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All Journal PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences. Jurnal Lentera Farma
Sambou, Christel N.
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Sam Ratulangi University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Uji aktivitas antioksidan ekstrak etanol daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oleifera) dengan metode 2,2-diphenyl-1-picrylhydrazyl Potalangi, Nerni Olvi; Palandi, Reky Royke; Manoppo, Amalia J.; Tewu, Tewsi M.; Kanter, Jabes Wolter; Sambou, Christel Nataniel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.626

Abstract

Free radicals can originate from within the human body as a result of metabolic processes from chemical reactions in the body, as well as from external sources or the environment, including emissions from motor vehicles, air pollution from factories, industrial chemicals, food and beverage substances, cigarette smoke, radiation, and sunlight. Antioxidants are components that can prevent cells or molecules from being oxidised by donating electrons or hydrogen atoms to free radicals. The impact of the reactivity of free radical compounds can result in cell or tissue damage, degenerative diseases, and even cancer. One of the parasites on the moringa plant, namely Helixanthera cylindrica (Jack) Danser, contains secondary metabolite compounds such as alkaloids, flavonoids, and saponins. This research aimed to determine whether the leaves of the Helixanthera cylindrica (Jack) Danser mistletoe have antioxidant activity using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The research method is a laboratory experiment with five concentrations and three repetitions. Subsequently, the antioxidant activity testing is conducted qualitatively using the DPPH method at a wavelength of 517 nm and utilising a Spectrophotometer UV-Vis. Based on the results of the antioxidant test, the extract of Helixanthera cylindrica (Jack) Danser leaves has extreme activity with an IC50 value of 28.74 ppm. In contrast, the comparison, vitamin C has an IC50 value of 1.57 ppm. The regression equation for the concentration of the mistletoe is y=0.3344x + 40.389 with an R2 value of 0.9726, and Vitamin C shows y=4.4065x + 43.079 with an R² value of 0.9677. It can be concluded that the leaves of Helixanthera cylindrica (Jack) Danser on the Moringa oleifera plant have extreme antioxidant activity.
Review : Identifikasi senyawa bioaktif utama dalam daun leilem (Clerodendrum minahassae) dan potensi farmakologis Sambou , Christel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.696

Abstract

Clerodendrum minahassae leaves contain various bioactive compounds, including flavonoids, alkaloids, saponins, and phenolic acids, contributing to their pharmacological activity. This study aims to identify the main bioactive compounds in Leilem leaves (Clerodendrum minahassae) and their pharmacological potential through a literature review of various relevant scientific sources. The methodology employed includes systematic observation and meta-analysis. This review article describes the compounds present in Leilem leaves and evaluates their pharmacological activities, thereby enhancing the understanding of this underexplored medicinal plant. The findings indicate that Leilem leaves hold substantial potential as a source of bioactive molecules with diverse pharmacological properties. Based on a review of multiple scientific research articles, it can be concluded that Leilem leaves exhibit considerable efficacy in antimicrobial, anti-inflammatory, and antioxidant activities, as well as in reducing blood glucose levels.
Integrasi Profil Fitokimia Berbasis GC–MS dan Evaluasi Farmakologis In Vivo dalam Menilai Potensi Antidiabetes Ekstrak Etanol Scleria sumatrensis Retz. pada Model Tikus Diabetes Induksi Aloksan. Pareta, Douglas Natan; Montolalu , Friska Mery; Keno , Aprillia Vincensia; Kanter , Jabes Wolter; Tombuku , Joke Luis; Sambou , Christel Nataniel; Natanel , Andri; Santoso , Rahmat; Hariyadi, Hariyadi; Runtu , Alter Yantje
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1198

