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All Journal Jurnal Anestesiologi Indonesia MEDIA MEDIKA INDONESIANA International Journal of Science and Engineering (IJSE) JURNAL GIZI INDONESIA Nurse Media Journal of Nursing Jurnal Kedokteran Diponegoro Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Interest : Jurnal Ilmu Kesehatan Jurnal Keperawatan dan Kesehatan Masyarakat CENDEKIA UTAMA Jurnal Epidemiologi Kesehatan Komunitas Medica Hospitalia Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Diponegoro International Medical Journal (DIMJ) Narra J JHeS (Journal of Health Studies) Neurona Jurnal Bidan Cerdas
Dwi Pudjonarko
Fakultas Kedokteran Universitas Diponegoro
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Effect of Binahong Leaf Extract Emulsion (Anredera cordifolia) on Histopathological Description of Common Carotid Artery Study on Male Wistar (Rattus novergicus) Rats Induced by Diabetes Mellitus Using Streptozotocin Fauzi, Muhammad Iqbal; Pudjonarko, Dwi; Indraswari, Darmawati Ayu; Istiadi, Hermawan; Wati, Arinta Puspita
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.23268

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disease that can cause microvascular and macrovascular complications. The formation of superoxide (O2-) by dysfunctional mitochondria in diabetes has been recognised as a major driver of diabetic complications. Consequently, the utilisation of antioxidants may prove advantageous. The plant Andredera cordifolia contains flavonoids, which act as antioxidants.Objective : to investigate the effect of binahong leaf extract on the development of atherosclerosis in the carotid artery.Methods: The research employed a laboratory experimental method with a randomised post-test control group design. The research subjects were 15 Wistar rats (Rattus norvegicus). In this research, the extraction of the active compounds was achieved through a maceration process using 96% ethanol (1:3) and emulsification by the addition of sunflower oil, CMC, Span80 and Tween 20. The analysis of Anredera cordifolia extract content included the determination of flavonoid content and IC50. The intervention will be conducted for a period of 14 days. The rats were administered 1 ml of aquades per day, 45 mg/kg BW of metformin (K+), 200 mg/kg BW of EAC (P1), and 400 mg/kg BW of EAC (P2). The diabetic model was induced using a single dose of 50 mg/kgBW streptozotocin intraperitoneally. On the fourteenth day following the induction of treatment, blood glucose measurements were taken using the GOD-PAP method, and a histopathological examination of the common carotid artery was conducted using eosin haematoxylin staining at a magnification of 100-400x.Results: The total flavonoid content of binahong leaves is 1525 mg/100 g extract, while the IC50 value is 1.9 ppm. The results of the ANOVA indicate a statistically significant difference between the fasting blood glucose levels of the two groups (p < 0.05). The post hoc test demonstrated that a 400 mg/kgBW dose can result in a reduction in glucose levels to 305.75 mg/dl, with a p-value of 0.001 (p < 0.05). The Mann-Whitney test revealed a statistically significant difference among the groups (p < 0.05) for the inhibition of atherosclerosis in the common carotid artery. Conclusion: A significant difference was observed in the administration of 400 mg/kgBB binahong leaf emulsion extract in comparison to a negative control group, with regard to the histopathological picture of atherosclerosis of the common carotid artery
GANGGUAN MEMORI EPISODIK PADA EPILEPSI LOBUS TEMPORAL DAN NONTEMPORAL Koestoer, Clara Krishanti; Bintoro, Aris Catur; Pudjonarko, Dwi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.41

