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Adawiyah, Ayuni
UIN Sunan Gunung Djati Bandung
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Journal : Jurnal Ilmu Kefarmasian Indonesia

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Acute toxicity of arumanis mango leaves (Mangifera indica L.) extract against zebrafish (Danio rerio) embryos Darniwa, Adisty Virakawugi; Cahyanto, Tri; Rahayu, Ira; Ulfa, Risda Arba; Adawiyah, Ayuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1209

Abstract

Arumanis is one of the cultivars of Indonesian mangoes used as a horticultural commodity. Young leaves arumanis can be used for traditional herbal medicine. Pharmacological activity of young leaf arumanis extract are known to be antidiabetic, anticancer, antibacterial, anti-inflammatory, and analgesic effects. However, it is necessary to carry out toxicity testing before young leaf arumanis extract is used in traditional herbal medicine. This study aimed to determine the LC50 value of young leaf arumanis extract and identify the hatching time of embryos, heart rate of larvae, swimming movement of larvae, and malformations in both embryos and larvae. Forty five embryos of zebrafish were exposed to several concentrations of young leaf arumanis extract at 24 h post-fertilization until 96 h post-fertilization. Percentage of embryonic death calculated using probit analysis model LC50. Hatching rate, swimming movements, and heart rate were analyzed using the IBM SPSS software version 26. The LC50 values of the young leaf arumanis extract were 42.65μg/mL at 96 hpf and also 42.65μg/mL at 72 hpf. The embryotoxic effects at high concentrations of the extract are hatching delay and decreasing heart rate. The extract also caused abnormalities in embryo morphology, including pericardial edema and tail bending.
Co-Authors Adisty Virakawugi Darniwa Aep Saepuloh Afriansyah Fadillah Akbar, Rahmat Taufiq Mustahiq Akmaliyah Akmaliyah Aldy Rialdy Atmadja Amiq Ana Widiana Anak Agung Istri Sri Wiadnyani Anggita Rahmi Hafsari, Anggita Rahmi Ateng Supriatna Ateng Supriatna Ateng Supriyatna Ateng Supriyatna Ateng Supriyatna Darniwa, Adisty Virakawugi Desi Nurjanah Dicky Dicky Fatiya Shofwaturrohmani Fitriyyah, Ita Hendar Riyadi Ida Kinasih Ida Yayu Nurul Hizqiyah Ikeu Winda Larasati Ira Rahayu Kulsum, Yuni Kurniawan, Isma Dwi M. Agus Salim Madani, Pameila Qaulan Tsaqila Meldania, Rindi Mohamad Agus Salim Muchfa Eprilia Muhsin Muchsin, Muchfa Eprilia Musa'adah Musa'adah Musa’adah, Musa’adah Nenden Nur Amalia Nenden Nur Amalia Nurjanah, Desi Rahmat Taufik MA Ratnasih, Teti Reni Annisa Reni Annisa Nurhanifah Risda Arba Ulfa Risda Arba Ulfa Shofwaturrohmani, Fatiya Sri Fitri Solihah Sri Fitri Solihah Tisnawati, Sophia Eka Tri Cahyanto Tridesianti, Siska Ucu Julita, Ucu Ulfa, Risda Arba Yani Suryani Yani Suryani Yuni Kulsum Yuni Kulsum Yuni Kulsum Yuni Kulsum Zashika Meidita Eka Putri