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All Journal Althea Medical Journal Jurnal Sain Peternakan Indonesia Naturalis : Jurnal Penelitian Pengelolaan Sumberdaya Alam dan Lingkungan Program Kreativitas Mahasiswa - Penelitian The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati ISM (Intisari Sains Medis) : Jurnal Kedokteran Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Journal of Telenursing (JOTING) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Kesehatan Tambusai Edu Masda Journal Jurnal Kedokteran Raflesia JAMAS: Jurnal Abdi Masyarakat

Elvira Yunita

Departemen Biokimia, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Bengkulu, Bengkulu, Indonesia

Author-ID : 3265212

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Epigenetic Regulation of Breast Cancer Stem Cells Elvira Yunita
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.289

Breast cancer arises as a result of abnormal breast cells forming at an uncontrolled rate. Death in this case of breast cancer is due to the ability of cancer cells to adapt so that it can have an effect on metastasis and recurrence of cancer that was previously thought to have been resolved. The results showed, there is a stem cell population in breast cancer cases which will cause breast cancer to become increasingly difficult to treat. Such cells are known as breast cancer stem cells. Breast cancer cells have the ability to differentiate and contribute greatly to the breast cancer program, as well as to resistance to therapy. Therefore, epigenetic regulation of breast cancer cells is important to study in order to overcome cancer so that it can overcome progression and resistance to cancer therapy being carried out.Epigenetic regulation that has been known in cancer cases includes DNA methylation, histone acetylation, histone methylation and epigenetic regulation by miRNA. DNA methylation is the addition of a methyl group to the nitrogen base of DNA cytosine which will force the DNA transcription process. Acetylation of the addition of an acetyl group at the end of the histone causes reduced chromatin condensation so that it will activate the transcription process. Methylation histones will also suppress transcription so that genes cannot be expressed. In addition, there is also a small RNA molecule known as miRNA which can bind to the transcribed mRNA. This binding will cause the mRNA to degrade or inhibit its translation.

Efek pemberian propolis pada fungsi ginjal dan hepar tikus putih (Rattus Norvegicus) yang diinduksi cisplatin Novriantika Lestari; Fajrianti Haniyah; Annisa Puspa Sari; Liya Agustin Umar; Elvira Yunita
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Cisplatin as an anticancer drug results in nephrotoxicity and hepatotoxicity. Accumulation of cisplatin in the body will produce reactive compounds in the form of free radicals which induce oxidative stress that affects kidney and liver functions. Propolis contains flavonoids, phenolic acid, and Caffeic Acid Phenethyl Ester (CAPE) which have the ability to prevent free radical formation and improve kidney and liver function. This study aims to determine the effect of propolis administration to ameliorate of BUN, creatinine, ALT and AST levels in cisplatin-induced rats (Rattus norvegicus).Methods: The experimental study was conducted with the pre-post-test with control group design approach. The research sample used 30 white rats which were divided into normal (aquadest), Cisplatin (5mg/kg i.p), and cisplatin+propolis groups. Propolis was given at a dose of 50mg/kg, 100mg/kg and 200mg/kg orally for seven days, four days after cisplatin induction. Rat blood was taken for analysis of Bloof Urea Nitrogen (BUN), Creatinine, ALT, and AST levels. Data were analyzed using SPSS version 26 for Windows.Results: The results showed that there were significant differences in levels of BUN, Creatinine, ALT and AST between groups (p<0.05). Propolis treatment at doses of 50 mg/kg, 100mg/kg and 200mg/kg can reduce levels of BUN/urea, creatinine, ALT, and AST in rats that have been induced by cisplatin significantly (p<0,05).Conclusion: Propolis has a therapeutic effect on cisplatin drug-induced nephrotoxicity and hepatotoxicity by affecting the BUN, creatinine, ALT, and AST levels in rats. Latar Belakang: Penggunaan cisplatin sebagai obat antikanker menghasilkan efek nefrotoksisitas dan hepatotoksisitas imbas obat. Akumulasi cisplatin di dalam tubuh akan menghasilkan senyawa reaktif berupa radikal bebas yang menginduksi terjadinya stress oksidatif sehingga akan berpengaruh ke fungsi ginjal dan hepar. Propolis mengandung flavonoid, asam fenolat, dan Caffeic Acid Phenethyl Ester (CAPE) yang memiliki kemampuan mencegah pembentukan radikal bebas dan memperbaiki fungsi ginjal dan hepar. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian propolis terhadap pemulihan kadar ureum, kreatinin, ALT dan AST darah pada tikus putih (Rattus norvegicus) yang telah diinduksi cisplatin.Metode: Penelitian eksperimental ini dilakukan dengan pendekatan pre-post-test with control group design. Sampel penelitian menggunakan 30 ekor tikus putih yang dibagi menjadi kelompok normal (aquadest), Cisplatin (5mg/kgbb i.p) dan kelompok cisplatin+propolis. Propolis diberikan dengan dosis 50mg/kgbb, 100mg/kgbb dan 200mg/kgbb secara oral selama tujuh hari, empat hari setelah induksi cisplatin. Darah tikus diambil untuk analisis kadar Blood Urea Nitrogen (BUN), Kreatinin, ALT, dan AST. Data dianalisis dengan SPSS versi 26 untuk Windows.Hasil: Hasil penelitian menunjukkan terdapat perbedaan kadar BUN, Kreatinin, ALT, dan AST yang bermakna antar kelompok (p<0,05). Pemberian propolis dengan dosis 50 mg/kgBB, 100 mg/kgBB dan 200 mg/kgBB dapat menurunkan kadar BUN/ureum, kreatinin, ALT, dan AST pada tikus yang telah diinduksi cisplatin secara bermakna (p<0,05).Kesimpulan: Propolis memiliki efek terapi pada nefrotoksisitas dan hepatotoksisitas akibat obat cisplatin dengan mempengaruhi kadar BUN/ureum, kreatinin, ALT, dan AST pada tikus.

