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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Jurnal Ilmu Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Jurnal Manajemen dan Bisnis Baja (JUMANIS BAJA) Journal of Midwifery and Reproduction Jurnal Biosense Jurnal Abdimas Bina Bangsa Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Baja Health Science Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat International Journal of Cell and Biomedical Science
Yuda Nabella Prameswari
Faculty Of Medicine And Health Sciences, Universitas Sultan Ageng Tirtayasa, Serang, Banten, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Polimorfisme Gen Cyclooxygenase-2 dan Prevalensi Hipertensi Masyarakat Indonesia Prameswari, Yuda Nabella
JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Vol 10, No 3 (2025): September 2025
Publisher : Universitas Al Azhar Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36722/sst.v10i3.4246

Abstract

Hypertension is a major risk factor for cardiovascular diseases, leading to serious health complications. Genetic polymorphisms in the COX-2 gene, especially the rs689466 variant, are associated with increased cardiovascular risk, but its link to hypertension in the Indonesian population remains limited. This study investigates the relationship between COX-2 rs689466 polymorphism and hypertension in Indonesia, using a cross-sectional design with 200 samples (100 hypertensive patients and 100 healthy individuals). DNA was isolated from whole blood using the salting-out method, and the COX-2 rs689466 polymorphism was analyzed by PCR-RFLP. Statistical analysis was performed using the Chi-square and Mann-Whitney tests. The results showed a significant association between the COX-2 rs689466 polymorphism and hypertension (p<0.001), with the AA genotype carrying a higher risk (p<0.001, OR=8.609) compared to individuals with the GG or AG genotypes. Smoking exacerbated this association, with smokers being more likely to carry the AA genotype and have an increased risk of hypertension (p<0.001, OR=6.091). This study highlights the role of COX-2 rs689466, particularly the AA genotype, in increasing hypertension risk in Indonesia, with smoking further worsening vascular inflammation and resistance, contributing to hypertension development.Keywords - Cyclooxygenase-2 (COX-2), Hypertension, Polymorphism, Smoking, Rs689466.
VEGF mRNA Expression in Epithelial Ovarian Cancer: Correlation with rs699947 Gene Variant Prameswari, Yuda Nabella; Suryandari, Dwi Anita; Sukmawati, Dewi; Yunaini, Luluk; Kodariah, Ria
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.26156

Abstract

Background: Angiogenesis is the formation of new blood vessels, is crucial for cancer growth and metastasis, including in epithelial ovarian cancer (EOC). Vascular Endothelial Growth Factor (VEGF) regulates angiogenesis, and its elevated mRNA expression is linked to poor prognosis in cancer. Genetic variations, such as the rs699947 polymorphism in the VEGF gene, can affect VEGF expression and contribute to cancer progression.Objective: The primary aim of this study is to examine the distribution of the VEGF rs699947 polymorphism and its correlation with VEGF mRNA expression levels in patients with low-grade and high-grade EOC at Dr. Cipto Mangunkusumo Hospital, Indonesia.Methods: This research is a cross-sectional analysis involving 65 normal female whole blood samples and a total of 80 ovarian cancer biopsy samples, including 15 ovarian cysts as expression calibrators, along with 36 low-grade and 29 high-grade EOC samples. The distribution of genotypes and alleles of the VEGF rs699947 polymorphism was assessed through ARMS PCR analysis, while VEGF mRNA expression was quantified using real-time qPCR.Results: Significant differences were observed in both genotype (p<0,01) and allele (p=0,000) distributions between the normal and cases group. The relative mRNA expression of VEGF was significantly elevated in both low-grade and high-grade EOC. Individuals with the homozygous VEGF rs699947 AA genotype exhibited the highest mRNA expression compared to other genotypes. In contrast, individuals carrying the CC genotype showed the lowest correlation with VEGF mRNA expression in both low-grade and high-grade EOC.Conclusion: This study shows that the A allele of VEGF rs699947 is correlated with increased VEGF mRNA expression in EOC patients, particularly in those with the AA genotype. Conversely, the C allele may offer a protective effect against EOC, as the CC genotype is linked to lower VEGF mRNA expression. Genetic screening for VEGF rs699947 could facilitate early detection and inform targeted therapeutic strategies.
Correlation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review Prameswari, Yuda Nabella; Dwi Anita Suryandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.484

Abstract

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.
Correlation Epidermal Growth Factor Receptor Mutation with Non-small Cell Lung Cancer in Passive Smokers: A Review Prameswari, Yuda Nabella; Dwi Anita Suryandari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.484

