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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences. Servitium Smart Journal
Jabes Wolter Kanter
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Tomohon Christian University Of Indonesia, 95362, North Sulawesi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji aktivitas antioksidan ekstrak etanol daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oleifera) dengan metode 2,2-diphenyl-1-picrylhydrazyl Potalangi, Nerni Olvi; Palandi, Reky Royke; Manoppo, Amalia J.; Tewu, Tewsi M.; Kanter, Jabes Wolter; Sambou, Christel Nataniel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.626

Abstract

Free radicals can originate from within the human body as a result of metabolic processes from chemical reactions in the body, as well as from external sources or the environment, including emissions from motor vehicles, air pollution from factories, industrial chemicals, food and beverage substances, cigarette smoke, radiation, and sunlight. Antioxidants are components that can prevent cells or molecules from being oxidised by donating electrons or hydrogen atoms to free radicals. The impact of the reactivity of free radical compounds can result in cell or tissue damage, degenerative diseases, and even cancer. One of the parasites on the moringa plant, namely Helixanthera cylindrica (Jack) Danser, contains secondary metabolite compounds such as alkaloids, flavonoids, and saponins. This research aimed to determine whether the leaves of the Helixanthera cylindrica (Jack) Danser mistletoe have antioxidant activity using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The research method is a laboratory experiment with five concentrations and three repetitions. Subsequently, the antioxidant activity testing is conducted qualitatively using the DPPH method at a wavelength of 517 nm and utilising a Spectrophotometer UV-Vis. Based on the results of the antioxidant test, the extract of Helixanthera cylindrica (Jack) Danser leaves has extreme activity with an IC50 value of 28.74 ppm. In contrast, the comparison, vitamin C has an IC50 value of 1.57 ppm. The regression equation for the concentration of the mistletoe is y=0.3344x + 40.389 with an R2 value of 0.9726, and Vitamin C shows y=4.4065x + 43.079 with an R² value of 0.9677. It can be concluded that the leaves of Helixanthera cylindrica (Jack) Danser on the Moringa oleifera plant have extreme antioxidant activity.
Antibakteri infusa akar mangrove Sonneratia alba pada Escherichia coli dan Staphylococcus aureus Tuda , Aletheia Marvla Windi; Mongi, Jeane; Kanter , Jabes W.; Pareta , Douglas; Ginting , Amal; Hariyadi, Hariyadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.636

Abstract

Antibacterial is a substance that stops and kills the growth of bacteria. Mangrove Sonneratia alba is an exciting plant to use as a medicine because of its antibacterial properties. Secondary metabolite compounds such as alkaloids, phenols, tannins, saponins, triterpenoids, and flavonoids present in the roots are antimicrobial. This study aims to determine the antibacterial activity of mangrove root infusion of Sonneratia alba in Staphylococcus aureus and Escherichia coli. This laboratory study uses the agar diffusion technique with a well to test antibacterial. Using three concentrations, namely 25%, 50%, and 100%, this study found that the infusion of the roots of the Sonneratia alba mangrove 25%, 50%, and 100% showed antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. The results of the Kruskal-Wallis test showed that Escherichia coli bacteria showed a P value of 0.010<0.05 and Staphylococcus aureus bacteria with a P value of 0.011<0.05, which showed that there was a significant difference between the two types of bacteria because the significant value was less than 0.05.
Integrasi Profil Fitokimia Berbasis GC–MS dan Evaluasi Farmakologis In Vivo dalam Menilai Potensi Antidiabetes Ekstrak Etanol Scleria sumatrensis Retz. pada Model Tikus Diabetes Induksi Aloksan. Pareta, Douglas Natan; Montolalu , Friska Mery; Keno , Aprillia Vincensia; Kanter , Jabes Wolter; Tombuku , Joke Luis; Sambou , Christel Nataniel; Natanel , Andri; Santoso , Rahmat; Hariyadi, Hariyadi; Runtu , Alter Yantje
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1198