Abstract

This study evaluated the antidiabetic activity and phytochemical profile of the ethanolic extract of Scleria sumatrensis Retz. Using an alloxan-induced diabetic rat model. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg BW) after a 12-hour fasting period, and fasting blood glucose was measured at three standardized time points: GD1 (baseline), GD2 (72 hours post-induction), and GD3 (day 14 post-treatment). GC–MS analysis revealed several major constituents, including ethyl α-D-glucopyranoside, ethyl linoleate, ethyl linolenate, phytol, tocopherol, and β-sitosterol, which are associated with improved insulin sensitivity, modulation of PPAR-γ–related pathways, antioxidant protection of pancreatic β-cells, and reduced intestinal carbohydrate digestion. Rats were assigned to negative control (vehicle), positive control (metformin 45 mg/kg BW), and extract-treated groups (75, 150, and 300 mg/kg BW). Percentage reduction from GD2 to GD3 was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The extract produced a significant and dose-dependent decrease in fasting glucose (p < 0.001). All extract doses differed significantly from the negative control, and the 300 mg/kg dose demonstrated glucose-lowering efficacy comparable to metformin. These findings indicate that Scleria sumatrensis possesses vigorous antihyperglycemic activity consistent with its lipophilic phytochemical composition. Further studies are required to verify the underlying mechanisms and identify the most active constituents.
Pengaruh Metode Ekstraksi (Maserasi dan Infusa) terhadap Potensi Antibakteri Ekstrak Daun Nasi (Phrynium pubinerve Blume) dalam Menghambat Pertumbuhan Propionibacterium acnes Sambou, Christel Nataniel; Yudistira, Adithya; Rumondor, Erladys Melindah; Lontaan, Gloria J.; Lumbu, Alisa W. R.; Rolos, Tesalonika N.; Kanter, Yabes
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64402

Abstract

Pencarian alternatif antibakteri berbasis tanaman menjadi krusial seiring dengan meningkatnya resistensi bakteri terhadap antibiotik konvensional, di mana metode ekstraksi merupakan faktor penentu potensi. Penelitian ini bertujuan mengevaluasi dan membandingkan efektivitas metode maserasi dan infusa dalam memperoleh ekstrak Phrynium pubinerve Blume yang aktif melawan Propionibacterium acnes, serta mengidentifikasi metode mana yang paling efektif. Dengan menggunakan metode difusi agar (kertas cakram), diameter zona hambat kedua jenis ekstrak diukur dan diuji secara statistik dengan Uji-t Welch. Hasil Uji-t menunjukkan adanya perbedaan signifikan pada rata-rata zona hambat kedua kelompok. Kesimpulannya, ekstrak Phrynium pubinerve Blume yang dihasilkan dari metode ekstraksi dengan rata-rata zona hambat terbesar yaitu maserasi menjadi metode yang paling efektif dalam aktivitas antibakteri.
Anti-Inflammatory Activity Test of Mangrove Root (Sonneratia alba) Ethanol Extract Gel Preparation in Carragenan-Induced White Rats (Rattus norvegicus) Alfared S. Simanjuntak; Jeane Mongi; Wilmar Maarisit; Yessie K. Lengkey; Christel N. Sambou; Douglas N. Pareta
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.493

Abstract

Nature provides various compounds that can provide anti-inflammatory activity, one of which is the compound contained in mangrove roots (Sonneratia alba). In these plants, especially in the roots, there are secondary metabolite compounds such as alkaloids, flavonoids, tannins, triterpenoids and from various reported research results, flavonoids have anti-inflammatory properties. The medicinal preparation that the researchers want to make is a gel preparation that is used for topical treatment therapy. The research was carried out with 15 rats into 5 test groups. Positive control group: given Diclofenac Sodium gel (Voltadex) 20 g (1%), negative control group: given gel without ethanol extract, 2.5% concentration group: given 2.5% ethanol extract gel, 5% concentration group: given 5% ethanol extract gel, 10% concentration group: 10% ethanol extract gel was given. The data was analyzed descriptively and presented in the form of tables and graphs. The research results showed that the Sonneratia alba ethanol extract gel preparation had anti-inflammatory activity. The research results show that the ethanol extract of Sonneratia alba mangrove roots can be used as a gel preparation and in in vivo testing the gel preparation of Sonneratia alba mangrove root ethanol extract has anti-inflammatory activity. The control group of Sonneratia alba mangrove root ethanol extract gel preparations of concentrations of 2.5%, 5% and 10% had a swelling inhibition percentage, which means that Sonneratia alba mangrove root ethanol extract gel preparations of 2.5%, 5% and 10% concentration had anti-inflammatory activity.
Gambaran Pola Polifarmasi pada Pasien Geriatri yang Menggunakan Obat Antihipertensi di Puskesmas Kakaskasen Tomohon Mait, Mutiara; Jayanti, Meilani; Sambou, Christel Nataniel
Jurnal Lentera Farma Vol. 5 No. 1 (2026): Jurnal Lentera Farma
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/h957xb43