A Fatal Outcome of SARS-COV-2 Infection: A Case Report of A 60 Years Old Man with Multiple Organ Failure Muhammad Ridwan; Elvira Yunita
Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Vol 8 No 4 (2022): Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Buton

The infection of Corona Virus Disease – 19 (COVID-19) has spread out in Indonesia. The number of deaths has increased in recent months. Cases of infection are followed by comorbidities such as diabetes, hypertension, cardiovascular and cerebrovascular condition have higher risk to develop severe illness. These conditions also give the higher risk of death in patients. Herein, we reported a 60 years old man that was infected with Sar-Cov-2 and had no comorbidities. Before the infection, patient was healthy. In the early phase of infection, clinical manifestations were seen in patients such as fever, cough, nausea and vomiting. A few days after being admitted to the hospital, the condition began to get worse which led to multiple organ failure. Acute kidney injury, liver injury, dysregulation of glucose level and acid base disorder were shown from laboratory tests. Unfortunately, clinical manifestations were poor and the patient passed away.

Probiotic Lactobacillus acidophilus FNCC 0051 Improves Pancreatic Histopathology in Streptozotocin-induced Type-1 Diabetes Mellitus Rats Mardhatillah Sariyanti; Tiara Ayoe Andita; Noor Diah Erlinawati; Elvira Yunita; Ahmad Azmi Nasution; Kartika Sari; Nikki Aldi Massardi; Sylvia Rianissa Putri
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2047

BACKGROUND: Intestinal microbial dysbiosis and its metabolites can affect the immune activity of intestinal mucosal cells, causing insulitis and pancreatic β-cell death. Probiotic Lactobacillus acidophilus plays an important role in reducing inflammatory cytokines, hence improves oxidative stress that affects pancreatic β-cell apoptosis. Current study examined the feature of pancreatic histopathology affected by the administration of probiotic L. acidophilus in rats with type-1 diabetes mellitus (DM) induced by streptozotocin (STZ).METHODS: Twelve rats were induced by STZ at double dose of 50 mg/kgBB before administered with probiotic L. acidophilus at a dose of 1.5x10 8 or 1.5x10 9 CFU/mL/day, while other 4 rats were used as control. After 21 days of the L. acidophilus treatment, the average of fasting blood glucose (FBG) levels of rats were measured, then the pancreatic histopathology was assessed to evaluate the degree of insulitis in islet of Langerhans.RESULTS: The induction of STZ had been succeeded to increase blood glucose levels, which indicate DM condition. The highest FBG level after 21 days of treatment was found in DM group with glucose level of 512±81.51 mg/dL. The administration of probiotic L. acidophilus during 21 days treatment at both dose 1.5x10 8 and 1.5x10 9 CFU/mL/day significantly improved pancreatic histopathology (p=0.04 and p=0.034, respectively), with significant decrease on insulitis scores compared to DM group.CONCLUSION: The administration of L. acidophilus at both dose of 1.5x10 8 and 1.5x10 9 CFU/mL/day for 21 days can improve pancreatic histopathology of type-1 DM rats induced by STZ, therefore probiotic L. acidophilus may be potential as supplementation treatment for type-1 DM.KEYWORDS: Lactobacillus acidophilus, pancreatic histopathology, streptozotocin, type-1 diabetes mellitus