Abstract

This study evaluated the antidiabetic activity and phytochemical profile of the ethanolic extract of Scleria sumatrensis Retz. Using an alloxan-induced diabetic rat model. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg BW) after a 12-hour fasting period, and fasting blood glucose was measured at three standardized time points: GD1 (baseline), GD2 (72 hours post-induction), and GD3 (day 14 post-treatment). GC–MS analysis revealed several major constituents, including ethyl α-D-glucopyranoside, ethyl linoleate, ethyl linolenate, phytol, tocopherol, and β-sitosterol, which are associated with improved insulin sensitivity, modulation of PPAR-γ–related pathways, antioxidant protection of pancreatic β-cells, and reduced intestinal carbohydrate digestion. Rats were assigned to negative control (vehicle), positive control (metformin 45 mg/kg BW), and extract-treated groups (75, 150, and 300 mg/kg BW). Percentage reduction from GD2 to GD3 was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The extract produced a significant and dose-dependent decrease in fasting glucose (p < 0.001). All extract doses differed significantly from the negative control, and the 300 mg/kg dose demonstrated glucose-lowering efficacy comparable to metformin. These findings indicate that Scleria sumatrensis possesses vigorous antihyperglycemic activity consistent with its lipophilic phytochemical composition. Further studies are required to verify the underlying mechanisms and identify the most active constituents.
Pengaruh Metode Ekstraksi (Maserasi dan Infusa) terhadap Potensi Antibakteri Ekstrak Daun Nasi (Phrynium pubinerve Blume) dalam Menghambat Pertumbuhan Propionibacterium acnes Sambou, Christel Nataniel; Yudistira, Adithya; Rumondor, Erladys Melindah; Lontaan, Gloria J.; Lumbu, Alisa W. R.; Rolos, Tesalonika N.; Kanter, Yabes
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64402

Abstract

Pencarian alternatif antibakteri berbasis tanaman menjadi krusial seiring dengan meningkatnya resistensi bakteri terhadap antibiotik konvensional, di mana metode ekstraksi merupakan faktor penentu potensi. Penelitian ini bertujuan mengevaluasi dan membandingkan efektivitas metode maserasi dan infusa dalam memperoleh ekstrak Phrynium pubinerve Blume yang aktif melawan Propionibacterium acnes, serta mengidentifikasi metode mana yang paling efektif. Dengan menggunakan metode difusi agar (kertas cakram), diameter zona hambat kedua jenis ekstrak diukur dan diuji secara statistik dengan Uji-t Welch. Hasil Uji-t menunjukkan adanya perbedaan signifikan pada rata-rata zona hambat kedua kelompok. Kesimpulannya, ekstrak Phrynium pubinerve Blume yang dihasilkan dari metode ekstraksi dengan rata-rata zona hambat terbesar yaitu maserasi menjadi metode yang paling efektif dalam aktivitas antibakteri.
Inovasi Pengolahan Limbah Organik Menjadi Pupuk Organik Cair Untuk Mendukung Pertanian Berkelanjutan di Kabupaten Sitaro Pinaria, Yeanly Wuena; Karuntu, Rilya Patricia Esther; Kanter, Jabes Wolter; Moko, Emma Mauren; Mege, Revolson Alexius; Mewengkang, Alfrina
Servitium Smart Journal Vol 4 No 1 (2025): Servitium Smart Journal
Publisher : Universitas Klabat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31154/servitium.v4i1.44

