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All Journal Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Jurnal Manajemen dan Bisnis Baja (JUMANIS BAJA) Journal of Midwifery and Reproduction Jurnal Biosense Jurnal Abdimas Bina Bangsa Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Baja Health Science Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Yuda Nabella Prameswari
Universitas Sultan Ageng Tirtayasa
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Polimorfisme Gen Cyclooxygenase-2 dan Prevalensi Hipertensi Masyarakat Indonesia Prameswari, Yuda Nabella
JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Vol 10, No 3 (2025): September 2025
Publisher : Universitas Al Azhar Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36722/sst.v10i3.4246

Abstract

Hypertension is a major risk factor for cardiovascular diseases, leading to serious health complications. Genetic polymorphisms in the COX-2 gene, especially the rs689466 variant, are associated with increased cardiovascular risk, but its link to hypertension in the Indonesian population remains limited. This study investigates the relationship between COX-2 rs689466 polymorphism and hypertension in Indonesia, using a cross-sectional design with 200 samples (100 hypertensive patients and 100 healthy individuals). DNA was isolated from whole blood using the salting-out method, and the COX-2 rs689466 polymorphism was analyzed by PCR-RFLP. Statistical analysis was performed using the Chi-square and Mann-Whitney tests. The results showed a significant association between the COX-2 rs689466 polymorphism and hypertension (p<0.001), with the AA genotype carrying a higher risk (p<0.001, OR=8.609) compared to individuals with the GG or AG genotypes. Smoking exacerbated this association, with smokers being more likely to carry the AA genotype and have an increased risk of hypertension (p<0.001, OR=6.091). This study highlights the role of COX-2 rs689466, particularly the AA genotype, in increasing hypertension risk in Indonesia, with smoking further worsening vascular inflammation and resistance, contributing to hypertension development.Keywords - Cyclooxygenase-2 (COX-2), Hypertension, Polymorphism, Smoking, Rs689466.
VEGF mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs699947 Gene Variant Prameswari, Yuda Nabella; Suryandari, Dwi Anita; Sukmawati, Dewi; Yunaini, Luluk; Kodariah, Ria
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.26156

Abstract

Background: Angiogenesis is the formation of new blood vessels, is crucial for cancer growth and metastasis, including in epithelial ovarian cancer (EOC). Vascular Endothelial Growth Factor (VEGF) regulates angiogenesis, and its elevated mRNA expression is linked to poor prognosis in cancer. Genetic variations, such as the rs699947 polymorphism in the VEGF gene, can affect VEGF expression and contribute to cancer progression.Objective: The primary aim of this study is to examine the distribution of the VEGF rs699947 polymorphism and its correlation with VEGF mRNA expression levels in patients with low-grade and high-grade EOC at Dr. Cipto Mangunkusumo Hospital, Indonesia.Methods: This research is a cross-sectional analysis involving 65 normal female whole blood samples and a total of 80 ovarian cancer biopsy samples, including 15 ovarian cysts as expression calibrators, along with 36 low-grade and 29 high-grade EOC samples. The distribution of genotypes and alleles of the VEGF rs699947 polymorphism was assessed through ARMS PCR analysis, while VEGF mRNA expression was quantified using real-time qPCR.Results: Significant differences were observed in both genotype (p<0,01) and allele (p=0,000) distributions between the normal and cases group. The relative mRNA expression of VEGF was significantly elevated in both low-grade and high-grade EOC. Individuals with the homozygous VEGF rs699947 AA genotype exhibited the highest mRNA expression compared to other genotypes. In contrast, individuals carrying the CC genotype showed the lowest correlation with VEGF mRNA expression in both low-grade and high-grade EOC.Conclusion: This study shows that the A allele of VEGF rs699947 is correlated with increased VEGF mRNA expression in EOC patients, particularly in those with the AA genotype. Conversely, the C allele may offer a protective effect against EOC, as the CC genotype is linked to lower VEGF mRNA expression. Genetic screening for VEGF rs699947 could facilitate early detection and inform targeted therapeutic strategies.
Correlation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review Prameswari, Yuda Nabella; Dwi Anita Suryandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.484

Abstract

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.
Correlation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review Prameswari, Yuda Nabella; Dwi Anita Suryandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.484

Abstract

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.
ANKILOSTOMIASIS PENYAKIT TROPIS TERABAIKAN: TINJAUANLITERATUR TENTANG EPIDEMIOLOGI, MANIFESTASI KLINIS,DIAGNOSIS, DAN STRATEGI PENGENDALIAN Irawati, Nur Bebi Ulfah; Hermawati, Luluk; Hilizza Awalina Zulfa; Prameswari , Yuda Nabella; Damayanti , Putri; Furqoni , Abdul Hadi
JURNAL BIOSENSE Vol 8 No 4 (2025): Edisi Oktober 2025
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v8i4.5721

Abstract

Ankilostomiasis merupakan penyakit parasitik yang disebabkan oleh cacing Ancylostoma duodenal dan Necator americanus, dan tergolong sebagai salah satu penyakit tropis terabaikan (Neglected Tropical Diseases, NTDs). Penyakit ini endemik di wilayah tropis dan subtropis, terutama di daerah dengan sanitasi lingkungan buruk dan kebiasaan tidak menggunakan alas kaki. Meskipun dapat ditangani dengan obat anthelmintik seperti albendazol dan mebendazol, reinfeksi sering terjadi karena akar masalah lingkungan dan sosial belum terselesaikan. Artikel ini bertujuan untuk meninjau secara komprehensif literatur ilmiah terkini mengenai agen penyebab, siklus hidup, epidemiologi, manifestasi klinis,diagnosis, serta strategi pencegahan dan pengendalian ankilostomiasis. Penelitian ini merupakan systematic literature review yang mengidentifikasi dan menganalisis literatur tahun 2014–2025 mengenai ankilostomiasis pada manusia, meliputi agen penyebab, siklushidup, prevalensi, manifestasi klinis, metode diagnosis, serta strategi pencegahan dan pengendalian, dengan seleksi artikel dilakukan berdasarkan pedoman PRISMA. Ankilostomiasis berkontribusi signifikan terhadap beban penyakit kronis melalui dampak seperti anemia defisiensi besi, gangguan tumbuh kembang anak, dan penurunan kapasitas produktif masyarakat. Diagnosis dini masih menjadi tantangan karena gejala yang tidak spesifik, sementara upaya pengendalian memerlukan intervensi lintas sektor, termasuk edukasi perilaku hidup bersih dan sehat, perbaikan sanitasi, serta program deworming massal. Pengendalian ankilostomiasis tidak dapat mengandalkan terapi farmakologis semata, tetapi harus disertai dengan pendekatan lingkungan dan sosial yang menyeluruh. Strategi terpadu sangat diperlukan untuk menurunkan prevalensi dan memutus siklus penularan, terutama diwilayah endemis.
Co-Authors Adhayati, Baety Aqila, Yasmin Nur Ardie Putra, Alfian Prayana Atmaja, Sukarta Damayanti , Putri Dewi Friska Dewi Sukmawati Dwi Anita Suryandari Furqoni , Abdul Hadi Hilizza Awalina Zulfa Irawati, Nur Bebi Ulfah Linardita Ferial, Linardita Luluk Hermawati Luluk Yunaini Mirza Abdi Khairusy Novita Armelia Ramadhani Nugroho, Muhammad Rachman Putra, Alfian Prayana Ardie Rachmat, Omat Ria Kodariah Rossa Amelia, Rossa Rukman Abdullah Utami, Louisa Ivana Wulansari, Ekawati Rini Zulfa, Hilizza Awalina