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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Medical Journal of Indonesia
Taufiqurrachman Nasihun
Department of Biochemistry and Andrology, Faculty of Medicine, Sultan Agung Islamic University, Semarang
Health Professions Medicine & Pharmacology

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Low Molecular Weight Antioxidant versus Flavonoids in Combating Oxidative Stress: Which One is Superior? Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): December 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (845.221 KB) | DOI: 10.30659/sainsmed.v9i2.5258

Abstract

According to the free radical theory of aging, firstly proposed by Denham Harman, the most prominent cause of aging and degenerative diseases (DD) is continuously chemical reaction in cells and tissues. In this context aging and or DD is manifested as chemical composition, whilst aging process is reflected by chemical reaction affected by environment (Harman, 1981). Thus, both aging and DD have similar process, predisposed with oxidative stress and characterized by the progressive cellular alteration accumulation in line with time and account for increase in susceptibility to diseases and death. The most prevalent chemical reaction is between free radical reactive oxygen species (ROS) and reactive nitrogen species (RNS) with cellular biomolecules such as lipids, protein, carbohydrate, and DNA (Lamichhane et al., 2013). In order to prevent the deleterious effect of that chemical reaction, human’s body provides an antioxidant defense system to counterbalance the free radical dangerous effect. However, owing to inappropriate life style, eating style, physical activity, and poor environment, production of ROS and RNS may be increased and induce cellular damages. Numerous publications indicated that oxidative stress and cellular damages can be reduced even prevented by exogenous antioxidant, thus intake antioxidant from external sources is necessary. There are two type of exogenous antioxidant consisting of low molecular weight antioxidant (LMWA) and flavonoids. Unfortunately, the effect of LMWA on delaying aging and ameliorating DD remain inconsistent. On the other hand, numerous data indicate that flavonoids a botanical antioxidant was capable of improving oxidative stress and emerging as an alternative promising antioxidant (Sudhakaran et al., 2019). However, the effect of LMWA and flavonoids in combating oxidative stress remain unknown which one is better.
The Administration of Orange Sweet Potato (Ipomoea Batatas L.) Extract Increases Sperm Consentration, Mortility and Viability in Male Mice Exposed to Cigarette Smoke Rizqy, Lintang Laila; Nida, Nor Anisatun; Noviana, Dwi Ayu; Nasihun, Taufiqurrachman; Widayati, Eni
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.622 KB) | DOI: 10.30659/sainsmed.v8i1.1624

Abstract

Introduction: Ipomoea batatas L (LIP) contains antioxidants beta-carotene, vitamin C and vitamin E. Cigarette smoke containing ROS has been proven to decrease sperm quality.Objective: this study aimed to confirm that orange sweet potato extract increases sperm consentration, motility, and viability in mice exposed to cigarette smoke.Methods: In this experimental study with post test only control group design, 30 male mice were divided into 6 groups. Normal group (Nor-G), no intervention, served as the normal control group. Negative control group (Neg-G) was only exposed to cigarette smoke. Positive control group was only treated with IPL 16mg/ml. IPL-15, IPL-16, and IPL-17 group were treated with IPL 15, 16, and 17mg/ml and exposed to cigarette smoke, respectively.Results: Post Hoc LSD analysis showed that means of sperm concentration and viability in IPL-15, IPL-16, and IPL-17 group were significantly higher compared to that of Neg-G (p < 0.05) and were lower compared to that of Nor-G and Pos-G (p < 0.05). Mann Whitney analysis indicated that the persentage of sperm motility in IPL-15, IPL-16, and IPL-17, were significant higher compared to that of Neg-G, p < 0.05. Whilst compared to that of Nor-G and Pos-G the persentage of sperm motility in IPL-15, IPL-16, and IPL-17, there was no significant differences, p > 0.05.Conclusion: treatment of IPL capable of increasing sperm concentration, motility, and viability in male mice were exposed to cigarrette smoke.
Co-Authors Adi Wiratno, Adi aisah, wipi sari Amalia, Helfi Arief Adi Saputro Atina Hussaana Auliya, Qurrotu A'yuni Budiarto, Agnes Catur Retno Lestari Chodidjah Chodidjah Djajadihardja, Andreas Yudi Prasetyo Djoko Trihadi Lukmono Subagyo Dwi Ayu Noviana, Dwi Ayu Dwi Juniatiningrum, Ratna Eko Naning Sofyanita Eni Widayati Erna Ridawati, Erna Firdaus, Chalid Heni Wijayanti, Heni Israhnanto Isradji Joko Wahyu Wibowo Laili, Ni'mah Hidayatul Lintang Laila Rizqy, Lintang Laila M. Saugi Abduh Miftahul Jannah Nor Anisatun Nida, Nor Anisatun Putro, Prabowo Wicaksono Yuwono Ragil Saptaningtyas, Ragil Rahmawati, Rahmawati Riyanto, Anwar Roy, Adryan Shofa Chasani Siti Thomas Zulaikhah Sri Maryanti Sriwiyati, Kati Titiek Sumarawati Wani, Elsayanti wibowo, subur Wiwik Handayani Yuniarifa, Conita