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All Journal IJCCS (Indonesian Journal of Computing and Cybernetics Systems) JITK (Jurnal Ilmu Pengetahuan dan Komputer) JMM (Jurnal Masyarakat Mandiri) Jurnal Matematika UNAND International Journal of Advances in Data and Information Systems Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Teknik Informatika (JUTIF) JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Jurnal EduHealth Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Hilirisasi Technology kepada Masyarakat (SITECHMAS) Jurnal Masyarakat Madani Indonesia eProceedings of Engineering Journal of Technology and Food Processing (JTFP) El-Mujtama: Jurnal Pengabdian Masyarakat Jurnal Kedokteran Meditek Jurnal Ecotipe (Electronic, Control, Telecommunication, Information, and Power Engineering) Folia Medica Indonesiana
Adanti Wido Paramadini
Universitas Telkom
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Fabrikasi dan Karakterisasi Membran Selulosa Bakteri-Kolagen dengan Metode Freeze Dryingsebagai Kandidat Dural Graft Paramadini, Adanti Wido; Kurniawati, Ajeng Dyah; Faizah; Wijaya, Rheynaldi; Dermawan, Muhammad Saldi
Jurnal Kedokteran Meditek Vol 32 No 4 (2026): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i4.4336

Abstract

Introduction: The dura mater protects the brain, maintains tissue stability, and prevents cerebrospinal fluid leakage. Dural defects from trauma, tumors, or neurosurgery often require duraplasty using a dural graft. Current materials—autologous, allogeneic, and synthetic—have limitations including infection risk, adhesion, immune reactions, and limited availability, prompting exploration of alternative materials. Bacterial cellulose offers high biocompatibility and a nanofibrillar structure resembling the extracellular matrix, while collagen enhances material bioactivity. Objective: This study evaluated bacterial cellulose-collagen biocomposites as candidate dural implants using FTIR and swelling tests. Methods: Bacterial cellulose was synthesized using Acetobacter xylinum in coconut water medium and freeze-dried for 48 hours. Biocomposites were prepared by immersing cellulose pellicles in collagen solutions at 0% (control), 0.5%, 1%, and 1.5% (w/v), dried at room temperature, and characterized by FTIR and swelling analysis. Results: Collagen incorporation altered the chemical structure, shown by increased O–H groups and a wavenumber shift with eventual disappearance of the C–H group as collagen concentration rose. Swelling ratio increased across all collagen-containing samples, indicating interactions that may modify the material's physical properties. Conclusion: Collagen addition improved the structural and swelling characteristics of the biocomposites, supporting their potential as artificial dura mater material, pending further evaluation of mechanical properties and biocompatibility.
Co-Authors Afifah Zen, Nur Afin Muhammad Nurtsani Afrianto, Arman Ajeng Dyah Kurniawati Alfin Hikmaturokhman Awaludin, Muhammad Tata Dading Qolbu Adi Dasril Aldo Dasril Aldo Dermawan, Muhammad Saldi Dian Maharani Dodi Zulherman Faiz, M. Hanif Al Faizah Faizah Faizah Fathan, Faizal Burhani Ulil Fau, Andrew Firmansyah, Muhammad Raafi'u Fitranaya Arlian Fitriawan, Taufiq Gusnita Linda Haibah, Wulan Nawwar Hidayat, Afifah Naurah Ichya Ulumiddiin Ida Saroya, Nikita Ihsan Maulana Ilwan Syafrinal Indah Permatasari Irmayatul Hikmah Irmayatul Hikmah Isfandiary, Andini Jabbar, Hajria Juan Timotius Prasetya, Yosafat Lina Fatimah Lishobrina M Yoka Fathoni M. Hanif Al Faiz Mahazam Afrad Marsaly, Silvia Van Maulana, Ihsan Miftahul Ilmi Muadin, Dika Alim Muhammad Afrizal Amrustian Muhammad Nafal Fiqrian Muhammad Tata Awaludin Muzakiyah, Lukvinda Asfi Nurul Latifasari Nyimas Ananda Putri Mulyono Pamuji, Yanuar Ikhsan Pratama, Rizal Wahyu Prihartini Widiyanti Putri Anjani, Isabella Putri, Dina Kartika Rizki Amalia Pratiwi Sa'adah, Aminatus Santoso, Dimas Sapta Eka Putra Sevia Indah Purnama Sevia Indah Purnama Shinta Romadhona Silvia Van Marsally Silvia Van Marsally Suci Rahma Sari, Deli Sulaeman, Gilang Sumarsini, Erin Suprapto, Amelia Rut Uzlifatul Arridla, Putri Wijaya, Rheynaldi Yasin, Feri Yohani Setiya Rafika Nur Yohani Setiya Rafika Nur Yoka Fathoni, M.