Article Per Year (5 Year)
p-Index From 2021 - 2026
1.203
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MANDALA of Health Research Journal of Life Science STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Fish Protech Amerta Nutrition E-Prodenta Journal of Dentistry Jurnal Impresi Indonesia Indonesian Health Journal Acta Odontologica Indonesia
Nur Permatasari
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 27 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : E-Prodenta Journal of Dentistry

 1 
PENGARUH PEMBERIAN LIMBAH CAIR TAHU SEBAGAI ISOFLAVON TERHADAP JUMLAH SEL OSTEOKLAS PADA TULANG MANDIBULAR TIKUS WISTAR (RATTUS NORVEGICUS) PASCA OVARIEKTOMI Devitaningtyas, Nungky; Permatasari, Nur; Sidharta, Rudhanton
E-Prodenta Journal of Dentistry Vol 2, No 2 (2018)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.158 KB) | DOI: 10.21776/ub.eprodenta.2018.002.02.3

Abstract

Menopause pada wanita akan menyebabkan terjadinya defisiensi hormon estrogen. Hormon estrogen memiliki peran dalam pembentukan dan remodeling tulang termasuk tulang alveolar dengan mempertahankan keseimbangan kerja osteoblas dan osteoklas. Penurunan hormon ini mengakibatkan proses remodeling tulang terganggu. Fitoestrogen dapat merangsang aktivitas osteoblastik dan menghambat osteoklas. Limbah cair tahu merupakan salah satu produk sampingan olahan kedelai yang masih memiliki kandungan fitoestrogen. Tujuan: untuk membuktikan efektivitas pemberian limbah cair tahu sebagai sumber fitoestrogen terhadap penurunan jumlah sel osteoklas pada tulang mandibula pasca ovariektomi. Metode: Penelitian ini menggunakan tikus wistar dengan 6 kelompok, yaitu K1 (tidak diovariektomi dan tidak diberi limbah cair tahu), K2 (ovariektomi 4 minggu dan tidak diberi limbah cair tahu), K3 (ovariektomi 8 minggu dan tidak diberi limbah cair tahu), K4 (ovariektomi + 1,2 ml/kgBB limbah cair tahu), K5 (ovariektomi + 6 ml/kgBB limbah cair tahu), K6 (ovariektomi + 12 ml/kgBB limbah cair tahu). Pemberian limbah cair tahu melalui sonde 3 kali sehari selama 4 minggu. Penurunan jumlah osteoklas diamati secara mikroskopis. Hasil: Uji Oneway anova, (p<0) terdapat perbedaan jumlah sel osteoklas tikus Wistar antar kelompok. Uji Post Hoc Multiple Comparison, K6 terdapat perbedaan signifikan dibandingkan K4 dan K5 dimana jumlah sel osteoklas K6 paling sedikit. Kesimpulan: Pemberian limbah cair tahu dengan dosis 12 mg/kgBB  dapat menurunkan jumlah sel osteoklas pada mandibula tikus pasca ovariektomi. Kata kunci: limbah cair tahu, fitoestrogen, sel osteoklas, ovariektomi
EFEKTIVITAS EKSTRAK AIR BATANG CIPLUKAN (Physalis minima L.) TERHADAP KADAR MALONDIALDEHID TULANG MANDIBULA TIKUS PUTIH (Rattus norvegicus) Strain Wistar Pasca Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.2

Abstract

Estrogen has function as an antioxidant that can reduce free radicals. Hipoestrogen condition will increase oxidative stress in the body. Periodontitis is one of the diseases associated with oxidative stress. Oxidative stress, characterized by increased levels of malondialdehid (MDA). Malondialdehid is usually used to assess the oxidative stress. Phytoestrogens are plant components that have biological activity of estrogen. Ciplukan is a natural ingredient or plant suspected to be a phytoestrogen compound. The theoretical study results showed that ciplukan stem contained physalin, which have a similar effect to estrogen. The purpose of this study is to determine the effectiveness of ciplukan stem extract on malondialdehyde levels in the rat mandibular bone post ovariectomy. Twenty four rats were randomly divided into 6 groups with each 4 rats, that are 3 control groups and 3 groups treated rats that were given the ciplukan stem extract at the end of the first 5 weeks ovariectomy with three different doses: 500 mg/kg BW (K4), 1.500 mg/kg BW (K5), and 2.500 mg/kg BW (K6) for 4 weeks. MDA levels calculated by thiobarbituric acid (TBA) test and read by a spectrophotometer and MDA standard curve created. The results showed the incease of MDA levels can be inhibited at the dose of 500 mg / kg, while at the dose of 1500 mg/kg BW and 2500 mg/kg BW can restore MDA levels similar to normal. There is a strong correlation between the negative direction doses of ciplukan stem extract with MDA levels in mandibular bone (r = -0.507). The conclusion of this study is the ciplukan stem extract can reduce MDA levels in mandibular bone strain of wistar rats after ovariectomy.
Co-Authors Abdur Razaq Komaruzzaman Adinda Chika Anindita Agustin Iskandar Agustine Hanafi Putri Ahmad Reza Fadhlurrahman, Ahmad Reza Akhmad Sabarudin Amandia Dewi Permana Shita Anik Puryatni Annasari Mustafa Aswin D Baskoro, Aswin D Cahyani, Dwi Indah Citra Tarannita Damayanti, Elok Delfi Fitriyani Devitaningtyas, Nungky Dewi, Ni Ketut Ayu Feriyanti Dian Nugrahenny Dicky Faizal Irnandi Edi Widjajanto Edi Widjajanto Edwin Widodo Fadhilah, Nadia Fardizia Putri Alia Ferdian Rizky Hutomo, Ferdian Fitriyani, Delfi Hafiedz Maulana Happy Kurnia P Hidayat Sujuti Ibrahim, Moh. Nuh Indriati Dwi Rahayu Joko Agus Gunawan Kartika Andari Wulan, Kartika Karyono Mintaroem Khadafi Indrawan Komaruzzaman, Abdur Razaq Lavina Sofia Ardani Loeki Enggar Fitri M Aris Widodo Mayangsari, Elly Meilia Aquina Meilia Aquina, Meilia Mohamad Nur Ibrahim Muhammad Nurul Amin Nathania Bella Claresta Niarti Ulan Sari Siarnu Noerpuspita, Putri Nour Athiroh Abdoes Sjakoer Nura Fattah Cantika Yoga Nuzulul Hikmah Putri Noerpuspita Putri, Agustine Hanafi Retty Ratnawati Retty Ratnawati Setyawati Soeharto Setyawati Soeharto Sidharta, Rudhanton Siti Nurfitria, Siti Sri Widyarti Stefania Widya Setyaningtyas Sudiarto Sudiarto Tika Ardhini Wardoyo Widodorini, Trining Zahrah, Annisa Lathifah