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All Journal Naturalis : Jurnal Penelitian Pengelolaan Sumberdaya Alam dan Lingkungan The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati ISM (Intisari Sains Medis) : Jurnal Kedokteran Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Journal of Telenursing (JOTING) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS JAMAS: Jurnal Abdi Masyarakat
Elvira Yunita
Department Biochemistry And Molecular Biology, Faculty Of Medicine And Health Sciences, Universitas Bengkulu, Bengkulu, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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A Fatal Outcome of SARS-COV-2 Infection: A Case Report of A 60 Years Old Man with Multiple Organ Failure Muhammad Ridwan; Elvira Yunita
Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Vol 8 No 4 (2022): Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Buton

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.947 KB) | DOI: 10.35326/pencerah.v8i4.2375

Abstract

The infection of Corona Virus Disease – 19 (COVID-19) has spread out in Indonesia. The number of deaths has increased in recent months. Cases of infection are followed by comorbidities such as diabetes, hypertension, cardiovascular and cerebrovascular condition have higher risk to develop severe illness. These conditions also give the higher risk of death in patients. Herein, we reported a 60 years old man that was infected with Sar-Cov-2 and had no comorbidities. Before the infection, patient was healthy. In the early phase of infection, clinical manifestations were seen in patients such as fever, cough, nausea and vomiting. A few days after being admitted to the hospital, the condition began to get worse which led to multiple organ failure. Acute kidney injury, liver injury, dysregulation of glucose level and acid base disorder were shown from laboratory tests. Unfortunately, clinical manifestations were poor and the patient passed away.
Probiotic Lactobacillus acidophilus FNCC 0051 Improves Pancreatic Histopathology in Streptozotocin-induced Type-1 Diabetes Mellitus Rats Mardhatillah Sariyanti; Tiara Ayoe Andita; Noor Diah Erlinawati; Elvira Yunita; Ahmad Azmi Nasution; Kartika Sari; Nikki Aldi Massardi; Sylvia Rianissa Putri
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2047

Abstract

BACKGROUND: Intestinal microbial dysbiosis and its metabolites can affect the immune activity of intestinal mucosal cells, causing insulitis and pancreatic β-cell death. Probiotic Lactobacillus acidophilus plays an important role in reducing inflammatory cytokines, hence improves oxidative stress that affects pancreatic β-cell apoptosis. Current study examined the feature of pancreatic histopathology affected by the administration of probiotic L. acidophilus in rats with type-1 diabetes mellitus (DM) induced by streptozotocin (STZ).METHODS: Twelve rats were induced by STZ at double dose of 50 mg/kgBB before administered with probiotic L. acidophilus at a dose of 1.5x10 8 or 1.5x10 9 CFU/mL/day, while other 4 rats were used as control. After 21 days of the L. acidophilus treatment, the average of fasting blood glucose (FBG) levels of rats were measured, then the pancreatic histopathology was assessed to evaluate the degree of insulitis in islet of Langerhans.RESULTS: The induction of STZ had been succeeded to increase blood glucose levels, which indicate DM condition. The highest FBG level after 21 days of treatment was found in DM group with glucose level of 512±81.51 mg/dL. The administration of probiotic L. acidophilus during 21 days treatment at both dose 1.5x10 8 and 1.5x10 9 CFU/mL/day significantly improved pancreatic histopathology (p=0.04 and p=0.034, respectively), with significant decrease on insulitis scores compared to DM group.CONCLUSION: The administration of L. acidophilus at both dose of 1.5x10 8 and 1.5x10 9 CFU/mL/day for 21 days can improve pancreatic histopathology of type-1 DM rats induced by STZ, therefore probiotic L. acidophilus may be potential as supplementation treatment for type-1 DM.KEYWORDS: Lactobacillus acidophilus, pancreatic histopathology, streptozotocin, type-1 diabetes mellitus
Hubungan Pengaruh Polimorfisme Genetik Terhadap Risiko Kejadian Diabetes Melitus Elvira Yunita; Cindy Ernica Putri; Audia Indrian; Liya Agustin Umar; Diah Ayu Aguspa Dita
Jurnal Medika Malahayati Vol 6, No 4 (2022): Volume 6 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v6i4.9004