Hubungan Pengaruh Polimorfisme Genetik Terhadap Risiko Kejadian Diabetes Melitus Elvira Yunita; Cindy Ernica Putri; Audia Indrian; Liya Agustin Umar; Diah Ayu Aguspa Dita
Jurnal Medika Malahayati Vol 6, No 4 (2022): Volume 6 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v6i4.9004

Diabetes adalah suatu keadaan adanya gangguan metabolik yang terjadi jangka panjang/kronis ditandai dengan tingginya kadar glukosa darah yang disebabkan oleh defisiensi insulin absolut maupun relatif, disfungsi sel β, resistensi insulin atau dapat terjadi keduanya. Diabetes melitus secara diklasifikasikan menjadi beberapa jenis, dan yang paling umum diketahui adalah diabetes melitus tipe 1 dan tipe 2. Faktor-faktor yang berhubungan dengan angka kejadian DM diantaranya adalah overweight, obesitas sentral/abdominal, derajat stress, kurangnya aktifitas fisik, hipertensi, dislipidemia, kondisi prediabetes, merokok, ras, etnik, umur, jenis kelamin, riwayat keluarga dengan diabetes melitus. Faktor genetik diketahui mempunyai peranan yang cukup penting dalam kejadian, perjalanan dana perkembangan penyakit DM. Faktor genetik yang paling umum berperan adalah Single Nucleotide Polimorphism (SNP). Gen yang diketahui mempunyai hubungan yang erat dengan DMT1 antara lain gen HLA, CTLA-4, PTPN22, dan IL2RA/CD25. Pada DMT2 terdapat beberapa gen yang berperan yaitu gen ABCC8, KCNJ11, PPAR-γ dan CALPN10.

Comparison of Propolis Extracts and Bioplacenton at Epidermal Re-epithelialization Process in Burn Wound of Mice (Mus musculus) Bhayu Baruna Bastari; Elvira Yunita; Kartika Sari; Marisadonna Asteria; Julian Famil; Oktoviani Oktoviani
Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Vol 9 No 2 (2023): Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton
Publisher : Lembaga Jurnal dan Publikasi Universitas Muhammadiyah Buton

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35326/pencerah.v9i2.3007

Effective treatment is needed in accelerating the healing process of burn. Propolis extract is a bee product that has a high flavonoid content. Propolis extract is thought to stimulate the process of re-epithelialization of the epidermis. This research was an experimental study with a post-test only control group design. This study used experimental animal, male mice (Mus musculus) Swiss webster strain. Mice were grouped randomly into a control group and a treatment group. Each mouse was given treatment in the form of burn on the back. The control group was the group that was not given propolis or bioplacenton extract. The treatment group was given 5%, 10%, and bioplacenton propolis extract, respectively. Skin histopathological tissue collection was carried out on day 1, day 4, and day 21 to observe the process of re-epithelialization of the epidermis. The results showed that the means of epithelial thickness in the control group and the 5% and 10% propolis extract treatment were significantly thicker on the 21st day of observation when compared to the control group. The administration of bioplacenton showed an increase in the re-epithelialization process of the epidermis on the 4th day. The administration of 10% propolis extract was better in increasing the mean epithelial thickness on the 4th day than the group given 5% propolis extract and bioplacenton.

