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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences. Servitium Smart Journal
Jabes Wolter Kanter
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Tomohon Christian University Of Indonesia, 95362, North Sulawesi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antibacterial Activity Test Of Epazote Leaf Infusion (Dysphania ambrosioides L.) Against Escherichia coli Bacteria Carolina, Saroinsong F.; Montolalu, Friska M.; Tumbel, Silvana L.; Kanter, Jabes W.; Maarisit, Wilmar; pakingki, Priska
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.458

Abstract

The most common health problem in Indonesia is bacterial infection. Dysphania ambrosioides L., also known as epazote leaves, is an herbal plant that has antimicrobial potential. This research was conducted to see at what concentration there is antibacterial activity of epazote leaf infusion Dysphania ambrosioides L. against Escherichia coli bacteria. This laboratory experimental study used a complete randomized design (RAL) research. Antibacterial activity testing of epazote leaves was carried out using the disc paper diffusion method with concentrations of 50%, 75%, and 100%. Epazote leaves are boiled in an infusion pan for 15 minutes, until the temperature reaches 90 degrees Celsius. Ampicillin positive control 10 ?g/disc. Based on the test results of secondary metabolites of positive epazote leaf infusion there are alkaloids, flavonoids, tannins, saponins, triterpenoids, and phenolics. The results of the study showed that infusion of epazote leaves inhibited Escherichia coli bacteria by diameter inhibition. Average at a concentration of 50% = 14.04 mm, 75% = 16.92 mm, 100% = 17.94 mm, which means that there is antibacterial activity of epazote leaf infusion against Escherichia coli bacteria.
Antibacterial Activity Test of Ethanol Extract of Sonneratia alba On Escherichia coli And Staphylococcus aureus wong, kevin; Mongi, Jeane; Untu, Sonny D.; Kanter, Jabes W.; Rumagit, Hanna M.; Potalangi, Nerni O.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.426

Abstract

Antibacterial is a compound used to control the growth of harmful bacteria. Mangrove plants are strongly suspected to have bioactive content, the bioactive content contained in mangrove plants is useful in the pharmaceutical field as a medicinal ingredient. Sonneratia alba root contains secondary metabolite compounds Flavanoids, tannins and alkaloids that act as antibacterials. The purpose of this study was to determine the antibacterial activity of S.alba ethanol extract against Staphylococcus aureus bacteria and Escherichia coli bacteria. Extraction method by maceration, long extraction time 3 days. The extract obtained is then evaporated solvent in the rotary evaporator then the extract results are made concentrations of 25?g, 50?g, 100?g, and 150?g. antibacterial testing using the Kirby-Bauer method. The results showed that at concentrations of 25?g, 50?g, 100?g, and 150?g Sonneratia alba mangrove roots had antibacterial activity. But those that have strong antibacterial activity in Escherichia coli bacteria are at a concentration of 50? with while in Staphylococcus aureus bacteria are at a concentration of 150?g with an inhibitory zone of 18.6mm, and in Escherichia coli bacteria with an inhibitory zone of 18,3mm.
Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Anti, Reski; Kanter, Jabes W.; Maarisit, Wilmar; Palandi, Reky R.; Pelealu, Nancy C.; Montolalu, Friska M.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Inhibitory Test of Scleria sumatrensis Stem Extract against Propionibacterium acnes Bacteria in Vitro Untu, Sonny D.; Pareta, Douglas N.; Tulandi, Selvana S.; Kanter, Jabes W.; Natanel, Andri
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.505

Abstract

This study aims to test the antibacterial activity of Scleria sumatrensis extract against Propionibacterium acnes, a bacteria that causes acne. Extraction was carried out using the maceration method using 96% ethanol, and the antibacterial activity test was carried out using the diffusion method using a concentration of 100–500 ?g/disc. The results showed that the extract provided moderate antibacterial activity at a concentration of 100 ?g/disc and increased to strong at a concentration of 200–500 ?g/disc. S. sumatrensis extract contains secondary metabolite compounds such as phenolics, flavonoids, alkaloids, tannins, steroids, and terpenoids that play a role in inhibiting the growth of P. acnes through various mechanisms, including cell membrane damage, inhibition of protein synthesis, and disruption of bacterial metabolism. Based on the results of the study, S. sumatrensis extract has the potential as a natural antibacterial alternative for acne treatment without significant side effects or the risk of antibiotic resistance.
Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Co-Authors Adinda Bee Aletheia Marvla Windi Tuda Amal Ginting Amal Ginting Amal Ginting Amalia J. Manoppo Anti, Reski Besin, Cecilia S. M. Carolina, Saroinsong F. Charly J. Watung Christin, Andriany M. Debora Christy Palit Deby Mongi Dian K. Ta’au Douglas N. Pareta Esterlina J. Watung Fadly Steven Jefry Rumondor Filia Krisna Wilar Fina Feronica Kotangon Fransisco Sumalong Friska Mery Montolalu Geyza O. Samalagi Gideon A. R. Tiwow Giseli Margareth Tampa Giska P. Mandagi Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi, Hariyadi Hetty V. Tulandi Inggrid G. Pondaag Irsaline Womsiwor Jeane Mongi Jesica N. Bawondes Jihan Marina Safitri Julianti Julianti Kalangi, Only Imando Karauwan, Ferdy Korua, Sammy Rommy Novie Lengkey, Yessie Michaela P Pauran Natanel, Andri Nerni Potolangi Olvie S. Datu Paat, Vlagia Indira Padoma, Chintya Pakingki, Priska Palandi, Reky Royke Pareta, Douglas N Pareta, Douglas Natan Pelealu, Nancy C. Polii, Ruland Priska C. Londoran Rahmat S. Santoso Randy Tampa'i Randy Tampa’i Renault Marsidi Royke R. Palandi Ryan Offeis Kolondam Sambou, Christel N. Sarah Sambow Sasambe Naka Indriyani Sawilan, Frensiska Severalen E. Saruan Silvana L. Tumbel Sindhy Ovellia Ofa Sonny Untu Tabita R. S. Rongkonusa Tampa'i, Randy Tenci Lie Sarbunan Tewsi M. Tewu Tombuku, Joke Luis Tresya Anuku Tulandi, Selvana Stien Wantah, Kezia T. Wilmar Maarisit wong, kevin