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All Journal journal of internal medicine Jurnal Kesehatan Andalas Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Care : Jurnal Ilmiah Ilmu Kesehatan JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Narra J Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Scientica: Jurnal Ilmiah Sains dan Teknologi
Ulfa Kholili
Division Of Gastroentero-hepatology, Department Of Internal Medicine, Faculty Of Medicine, Airlangga University/Dr. Soetomo General Hospital, Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Narra J

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Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia Maimunah, Ummi; Kholili, Ulfa; Vidyani, Amie; Sugihartono, Titong; Tanaya, Willa M.; Wessels, Firda I.; Alshawsh, Mohammed A.; Miftahussurur, Muhammad
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.816

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by an acute respiratory infection with multisystem involvement and the association of its severity to liver function abnormalities is not well characterized. The aim of this study was to assess the association between the severity of COVID-19 patients and liver function abnormalities. This retrospective study included adult patients with confirmed COVID-19, which were classified as non-severe or severe according to World Health Organization guidelines. Liver function test results were compared between the severity groups. A total of 339 patients were included of which 150 (44.25%) were severe cases. The male-to-female ratio was 0.9:1 and 3:2 in the non-severe and severe groups, respectively (p=0.031). Aspartate aminotransferase (AST), alanine transaminase (ALT), and total bilirubin levels and acute liver injury (ALI) incidence were significantly higher in the severe group compared to non-severe group (p<0.001, p<0.001, p=0.025, p=0.014, respectively). In contrast, albumin levels were significantly lower (p=0.001). Multivariate analysis showed that ALI was significantly associated with human immunodeficiency virus (HIV) infection (odds ratio (OR): 5.275; 95% confidence interval (CI): 1.165–23.890, p=0.031), hemoglobin level (OR: 1.214; 95%CI: 1.083–1.361, p=0.001), and hypoalbuminemia (OR: 2.627; 95%CI: 1.283–5.379, p=0.008). Pre-existing liver diseases were present in 6.5% of patients. No significant differences were observed between the groups based on COVID-19 severity and ALI presence. Liver function test abnormalities, including ALI, are more prevalent in patients with severe COVID-19 infection. HIV infection, high hemoglobin levels, and hypoalbuminemia may be potential risk factors for ALI.
Co-Authors Abdurachman Adaninggar PN Agung Dwi Wahyu Widodo Alshawsh, Mohammed A. Alvin Hartanto Kurniawan Alvin Hartanto Kurniawan Amie Vidyani Andreas Novaldi Watang Anita Zara Weinheimer Annisa Zahra Mufida Annisya Dinda Paramitha Aryati Aryati Bagus Setyoboedi Benedictus Hanjaya Suwandi Brimantyo, Dio Budi W Budi Widodo Budi Widodo Delwi Novita Denada Aisyah Syalini Denny Vianto Diah Rizki Rahma Dini Dwicahya, Fatrian Erlina, Rina Fardah Athiyyah, Alpha Fauziah Diayu Retnaningtyas Ghaniyya, Willandra Fitriyanri Hamzah, Arshq Mirza Herry Purbayu Humairah, Ira Isna Mahmudah Iswan A Nusi Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Maria Inge Lusida MOCHAMAD AMIN Mochamad Amin Muhammad Miftahussurur Muhammad Rivai Muhammad Vitanata Arfijanto, Muhammad Vitanata Nasronudin Nasronudin Novira Widajanti, Novira Nurhidayah, Meiwinda Rizky Pangestu Adi Paramitha, Annisya Dinda PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Priyo Budi Purwono Puspa Wardhani Puspitasari, Yessy Putra, Rheza Rahmadika Retno Handajan Retno Handajani Rina Erlina Ruslan, S. Eriaty N. Setiawan, Poernomo B Setiawati, Rosy Shahnaz Azzahra SOETJIPTO SOETJIPTO . Soetjipto Soetjipto Sulistiawati, Sulistiwati Syalini, Denada Aisyah Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tri Yanti Ummi Maimunah Vania Azalia Gunawan Viorelina, Angela Romauli Wessels, Firda I. Widodo, Budi Wirantara, Hendy Wungu, Citrawati Dyah Kencono Yanti, Tri