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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences. Servitium Smart Journal
Jabes Wolter Kanter
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Tomohon Christian University Of Indonesia, 95362, North Sulawesi, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antibacterial Activity of Ethanol Extract from Chromolaena odorata L. Against Staphylococcus aureus Bacteria Anti, Reski; Kanter, Jabes W.; Maarisit, Wilmar; Palandi, Reky R.; Pelealu, Nancy C.; Montolalu, Friska M.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.451

Abstract

Chromolaena odorata L. has bioactive compounds that can be used as raw medicine materials. Bioactive compounds from Chromolaena odorata L. are reported to have pharmacological and antibacterial properties. This study aims to  the antibacterial activity. The antibacterial activity testing used the agar diffusion method using paper discs with 25, 50, 75, 100, and 125 µg/disc extract concentrations. Based on the results obtained, the ethanol extract of Chromolaena odorata L. has antibacterial activity of S. aureus with inhibition zone diameters of 12.14, 11.99, 12.63, 12.62, and 13.85 mm.
Inhibitory Test of Scleria sumatrensis Stem Extract against Propionibacterium acnes Bacteria in Vitro Untu, Sonny D.; Pareta, Douglas N.; Tulandi, Selvana S.; Kanter, Jabes W.; Natanel, Andri
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.505

Abstract

This study aims to test the antibacterial activity of Scleria sumatrensis extract against Propionibacterium acnes, a bacteria that causes acne. Extraction was carried out using the maceration method using 96% ethanol, and the antibacterial activity test was carried out using the diffusion method using a concentration of 100–500 ?g/disc. The results showed that the extract provided moderate antibacterial activity at a concentration of 100 ?g/disc and increased to strong at a concentration of 200–500 ?g/disc. S. sumatrensis extract contains secondary metabolite compounds such as phenolics, flavonoids, alkaloids, tannins, steroids, and terpenoids that play a role in inhibiting the growth of P. acnes through various mechanisms, including cell membrane damage, inhibition of protein synthesis, and disruption of bacterial metabolism. Based on the results of the study, S. sumatrensis extract has the potential as a natural antibacterial alternative for acne treatment without significant side effects or the risk of antibiotic resistance.
Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Uji aktivitas antioksidan ekstrak etanol daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oleifera) dengan metode 2,2-diphenyl-1-picrylhydrazyl Potalangi, Nerni Olvi; Palandi, Reky Royke; Manoppo, Amalia J.; Tewu, Tewsi M.; Kanter, Jabes Wolter; Sambou, Christel Nataniel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.626

Abstract

Free radicals can originate from within the human body as a result of metabolic processes from chemical reactions in the body, as well as from external sources or the environment, including emissions from motor vehicles, air pollution from factories, industrial chemicals, food and beverage substances, cigarette smoke, radiation, and sunlight. Antioxidants are components that can prevent cells or molecules from being oxidised by donating electrons or hydrogen atoms to free radicals. The impact of the reactivity of free radical compounds can result in cell or tissue damage, degenerative diseases, and even cancer. One of the parasites on the moringa plant, namely Helixanthera cylindrica (Jack) Danser, contains secondary metabolite compounds such as alkaloids, flavonoids, and saponins. This research aimed to determine whether the leaves of the Helixanthera cylindrica (Jack) Danser mistletoe have antioxidant activity using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The research method is a laboratory experiment with five concentrations and three repetitions. Subsequently, the antioxidant activity testing is conducted qualitatively using the DPPH method at a wavelength of 517 nm and utilising a Spectrophotometer UV-Vis. Based on the results of the antioxidant test, the extract of Helixanthera cylindrica (Jack) Danser leaves has extreme activity with an IC50 value of 28.74 ppm. In contrast, the comparison, vitamin C has an IC50 value of 1.57 ppm. The regression equation for the concentration of the mistletoe is y=0.3344x + 40.389 with an R2 value of 0.9726, and Vitamin C shows y=4.4065x + 43.079 with an R² value of 0.9677. It can be concluded that the leaves of Helixanthera cylindrica (Jack) Danser on the Moringa oleifera plant have extreme antioxidant activity.
Antibakteri infusa akar mangrove Sonneratia alba pada Escherichia coli dan Staphylococcus aureus Tuda , Aletheia Marvla Windi; Mongi, Jeane; Kanter , Jabes W.; Pareta , Douglas; Ginting , Amal; Hariyadi, Hariyadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.636