Abstract

Diabetes adalah suatu keadaan adanya gangguan metabolik yang terjadi jangka panjang/kronis ditandai dengan tingginya kadar glukosa darah yang disebabkan oleh defisiensi insulin absolut maupun relatif, disfungsi sel β, resistensi insulin atau dapat terjadi keduanya. Diabetes melitus secara diklasifikasikan menjadi beberapa jenis, dan yang paling umum diketahui adalah diabetes melitus tipe 1 dan tipe 2. Faktor-faktor yang berhubungan dengan angka kejadian DM diantaranya adalah overweight, obesitas sentral/abdominal, derajat stress, kurangnya aktifitas fisik, hipertensi, dislipidemia, kondisi prediabetes, merokok, ras, etnik, umur, jenis kelamin, riwayat keluarga dengan diabetes melitus. Faktor genetik diketahui mempunyai peranan yang cukup penting dalam kejadian, perjalanan dana perkembangan penyakit DM. Faktor genetik yang paling umum berperan adalah Single Nucleotide Polimorphism (SNP). Gen yang diketahui mempunyai hubungan yang erat dengan DMT1 antara lain  gen HLA, CTLA-4, PTPN22, dan IL2RA/CD25. Pada DMT2 terdapat beberapa gen yang berperan yaitu gen ABCC8, KCNJ11, PPAR-γ dan CALPN10.
Comparison of Propolis Extracts and Bioplacenton at Epidermal Re-epithelialization Process in Burn Wound of Mice (Mus musculus) Bhayu Baruna Bastari; Elvira Yunita; Kartika Sari; Marisadonna Asteria; Julian Famil; Oktoviani Oktoviani
Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Vol 9 No 2 (2023): Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton
Publisher : Lembaga Jurnal dan Publikasi Universitas Muhammadiyah Buton

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35326/pencerah.v9i2.3007

Abstract

Effective treatment is needed in accelerating the healing process of burn. Propolis extract is a bee product that has a high flavonoid content. Propolis extract is thought to stimulate the process of re-epithelialization of the epidermis. This research was an experimental study with a post-test only control group design. This study used experimental animal, male mice (Mus musculus) Swiss webster strain. Mice were grouped randomly into a control group and a treatment group. Each mouse was given treatment in the form of burn on the back. The control group was the group that was not given propolis or bioplacenton extract. The treatment group was given 5%, 10%, and bioplacenton propolis extract, respectively. Skin histopathological tissue collection was carried out on day 1, day 4, and day 21 to observe the process of re-epithelialization of the epidermis. The results showed that the means of epithelial thickness in the control group and the 5% and 10% propolis extract treatment were significantly thicker on the 21st day of observation when compared to the control group. The administration of bioplacenton showed an increase in the re-epithelialization process of the epidermis on the 4th day. The administration of 10% propolis extract was better in increasing the mean epithelial thickness on the 4th day than the group given 5% propolis extract and bioplacenton.
EDUKASI COVID-19 DI SMAN 3 BENGKULU TENGAH: TINJAUAN KHUSUS PADA ADAPTASI KEBIASAAN BARU DAN URGENSI PEMENUHAN PROTEIN HEWANI: Covid-19 Education in Senior High School 3 at The Middle of Bengkulu: A Special Topic on The Adaptation of New Habits and The Urgency of Fulfilling Animal Protein Elvira Yunita; Liya Agustin Umar; Nurmeiliasari; Diah Ayu Aguspa Dita
JAMAS : Jurnal Abdi Masyarakat Vol. 1 No. 2 (2023)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.89 KB)

Abstract

Sar-Cov2 infection is still occurring, although in some areas there has been a decrease in infection cases. This condition has become the basis for policy makers in Bengkulu Province to issue a circular letter so that schools can be carried out face-to-face. The condition of facing the adaptation of new habits that are currently being carried out really requires good knowledge and understanding of health protocols. In addition, preventive measures from cases of infection that occur, one of which can be pursued by increasing the body's immune system through meeting the needs of animal protein. The method applied to this Community Service Program (PKM) is through interactive counseling to SMAN 03 Bengkulu Tengah and distribution of dairy products to the academic community at SMAN 03 Bengkulu Tengah. The results of this PKM show that the socialization of adaptation to new habits can provide understanding to teachers and students at SMAN 3 Bengkulu Tengah so that they can implement clean and healthy living behaviors. In addition, the provision of dairy products can be the first step in efforts to meet the needs of animal protein that supports the body's immune system. Based on the analysis of this PKM activity, continuous implementation in increasing knowledge about adapting new habits and fulfilling balanced nutrition must continue to be carried out. This is carried out to prepare the community so that they can continue their activities in the new normal conditions.
KAJIAN PUSTAKA: POLIMORFISME GENETIK SEBAGAI FAKTOR RISIKO OBESITAS Diah Ayu Aguspa Dita; Elvira Yunita; Risti Dwi Ocktaviani; Putjha Melati
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 7 (2023): Volume 10 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i7.10203

