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Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Co-Authors . RUSTIKAWATI Aditia Biasa Alice Valencia Alice Valencia Amal Ginting Amal Ginting Ana Neman Anti, Reski ARIANDANA WANTHO Asmiati Mulkin Asmuruf, Yunice Besin, Cecilia S. M. Carolina, Saroinsong F. Christin, Andriany M. Citra Mentari Payow Debora Christy Palit Debora J.A Tumbel Deby Mongi dengen, Alvina maria Deo Tampongangoy Desi E. Gusungi Desmita Muada Dicki Huga Tangiono Douglas N. Pareta Effie Karlin Nathania Einstein Karundeng Einstein Z. Karundeng Einstein Z. Z. S. Karundeng Esterlina J. Watung Febrilia Mangirang Ferdinand Palit Frengky Mawea Friska Mery Montolalu Gideon A. R. Tiwow Ginting, Margaretha S. Glaudia Tawi Glorya Sevani Pongoh Greti M. Kurama Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Haryadi Haryadi Indriani Maitulung Iteke Tuda Jabes Wolter Kanter Jeane Mongi Jeivia Matialo Jesica N. Bawondes Julianti Julianti Kalalo, Michael R. C. Kalalo, Reine Kalangi, Only Imando Karauwan, Ferdy Katsuhiro Ueda Kojongian, Cliveno Kristian Stefano Pinatik Lengkey, Yessie Maarisit, Abigail F. Marsela Pauner Marshella Mokoagouw Marstella Minelko Marstella Minelko, Marstella Meisy Permata Citra Nayoan Misran Lawani Nerni Potolangi Nesti F. Sianipar Nesti F. Sianipar NESTI FRONIKA SIANIPAR Olvie Datu Olvie S. Datu Paat, Vlagia Indira Pakingki, Priska Pangkei, Octry M. Pareta, Douglas Natan Patrick Rambe Pelealu, Nancy C. Priska Juanita Pakingki Rahmat S. Santoso Rallia Binuni Randi Tampa’i Rawung, Intan J. F. Reinhard Pinontoan Rivaldy Lobot Rondonuwu, Tesalonika Royke R. Palandi Rudy Pareda Sambou, Christel N. Sarah Sambow Sheren J. Bermula Silvana L. Tumbel Simanjuntak, Alfared S. Sonny Untu Sumagando, Adolfina Supit, Arter Tampa'i, Randy Tan Tjie Jan, Tan Tjie Tenci Lie Sarbunan Tombuku, Joke Luis Tulandi, Selvana Stien Veronica Davis Yapi Saroinsong Yappi Saroinsong Yosna Yundu Yuliana Polopadang Yunita Syawal Yusuf Tapehe