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All Journal VALENSI Jurnal Sains dan Teknologi Kimia Indonesian Journal of Biotechnology IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Jurnal Tadris Kimiya Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Chimica et Natura Acta Indonesian Journal of Chemistry Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan Jurnal Kartika Kimia Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Journal of Vocational Education Studies Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Indonesian Journal Of Educational Research and Review ICONESTH Jurnal Pengabdian Isola Jurnal Riset dan Praktik Pendidikan Kimia
Iqbal Musthapa
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Anti-tyrosinase Activity of 3’,4’,5’-Trimethoxychalcones: Experimental and Computational Studies Danova, Ade; Hermawati, Elvira; Chavasiri, Warinthorn; Mujahidin, Didin; Musthapa, Iqbal; Kurniadewi, Fera
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.982-989

Abstract

Tyrosinase inhibitors are utilized as preservatives in the food industry and skin-lightening agents in the medical and cosmetic sectors. However, there has been little progress in clinical trials owing to challenges such as low bioavailability, significant skin irritation, and instability. Hence, the objective of this study was to evaluate the inhibitory activity of 3’,4’,5’-trimethoxychalcones through in vitro, molecular docking and molecular dynamics studies targeting tyrosinase. Five 3’,4’,5’-trimethoxychalcones (1-5) were evaluated their biological activity against tyrosinase for the first time. Compounds 4 and 5 were excellent inhibitory activity against tyrosinase with IC50 values of 1.9 and 1.7 μm compared with kojic acid and ascorbic acid. Isovanillin and catechol moieties are vital in this present study. This result was supported with molecular docking by shaping interaction in the catalytic site with histidine residues and the stability evaluation of the inhibitor-protein complexes using molecular dynamics simulation. The lipinski’s rules showed a fit with two potential inhibitors (4, 5). Therefore, 3’,4’,5’-trimethoxychalcones possessing isovanillin and catechol parts in the B ring are promising candidate for further study as tyrosinase inhibitors by evaluating their efficacy in vitro and in vivo.
A BIBLIOMETRIC ANALYSIS OF RESEARCH TRENDS ON CONTEXTUAL LEARNING IN SCIENCE EDUCATION Hasanah, Ika; Anwar, Sjaeful; Musthapa, Iqbal
Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan Vol 15, No 3 (2024): Juli
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/paedagoria.v15i3.22999