EDUKASI COVID-19 DI SMAN 3 BENGKULU TENGAH: TINJAUAN KHUSUS PADA ADAPTASI KEBIASAAN BARU DAN URGENSI PEMENUHAN PROTEIN HEWANI: Covid-19 Education in Senior High School 3 at The Middle of Bengkulu: A Special Topic on The Adaptation of New Habits and The Urgency of Fulfilling Animal Protein Elvira Yunita; Liya Agustin Umar; Nurmeiliasari; Diah Ayu Aguspa Dita
JAMAS : Jurnal Abdi Masyarakat Vol. 1 No. 2 (2023)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.89 KB)

Sar-Cov2 infection is still occurring, although in some areas there has been a decrease in infection cases. This condition has become the basis for policy makers in Bengkulu Province to issue a circular letter so that schools can be carried out face-to-face. The condition of facing the adaptation of new habits that are currently being carried out really requires good knowledge and understanding of health protocols. In addition, preventive measures from cases of infection that occur, one of which can be pursued by increasing the body's immune system through meeting the needs of animal protein. The method applied to this Community Service Program (PKM) is through interactive counseling to SMAN 03 Bengkulu Tengah and distribution of dairy products to the academic community at SMAN 03 Bengkulu Tengah. The results of this PKM show that the socialization of adaptation to new habits can provide understanding to teachers and students at SMAN 3 Bengkulu Tengah so that they can implement clean and healthy living behaviors. In addition, the provision of dairy products can be the first step in efforts to meet the needs of animal protein that supports the body's immune system. Based on the analysis of this PKM activity, continuous implementation in increasing knowledge about adapting new habits and fulfilling balanced nutrition must continue to be carried out. This is carried out to prepare the community so that they can continue their activities in the new normal conditions.

The Effects of Papaya Leaf Extract and Turmeric Extract Inclusion on Total Apparent Digestibility of Nutrients and Methane Gas Production in Bali Cattle Nurmeiliasari Nurmeiliasari; N. J. Rangkuti; H. D. Putranto; E. Yunita; J. Firison; H. Kusnadi
Jurnal Sain Peternakan Indonesia Vol 18 No 3 (2023)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31186/jspi.id.18.3.185-192

This research evaluated the effects of papaya leaf and turmeric extract supplementation on the total apparent digestibility of nutrients and methane gas production in Bali cattle. The livestock used were 18 Bali cattle that were distributed into treatment without papaya leaf and turmeric extract supplementation (P0), Supplementation of 0.0075% turmeric extract g/kg live weight/day (P1), and supplementation of 0.00375% turmeric extract per kg live weight per day + 0.00375% papaya leaf extract per kg live weight per day (P2). The basal diets were 60% elephant grass cv. Taiwan (Pennisetum purpureum cv. Taiwan) and 40% concentrate. The ration provision was three per cent dry matter of body weight. The observed parameters included feed consumption, feces production, dry matter digestibility, organic matter digestibility, crude protein digestibility, crude fat digestibility, crude fibre digestibility, nitrogen-free extract digestibility, and methane gas production. The research results indicated that the treatment did not significantly affect feed consumption (P>0.05) but did affect crude protein digestibility, crude fibre digestibility, nitrogen-free extract digestibility, and methane gas production. This study concludes that the feeding of elephant grass cv. Taiwan (Pennisetum purpureum cv. Taiwan), with the addition of papaya leaf extract and turmeric extract, does not have a positive effect on feed consumption and feed digestibility; thus, it cannot suppress methane gas production in livestock.

Andrographolide Reverses Doxorubicin Resistance in Human Breast Cancer Stem Cells by Regulating Apoptotic Gene Expressions Septelia Inawati Wanandi; Resda Akhra Syahrani; Ayu Suraduhita; Elvira Yunita; Melva Louisa
The Indonesian Biomedical Journal Vol 15, No 5 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i5.2596