Abstract

Hipertensi merupakan salah satu penyakit kronis dengan prevalensi tinggi yang memerlukan pengelolaan jangka panjang. Salah satu tantangan dalam terapi hipertensi adalah polifarmasi, yaitu penggunaan beberapa obat secara bersamaan, yang dapat memengaruhi keberhasilan kontrol tekanan darah. Penelitian ini bertujuan untuk mengevaluasi penggunaan polifarmasi pada pasien geriatri yang menggunakan obat antihipertensi di Puskesmas Kakaskasen Tomohon. Penelitian ini menggunakan desain deskriptif observasional dengan pendekatan cross sectional. Data diperoleh secara retrospektif dari rekam medis pasien hipertensi periode Oktober–Desember 2025 dengan teknik consecutive sampling, sehingga diperoleh sampel sebanyak 389 pasien. Data yang dikumpulkan meliputi karakteristik pasien, diagnosis, jumlah obat yang digunakan, serta kombinasi terapi antihipertensi dan obat komorbid. Kombinasi terapi yang paling banyak digunakan melibatkan golongan Calcium Channel Blocker (CCB), Angiotensin Receptor Blocker (ARB), β-blocker, diuretik, antidiabetik, antihiperlipidemia, dan antihiperurisemia. Kombinasi yang paling sering ditemukan adalah Amlodipin–Bisoprolol–Candesartan dengan variasi tambahan obat komorbid. Seluruh sampel yang dianalisis menunjukkan penggunaan ≥5 jenis obat sehingga termasuk kategori polifarmasi.
Evaluasi Tingkat Kepatuhan Penggunaan Obat Pasien Geriatri yang Menderita Hipertensi di Puskesmas Motoling Hasani, Triani; Jayanti, Meilani; Sambou, Christel
Jurnal Lentera Farma Vol. 5 No. 1 (2026): Jurnal Lentera Farma
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/mhw27z44

Abstract

Keberhasilan terapi hipertensi sangat dipengaruhi oleh tingkat kepatuhan pasien dalam mengonsumsi obat antihipertensi. Penelitian ini bertujuan untuk mengidentifikasi tingkat kepatuhan penggunaan obat pada pasien geriatri yang menderita hipertensi di Puskesmas Motoling. Penelitian ini menggunakan metode observasional deskriptif dengan pendekatan cross sectional. Pengambilan sampel dilakukan secara consecutive sampling pada pasien geriatri hipertensi yang memenuhi kriteria inklusi dengan jumlah sampel sebanyak 107 responden. Pengumpulan data dilakukan menggunakan kuesioner Morisky Medication Adherence Scale-8 (MMAS-8) untuk menilai tingkat kepatuhan penggunaan obat antihipertensi serta kuesioner data demografi pasien. Hasil penelitian menunjukkan bahwa prevalensi tingkat kepatuhan penggunaan obat antihipertensi pada pasien geriatri di Puskesmas Motoling didominasi oleh kategori kepatuhan rendah yaitu sebanyak 51 responden (48%), diikuti kepatuhan tinggi sebanyak 32 responden (30%), dan kepatuhan sedang sebanyak 24 responden (22%). Penelitian ini menyimpulkan bahwa tingkat kepatuhan penggunaan obat antihipertensi pada pasien geriatri di Puskesmas Motoling masih didominasi oleh kategori kepatuhan rendah, sehingga diperlukan perhatian lebih terhadap upaya peningkatan kepatuhan pasien dalam menjalani pengobatan hipertensi.
Antipyretic Activity of Ethanol Extract of Malay Apple Leaves (Syzygium malaccense L.) in Peptone-Induced Male White Rats (Rattus norvegicus) Jeane Mongie; Rosalia V. Manti; Ferdy A. Karauwan; Silvana L. Tumbel; Nerni O. Potalangi; Rachmat Santoso; Christel N. Sambou
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.543

