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Kajian Kimia Dari Fraksi Etil Asetat Kulit Batang Kayu Pahit (Picrasma Javanica Bl.) Sri Hainil; Dayar Arbain; Deddi Prima Putra
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

N-1 main compound from ethyl acetate fraction of kayu pahit bark (Picrasma Javanica B1) has been isolated and characterized with colom chromatography and continued with preparative chromatography. According to analized from spectrum data used ultraviolet (UV) spectroscopy, infra red (IR), 1H RMI (Resonansi Magnet Inti), 13 C RMI, Massa , COSY (Correlated Spectroscopy), HSQC (Heteronuclear Single Quantum Correlation), HMBC ( Heteronuclear Multiple Bond Correlation) and literature study showed that the compound of isolation was javanicin A.

Kajian Fitokimia Fraksi Etil Asetat dari Lichen Stereocaulon massartianum Hue. dan Uji Aktivitas Antibakteri dengan Metode KLT-Bioautografi Friardi Ismed; Nadhifa Putri; Deddi Prima Putra
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

This research is a continuation study in the inventory of lichens of the genus Stereocaulon which is currently focused on the Stereocaulon massartianum Hue collected in the rocks of Diatas Lake, West Sumatera, Indonesia. Reports on phytochemical studies and pharmacological activities of this species are still limited, based on literature studies that have been carried out. This research was conducted to determine their secondary metabolites and potential antibacterial activity. The air-dried thallus of lichen S. massartianum was macerated successively using n-hexane, ethyl acetate and methanol solvents. The compounds were separated by chromatography and recrystallization methods, then analyzed by spectroscopy (UV-Vis, FTIR, 1H and 13C-NMR). Furthermore, the antibacterial activity assay was performed by agar diffusion method on ethyl acetate extract, and TLC-Bioautography for the isolated compound. Three compounds have been isolated from ethyl acetate extract, i.e. atranorin (1), stictic acid (2) and norstictic acid (3). The results of antibacterial assay from the extract showed antagonistic activity against pathogenic bacteria S. aureus, E. faecalis, E. coli, and P. aeruginosa at concentrations of 10 and 20%, while TLC-bioautography of compound 3 exhibited growth inhibition area in all test bacteria.

Analisis Kadar Kofein Kopi Luwak Dengan Variasi Jenis Kopi, Spesies Luwak Dan Cara Pengolahan Dengan Metoda TlC Scanner Rahma Yulia; Adek Zamrud Adnan; Deddi Prima Putra
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Caffeine analysis from Luwak coffee in different types of coffees, Luwak species and processed by using TLC Scanner method had been done. 8 samples of Luwak coffee, that is R.Ab.K ; R.Ab.B ; R.Ph.K ; R.Ph.B ; A.Ab.K ; A.Ab.B ; A.Ph.K ; A.Ph.B which were extracted by dichloromethane (DCM). TLC separation had been done through stationary phase with silica gel GF254 and mobile phase are solute of dichloromethane (DCM) : methanol (9,5 : 0,5). Caffeine content had been counted by using regression equality y = 2715,112 + 4,389x and giving percentage in succession 1,91 ; 2,04 ; 1,30 ; 1,89 ; 1,29 ; 1,45 ; 1,25 ; 1,42 %. The highest of caffeine had been given by Robusta coffee which has been given before to A. binturong luwak and processed wetly 2,04 %. The lowest of caffeine content had been given to Arabica coffee which has been given before to P. hermophroditus luwak 1,25 %. Three way – Anova statistic SPSS 21 tabulation had showed the result that the kind of coffee, variety of Luwak and the way of processing gave significant value toward caffeine content in p < 0,05.

Formulasi Liposom Ekstrak Terpurifikasi Centella asiatica Menggunakan Fosfatidilkolin dan Kolesterol Febriyenti Febriyenti; Deddi Prima Putra; Elyana Indah Wicaksanti; Citra Dewi Hamami
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Penelitian mengenai pembuatan liposom ekstrak terpurifikasi Centella asiatica menggunakan fosfatidilkolin dan kolesterol telah dilakukan. Tujuan penelitian ini adalah untuk mengetahui komposisi atau perbandingan yang ideal antara ekstrak terpurifikasi Centella asiatica dengan fosfatidilkolin dan pengaruh penambahan kolesterol terhadap liposom yang dihasilkan. Metoda pembuatan liposom yang digunakan adalah hidrasi lapis tipis. Rasio ekstrak dengan fosfatidilkolin dibuat tiga variasi formula: F1 (1:40 b/b), F2 (1:60 b/b), F3 (1:100 b/b). Lapis tipis lipid F2 paling mudah dihidrasi. Hasil hidrasi ketiga formula menunjukkan suspensi liposom yang bewarna putih susu. Kemudian dibuat tiga formula dengan penambahan kolesterol yaitu FK1 (1:30:30 b/b), FK2 (1:20:40 b/b), FK3 (1:10:50 b/b). Hasil pengamatan suspensi liposom menggunakan SEM (scanning electron microscope) menunjukkan morfologi vesikel berbentuk sferis. Lapis tipis lipid FK1 mudah dihidrasi dan tidak menggumpal. FK1 memiliki daya penjerapan terbesar. Vesikel liposom yang mengandung kolesterol tidak mengalami perubahan warna setelah disimpan selama 6 bulan, sedangkan yang tidak mengandung kolesterol, warnanya menjadi kekuningan.