Abstract

Abstrak: Penerapan pembelajaran kontekstual telah menjadi tren dominan dalam pendidikan di berbagai negara. Metode pembelajaran ini telah berkembang dengan beragam pendekatan yang menekankan kerjasama lintas disiplin, domain, dan wilayah. Penelitian ini bertujuan untuk memberikan kontribusi signifikan bagi peneliti dan pendidik dalam Pendidikan Sains dengan melakukan analisis bibliometrik global tentang pembelajaran kontekstual, menggunakan karakteristik publikasi sebagai dasar. Penelitian ini menggunakan metode analisis bibliometrik dengan mengambil database Scopus dan berhasil mengumpulkan 782 artikel yang diterbitkan dari tahun 2010 hingga 2022. Analisis bibliometrik yang dilakukan menggunakan alat seperti VOSviewer dan Microsoft Excel. Hasil penelitian menunjukkan bahwa Bialocerkowski, A. dan Olson R., adalah penulis yang paling banyak dikutip dalam penelitian tentang pembelajaran kontekstual dalam Pendidikan Sains. Artikel yang paling banyak dikutip adalah "Interprofessional Education in Allied Health: A Systematic Review". Berdasarkan peta kolaborasi antar negara, Amerika Serikat tampaknya menjadi pusat kolaborasi paling signifikan dalam penelitian tentang pembelajaran kontekstual dalam Pendidikan Sains. Selain itu, jurnal "Journal of Research in Science Teaching" terlihat menonjol dalam publikasi Pembelajaran Kontekstual dalam Pendidikan Sains, berdasarkan jumlah kutipan dan kuartil (Q1). Studi bibliometrik ini juga menemukan korelasi antara kata kunci yang digunakan oleh penulis, antara lain "Pendidikan Profesional", "Pendidikan Sains", "Pendidikan", "Konteks", dan "Pembelajaran Kontekstual". Temuan-temuan ini menyoroti pentingnya penelitian multidisiplin dan interdisiplin dalam memahami pembelajaran kontekstual dalam konteks pendidikan dan mengadvokasi untuk memasukkan konteks geografis yang lebih luas dalam penelitian tentang pembelajaran kontekstual.Abstract:  Implementing contextual learning has become a dominant trend in education across various countries. This learning method has evolved with diverse approaches emphasizing collaboration across disciplines, domains, and regions. This research aims to contribute significantly to researchers and educators in Science Education by conducting a global bibliometric analysis of contextual learning, using publication characteristics as the basis. This research uses bibliometric analysis method by taking the Scopus database and successfully collecting 782 articles published from 2010 to 2022. Bibliometric analysis is conducted using tools such as VOSviewer and Microsoft Excel. The analysis results show that Bialocerkowski, A. and Olson, R., is the most cited author in research on contextual learning in Science Education. The most cited article is "Interprofessional Education in Allied Health: A Systematic Review". Based on the map of collaboration between countries, the United States appears to be the most significant center for collaboration in research on contextual learning in Science Education. Furthermore, the journal "Journal of Research in Science Teaching" stands out in the publication of Contextual Learning in Science Education, based on the number of citations and quartile (Q1). This bibliometric study also found a correlation between the keywords used by authors, including "Professional Education," "Science Education," "Education," "Context," and "Contextual Learning". These findings highlight the importance of multidisciplinary and interdisciplinary research in understanding contextual learning in the educational context and advocating for including broader geographic contexts in research on contextual learning.
A Trend Analysis of Project-based Learning in Chemistry Experiment: A Bibliometric Analysis Hasanah, Ika; Anwar, Sjaeful; Musthapa, Iqbal
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8642

Abstract

Project-based learning is a global trend, widely adopted across countries. Project-based learning has developed diversely by emphasizing interdisciplinary, cross-domain, and regional collaboration. To provide in-depth resources for researchers and educators on project-based learning in chemistry experiments, this study aims to make a bibliometric analysis on the topic of project-based learning globally using publication characteristics analysis. The database used in this study used Scopus and obtained 5900 articles from 2018-2023. Bibliometric analysis was analyzed using VOSviewer and Microsoft Excel. The results of the bibliometric analysis show that Boone, C.D. is the author with the highest number of citations on the research topic, Project-based learning in a chemistry experiment. The United States is the most productive country in researching this topic, with 1351 articles. The most influential journal with the highest number of articles is the Journal of Physics Conference Series, with 243 articles. The major contextualized learning literatures in this study tend to fall into broad groups such as Project-based Learning, Education, and STEM Education. These findings suggest the need for multidisciplinary and cross-disciplinary studies on project-based learning research on chemistry learning and advocate for the inclusion of project-based learning research in education from a broader geographical context.
Experimental and Molecular Docking Study of 3′,4′,5′-Trimethoxychalcones Targeting Overexpressed Protein in HCT-116 Colon Cancer Cells Danova, Ade; Wonganan, Piyanuch; Hermawati, Elvira; Kurniadewi, Fera; Musthapa, Iqbal; Chavasiri, Warinthorn
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46483