Abstract

  EPISODIC MEMORY DISORDER IN TEMPORAL AND NONTEMPORAL LOBE EPILEPSYABSTRACTIntroduction: Memory is the most defected cognitive function in neurological problems including epilepsy. Amnesia, refers to episodic memory impairment (EMI), which components are regulated by various areas related to brain lobes especially the temporal lobe. EMI represents a major cognitive component in temporal lobe epilepsy (TLE) but also encounter in focal epilepsy outside the temporal lobe.Aim: To prove the difference between EMI that occurs in TLE and nontemporal lobe epilepsy (NTLE) patients.Method: A cross-sectional study on epilepsy patients in Neurology Clinic of dr. Kariadi Hospital, Semarang from November 2016 until January 2017. Subjects were devided into TLE and NTLE group based on clinical semiology and electroencephalography (EEG). Interviews and questionnaires were done to the characteristics of subjects which can aggravate EMI, and memory tests was performed using Word List Memory Task, Word List Memory Recall, and Word List Memory Recognition. Statistical analysis using Chi-square test and multivariate logistic regression.Results: Subjects obtained were 43 respondents consisting of 21 TLE and 22 NTLE subjects. Significant difference of EMI occurrence was shown in TLE compared to NTLE, especially on delayed recall component. Patients with history of epilepsy >10 years tend to have a significant EMI, while patients with first seizure >10 years old do not tend to have EMI with or without other confounding factors.Discussion: There are differences in the occurrence of EMI on the TLE and NTLE independently, especially delayed recall.Keywords: Episodic memory impairment, temporal lobe epilepsyABSTRAKPendahuluan: Memori merupakan fungsi kognitif yang paling rentan terkena gangguan neurologis termasuk epilepsi. Salah satunya adalah amnesia, merujuk pada gangguan memori episodik (GME) yang komponennya diatur oleh berbagai area terkait lobus otak terutama lobus temporal. Gangguan memori episodik (GME) mewakili komponen kognitif utama pada epilepsi lobus temporal (ELT), namun juga tidak jarang ditemui pada epilepsi fokal di luar lobus temporal.Tujuan: Mengetahui perbedaan GME pada penderita epilepsi lobus temporal dengan epilepsi lobus nontemporal (ELNT).Metode: Penelitian potong lintang terhadap pasien epilepsi yang berobat ke Poli Saraf RSUP dr. Kariadi, Semarang pada bulan November 2016 hingga Januari 2017. Subjek dikelompokkan menjadi ENT dan ELNT berdasarkan gambaran semiologi klinis dan elektroensefalografi (EEG). Dilakukan wawancara dan pemakaian kuesioner terhadap karakteristik subjek yang dapat memperberat GME, serta tes memori menggunakan Word List Memory Task, Word List Memory Recall, dan Word List Memory Recognition. Analisis statistik menggunakan uji Chi-square dan uji multivariat dengan regresi logistik.Hasil: Didapatkan 43 subjek yang terdiri dari 21 subjek ELT dan 22 subjek ELNT. Didapatkan subjek yang mengalami GME pada ELT lebih banyak secara bermakna dibandingkan ELNT, terutama pada komponen delayed recall. Subjek yang menderita epilepsi >10 tahun cenderung mengalami GME secara bermakna, sedangkan subjek yang mengalami serangan awal pada usia >10 tahun lebih cenderung tidak mengalami GME, baik secara independen maupun bersama-sama dengan faktor perancu yang lain.Diskusi: Terdapat perbedaan terhadap terjadinya GME pada ELT dan ELNT secara independen, terutama pada komponen delayed recall.Kata kunci: Epilepsi lobus temporal, gangguan memori episodik
PERBEDAAN KUALITAS HIDUP BERDASARKAN SHORT FORM-36 ANTARA PENDERITA STROKE ISKEMIK SERANGAN PERTAMA DENGAN KEDUA Hassa, Nazwan; Hartono, Jimmy Eko Budi; Pudjonarko, Dwi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.44

