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All Journal Jurnal Penelitian Farmasi Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Jurnal Teknologi Pertanian Andalas Jurnal Farmasi Higea Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Hewan Jurnal Katalisator
Deddi Prima Putra
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Isolation and Structural Analysis of Active Antioxidant Phenolic Compounds from Elephantopus mollis Kunth Verawati Verawati; Almahdy Almahdy; Febriyenti Febriyenti; Deddi Prima Putra
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a2hcyr24

Abstract

Elephantopus mollis is a common weed found in West Sumatra, known for its diverse traditional uses and rich phytochemical content. This study aimed to isolate phenolic compounds and evaluate the antioxidant activity of the polar extract of E. mollis herb. The polar extract was obtained through successive extraction using solvents of increasing polarity. Separation of the polar extract was carried out using Amberlite XAD-4 resin chromatography with methanol and water eluents, followed by isolation through silica gel column chromatography using a step-gradient polarity elution system. The separation and isolation processes were monitored by thin-layer chromatography (TLC). Total phenolic content was determined by the Folin–Ciocalteu method, while antioxidant activity was assessed using the DPPH radical scavenging assay. Structural identification of the isolated compound was performed using UV-Vis, IR, NMR, and LC-MS spectroscopic techniques. Subfraction D of the polar extract exhibited a high phenolic content of 618.06 ± 3.38 mg GAE /g. From subfraction D, a phenolic compound designated D3a was isolated as a yellowish-white powder (95.30 mg) with an Rf value of 0.64, producing a dark blue color upon reaction with 10% FeCl₃. The antioxidant activity of compound D3a was classified as very strong, with an IC₅₀ value of 12.42 ppm. Based on physicochemical characterization, compound D3a was identified as caffeic acid with a molecular formula of C₉H₈O₄ and a molecular weight of 180.049.
Essential oils from Homalomena aff. pendula (Blume) Bakh F. and Its Antioxidant Activities Rifaldi Harfiyantama; Nurainas Nurainas; Deddi Prima Putra; Nova Syafni
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.21-27.2026

Abstract

Homalomena is a genus from the family Aracaceae that is characterized by scent. Most Homalomena species from Indonesia have limited information on the chemical components of their essential oils, including those found in West Sumatra Province. The species of Homalomena aff. pendula (Blume) Bakh. F. is found in large amounts in Padang city, and it has the potential to explore its profile of essential oil substances in its leaves, petioles, and rhizomes. In this research, the antioxidant activity of the essential oils was screened using three methods: DPPH, ABTS, and FRAP. The essential oils are extracted through hydro-distillation, and their components are analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The results show that the three major components in the leaves and petioles were β-bisabolene, α-selinene, and α-bergamotene with different percentages. The rhizomes had the same higher component as β-bisabolene, followed by trans-caryophyllene and α-bergamotene. The antioxidant activity, as measured by DPPH and ABTS, showed an IC50 greater than 200 μg/mL. That result is also supported by the FRAP value of leaves, petioles, and rhizomes, 0.165±0.0081;  0.168±0.0019;  0.191±0.0003 µmol Fe(II)/mg sample and 0.013±0.0006; 0.014±0.0001; 0.015±0.0001 µmol trolox/mg sample, respectively. Although the essential oils from H. aff. pendula do not exhibit antioxidant activity, the primary compound, β-bisabolene, has been shown to possess other potential activities.
Pemberdayaan Petani Melalui Pemanfaatan Limbah Kayu Manis Sebagai Energi Alternatif Dengan Pirolisis Drum Tertutup di Nagari Malalak Kabupaten Agam: Empowerment of Farmers through the Utilization of Cinnamon Wood Waste as an Alternative Energy Source Using Closed-Drum Pyrolysis in Nagari Malalak, Agam Regency Darwison Darwison; Zaini Zaini; Silvia Permata Sari; Deddi Prima Putra; Firman Ridwan; Fauzan Wafi; Annita Elfia Rosa; Afwan Nasution; Ghina Salsabila
Jurnal Hilirisasi IPTEKS Vol. 9 No. 1 (2026)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v9i1.936

Abstract

Nagari Malalak Timur is a major cinnamon (Cinnamomum burmannii) production center, but faces critical post-harvest challenges. Weather-dependent drying processes delay sales, while abundant stem and leaf waste are openly burned, causing severe air pollution and energy loss. This community empowerment program explicitly aims to solve these environmental and economic issues by converting cinnamon stem waste into clean alternative energy using an optimized closed-drum pyrolysis system, while simultaneously enhancing farmers' technical capacities. The participatory action research approach involved the Toboh Organik Farmers Group. Implementation stages included waste potential mapping, fabricating a 30-kg-capacity pyrolyzer equipped with a Raspberry Pi Pico microcontroller and an electric blower for precise thermal control, and conducting comprehensive operational, maintenance, and safety (K3) training. Charcoal quality was evaluated against the SNI 01-6235-2000 standard. The intervention yielded significant improvements. Technologically, the pyrolyzer achieved a high conversion efficiency of 38%, producing premium charcoal with a calorific value of 6,780 kcal/kg and 6.2% moisture content. Environmentally, the integrated re-burning system reduced hazardous smoke emissions by 60% compared to open burning. Socio-economically, the program successfully decreased agricultural waste by over 60% and increased farmers' overall income by 30–35% through the creation of a new marketable product. These findings confirm that the introduction of controlled, locally adapted pyrolysis technology not only resolves waste and weather-dependency problems but also fosters rural energy self-sufficiency. The establishment of the "Malalak Hijau" enterprise highlights the program's substantial contribution to sustainable community empowerment and circular economy practices.
Co-Authors . Darwison . Nasrun Adek Zamrud Adnan Afwan Nasution Ahsol Hasyim Ahsol Hasyim Almahdy Almahdy A Almahdy A Almahdy Almahdy Amri Bakhtiar Amri Bakhtiar Annita Elfia Rosa Anwar Kasim Asmah Indrawati Citra Dewi Hamami Cokorda Istri Tirta Rusmala Dewi Daan Khambri DAYAR ARBAIN Dewi, Cokorda Istri Tirta Rusmala Dian Handayani Dominica, Dwi Elyana Indah Wicaksanti Fakhriadi, Athallah Fatma Sri Wahyuni Fauzan Wafi Febriyenti F. Firman Ridwan Frengki Frengki Frengki Frengki, Frengki Friardi Ismed Ghina Salsabila Hafizatur Rahma Hajatri, Prima Henni Vanda Henni Vanda Henni Vanda I Gusti Ayu Made Srinadi I Made Agus Gelgel Wirasuta Kamal Uyun, Hendri Satria Laura Syahrul Mardinus Mardinus Mardinus, Mardinus Nadhifa Putri Nasrum ., Nasrum Nasrun . Ni Putu Linda Laksmiani Nofrizal Nova Syafni Noveri Rahmawati Nurainas Nurainas Nurmiati, N Periadnadi Periadnadi Pratiwi, Erniza Purwoko, Agus Putri, Nadhifa Rahma Yulia Rifaldi Harfiyantama Rilma Novita Saharman Gea Silvia Permata Sari Slamat Tarigan Sopan Sinamo Sri Hainil Suswati . TRIMURTI HABAZAR Tuty Anggraini Verawati Vivi Sofia Wiza Leila Puspita Sari Yulianis Yulianis Yulihasri Zaini Zaini Zurai Resti