Article Per Year (5 Year)
p-Index From 2021 - 2026
4.23
P-Index
This Author published in this journals
All Journal PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences.
Sambou, Christel N.
Program Studi Farmasi, Fakultas MIPA , Universitas Sam Ratulangi, 95115, Sulawesi Utara, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 46 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 46 Documents
Search

 1   2   3   4   5 
Anti-Inflammatory Activity Test of Mangrove Root (Sonneratia alba) Ethanol Extract Gel Preparation in Carragenan-Induced White Rats (Rattus norvegicus) Simanjuntak, Alfared S.; Mongi, Jeane; Maarisit, Wilmar; Lengkey, Yessie K.; Sambou, Christel N.; Pareta, Douglas N.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.493

Abstract

Nature provides various compounds that can provide anti-inflammatory activity, one of which is the compound contained in mangrove roots (Sonneratia alba). In these plants, especially in the roots, there are secondary metabolite compounds such as alkaloids, flavonoids, tannins, triterpenoids and from various reported research results, flavonoids have anti-inflammatory properties. The medicinal preparation that the researchers want to make is a gel preparation that is used for topical treatment therapy. The research was carried out with 15 rats into 5 test groups. Positive control group: given Diclofenac Sodium gel (Voltadex) 20 g (1%), negative control group: given gel without ethanol extract, 2.5% concentration group: given 2.5% ethanol extract gel, 5% concentration group: given 5% ethanol extract gel, 10% concentration group: 10% ethanol extract gel was given. The data was analyzed descriptively and presented in the form of tables and graphs. The research results showed that the Sonneratia alba ethanol extract gel preparation had anti-inflammatory activity. The research results show that the ethanol extract of Sonneratia alba mangrove roots can be used as a gel preparation and in in vivo testing the gel preparation of Sonneratia alba mangrove root ethanol extract has anti-inflammatory activity. The control group of Sonneratia alba mangrove root ethanol extract gel preparations of concentrations of 2.5%, 5% and 10% had a swelling inhibition percentage, which means that Sonneratia alba mangrove root ethanol extract gel preparations of 2.5%, 5% and 10% concentration had anti-inflammatory activity.
Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Uji aktivitas antioksidan ekstrak etanol daun benalu Helixanthera cylindrica (Jack) Danser pada tumbuhan kelor (Moringa oleifera) dengan metode 2,2-diphenyl-1-picrylhydrazyl Potalangi, Nerni Olvi; Palandi, Reky Royke; Manoppo, Amalia J.; Tewu, Tewsi M.; Kanter, Jabes Wolter; Sambou, Christel Nataniel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.626

Abstract

Free radicals can originate from within the human body as a result of metabolic processes from chemical reactions in the body, as well as from external sources or the environment, including emissions from motor vehicles, air pollution from factories, industrial chemicals, food and beverage substances, cigarette smoke, radiation, and sunlight. Antioxidants are components that can prevent cells or molecules from being oxidised by donating electrons or hydrogen atoms to free radicals. The impact of the reactivity of free radical compounds can result in cell or tissue damage, degenerative diseases, and even cancer. One of the parasites on the moringa plant, namely Helixanthera cylindrica (Jack) Danser, contains secondary metabolite compounds such as alkaloids, flavonoids, and saponins. This research aimed to determine whether the leaves of the Helixanthera cylindrica (Jack) Danser mistletoe have antioxidant activity using the 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. The research method is a laboratory experiment with five concentrations and three repetitions. Subsequently, the antioxidant activity testing is conducted qualitatively using the DPPH method at a wavelength of 517 nm and utilising a Spectrophotometer UV-Vis. Based on the results of the antioxidant test, the extract of Helixanthera cylindrica (Jack) Danser leaves has extreme activity with an IC50 value of 28.74 ppm. In contrast, the comparison, vitamin C has an IC50 value of 1.57 ppm. The regression equation for the concentration of the mistletoe is y=0.3344x + 40.389 with an R2 value of 0.9726, and Vitamin C shows y=4.4065x + 43.079 with an R² value of 0.9677. It can be concluded that the leaves of Helixanthera cylindrica (Jack) Danser on the Moringa oleifera plant have extreme antioxidant activity.
Review : Identifikasi senyawa bioaktif utama dalam daun leilem (Clerodendrum minahassae) dan potensi farmakologis Sambou , Christel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.696

Abstract

Clerodendrum minahassae leaves contain various bioactive compounds, including flavonoids, alkaloids, saponins, and phenolic acids, contributing to their pharmacological activity. This study aims to identify the main bioactive compounds in Leilem leaves (Clerodendrum minahassae) and their pharmacological potential through a literature review of various relevant scientific sources. The methodology employed includes systematic observation and meta-analysis. This review article describes the compounds present in Leilem leaves and evaluates their pharmacological activities, thereby enhancing the understanding of this underexplored medicinal plant. The findings indicate that Leilem leaves hold substantial potential as a source of bioactive molecules with diverse pharmacological properties. Based on a review of multiple scientific research articles, it can be concluded that Leilem leaves exhibit considerable efficacy in antimicrobial, anti-inflammatory, and antioxidant activities, as well as in reducing blood glucose levels.
Integrasi Profil Fitokimia Berbasis GC–MS dan Evaluasi Farmakologis In Vivo dalam Menilai Potensi Antidiabetes Ekstrak Etanol Scleria sumatrensis Retz. pada Model Tikus Diabetes Induksi Aloksan. Pareta, Douglas Natan; Montolalu , Friska Mery; Keno , Aprillia Vincensia; Kanter , Jabes Wolter; Tombuku , Joke Luis; Sambou , Christel Nataniel; Natanel , Andri; Santoso , Rahmat; Hariyadi, Hariyadi; Runtu , Alter Yantje
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1198