BACKGROUND: Breast cancer stem cells (BCSCs) have been identified as playing a crucial role in therapeutic resistance. This resistance can be attributed to the anti-apoptotic protein survivin and the antioxidant MnSOD high expression. To overcome the resistance to doxorubicin (DOX), this study proposed the utilization of andrographolide (ANDRO), the primary bioactive compound in Andrographis paniculata leaves. The objective was to examine the role of andrographolide in regulating survivin, caspase-9, and caspase-3 gene expressions to reverse doxorubicin resistance in human BCSCs.METHODS: BCSCs were exposed to 0.1 µM DOX every two days or 50 µM rotenone (ROT) for 6 hours, subsequently supplemented with 0.3 mM ANDRO. Superoxide and peroxide levels were measured using DHE and DCFH-DA assay. The MnSOD, survivin, caspase-9, and caspase-3 mRNA expression levels were analyzed using qRT-PCR. Protein expressions were evaluated using Western blotting assay. MnSOD activity was determined using xanthine oxidase inhibition assay. The apoptotic cells were determined using Annexin-V/PI staining.RESULTS: This study indicated that the cytotoxic mechanisms of DOX, similar to ROT, in BCSCs were attributed to oxidative stress, as evidenced by an elevation in superoxide rather than peroxide levels, accompanied by a decrease in MnSOD activity. This study also highlighted that ANDRO reversed DOX resistance in BCSCs subjected to repeated DOX treatment by downregulating survivin and upregulating caspase-9 and caspase-3 mRNA expressions, thereby activating the intrinsic apoptotic pathway.CONCLUSION: This study provides insights into the role of ANDRO in modulating the expression of apoptotic genes, such as survivin, caspase-9, and caspase-3, to overcome DOX resistance in BCSCs.KEYWORDS: breast cancer, breast cancer stem cell, andrographolide, doxorubicin, oxidative stress, apoptosis

KAJIAN PUSTAKA: POLIMORFISME GENETIK SEBAGAI FAKTOR RISIKO OBESITAS Diah Ayu Aguspa Dita; Elvira Yunita; Risti Dwi Ocktaviani; Putjha Melati
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 7 (2023): Volume 10 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i7.10203

Abstrak: Polimorfisme Genetik Sebagai Faktor Risiko Obesitas: Pendekatan Telaah Literatur. Obesitas semakin meningkat kejadiannya terutama jika dikaitkan dengan pola konsumsi makanan berlebih dan kurangnya aktivitas fisik. Etiologi dan patologi obesitas hingga saat ini masih secara dinamis dilaporkan oleh peneliti. Faktor risiko obesitas tidak hanya berhubungan dengan faktor risiko eksternal yang dapat dimodifikasi seperti pola makan dan gaya hidup, melainkan juga faktor intenal seperti genetik yang tidak dapat dimodifikasi. Faktor risiko internal tersebut dikaitkan dengan polimorfisme genetik gen FTO rs9939609. Polimorfisme gen ini dikaitkan dengan kontrol asupan energi yang mengarahkan pada kejadian obesitas. Pengaruh varian genetik FTO terhadap obesitas semakin kuat sepanjang rentang umur. Selain itu, varian gen ini juga berhubungan dengan resistensi insulin pada beberapa kasus yang telah dilaporkan.

Co-Authors Ahmad Azmi Nasution Amellia Amellia Angelina Stevany Regina Masengi Annisa Puspa Sari Ashan, Hesty Rhauda Audia Indrian Aurora Fajria Anwari Ayu Suraduhita Bhayu Baruna Bastari Cindy Ernica Putri Debie Rizqoh Dessy Triana Diah Ayu Aguspa Dita Dyah Fitriani Ellen Maidia Djatmiko Enny Nugraheni Fahira, Dita Fajrianti Haniyah Gina Fendiati Putri Gustria Ernis H. D. Putranto H. Kusnadi Hardiansyah Hardiansyah Hasanah, Qomariah Hilda Taurina Inta Cantika Ismir Fahri J. Firison Jihan Vira Yuniar Julian Famil Kartika Sari Kartika Sari Liya Agustin Umar Liya Agustin Umar Liya Agustin Umar Mardhatillah Sariyanti Maria Eka Patri Y Marisadonna Asteria Marisadonna Asteria Meiny Suzery Melva Louisa Miftahul Haniyah Muhammad Ridwan N. J. Rangkuti Nailatul Karomah Neni Susilaningsih Nikki Aldi Massardi Noor Diah Erlinawati Notriawan, Doni Novriantika Lestari Novriantika Lestari Nur Hasanah Nurmeiliasari Oktoviani Putjha Melati Putri Maulida Resda Akhra Syahrani Riry Ambarsarie Risti Dwi Ocktaviani Rizkianti Anggraini Sariyanti, Mardhatillah Septelia Inawati Wanandi Sipriyadi Sri Yunita Suhartono, Suhartono Sylvia Rianissa Putri Tiara Ayoe Andita Waliyuddin Waliyuddin Yusuf Irshan Zhafran Hafizhki

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