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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MANDALA of Health Research Journal of Life Science STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Fish Protech Amerta Nutrition E-Prodenta Journal of Dentistry Jurnal Impresi Indonesia Indonesian Health Journal Acta Odontologica Indonesia
Nur Permatasari
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Indonesian Health Journal

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Effectiveness Of Ciplukan Stem Water Extract (Physalis Minima L.) On Malondialdehyde Levels Of Mandibular Bones Of White Rats (Rattus Norvegicus) Wistar Strain Post Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
Indonesian Health Journal Vol. 4 No. 3 (2025): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v4i3.808

Abstract

Estrogen functions as an antioxidant that can suppress free radicals. Hypoestrogenic conditions will increase oxidative stress. Periodontitis is a disease related to oxidative stress. The occurrence of oxidative stress is characterized by increased levels of malondialdehyde (MDA). Malondialdehyde is commonly used to assess oxidative stress. Phytoestrogens are components of plants that have biological activity similar to estrogen. Ciplukan plants are suspected to be phytoestrogen compounds. Based on theoretical studies, it is suspected that the ciplukan stem contains physalin, which has a similar effect to the action of estrogen. The purpose of this study was to determine the effectiveness of ciplukan stem water extract on the level of malondialdehyde of the mandibular bone in white rats of the post-wistar strain ovariectomy. Twenty-four mice were randomly divided into 6 groups with 4 mice each, namely 3 control groups and 3 treatment groups of mice given an extract dose of 500 mg/kgBB, 1,500 mg/kgBB, and 2,500 mg/kgBB for 4 weeks. MDA levels were calculated by thiobarbituric acid (TBA) test and read with a spectrophotometer, kemudian made MDA work curve. The results showed that the increase in MDA levels could be inhibited by the administration of a dose of 500 mg/kg BB, while a dose of 1500 mg/kg BB 2500 mg/kg BB could improve MDA levels close to normal. There was a strong correlation with a negative direction between the dose of ciplukan stem water extract and the MDA level of the mandibular bone (r=--0.507). The conclusion of this study is that the administration of ciplukan stem water extract can reduce the MDA level of mandibular bone in white rats of wistar strain after oophorectomy.
Co-Authors Abdur Razaq Komaruzzaman Adinda Chika Anindita Agustin Iskandar Agustine Hanafi Putri Ahmad Reza Fadhlurrahman, Ahmad Reza Akhmad Sabarudin Amandia Dewi Permana Shita Anik Puryatni Annasari Mustafa Aswin D Baskoro, Aswin D Cahyani, Dwi Indah Citra Tarannita Damayanti, Elok Delfi Fitriyani Devitaningtyas, Nungky Dewi, Ni Ketut Ayu Feriyanti Dian Nugrahenny Dicky Faizal Irnandi Edi Widjajanto Edi Widjajanto Edwin Widodo Fadhilah, Nadia Fardizia Putri Alia Ferdian Rizky Hutomo, Ferdian Fitriyani, Delfi Hafiedz Maulana Happy Kurnia P Hidayat Sujuti Ibrahim, Moh. Nuh Indriati Dwi Rahayu Joko Agus Gunawan Kartika Andari Wulan, Kartika Karyono Mintaroem Khadafi Indrawan Komaruzzaman, Abdur Razaq Lavina Sofia Ardani Loeki Enggar Fitri M Aris Widodo Mayangsari, Elly Meilia Aquina Meilia Aquina, Meilia Mohamad Nur Ibrahim Muhammad Nurul Amin Nathania Bella Claresta Niarti Ulan Sari Siarnu Noerpuspita, Putri Nour Athiroh Abdoes Sjakoer Nura Fattah Cantika Yoga Nuzulul Hikmah Putri Noerpuspita Putri, Agustine Hanafi Retty Ratnawati Retty Ratnawati Setyawati Soeharto Setyawati Soeharto Sidharta, Rudhanton Siti Nurfitria, Siti Sri Widyarti Stefania Widya Setyaningtyas Sudiarto Sudiarto Tika Ardhini Wardoyo Widodorini, Trining Zahrah, Annisa Lathifah