Abstract

Modern agriculture faces challenges in the form of dependence on chemical fertilizers and increasing organic waste that has not been optimally utilized. This activity aims to develop innovation in processing organic waste into liquid organic fertilizer (POC) as part of a sustainable agricultural system in Beong Village, Siau Tagulandang Biaro Islands Regency (SITARO). The implementation method used a Participatory Rural Appraisal (PRA) approach and the application of appropriate technology through training, manufacturing, and POC application tests. The main ingredients consisted of chicken manure, nutmeg leaves, and vegetable waste fermented using EM4 bioactivator for 24 days in two fermentation stages, namely anaerobic and aerobic. The analysis showed that the POC contained 1.14% N, 0.01% P, 0.38% K, pH 6.8, and a C/N ratio of 14.5 in accordance with SNI 19-7030-2004. The application of POC increased the growth of mustard plants by 35% and tomatoes by 32%, and reduced the use of chemical fertilizers by 55%. This innovation reduced the volume of organic waste by 60% and increased farmer group productivity by 70%. The novelty of this activity lies in the integration of local agricultural waste management into economically valuable liquid fertilizer that supports circular economy and low-emission agriculture.
Antibacterial Activity Test of Ethanol Extract of Sonneratia alba On Escherichia coli And Staphylococcus aureus kevin wong; Jeane Mongi; Sonny D. Untu; Jabes W. Kanter; Hanna M. Rumagit; Nerni O. Potalangi
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.426

Abstract

Antibacterial is a compound used to control the growth of harmful bacteria. Mangrove plants are strongly suspected to have bioactive content, the bioactive content contained in mangrove plants is useful in the pharmaceutical field as a medicinal ingredient. Sonneratia alba root contains secondary metabolite compounds Flavanoids, tannins and alkaloids that act as antibacterials. The purpose of this study was to determine the antibacterial activity of S.alba ethanol extract against Staphylococcus aureus bacteria and Escherichia coli bacteria. Extraction method by maceration, long extraction time 3 days. The extract obtained is then evaporated solvent in the rotary evaporator then the extract results are made concentrations of 25?g, 50?g, 100?g, and 150?g. antibacterial testing using the Kirby-Bauer method. The results showed that at concentrations of 25?g, 50?g, 100?g, and 150?g Sonneratia alba mangrove roots had antibacterial activity. But those that have strong antibacterial activity in Escherichia coli bacteria are at a concentration of 50? with while in Staphylococcus aureus bacteria are at a concentration of 150?g with an inhibitory zone of 18.6mm, and in Escherichia coli bacteria with an inhibitory zone of 18,3mm.
Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Reski Anti; Jabes W. Kanter; Wilmar Maarisit; Reky R. Palandi; Nancy C. Pelealu; Friska M. Montolalu
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Inhibitory Test of Scleria sumatrensis Stem Extract against Propionibacterium acnes Bacteria in Vitro Sonny D. Untu; Douglas N. Pareta; Selvana S. Tulandi; Jabes W. Kanter; Andri Natanel
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.505

Abstract

This study aims to test the antibacterial activity of Scleria sumatrensis extract against Propionibacterium acnes, a bacteria that causes acne. Extraction was carried out using the maceration method using 96% ethanol, and the antibacterial activity test was carried out using the diffusion method using a concentration of 100–500 ?g/disc. The results showed that the extract provided moderate antibacterial activity at a concentration of 100 ?g/disc and increased to strong at a concentration of 200–500 ?g/disc. S. sumatrensis extract contains secondary metabolite compounds such as phenolics, flavonoids, alkaloids, tannins, steroids, and terpenoids that play a role in inhibiting the growth of P. acnes through various mechanisms, including cell membrane damage, inhibition of protein synthesis, and disruption of bacterial metabolism. Based on the results of the study, S. sumatrensis extract has the potential as a natural antibacterial alternative for acne treatment without significant side effects or the risk of antibiotic resistance.
Analysis Of Rhodamine B Dye Content In Lipstick At Beriman Tomohon Market Friska M. Montolalu; Christien Kiroh; Wilmar Maarisit; Jabes W. Kanter; Andry Natanel; Amal R. Ginting; Rachmat Santoso
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.521