Abstract

  DIFFERENCES QUALITY OF LIFE BASED ON SHORT FORM–36 BETWEEN FIRST AND SECOND ATTACK ISCHEMIC STROKE PATIENTSABSTRACTIntroduction: Stroke is the biggest cause of physical disability, emotional, and social life in adults. The recurrent stroke let to decreased the quality of life.Aims: To know whether there is a difference in quality of life based on the Short Form-36 (SF-36) between first and second attack ischemic stroke patients.Methods: Observational analytic with retrospective cross sectional study in Neurology Polyclinic Dr. Kariadi Hospital, Semarang form July-September 2016. Inclusion criteria are patients with first or second attack of ischemic stroke, level education at least elementary school, age between 50-70 years old, and last attack 4 week or less before the sampling conducted. Quality of life were scored based on SF-36 between first and second attack patients. T-test and Mann- Whitney were used to analyze the data.Results: Fifty subject (25 in each group) included with mean age 57.72 (51-65) and 60.24 (51-70) years old in first attack and second attack group respectively. Older age showed lower quality of life score. The quality of life score is lower in older, stroke onset >1 year, and lower education. There was significant quality of life score difference between first and second attack group. Quality of life patients with first attack is better significantly compared to the second attack group in functional and physical domain, energy, and total score.Discussion: There is a significant difference in quality of life based on the SF-36 between first and second attack ischemic stroke patients.Keywords: Ischemic stroke, quality of  life, SF-36ABSTRAKPendahuluan: Stroke merupakan penyebab terbesar ketidakmampuan fisik, emosi, dan kehidupan sosial pada orang dewasa. Serangan stroke berulang menyebabkan peningkatan risiko penurunan kualitas hidup.Tujuan: Mengetahui perbedaan kualitas hidup pasien stroke iskemik serangan pertama dan kedua berdasarkan Short Form-36 (SF-36).Metode: Penelitian analitik observasional secara potong lintang retrospektif di Poliklinik Neurologi RSUP Dr. Kariadi, Semarang pada bulan Juli-September 2016. Kriteria inklusi adalah pasien stroke iskemik serangan pertama atau kedua, berpendidikan minimal SD atau sederajat, berusia antara 50-70 tahun, dan mengalami serangan stroke terakhir minimal 4 minggu sebelum penelitian. Dilakukan penilaian skor kualitas hidup berdasarkan SF–36 antara pasien stroke iskemik serangan pertama dengan kedua. Analisis menggunakan uji T-tes dan Mann-Whitney.Hasil: Terdapat 50 subjek yang terdiri dari masing-masing 25 subjek pada kelompok dengan stroke iskemik serangan pertama dan kelompok dengan serangan kedua dengan rerata usia 57,72 (51–65) tahun dan 60,24 (51–70) tahun. Usia yang semakin meningkat menunjukkan skor kualitas hidup semakin menurun. Skor kualitas hidup lebih rendah pada usia yang lebih tinggi, lama menderita stroke >1 tahun, dan pendidikan yang lebih rendah. Didapatkan perbedaan bermakna antara rerata skor kualitas hidup pasien stroke serangan pertama dan kedua. Kualitas hidup subjek pada serangan stroke pertama lebih baik secara bermakna dibandingkan pada kelompok serangan kedua, dalam domain fungsi dan peranan fisik, energi, serta total skor secara keseluruhan.Diskusi: Terdapat perbedaan bermakna kualitas hidup berdasarkan SF-36 antara pasien stroke iskemik serangan pertama dengan kedua.Kata kunci: SF-36, skor kualitas hidup, stroke iskemik
The Comparison between Preoperative Maltodextrine and Sugar Water Administration on Random Blood Glucose Levels in Enhanced Recovery After Cesarean Surgery (ERACS) Patients Wicaksono, Satrio Adi; Pudjonarko, Dwi; Riwanto, Ignatius
JAI (Jurnal Anestesiologi Indonesia) Vol 16, No 3 (2024): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.65043

Abstract

Background: Oral carbohydrate administration reduces post-operative insulin resistance and improves post-operative recovery. Sugar water and maltodextrin are oral carbohydrates that can be given to enhanced recovery after caesarean surgery (ERACS) patients.Objective: To compare the effect between pre-operative maltodextrin treatment and sugar water treatment on random blood glucose (RBG) levels in enhanced recovery after caesarean section (ERACS) patients.Methods: A randomized control study with pre-test and post-test design was used on 48 patients who underwent ERACS surgery at Dr. Kariadi hospital Semarang Indonesia and met the inclusion and exclusion criteria. Study subjects were divided into two groups: a pre-operative maltodextrin treatment group (n=24) and a pre-operative sugar water control group (n=24). RBG levels were checked with point-of-care testing (POCT) at soon before surgery and at 2 hours after surgery. Mann-Whitney test was used to analyse the difference of RBG levels between group with Maltodextrin and group with sugar water. Wilcoxon test was used to analyse the difference of RBG levels before surgery (pre-operative RBG) and 2 hours after surgery (post-operative RBG). The p value of <0.05 was considered as statistically significant.Result: There were significant lower RBG levels in group with pre-operative maltodextrin treatment compared to group with pre-operative sugar water at soon before surgery (pre-operative) (83.5 ± 9.73 vs 96.2 ± 12.99 mg/dL, p=0.003) and at 2 hours post-operative (101.7 ± 15.81 vs 118.9 ± 28.38, p=0.035) in ERACS patients.Conclusion: If confirmed by further studies, pre-operative maltodextrin administration might provide better outcome in reducing post-operative catabolic status by reducing post-operative insulin resistance and improving RBG levels before and after ERACS compared to sugar water control.
Impact of vitamin D supplementation on post-stroke rehabilitation outcomes: A systematic review and meta-analysis Murbawani, Etisa A.; Pramukarso, Dodik T.; Muis, Siti F.; Pudjonarko, Dwi; Subagio, Hertanto W.; Tjandra, Kevin C.; Respati, Danendra RP.; Nugraha, Laksmana AK.; Ramadhany, Ghifarie A.; Pranoto, Stephano
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1848

