This research was trying to discover the implementation of strategy Directed Reading Thinking Activity in learning reading comprehension. The research questions of this study were how does the process of learning reading comprehension through Directed Reading Thinking Activity? Then what are the students’ responses in learning reading comprehension through Directed Reading Thinking Activity? To answer these research questions, the researcher conducted a qualitative research. The respondents were six students of class X in Vocational School Tri Jaya Sakti Karawang, Observation, interview, and documentations were used in this research. The process of learning reading comprehension through Directed Reading Thinking Activity showed in this research, from the first step until the last step of using Directed Reading Thinking Activity. The result showed that the students had a positive response toward Directed Reading Thinking Activity. The students’ responses in cognitive aspect were Directed Reading Thinking Activity strategy assisted the students to comprehend various texts, improved their ability to answer and generate questions, developed to predict what the author writes, assisted the students to think rationally, defined unfamiliar words, and concluded the next plot. Meanwhile, the students’ responses in affective aspect were Directed Reading Thinking Activity strategy supported students to overcome difficulties during reading text, it was practical, interactive, easy to do, and made the students discuss actively.