Abstract

Cancer poses a substantial global health challenge. Colorectal cancer (CRC) is the second leading cause of cancer-related mortality after lung cancer and is associated with high mortality rates worldwide. Chalcones have attracted significant interest because of their diverse biological properties, including potential anticancer effects. In this study, five 3′,4′,5′-trimethoxychalcones (1-5) were tested against HCT-116 colon cancer cells using an MTT assay for the first time. Molecular docking was conducted to predict molecular interactions targeting three proteins (tubulin, EGFR, and CDK2). Among the five, four compounds (1, 3, 4, and 5) exhibited strong inhibitory activity against HCT-116 colon cells, with IC50 values < 10 µM. Compounds 1-5 showed potency as drug candidates based on the Lipinski rules and pharmacokinetic profiles using SwissADME and pkCSM online tools. Moreover, molecular docking was performed on compound 5 against three protein targets (tubulin, EGFR, CDK2) with binding affinities of -7.4, -7.3, and -8.5 kcal/mol, respectively, and showed major H-bond interactions. Therefore, these results suggest that compound 5 could be a potential inhibitor to be developed in future studies, both in vitro and in vivo, to understand its inhibition mechanism and efficacy.
Study and Characterization of Nitration of Isovanillic Acid Derivatives using NMR and Mass Spectroscopy Hermawati, Elvira; Sa'adah, Pipih Lutfi; Danova, Ade; Mujahidin, Didin; Musthapa, Iqbal
Chimica et Natura Acta Vol 13, No 3 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n3.62271

Abstract

Isovanillic acid and its derivatives serve as precursors in the synthesis of EGFR tyrosine kinase inhibitors, which are used to treat cancer cell lines. A crucial step in this process is the nitration of isovanillic acid through nucleophilic aromatic substitution, resulting in 6-nitroisovanilic acid and its derivatives, which act as intermediates for forming a quinazolinone ring. However, this study revealed that direct nitration of isovanillic acid derivatives led to unexpected products, such as 3-hydroxy-4-methoxy-2,6-dinitrobenzoic acid (1) and 4-(3-(2-methoxy-4-nitrophenoxy)propyl)morpholine (4). Additionally, the optimal conditions for etherification of 2 with N-(3-chloropropyl)morpholine to produce 3 involved using Cs2CO3 in DMF and refluxing for 7 hours, achieving an 89% yield. All synthesized compounds were characterized using NMR spectroscopy, and mass spectrometry was employed for two compounds (3, 4). Compound 1 represents the first report of direct nitration of isovanillic acid. Compound 4 was synthesized for the first time from 3 through a one-pot process involving hydrolysis and decarboxylation, followed by nitration at carbon C-1 without metal catalysis, as confirmed by a NOESY 1D experiment. Moreover, the application of 4 could hold promise for future advancements in medicinal chemistry.
Co-Authors - Ruchiyat Ade Danova Ahmad Aminudin Ahmad Sanusi Al Arofatus Naini Asep Supriatna Atep Rian Nurhadi Cecep Jaenudin Chavasiri, Warinthorn Danova, Ade Dessi Nur Adiska Desti Nursaleh Dhini Anisa Didin Mujahidin Fadilawati, Siti Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajeriyati, Nurul Fandi Ahmad Fitri Khoerunnisa Florentina Maria Titin Supriyanti Galuh Yuliani Gun Gun Gumilar Gun Gun Gumilar Gun Gun Gumilar Hasanah, Ika Heli Siti Halimatul Hendrawan Hendrawan Herlan Herdiawan Hermawati, Elvira HERNANI - Humairo, Ristvi Iis Rosliana Ika Nurhayati Irawan, Nisrina Zahira Putri Kurniadewi, Fera Lestari, Nanda Ayu Liliasari Liliasari Liliasari Mahmudah, Eneng Mr Sjaeful Anwar Nenden Fauziah NFN Noviyanti Nuky Dwifirly Pratiwi Arhatha Nur Indah Sari Nuraini, Vidia Afina Perdana, Farid Pratiwi, Eka Nikita Ratnaningsih Eko S. Riza Apriani Rosi Oktiani Ruchiyat Ruchiyat Sa'adah, Pipih Lutfi Siti Aisyah Sjaeful Anwar Soja Siti Fatimah Soja Siti Fatimah Tati Herlina Unang Supratman Wonganan, Piyanuch Yaya Sonjaya Yayan Sunarya