Abstract

Each year, there are approximately 12.2 million new stroke cases and 6.5 million stroke-related deaths, with low- and middle-income countries shouldering a disproportionately high financial burden. Studies have associated vitamin D deficiency with arteriosclerosis, left ventricular hypertrophy, and vascular dysfunction, contributing to an elevated risk of stroke. The aim of this study was to evaluate how vitamin D supplementation affects post-stroke outcomes. A comprehensive literature search was performed across PubMed, Scopus, the Cochrane Library, ScienceDirect, Springer Link, ProQuest, and Epistemonikos from April to May 2024. This study focused on comparing the efficacy of vitamin D supplementation versus no supplementation in stroke patients of all ages. Outcome measures included the Functional Ambulation Classification (FAC), Brunnstrom Recovery Stage (BRS), Modified Rankin Scale (mRS), and National Institutes of Health Stroke Scale (NIHSS). Case reports, reviews, and research on other cardiovascular or metabolic issues were excluded. Five authors extracted data and analyzed bias separately using the Risk of Bias Version 2 (RoB V2) algorithms. The results of continuous variables were pooled into the mean difference (MD) along with 95% confidence intervals (CI) using random-effect models. Review Manager 5.4 was used to evaluate the data. Out of the 1,152,449 papers evaluated, six met the inclusion criteria, with a sample size ranging from 42 to 123 patients. Vitamin D supplementation was found to yield better outcomes after stroke. BRS in lower extremities showed better results (MD: 0.59 (95%CI: 0.27–0.91)), NIHSS improved with an MD of -1.47 (95%CI: -2.03–(-0.90)). Furthermore, there was also an improvement in mRS, with an MD of -0.91 (95%CI: -1.25–(-0.56)). In conclusion, vitamin D improved post-stroke outcomes, which supported its supplementation as a part of stroke rehabilitation.
Model spiritual care with an adaptation theory approach Callista Roy on cortisol levels Kusuma, Aria Nurahman Hendra; Pudjonarko, Dwi; Sujianto, Untung; Susanto, Hardhono; Ibrahim, Kusman; Dwidiyanti, Meidiana
JHeS (Journal of Health Studies) Vol. 9 No. 2 (2025): September
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4283

Abstract

Ischemic stroke is a cause of physical disability. These defects result in impaired biopsychosociospiritual adaptation in stroke patients. The inability to adapt will cause an anxiety reaction which triggers an increase in cortisol levels. The spiritual care model helps patients find meaning and purpose in life as well as an optimistic attitude so that they have better adaptability. This type of research is Quasy Experimental with a pretest-posttest control group design. The study population was ischemic stroke patients in the Outpatient Department of Dr. Regional General Hospital. Moewardi Surakarta. The total sample consisted of 60 respondents, divided into 30 control group respondents and 30 intervention group respondents, who received a spiritual care model intervention in the outpatient room of Dr RSUD. Moewardi Surakarta. The research results show the influence of the Spiritual Care Model Using Callista Roy's Adaptation Theory Approach on Cortisol Levels in Ischemic Stroke Sufferers with a significance value of 0.043 < 0.05. The Spiritual care model influences the amygdala, which stimulates the hypothalamus through the hypothalamic-pituitary-adrenal (HPA) axis, thereby inhibiting the excretion of corticotropin-releasing factor (CRF). The pituitary gland then stimulates adrenocorticotropic hormone (ACTH), which reduces cortisol. This research has a contribution that spiritual care interventions can improve the adaptability of biopsychosocial rehabilitation of stroke patients. This research has a contribution that spiritual care interventions can improve the ability to adapt biopsychosocial rehabilitation of stroke patients.
Scoping Review: WhatsApp-based Education to Increase Iron Intake to Prevent Pregnancy Anemia Herinawati, Herinawati; Margawati, Ani; Nugraheni, Sri Achadi; Pudjonarko, Dwi
Jurnal Bidan Cerdas Vol. 7 No. 2 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jbc.v7i2.4077