Abstract

The use of cosmetics such as lipstick aims to improve the natural appearance of the lips and induce discoloration. A problem that is often worrying about today is the presence of prohibited dyes in lipstick preparations' main components. Rhodamine B is a synthetic dye prohibited in cosmetics, especially lipsticks. This research aims to analyze the Rhodamine B dye in lipsticks that do not have a distribution permit from BPOM circulating in the Beriman Tomohon market.The research method was Thin Layer Chromatography (TLC), followed by wavelength measurement on UV-Vis Spectrophotometry. The research population was all red lipstick preparations and 10 (ten) different lipsticks as a sample.Data analysis in this research is to find the RF value obtained from TLC then make a graph of the equation y = bx + a then look for the x value to measure the Rhodamine B content in lipstick. The results of this research were obtained from 1 (one) sample of lipstick label L(I) positive containing Rhodamine B. Visually, the lipstick of the L(I) label has a pink color and fluorescence orange when irradiated with 366nm UV, Rhodamine B has an Rf value of 0.85. In contrast, the L(I) sample has an Rf value of 0.84. Rhodamine B has a wavelength of 544nm, and the lipstick sample L(I) has an absorbance of 0.362 which has a Rhodamine B content of 0.4115%.
Co-Authors Adinda Bee Adithya Yudistira Alfrina Mewengkang Amal Ginting Amal Ginting Amal R. Ginting Andri Natanel Andry Natanel Besin, Cecilia S. M. Carolina, Saroinsong F. Charly J. Watung Christien Kiroh Christin, Andriany M. Debora Christy Palit Deby Mongi Dian K. Ta’au Douglas N. Pareta Douglas N. Pareta Emma M Moko ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Esterlina J. Watung Fadly Steven Jefry Rumondor Filia Krisna Wilar Fina Feronica Kotangon Fransisco Sumalong Friska M. Montolalu Friska Mery Montolalu Geyza O. Samalagi Gideon A. R. Tiwow Ginting , Amal Giseli Margareth Tampa Giska P. Mandagi Hanna M. Rumagit Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Hariyadi, Hariyadi Hetty V. Tulandi Inggrid G. Pondaag Irsaline Womsiwor Jeane Mongi Jeane Mongi Jesica N. Bawondes Jihan Marina Safitri Julianti Julianti Kalangi, Only Imando Karauwan, Ferdy Karuntu, Rilya Patricia Esther Keno , Aprillia Vincensia kevin wong Korua, Sammy Rommy Novie Lengkey, Yessie Lontaan, Gloria J. Lumbu, Alisa W. R. Manoppo, Amalia J. Michaela P Pauran Montolalu , Friska Mery Nancy C. Pelealu Natanel , Andri Nerni O. Potalangi Nerni Potolangi Olvie S. Datu Paat, Vlagia Indira Padoma, Chintya Pakingki, Priska Palandi, Reky Royke Pareta , Douglas Pareta, Douglas N Pareta, Douglas Natan Pinaria, Yeanly Wuena Polii, Ruland Potalangi, Nerni Olvi Priska C. Londoran Rachmat Santoso Rahmat S. Santoso Randy Tampa'i Randy Tampa’i Reky R. Palandi Renault Marsidi Reski Anti Revolson Mege Rolos, Tesalonika N. Royke R. Palandi Runtu , Alter Yantje Ryan Offeis Kolondam Sambou, Christel N. Santoso , Rahmat Sarah Sambow Sasambe Naka Indriyani Sawilan, Frensiska Selvana S. Tulandi Severalen E. Saruan Silvana L. Tumbel Sindhy Ovellia Ofa Sonny D. Untu Sonny Untu Tabita R. S. Rongkonusa Tampa'i, Randy Tenci Lie Sarbunan Tewu, Tewsi M. Tombuku , Joke Luis Tombuku, Joke Luis Tresya Anuku Tuda , Aletheia Marvla Windi Tulandi, Selvana Stien Wantah, Kezia T. Wilmar Maarisit Wilmar Maarisit