Abstract

Antibacterial is a substance that stops and kills the growth of bacteria. Mangrove Sonneratia alba is an exciting plant to use as a medicine because of its antibacterial properties. Secondary metabolite compounds such as alkaloids, phenols, tannins, saponins, triterpenoids, and flavonoids present in the roots are antimicrobial. This study aims to determine the antibacterial activity of mangrove root infusion of Sonneratia alba in Staphylococcus aureus and Escherichia coli. This laboratory study uses the agar diffusion technique with a well to test antibacterial. Using three concentrations, namely 25%, 50%, and 100%, this study found that the infusion of the roots of the Sonneratia alba mangrove 25%, 50%, and 100% showed antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. The results of the Kruskal-Wallis test showed that Escherichia coli bacteria showed a P value of 0.010<0.05 and Staphylococcus aureus bacteria with a P value of 0.011<0.05, which showed that there was a significant difference between the two types of bacteria because the significant value was less than 0.05.
Integrasi Profil Fitokimia Berbasis GC–MS dan Evaluasi Farmakologis In Vivo dalam Menilai Potensi Antidiabetes Ekstrak Etanol Scleria sumatrensis Retz. pada Model Tikus Diabetes Induksi Aloksan. Pareta, Douglas Natan; Montolalu , Friska Mery; Keno , Aprillia Vincensia; Kanter , Jabes Wolter; Tombuku , Joke Luis; Sambou , Christel Nataniel; Natanel , Andri; Santoso , Rahmat; Hariyadi, Hariyadi; Runtu , Alter Yantje
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1198

Abstract

This study evaluated the antidiabetic activity and phytochemical profile of the ethanolic extract of Scleria sumatrensis Retz. Using an alloxan-induced diabetic rat model. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg BW) after a 12-hour fasting period, and fasting blood glucose was measured at three standardized time points: GD1 (baseline), GD2 (72 hours post-induction), and GD3 (day 14 post-treatment). GC–MS analysis revealed several major constituents, including ethyl α-D-glucopyranoside, ethyl linoleate, ethyl linolenate, phytol, tocopherol, and β-sitosterol, which are associated with improved insulin sensitivity, modulation of PPAR-γ–related pathways, antioxidant protection of pancreatic β-cells, and reduced intestinal carbohydrate digestion. Rats were assigned to negative control (vehicle), positive control (metformin 45 mg/kg BW), and extract-treated groups (75, 150, and 300 mg/kg BW). Percentage reduction from GD2 to GD3 was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The extract produced a significant and dose-dependent decrease in fasting glucose (p < 0.001). All extract doses differed significantly from the negative control, and the 300 mg/kg dose demonstrated glucose-lowering efficacy comparable to metformin. These findings indicate that Scleria sumatrensis possesses vigorous antihyperglycemic activity consistent with its lipophilic phytochemical composition. Further studies are required to verify the underlying mechanisms and identify the most active constituents.
Co-Authors Adinda Bee Amal Ginting Amal Ginting Anti, Reski Besin, Cecilia S. M. Carolina, Saroinsong F. Charly J. Watung Christin, Andriany M. Debora Christy Palit Deby Mongi Dian K. Ta’au Douglas N. Pareta Esterlina J. Watung Fadly Steven Jefry Rumondor Filia Krisna Wilar Fina Feronica Kotangon Fransisco Sumalong Friska Mery Montolalu Geyza O. Samalagi Gideon A. R. Tiwow Ginting , Amal Giseli Margareth Tampa Giska P. Mandagi Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Hariyadi, Hariyadi Hetty V. Tulandi Inggrid G. Pondaag Irsaline Womsiwor Jeane Mongi Jesica N. Bawondes Jihan Marina Safitri Julianti Julianti Kalangi, Only Imando Karauwan, Ferdy Keno , Aprillia Vincensia Korua, Sammy Rommy Novie Lengkey, Yessie Manoppo, Amalia J. Michaela P Pauran Montolalu , Friska Mery Natanel , Andri Natanel, Andri Nerni Potolangi Olvie S. Datu Paat, Vlagia Indira Padoma, Chintya Pakingki, Priska Palandi, Reky Royke Pareta , Douglas Pareta, Douglas N Pareta, Douglas Natan Pelealu, Nancy C. Polii, Ruland Potalangi, Nerni Olvi Priska C. Londoran Rahmat S. Santoso Randy Tampa'i Randy Tampa’i Renault Marsidi Royke R. Palandi Runtu , Alter Yantje Ryan Offeis Kolondam Sambou , Christel Nataniel Sambou, Christel N. Santoso , Rahmat Sarah Sambow Sasambe Naka Indriyani Sawilan, Frensiska Severalen E. Saruan Silvana L. Tumbel Sindhy Ovellia Ofa Sonny Untu Tabita R. S. Rongkonusa Tampa'i, Randy Tenci Lie Sarbunan Tewu, Tewsi M. Tombuku , Joke Luis Tombuku, Joke Luis Tresya Anuku Tuda , Aletheia Marvla Windi Tulandi, Selvana Stien Wantah, Kezia T. Wilmar Maarisit wong, kevin