Abstract

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein with an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain through signaling pathways to regulate cellular proliferation. Epidermal growth factor receptor binding to its ligand will result in autophosphorylation by intrinsic tyrosine kinase activity, thereby triggering multiple signal transduction cascades. Constant or sustained activation of these downstream target sequences is thought to result in a more aggressive tumor phenotype. Mutations in EGFR are associated with non-small cell lung cancer in passive smokers.
ANKILOSTOMIASIS PENYAKIT TROPIS TERABAIKAN: TINJAUANLITERATUR TENTANG EPIDEMIOLOGI, MANIFESTASI KLINIS,DIAGNOSIS, DAN STRATEGI PENGENDALIAN Irawati, Nur Bebi Ulfah; Hermawati, Luluk; Hilizza Awalina Zulfa; Prameswari , Yuda Nabella; Damayanti , Putri; Furqoni , Abdul Hadi
JURNAL BIOSENSE Vol 8 No 4 (2025): Edisi Oktober 2025
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v8i4.5721

Abstract

Ankilostomiasis merupakan penyakit parasitik yang disebabkan oleh cacing Ancylostoma duodenal dan Necator americanus, dan tergolong sebagai salah satu penyakit tropis terabaikan (Neglected Tropical Diseases, NTDs). Penyakit ini endemik di wilayah tropis dan subtropis, terutama di daerah dengan sanitasi lingkungan buruk dan kebiasaan tidak menggunakan alas kaki. Meskipun dapat ditangani dengan obat anthelmintik seperti albendazol dan mebendazol, reinfeksi sering terjadi karena akar masalah lingkungan dan sosial belum terselesaikan. Artikel ini bertujuan untuk meninjau secara komprehensif literatur ilmiah terkini mengenai agen penyebab, siklus hidup, epidemiologi, manifestasi klinis,diagnosis, serta strategi pencegahan dan pengendalian ankilostomiasis. Penelitian ini merupakan systematic literature review yang mengidentifikasi dan menganalisis literatur tahun 2014–2025 mengenai ankilostomiasis pada manusia, meliputi agen penyebab, siklushidup, prevalensi, manifestasi klinis, metode diagnosis, serta strategi pencegahan dan pengendalian, dengan seleksi artikel dilakukan berdasarkan pedoman PRISMA. Ankilostomiasis berkontribusi signifikan terhadap beban penyakit kronis melalui dampak seperti anemia defisiensi besi, gangguan tumbuh kembang anak, dan penurunan kapasitas produktif masyarakat. Diagnosis dini masih menjadi tantangan karena gejala yang tidak spesifik, sementara upaya pengendalian memerlukan intervensi lintas sektor, termasuk edukasi perilaku hidup bersih dan sehat, perbaikan sanitasi, serta program deworming massal. Pengendalian ankilostomiasis tidak dapat mengandalkan terapi farmakologis semata, tetapi harus disertai dengan pendekatan lingkungan dan sosial yang menyeluruh. Strategi terpadu sangat diperlukan untuk menurunkan prevalensi dan memutus siklus penularan, terutama diwilayah endemis.
Clinical Interpretation of Urinalysis for Early Detection of Kidney Disorders: A Narrative Review Adinda Puspita Dewi; Selfie Selfie; Baety Adhayati; Yuda Nabella Prameswari; Lola Febriana Dewi; Luluk Hermawati
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.79

Abstract

Background: Chronic kidney disease (CKD) is a global health issue with a steadily increasing prevalence and often remains asymptomatic in its early stages. This silent progression contributes to delayed diagnosis and limited therapeutic options. Urinalysis is a simple, inexpensive, and noninvasive examination that remains relevant as an early screening tool to detect renal abnormalities before clinical manifestations appear. Methods: This narrative review summarizes the latest scientific evidence regarding the diagnostic value of urinalysis in the early detection of kidney disorders by highlighting the physical, chemical, and microscopic parameters of urine. Literature searches were conducted using PubMed, Scopus, and Google Scholar databases for studies published between 2020 and 2025 with the keywords urinalysis, kidney disease, early detection, uACR, and eGFR. Only English- or Indonesian-language articles relevant to the topic and containing empirical data were included. Results: Urinalysis has been shown to provide early indicators of proteinuria, hematuria, and pathological casts that reflect glomerular and tubular injury. Integration of urinalysis results with uACR and eGFR measurements, as recommended by KDIGO 2024, improves diagnostic accuracy and risk stratification. Additionally, automated digital microscopy and emerging biomarkers such as NGAL and KIM-1 show substantial potential in strengthening early detection capabilities. Discussion and Clinical Implications: Urinalysis not only serves as a screening tool but also holds prognostic value in guiding follow-up and clinical management of high-risk individuals. Proper interpretation of urinalysis findings can assist clinicians in determining the need for further assessment, initiating earlier interventions, and optimizing prevention of CKD progression. Conclusion: Urinalysis remains an essential basic examination for the early detection of kidney impairment. Its integrated application with modern laboratory parameters can enhance diagnostic effectiveness, accelerate clinical intervention, and reduce the global burden of chronic kidney disease.
Skrining Tekanan Darah Sebagai Langkah Preventif Komplikasi Hipertensi Pada Masyarakat Desa Kasemen, Provinsi Banten: Blood Pressure Screening as a Preventive Effort to Reduce Hypertension Complications in Kasemen Village Community, Banten Province Adhayati, Baety; Prameswari, Yuda Nabella; Hermawati, Luluk; Wulansari, Ekawati Rini; Zulfa, Hilizza Awalina; Putri, Neshya Ruriana
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 12 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i12.10337