3,4-DIHYDROXYBENZOIC ACID AND 3,4-DIHYDROXYBENZALDEHYDE FROM THE FERN Trichomanes chinense L.; ISOLATION, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES Nova Syafni; Deddi Prima Putra; Dayar Arbain
Indonesian Journal of Chemistry Vol 12, No 3 (2012)
Publisher : Universitas Gadjah Mada

3,4-dihydroxybenzoic acid (1) and 3,4-dihydroxybenzaldehyde (2) have been isolated from ethyl acetate fraction of methanolic fractions of leaves, stems and roots of the fern Trichomanes chinense L. (Hymenophyllaceae). These two compounds also showed significant antioxidant using DPPH and antimicrobial activities using the disc diffusion assay.

Utilization of Silica Nanoparticles from Rice Husks for Improving the Mechanical Properties of Dental Materials: A Literature Review Sopan Sinamo; Slamat Tarigan; Saharman Gea; Deddi Prima Putra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.662

Rice husk is a waste product whose utilization is not optimal in Indonesia. Rice husks contain organic materials in the form of cellulose, hemicellulose, and lignin; and minerals in the form of silica, alkali, and trace elements. The silica content in rice husks is very high, ranging from 87-97% to other minerals. Silica nanoparticles from rice husks were synthesized through various methods, including the sol-gel method, the combustion method, and the combination method, to obtain the purity and size of the silica particles up to the manometer scale. Mixing silica nanoparticles from rice husk to dental material at a certain concentration is effective in producing better mechanical properties. Silica nanoparticles synthesized from rice husks have the potential as fillers and reinforcements that can improve the mechanical properties of dental materials. Besides that, the price is more economical because the raw materials come from Indonesian natural waste. This literature review aims to describe the method of synthesizing silica nanoparticles from rice husks and their effectiveness in improving the mechanical properties of dental materials.

Utilization of Silica Nanoparticles from Rice Husks for Improving the Mechanical Properties of Dental Materials: A Literature Review Sopan Sinamo; Slamat Tarigan; Saharman Gea; Deddi Prima Putra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 14 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i14.662

Rice husk is a waste product whose utilization is not optimal in Indonesia. Rice husks contain organic materials in the form of cellulose, hemicellulose, and lignin; and minerals in the form of silica, alkali, and trace elements. The silica content in rice husks is very high, ranging from 87-97% to other minerals. Silica nanoparticles from rice husks were synthesized through various methods, including the sol-gel method, the combustion method, and the combination method, to obtain the purity and size of the silica particles up to the manometer scale. Mixing silica nanoparticles from rice husk to dental material at a certain concentration is effective in producing better mechanical properties. Silica nanoparticles synthesized from rice husks have the potential as fillers and reinforcements that can improve the mechanical properties of dental materials. Besides that, the price is more economical because the raw materials come from Indonesian natural waste. This literature review aims to describe the method of synthesizing silica nanoparticles from rice husks and their effectiveness in improving the mechanical properties of dental materials.

POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki Frengki; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda; Vivi Sofia
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method “pharmacokinetics screening and molecular docking”. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.

FORMULASI KRIM TABIR SURYA DARI FRAKSI TERPURIFIKASI HERBA Elephantopus mollis Kunth Verawati; Almahdy; Febriyenti; Deddi Prima Putra
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Elephantopus mollis Kunth merupakan tumbuhan obat tradisional yang kaya akan komponen polifenol seperti derivat asam kafeat, kaempferol dan rutin yang dapat berperan sebagai tabir surya organik. Penelitian ini bertujuan untuk mengevaluasi potensi tabir surya dari sediaan krim yang mengandung fraksi terpurifikasi dari E. mollis. Fraksi terpurifikasi E. mollis diperoleh melalui serangkaian prosedur ekstraksi dan pemisahan secara kromatografi pada herba E. mollis. Fraksi terpurifikasi yang kaya akan polifenol kemudian diformula menjadi sediaan krimtipe M/A dan dilakukan pengujian stabilitas fisik dan uji penetrasi dengan metode difusi Franz. Aktivitas tabir surya dievaluasi secara invitro menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan bahwa krim fraksi terpurifikasi E. mollis stabil secara fisik pada pengamatan selama 6 minggu dan dapat berpenetrasi dengan baik dimana peningkatan laju penetrasi linier terhadap waktu. Penentuan nilai SPF menunjukkan bahwa sediaan krim fraksi terpurifikasi ini memberikan perlindungan Ultra terhadap sinar UV dengan nilai SPF 17,55. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa fraksi terpurifikasi dari E. mollis memiliki potensi yang sangat bagus untuk dikembangkan sebagai sediaan tabir surya.

Kajian Fitokimia Fraksi Etil Asetat dari Lichen Stereocaulon massartianum Hue. dan Uji Aktivitas Antibakteri dengan Metode KLT-Bioautografi Ismed, Friardi; Putri, Nadhifa; Putra, Deddi Prima
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.164-171.2020

This research is a continuation study in the inventory of lichens of the genus Stereocaulon which is currently focused on the Stereocaulon massartianum Hue collected in the rocks of Diatas Lake, West Sumatera, Indonesia. Reports on phytochemical studies and pharmacological activities of this species are still limited, based on literature studies that have been carried out. This research was conducted to determine their secondary metabolites and potential antibacterial activity. The air-dried thallus of lichen S. massartianum was macerated successively using n-hexane, ethyl acetate and methanol solvents. The compounds were separated by chromatography and recrystallization methods, then analyzed by spectroscopy (UV-Vis, FTIR, 1H and 13C-NMR). Furthermore, the antibacterial activity assay was performed by agar diffusion method on ethyl acetate extract, and TLC-Bioautography for the isolated compound. Three compounds have been isolated from ethyl acetate extract, i.e. atranorin (1), stictic acid (2) and norstictic acid (3). The results of antibacterial assay from the extract showed antagonistic activity against pathogenic bacteria S. aureus, E. faecalis, E. coli, and P. aeruginosa at concentrations of 10 and 20%, while TLC-bioautography of compound 3 exhibited growth inhibition area in all test bacteria.

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