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All Journal METAMORFOSA Journal of Biological Sciences Jurnal Penelitian Farmasi Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Teknologi Pertanian Andalas Jurnal Farmasi Higea Jurnal Mandala Pharmacon Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Hewan Jurnal Katalisator
Deddi Prima Putra
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Essential Oils from Etlingera elatior Inflorescence against α-Amylase and α-Glucosidase Inhibition Syafni, Nova; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.812

Abstract

The increasing number of diabetes mellitus cases every year is alarming for every country. More than 90% of the cases are type-2 diabetes mellitus. The range of diabetes mellitus patients is at a productive age, including in Indonesia. Type-2 diabetes mellitus can be managed by reducing postprandial glucose levels. The approach inhibits α-amylase and α-glucosidase enzymes. A preliminary study on the local edible plants in Solok district, Etlingera elatior, showed potential against the α-glucosidase enzyme by TLC-bioautography screening. The essential oils from the inflorescence of E. elatior were extracted by hydro-distillation. The analysis of components from the essential oils identified 20 compounds. GC-MS data showed that the highest abundance percentages were 1-dodecanol (39.79%), dodecanal (28.20%), α-pinene (13.11%), decanal (4.16%), and dodecanol acetate (2.75%). The inhibition against the α-glucosidase enzyme obtains the IC50 value of 73.95 and 67.55 ?g/mL for the essential oils and acarbose, respectively. The inhibition against the α-amylase enzyme obtains the IC50 value of 70.87 and 12.28 ?g/mL for the essential oils and acarbose, respectively. The essential oils from the inflorescence of E. elatior could inhibit α-amylase and α-glucosidase enzymes, even though the potential was lower than that of acarbose as a positive control.
Inhibition of Edible Plant Torch Ginger (Etlingera elatior (Jack) R. M. Sm.) against α-Glucosidase and α-Amylase Syafni, Nova; Fakhriadi, Athallah; Nofrizal, Nofrizal; Ismed, Friardi; Putra, Deddi Prima
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.348-352.2023

Abstract

Indonesia's diabetes cases were in the top ten list globally, with 90% of the patients being type-2 diabetes mellitus (T2DM).  An approach for screening the local edible plants is made for managing or treating T2DM by inhibiting α-glucosidase and α-amylase enzymes. Results showed that inflorescence of Etlingera elatior inhibition toward both enzymes. TLC-autography and IC50 value of fractions from E. elatior were used to identify the potential fractions and possible compounds for the activity. The non-polar fraction was spotted in the active substances based on TLC-autography. Then, the targeted compounds were separated by column chromatography to obtain stigmasterol as one of the active compounds. The IC50 values of total extract, n-hexane, EtOAc, BuOH, and isolated compound against α-glucosidase were 16.0, 7.5, 13.5, 9.7, and 2.0 ppm, respectively. The IC50 values for α-amylase inhibition were respectively 88.6, 48.6, 23.2, 29.1, and 27.5 ppm. The positive control (acarbose) against α-glucosidase and amylase exhibited IC50 values of 153.2 and 12.3 ppm. The inhibition of E. elatior against the two enzymes could be an alternative to delay carbohydrate absorption.
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Co-Authors . Nasrun Adek Zamrud Adnan Ahsol Hasyim Ahsol Hasyim Almahdy Almahdy A Almahdy A Amri Bakhtiar Amri Bakhtiar Anwar Kasim Asmah Indrawati Citra Dewi Hamami Cokorda Istri Tirta Rusmala Dewi Daan Khambri DAYAR ARBAIN Dewi, Cokorda Istri Tirta Rusmala Dian Handayani Dominica, Dwi Elyana Indah Wicaksanti Fakhriadi, Athallah Fatma Sri Wahyuni Febriyenti F. Frengki Frengki Frengki Frengki, Frengki Friardi Ismed Hafizatur Rahma Hajatri, Prima Henni Vanda Henni Vanda Henni Vanda I Gusti Ayu Made Srinadi I Made Agus Gelgel Wirasuta Kamal Uyun, Hendri Satria Laura Syahrul Mardinus Mardinus Mardinus, Mardinus Nadhifa Putri Nasrum ., Nasrum Nasrun . Ni Putu Linda Laksmiani Nofrizal Nofrizal Nova Syafni Noveri Rahmawati Nurmiati, N Periadnadi Periadnadi Pratiwi, Erniza Purwoko, Agus Putri, Nadhifa Rahma Yulia Rilma Novita Saharman Gea Slamat Tarigan Sopan Sinamo Sri Hainil Suswati . TRIMURTI HABAZAR Tuty Anggraini Verawati Vivi Sofia Vivi Sofia Vivi Sofia Wiza Leila Puspita Sari Yulianis Yulianis Yulihasri Zurai Resti