Abstract

Hypertension is a non-communicable disease that is a leading cause of global morbidity and mortality. In Indonesia, the prevalence of hypertension continues to rise, particularly among the productive and elderly populations. This community service activity aims to conduct early detection and provide education on hypertension through blood pressure screening in Kasemen Village, Serang City, Banten Province. The method employed is a participatory approach involving faculty members and medical students from the Faculty of Medicine and Health Sciences at UNTIRTA. A total of 247 village residents participated in this activity, and from 230 valid data, it was found that 51.30% of respondents had hypertension. The highest proportion of hypertension was observed among the elderly group (71.6%) and men (80%). In addition to blood pressure measurement, education on the importance of regular blood pressure monitoring and healthy lifestyle changes was also provided to raise community awareness. The results of this activity demonstrate that community-based screening, combined with health education, is an effective strategy for preventing and controlling hypertension, while also serving as a field-based learning opportunity for medical students.
IDENTIFYING THE RELATIONSHIP BETWEEN MENTAL HEALTH AND WORK PERFORMANCE: A CROSS-SECTIONAL STUDY IN BANTEN PROVINCE Yuda Nabella Prameswari; Ichwan Delfecio; Siti Darifah
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 1 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i1.49295

Abstract

Background: In the context of global competition, industrial companies must prioritize strategic factors, particularly the development and well-being of human resources. In Indonesia’s manufacturing sector, especially in Banten Province, employees are often subjected to considerable stress resulting from irregular working hours and demanding production targets. Mental health frequently overlooked by employers and organizational systems has a direct and significant impact on employee performance, influencing productivity, motivation, and work quality. Objective: To identify the relationship between mental health and work performance of manufacturing plant employees at PT. X in Banten Province. Methods: This study uses an analytical observational method with a cross-sectional design to examine 396 employees at PT. X's paper packaging plant in Serang City, selected through purposive sampling based on inclusion and exclusion criteria. Data were collected with a questionnaire using the DASS and IWPQ scales and analyzed using the Chi-square test. Results: This study found that depression, anxiety, and stress were each significantly associated with work performance (all p < 0,001), with stress having the strongest effect (OR = 4,062; 95% CI = 2,362–6,985). Conclusion: Depression, anxiety, and stress are significantly associated with reduced work performance among employees at PT. X. Therefore, employers and policymakers should prioritize implementing comprehensive mental health programs and supportive workplace policies to enhance employee well-being and improve productivity in the manufacturing sector.
Hubungan Posisi Dan Durasi Duduk Saat Penggunaan Komputer Dengan Keluhan LBP Pada Tenaga Kependidikan Di Universitas Sulltan Ageng Tirtayasa Prameswari, Yuda Nabella; Gayatri, Alya Indah; Sianipar, Imelda Rosalyn
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 1 (2026): Volume 13 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i1.20880

Abstract

Low back pain (LBP) merupakan masalah kesehatan global yang sering dialami oleh pekerja dengan aktivitas duduk berkepanjangan, termasuk tenaga kependidikan. Tujuan studi ini adalah menganalisis hubungan posisi dan durasi duduk saat menggunakan komputer dengan kejadian LBP pada tenaga kependidikan Universitas Sultan Ageng Tirtayasa. Desain yang digunakan adalah observasional analitik dengan pendekatan potong lintang yang dilaksanakan di seluruh fakultas dan rektorat Universitas Sultan Ageng Tirtayasa. Analisis bivariat menggunakan uji Chi-square dan Fisher’s Exact menunjukkan bahwa postur duduk yang tidak ergonomis serta durasi duduk yang lama berhubungan signifikan dengan kejadian LBP, sedangkan indeks massa tubuh tidak menunjukkan hubungan yang bermakna. Kesimpulannya, postur duduk yang tidak tepat dan durasi duduk yang berkepanjangan merupakan faktor yang berhubungan signifikan dengan kejadian LBP pada tenaga kependidikan.
Co-Authors Adhayati, Baety Adinda Puspita Dewi Aqila, Yasmin Nur Atmaja, Sukarta Damayanti , Putri Dewi Friska Dewi Sukmawati Dwi Anita Suryandari Ekawati Rini Wulansari Furqoni , Abdul Hadi Gayatri, Alya Indah Hilizza Awalina Zulfa Ichwan Delfecio Imelda Rosalyn Sianipar Irawati, Nur Bebi Ulfah Linardita Ferial, Linardita Lola Febriana Dewi Luluk Hermawati Luluk Yunaini Mirza Abdi Khairusy Neshya Ruriana Putri, Neshya Ruriana Novita Armelia Ramadhani Nugroho, Muhammad Rachman Putra, Alfian Prayana Ardie Rachmat, Omat Ria Kodariah Rossa Amelia, Rossa Rukman Abdullah Selfie Selfie Siti Darifah Utami, Louisa Ivana Zulfa, Hilizza Awalina