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All Journal International Journal of Public Health Science (IJPHS) BULETIN PENELITIAN SISTEM KESEHATAN Jurnal Berkala Epidemiologi Jurnal Populasi Jurnal Biometrika dan Kependudukan (Journal of Biometrics and Population) The Indonesian Journal of Public Health Majalah Obstetri dan Ginekologi Health Notions Jurnal Wiyata : Penelitian Sains dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Journal of Stem Cell Research and Tissue Engineering The Indonesian Journal of Health Science Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Media Gizi Kesmas Indian Journal of Forensic Medicine & Toxicology Jurnal Promotif Preventif Jurnal Keperawatan Berita Kedokteran Masyarakat Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana
Windhu Purnomo
Departemen Biostatistika And Kependudukan, Faculty Of Public Health, Universitas Airlangga
Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Stem Cell Research and Tissue Engineering

 1 
COMPARISON IN CORNEAL COLLAGEN STRUCTURE BETWEEN 20% PLATELET RICH PLASMA AND 20% AUTOLOGOUS SERUM THERAPY POST NATRIUM HIDROKSIDA EXPOSURE (EXPERIMENTAL STUDY ON ORYCTOLAGUS CUNICULUS) Marisca; Kurniasari, Nila; Retnowati, Endang; Purnomo, Windhu
Journal of Stem Cell Research and Tissue Engineering Vol. 7 No. 1 (2023): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v7i1.45746

Abstract

Objective to compare therapy response between 20% PRP and AS 20% on cornea post sodium hydroxide exposure on collagen structure. Methods this is a true experimental study with post test only design on 18 New Zealand white rabbits. Sample were divided randomly to two groups, each with 9 rabbits. The right eye of each rabbit were exposed to alkali injury with 1N NaOH under general anesthesia. First group was given 20% PRP eyedrops and 20% AS for the second group. And the end of the 7 day periode, all rabbits were euthanized and enucleated to obtain histopthological data. Collagen density, collagen thickness and keratosit cell were evaluated. The result will be analyzed, ratio scale data will be tested with independent T- test, and ordinal scaled data will be tested with Mann-Whitney test. Result The collagen density in the 20% PRP group shows 88.9% grade 2 and 44.4 % grade 2 for the 20% AS group. The collagen thickness in the 20% PRP group is 55.41 and 67.62 for the 20% AS group. The keratosit cell count in the 20% PRP group are 54.56 and 45.47 in the 20% AS group. There is significant difference in the collagen density between 20% PRP and 20% AS treatment (p= 0.066). There is significant difference in the collagen thickness between 20% PRP and 20% AS treatment (p= 0,224). There is significant difference in the keratosit cell count between 20% PRP and 20% AS treatment (p= 0,227). Conclusion From the statistik analysis shows that there is no significant difference in corneal collagen structure between 20% PRP and 20% AS therapy post natrium hidroksida exposure, from our study there is no significant better corneal healing parameters in post alkali chemical ocular injury with 20% PRP eyedrops compare to 20% AS eyedrops.
Co-Authors Adelia Dwi Pratiwi Afif Nurul Hidayati Agus Sulistyono Ardianah, Eva Arief Wibowo Astik Umiyah A`im Matun Nadhiroh Bambang Trijanto Bambang Trijanto, Bambang Bangun Cahyo Utomo Boerhan Hidayat Boerhan Hidayat, Boerhan Budi Santoso Chatarina Umbul Wahyuni Christine Ohee Desiansi Merlinda Niga Diah Indriani Dias Lidiana A.S Dina Dewi Anggraini Dina Dewi Anggraini Diyah Herowati Djazuly Chalidyanto Eddy Rahardjo Efri Tri Ardianto Eka Mawang Susanti Eka Nasrur Maulana Endang Retnowati Endang Retnowati Frieska Piesesha Galuh Pradian Yanuaringsih Gede Danu Widarta Hanindita, Meta Herdiana Hari Basuki Notobroto HERAWATI, LILIK Hermanto Tri Joewono Heru Santoso Wahito Nugroho Hikma Rafiah Nadjib Ikhtiar, Ilham Ilham Ikhtiar Irwan A. Hi. Mustafa Irwanto Irwanto Irwanto, Irwanto Iswari Hariastuti Karinda Permata Sari Kumala, Hasniyah Rizka KUNTORO Laksana, Muhammad Ardian Cahya Lestari Basoeki Lila Tri Harjana Lutfiya, Indah Lutfiya, Indah Maemonah, Maemonah Mardiyono Mardiyono Marisca Mega Widya Puspa Ningrum Merryana Adriani Mohamad Nurdin Zuhri Najakhatus Sa’adah Najib, Hikmah Rafiah Nila Kurniasari Ningtyas, Amalia Dwi Niniek Lely Pratiwi Nur Aisiyah Widjaja, Nur Aisiyah Nurfidaus, Yasmine Nurwasis Nurwasis Nurwasis, Nurwasis Nyoman Anita Damayanti Pebriaini, Prisma Andita Piesesha, Frieska Rachmah Indawati Rachmat Hargono Rahayu, Almirah Nareswari Rehatta, Nancy Margarita Ria Puspitasari Roedi Irawan Royke Tony Kalalo Santi Martini Santoso, Febrina Mustika Sarah Christiawan Sari, Karinda Permata Shrimarti Rukmini Devy Sigit Ari Saputro Sinawan Sinawan Sinawan Sinawan, Sinawan SITI NURUL HIDAYATI Soenarnatalina Meilanani Soenarnatalina Melaniani Suhatno Susanti, Eka Mawang Teguh Prawono Sabat Teguh Prawono Sabat, Teguh Prawono Tri Ratna Ariestini Tumbelaka, Reyner Valiant Udin Kurniawan Aziz Uktutias, Sendy Ayu Mitra Wandera Ahmad Religia Widjiati Widjiati Yanuaringsih, Galuh Pradian Yuly Sulistyorini Zuhri, Mohamad Nurdin