menunjukkan spesifisitas yang baik dan uji kekuatan yang dapat diterima dengan nilai rata-rata % RSD = 3,7%, hasil uji akurasi dengan konsentrasi 20 ppm, 30 ppm, 40 ppm bahwa % recovery yang diperoleh berada pada rentan 103,1% – 109,3%, sedangkan hasil uji presisi memiliki nilai rata-rata % RSD = 3,7%. Berdasarkan hasil tersebut dapat disimpulkan bahwa metode titrasi iodometri dapat digunakan sebagai metode analisis kadar beriodium pada garam.

ANALISIS DAN VALIDASI KANDUNGAN IODIUM PADA GARAM RAKYAT DENGAN METODE TITRASI IODOMETRI Baiq Mina Ahlul Taqwa; Yuyun Febriani; Muhlisun Azim
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.21966

Garam beriodium yang digunakan sebagai garam konsumsi harus memenuhi standar Nasional Indonesia (SNI No.01-3556-2010) yang mengandung iodium sebesar 30-80ppm. Proses validitas hasil data suatu metode menjadi penting sebelum melakukan suatu analisis karena dengan melakukannya diharapkan menghasilkan data yang baik dan akurat. Penelitian ini bertujuan untuk mengetahui kadar garam dan validitas metode iodometri yang digunakan dan data validasi dikumpulkan dengan mengamati beberapa parameter yaitu presisi, akurasi, kekuatan dan spesifisitas. Sampel yang digunakan adalah 3 sampel yang beredar di wilayah Lombok timur terutama bagian selatan yang di ambil dari 3 wilayah. Penelitian ini bersifat eksperimental berskala laboratorium. Hasil penelitian menggunakan metode titrasi iodometri, dalam 3 sampel yang dititrasi langsung sudah memenuhi kadar iodium menurut SNI (30-80ppm) namun garam yang diberikan perlakuan yang berbeda dari segi suhu mengalami penurunan kadar akan tetapi masih dapat memenuhi kadar iodium menurut SNI (30-80) namun 2 sampel yang disimpan pada kantong pelastik diluar ruangan tidak memenuhi kadar iodium menurut SNI (30-80). Karna sampel 1 dengan konsentrasi 20 ppm kadarnya 28,52ppm dan sampel 2 dengan konsentrasi 20ppm,30ppm,40ppm yang berada pada rentan 26,14-28,52ppm. Sedangkan hasil dari validasi metode iodometri menunjukkan spesifisitas yang baik dan uji kekuatan yang dapat diterima dengan nilai rata-rata % RSD = 3,7%, hasil uji akurasi dengan konsentrasi 20 ppm, 30 ppm, 40 ppm bahwa % recovery yang diperoleh berada pada rentan 103,1% – 109,3%, sedangkan hasil uji presisi memiliki nilai rata-rata % RSD = 3,7%. Berdasarkan hasil tersebut dapat disimpulkan bahwa metode titrasi iodometri dapat digunakan sebagai metode analisis kadar beriodium pada garam.

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