Abstract

Background: Pregnancy anemia is a global health problem that affects both mother and fetus. One solution to address pregnancy anemia is to increase iron intake, which can be done through various educational methods, including the use of technology platforms such as WhatsApp. This scoping review explores the academic literature on WhatsApp-based education to increase iron intake to prevent pregnancy anemia. Methods: This review used a scoping review method based on the Arksey and O'Malley framework. The literature search was conducted through several electronic databases, namely Google Scholar and PubMed by determining keywords using the PICO format, namely P (pregnancy anemia), I (WhatsApp), C (nil), O (iron supplementation) which captured articles from national and international journals, in English and Indonesian, using the PRISMA Method. Studies were selected from 2014-2024. Found in the initial search as many as 3427 articles and filtered to get 9 articles to synthesize. Results: The results of the article review obtained seven articles. The results showed that technology-based interventions, especially mobile applications and WhatsApp, were effective in improving the health of pregnant women through increased knowledge, anemia prevention practices, hemoglobin levels, and compliance with iron and folic acid consumption. Conclusion: WhatsApp-based education is effective in improving knowledge and anemia prevention practices among pregnant women.
Co-Authors Amin Husni Ani Margawati Annastasia Ediati Aria Nurahman Hendra Kusuma Arif Iskandar Arinta Puspita Wati, Arinta Puspita Aris Catur Bintoro Arlina, Yani Armatussolikha, Herna Rizkia Bagaskoro, Yoseph Cahyo Budisulistyo, Trianggoro Darmawati Ayu Indraswari Dewi Siyamti Diah Pasmanasari, Elta Dian Ratna Sawitri Dodik Pramukarso Dodik Tugasworo Dodik Tugasworo Dodik Tugasworo Pramukarso Edi Dharmana Endang Mahati Fauzi, Muhammad Iqbal Fitria Handayani Fitria Handayani Handayani Fitria Handayani Handayani Handayani, Fitria Hardhono Susanto Hari Peni Julianti Hartono, Jimmy Eko Budi Hassa, Nazwan Hastaning Sakti Herinawati, Herinawati Herman Kristanto Hermawan Istiadi Hermina Sukmaningtyas Ignatius Riwanto, Ignatius Julian Dewantiningrum Koestoer, Clara Krishanti Kusman Ibrahim Latifah Latifah Lestari, Lis Mukti Lis Mukti Lestari M Naharuddin Jenie Mardiyono, Mardiyono Maria Mexitalia Martha Irene Kartasurya Mateus Sakundarno Adi, Mateus Sakundarno Meidiana Dwidiyanti Meutia, Yurida Binta Muis, Siti F. Murbawani, Etisa A. Noegroho, Aji Nugraha, Laksmana AK. Nurahman Hendra Kusuma, Aria OS Hartanto Pangesti, Adelia Pradesta, Rizki Rudwi Pramukarso, Dodik T. Pranoto, Stephano Rahmawati, Maria Belladonna Ramadhany, Ghifarie A. Respati, Danendra RP. Retnaningsih Retnaningsih Rifky Ismail Satrio Adi Wicaksono Setyowati Setyowati Soejoenoes, Ariawan Sri Achadi Nugraheni Stephani Nesya Renamastika Subagio, Hertanto W. Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Sunjata, Winda Putri Suparyatmo, J.B Suryawati, Herlina Tjandra, Kevin C. Udadi Sadhana, Udadi Untung Sujianto Vania Pangestika Purwaningrum