Abstract

This study evaluated the antidiabetic activity and phytochemical profile of the ethanolic extract of Scleria sumatrensis Retz. Using an alloxan-induced diabetic rat model. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg BW) after a 12-hour fasting period, and fasting blood glucose was measured at three standardized time points: GD1 (baseline), GD2 (72 hours post-induction), and GD3 (day 14 post-treatment). GC–MS analysis revealed several major constituents, including ethyl α-D-glucopyranoside, ethyl linoleate, ethyl linolenate, phytol, tocopherol, and β-sitosterol, which are associated with improved insulin sensitivity, modulation of PPAR-γ–related pathways, antioxidant protection of pancreatic β-cells, and reduced intestinal carbohydrate digestion. Rats were assigned to negative control (vehicle), positive control (metformin 45 mg/kg BW), and extract-treated groups (75, 150, and 300 mg/kg BW). Percentage reduction from GD2 to GD3 was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The extract produced a significant and dose-dependent decrease in fasting glucose (p < 0.001). All extract doses differed significantly from the negative control, and the 300 mg/kg dose demonstrated glucose-lowering efficacy comparable to metformin. These findings indicate that Scleria sumatrensis possesses vigorous antihyperglycemic activity consistent with its lipophilic phytochemical composition. Further studies are required to verify the underlying mechanisms and identify the most active constituents.
Pengaruh Metode Ekstraksi (Maserasi dan Infusa) terhadap Potensi Antibakteri Ekstrak Daun Nasi (Phrynium pubinerve Blume) dalam Menghambat Pertumbuhan Propionibacterium acnes Sambou, Christel Nataniel; Yudistira, Adithya; Rumondor, Erladys Melindah; Lontaan, Gloria J.; Lumbu, Alisa W. R.; Rolos, Tesalonika N.; Kanter, Yabes
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64402

Abstract

Pencarian alternatif antibakteri berbasis tanaman menjadi krusial seiring dengan meningkatnya resistensi bakteri terhadap antibiotik konvensional, di mana metode ekstraksi merupakan faktor penentu potensi. Penelitian ini bertujuan mengevaluasi dan membandingkan efektivitas metode maserasi dan infusa dalam memperoleh ekstrak Phrynium pubinerve Blume yang aktif melawan Propionibacterium acnes, serta mengidentifikasi metode mana yang paling efektif. Dengan menggunakan metode difusi agar (kertas cakram), diameter zona hambat kedua jenis ekstrak diukur dan diuji secara statistik dengan Uji-t Welch. Hasil Uji-t menunjukkan adanya perbedaan signifikan pada rata-rata zona hambat kedua kelompok. Kesimpulannya, ekstrak Phrynium pubinerve Blume yang dihasilkan dari metode ekstraksi dengan rata-rata zona hambat terbesar yaitu maserasi menjadi metode yang paling efektif dalam aktivitas antibakteri.
Co-Authors Adithya Yudistira Alfiano H. Mbaubedari Amal Ginting Anastasia Walukow Ayu Brenda Sumariangen Charly J. Watung Christi Wuisan Citra Mentari Payow Diana V. Hamel Douglas N. Pareta Einstein Z. Z. S. Karundeng ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Esterlina J. Watung Feby L. Bala Fina Feronica Kotangon Friska Mery Montolalu Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Hariyadi Hariyadi Hariyadi, Hariyadi Inggrid G. Pondaag Injilia V. Anis Iteke Tuda Ivone Katiandagho Jabes Wolter Kanter Jacky Rarung Jeane Mongi Jeivia Matialo Jessica I Mampouw Kalalo, Michael R. C. Kalangi, Only Imando Kanter, Yabes Karauwan, Ferdy Keno , Aprillia Vincensia Lahope, Joice M. Lengkey, Yessie Lontaan, Gloria J. Lumbu, Alisa W. R. Manoppo, Amalia J. Margaretha Ginting Martina G. Laloan Montolalu , Friska Mery Natanel , Andri Nerni Potolangi Paat, Vlagia Indira Palandi, Reky Royke Pareta, Douglas Natan Patricia Sulianti Mona Potalangi, Nerni Olvi Priska C. Londoran Priska S. Kolopita Raden Mohamad Herdian Bhakti Rahmat S. Santoso Randi Tampa’i Randy Tampa'i Randy Tampa’i Rolos, Tesalonika N. Royke R. Palandi Runtu , Alter Yantje Ryan Offeis Kolondam Santoso , Rahmat Sarah Sambow Sawilan, Frensiska Sesilia Agata Soriton Silvana L. Tumbel Simanjuntak, Alfared S. Sonny Untu Tampa'i, Randy Tewu, Tewsi M. Tombuku , Joke Luis Tombuku, Joke Luis Tri Nugrahani I.M Kilis Tulandi, Selvana Stien Vania V. Liling Wilmar Maarisit Yanti Paula Ranti Yuri Namotemo