Abstract

Malay apple leaves (Syzygium malaccense L.) have traditionally been used to reduce fever. This study aimed to evaluate the antipyretic activity of the ethanol extract of Malay apple leaves in peptone-induced male white rats (Rattus norvegicus). A completely randomized design was used with five treatment groups: negative control (distilled water), positive control (paracetamol), and ethanol extract doses of 125, 250, and 500 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight), and rectal temperature was recorded every 30 minutes for 180 minutes. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney tests. The results showed that all extract doses reduced rectal temperature compared with the negative control, with the 500 mg dose producing the greatest antipyretic effect. Statistical analysis indicated significant differences among treatment groups (p < 0.05). In conclusion, the ethanol extract of Malay apple leaves possesses antipyretic activity in peptone-induced male white rats, with the 500 mg dose showing the highest effectiveness.
Formulasi Pasta Gigi Kombinasi Ekstrak Daun Jambu Biji(Psidium guajava L) dan Daun Mint(Mentha piperita L) Serta Aktivitas Terhadap Bakteri Streptococcus mutans Fajar Riza Harianto; Surya Sumantri Abdullah; Christel Sambou
Jurnal Lentera Farma Vol. 5 No. 1 (2026): Jurnal Lentera Farma
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/5yw97425

Abstract

Dental caries is one of the most common oral health problems, mainly caused by the bacterium Streptococcus mutans . One of the preventive efforts is the use of toothpaste containing natural antibacterial agents. Guava leaves (Psidium guajava L.) and mint leaves (Mentha piperita L.) are known to possess antibacterial activity against Streptococcus mutans . This study aimed to formulate a combination of extracts from both plants into a toothpaste preparation and to evaluate its antibacterial activity. The extracts were obtained by maceration using 96% ethanol and formulated into three formulas with a total concentration of 10%. The evaluation included organoleptic test, homogeneity, spreadability, adhesion, pH, foaming ability, and antibacterial activity test using the well diffusion method. The results showed that formula F2 (5%:5%) provided the best physical characteristics and the highest antibacterial activity, with an inhibition zone of 11.4 ± 0.9 mm, which was categorized as strong. The combination of these extracts can be formulated as an antibacterial herbal toothpaste.
Co-Authors Adithya Yudistira Alfared S. Simanjuntak Alfiano H. Mbaubedari Amal Ginting Anastasia Walukow Ayu Brenda Sumariangen Charly J. Watung Christi Wuisan Citra Mentari Payow Diana V. Hamel Douglas N. Pareta Douglas N. Pareta Einstein Z. Z. S. Karundeng ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Esterlina J. Watung Fajar Riza Harianto Feby L. Bala Ferdy A. Karauwan Fina Feronica Kotangon Friska Mery Montolalu Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi, Hariyadi Hasani, Triani Inggrid G. Pondaag Injilia V. Anis Iteke Tuda Ivone Katiandagho Jabes Wolter Kanter Jacky Rarung Jeane Mongi Jeane Mongi Jeane Mongie Jeivia Matialo Jessica I Mampouw Kalalo, Michael R. C. Kalangi, Only Imando Karauwan, Ferdy Keno , Aprillia Vincensia Lahope, Joice M. Lengkey, Yessie Lontaan, Gloria J. Lumbu, Alisa W. R. Mait, Mutiara Manoppo, Amalia J. Margaretha Ginting Martina G. Laloan Mega Fatimah Rosana Meilani Jayanti Montolalu , Friska Mery Natanel , Andri Nerni O. Potalangi Nerni Potolangi Paat, Vlagia Indira Palandi, Reky Royke Pareta, Douglas Natan Patricia Sulianti Mona Potalangi, Nerni Olvi Priska C. Londoran Priska S. Kolopita Rachmat Santoso Raden Mohamad Herdian Bhakti Rahmat S. Santoso Randi Tampa’i Randy Tampa'i Randy Tampa’i Rolos, Tesalonika N. Rosalia V. Manti Royke R. Palandi Runtu , Alter Yantje Ryan Offeis Kolondam Santoso , Rahmat Sarah Sambow Sawilan, Frensiska Sesilia Agata Soriton Silvana L. Tumbel Silvana L. Tumbel Sonny Untu Sumaa, Ivona Katrin Surya Sumantri Abdullah Tampa'i, Randy Tewu, Tewsi M. Tombuku , Joke Luis Tombuku, Joke Luis Tri Nugrahani I.M Kilis Tulandi, Selvana Stien Vania V. Liling Wilmar Maarisit Wilmar Maarisit Wiyono, Weny Indayany Yanti Paula Ranti Yessie K. Lengkey Yuri Namotemo