Abstract

Abstrak: Polimorfisme Genetik Sebagai Faktor Risiko Obesitas: Pendekatan Telaah Literatur. Obesitas semakin meningkat kejadiannya terutama jika dikaitkan dengan pola konsumsi makanan berlebih dan kurangnya aktivitas fisik. Etiologi dan patologi obesitas hingga saat ini masih secara dinamis dilaporkan oleh peneliti. Faktor risiko obesitas tidak hanya berhubungan dengan faktor risiko eksternal yang dapat dimodifikasi seperti pola makan dan gaya hidup, melainkan juga faktor intenal seperti genetik yang tidak dapat dimodifikasi. Faktor risiko internal tersebut dikaitkan dengan polimorfisme genetik gen FTO rs9939609. Polimorfisme gen ini dikaitkan dengan kontrol asupan energi yang mengarahkan pada kejadian obesitas. Pengaruh varian genetik FTO terhadap obesitas semakin kuat sepanjang rentang umur. Selain itu, varian gen ini juga berhubungan dengan resistensi insulin pada beberapa kasus yang telah dilaporkan.
ANALISA BASIL TAHAN ASAM PADA DAHAK PENDERITA TUBERKULOSIS SEBELUM DAN SESUDAH MENDAPAT PENGOBATAN OBAT ANTI TUBERKULOSIS DI UPT. RUMAH SAKIT KHUSUS PARU MEDAN Ellen Maidia Djatmiko; Debie Rizqoh; Putri Maulida; Elvira Yunita
Jurnal Medika Malahayati Vol 7, No 3 (2023): Volume 7 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i3.10845

Abstract

Abstrak: Analisa Basil Tahan Asam pada Dahak Penderita Tuberculosis Sebelum dan Sesudah Mendapat Pengobatan Obat Anti Tuberculosis di UPT. Rumah Sakit Khusus Paru Medan. Tuberkulosis (TB) adalah penyakit menular akut maupun kronis, terutama menyerang paru, yang disebabkan oleh Mycobacterium tuberculosis. Tuberkulosis merupakan penyakit yang menjadi perhatian global. Obat Anti Tuberkulosis (OAT) adalah komponen terpenting dalam pengobatan tuberkulosis untuk mencegah penyebaran lebih lanjut dari kuman tuberkulosis dan mempercepat proses penyembuhan pasien TB. Tujuan penelitian ini adalah untuk mengetahui BTA pada dahak penderita TB paru sebelum dan sesudah mendapat pengobatan OAT. Jenis penelitian ini bersifat deskriptif yang dilakukan di UPT. Rumah Sakit Khusus Paru Medan pada bulan Juli–Agustus 2017. Pemeriksaan ini dilakukan secara mikroskopis dengan menggunakan metode pewarnaan Ziehl Neelsen terhadap 17 sampel yang telah mendapat pengobatan OAT selama 6 bulan secara teratur. Dari hasil penelitian ini dapat menunjukkan adanya perubahan pada pasien TB Paru sebelum dan sesudah mendapat pengobatan OAT selama 6 bulan secara teratur. Data pemeriksaan awal sebelum mendapat pengobatan terdapat 100% dengan hasil pemeriksaan BTA (+3) dan sesudah mendapat pengobatan OAT selama 6 bulan secara teratur tidak ditemukan BTA (negatif) yaitu 0%. Hal ini menunjukkan bahwa efektifitas pengobatan di Labotratorium UPT. Rumah Sakit Khusus Paru Medan dapat dikatakan baik.
Co-Authors Ahmad Azmi Nasution Annisa Puspa Sari Audia Indrian Aurora Fajria Anwari Bhayu Baruna Bastari Cindy Ernica Putri Debie Rizqoh Dessy Triana Diah Ayu Aguspa Dita Dyah Fitriani Ellen Maidia Djatmiko Enny Nugraheni Fajrianti Haniyah Gina Fendiati Putri Gustria Ernis Hardiansyah Hardiansyah Hilda Taurina Inta Cantika Ismir Fahri Jihan Vira Yuniar Julian Famil Kartika Sari Kartika Sari Liya Agustin Umar Liya Agustin Umar Liya Agustin Umar Mardhatillah Sariyanti Maria Eka Patri Y Marisadonna Asteria Marisadonna Asteria Meiny Suzery Miftahul Haniyah Muhammad Ridwan Neni Susilaningsih Nikki Aldi Massardi Noor Diah Erlinawati Notriawan, Doni Novriantika Lestari Novriantika Lestari Nurmeiliasari Oktoviani Putjha Melati Putri Maulida Riry Ambarsarie Risti Dwi Ocktaviani Rizkianti Anggraini Sipriyadi Sri Yunita Suhartono, Suhartono Sylvia Rianissa Putri Tiara Ayoe Andita Zhafran Hafizhki