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All Journal Journal of Agromedicine and Medical Sciences JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Katalisator Jurnal Farmasi Higea JAFP (Jurnal Akademi Farmasi Prayoga) SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi
Nessa Nessa
Universitas Perintis Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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THE EFFECT OF CORN SILK ETHANOL EXTRACT (Zea mays L.) ON THE BLOOD GLUCOSE LEVELS AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED MICE Nessa, Nessa; Ifmaily; Wahyu Putri, Sri
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 4 No. 1 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v4i1.110

Abstract

Diabetes Mellitus is a metabolic disorder that occurs because pancreatic cells produce insulin in small amounts. The purpose of this study was to determine the effect of giving corn silk (Stigma maydis) to alloxan-induced mice to determine the effective dose of corn silk extract that can reduce blood glucose levels in hyperglycemic mice and histopathological features. This research is an experimental type that uses 24 male white mice as experimental animals, divided into 6 groups and each group consists of 4 mice consisting of negative control, positive control, dose variation 100mg/kgBW, 200mg/kgBW, 400mg/kgBW and the comparison group (Glibenclamide 0.65mg/kgBW). The inducer used was alloxan 150 mg/kg bw. Alloxan induction was carried out for 3 days and then the test preparation was given until the 17th day. Mice's blood was taken through the lateral tail vein to see blood sugar levels. Based on the results of measuring the blood glucose levels of mice on day 17, the average value of blood glucose levels was negative control (86.25 mg/dl), positive control (223 mg/dl), dose 100 mg/kgbb (109.75 mg /dl), dose 200 mg/kgbb (103.5 mg/dl), dose 400 mg/kgbb (92.5 mg/dl), glibenclamide 0.65mg/kgbb (95 mg/dl). Based on the results of statistical data analysis, two-way ANOVA showed significantly different results (p<0.05). The results of reducing blood glucose levels that were closest to the negative control were shown by corn silk extract at a dose of 400 mg/kgbb, while histopathological observations of the pancreas after administration of ethanol extract of corn silk at a dose of 200 mg/kgbb showed the best healing in the islets of Langerhans.
Anti-Inflamatory Activity Evaluation of Sungkai Leaf Ethanol Extract (Peronema Canescens Jack) Using the Red Blood Cell Membrane Stabilization Method Aria, Mimi; Nessa, Nessa; Ilona, Sandra; Lestari, Wahyu
Jurnal Riset Multidisiplin dan Inovasi Teknologi Том 3 № 01 (2025): Jurnal Riset Multidisiplin dan Inovasi Teknologi
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jimat.v3i01.1473

Abstract

Research has been carried out on the anti-inflammatory activity test of the ethanol extract of Sungkai leaf (Peronema canescens Jack) with the red blood cell membrane stabilization method. Purpose of study was to determine the anti-inflammatory activity the effect of the concentration of ethanol extract of sungkai leaves. Anti-inflammatory activity can be determined by measuring stability red blood cells, looking at absorbance of  decomposition of hemoglobin so that the percentage of stability is obtained. Variations in the concentration of the test solution made were 4 variations in concentration, namely 15, 30, 60 and 120 ppm. The extract's ability to reduce inflammation. was then compared standard ibuprofen. Based on the study's findings, the percentage of erythrocyte membrane stability of sungkai leaf extract sequentially with concentrations of 15, 30, 60 and 120 ppm was 2.24%, 32.61%, 37.72%, 44.31%, while the comparison (ibuprofen) The percentage of erythrocyte membrane stability, respectively, with concentrations of 15, 30, 60 and 120 ppm were 24.1%, 36.2%, 49.4%, 63.4% and control 0.98%. The data from study were analyzed using one-way ANOVA which was followed by Duncan test. From this research is isconcluded The activity that reduces inflammation of the ethanolic extract of the sungkai leaf variation of the concentration regarding ethanolic extract of sungkai leaf (Peronema canescens Jack) gave an influence on the anti-inflammatory activity with an increase in the proportion of the stability of the red blood cell membrane following The rise in the concentration of the ethanol extractf the sungkai leaf.
Aktivitas Hepatoprotektor Fraksi Polar n-Butanol Rambut Jagung (Zea mays L.) Terhadap Tikus Putih Jantan yang Diinduksi Paracetamol Nessa, Nessa; Putri , Noni Rahayu; Mutmaina , Iim
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1277

Abstract

Corn silk is a part of the corn plant that is known to contain beneficial chemical compounds, including flavonoid compounds that have antioxidant activity and have the potential as hepatoprotective compounds that can protect the liver from damage caused by free radicals. The purpose of this study was to determine the hepatoprotective effect of the polar fraction of corn silk on male white rats induced by paracetamol. The animals used were 25 male white rats divided into 5 groups, namely group 1 (Negative control), group 2 (positive control) induced by toxic doses of paracetamol, and groups 3, 4, 5 polar fractions of corn silk doses (200, 400, 800 mg/kgBW). The measurement parameters were SGOT-SGPT levels, liver organ weight ratio, and histopathological examination of the liver. The data obtained were analyzed descriptively and statistically with two-way ANOVA followed by Duncan's test. The results of observations of SGOT enzyme levels on days 7 and 14 were group 1 (18.5 and 20.5 U/L), group 2 (50.5 and 113.75 U/L), group 3 (21.5 and 45.25 U/L), group 4 (23.25 and 83.75 U/L), group 5 (26.5 and 105.75 U/L). SGPT enzyme levels on days 7 and 14 were group 1 (39.75 and 42 U/L), group 2 (70.25 and 82.25 U/L), group 3 (42.5 and 48 U/L), group 4 (46.26 and 64.75 U/L), group 5 (48.75 and 70.25 U/L). The results of histopathological observations with score values of group 1 (0), group 2 (4), group 3 (1), group 4 (3), group 5 (3). Based on the research results obtained, it can be concluded that the polar fraction of corn silk has the most effective hepatoprotective activity at the lowest dose of 200 mg/kgBW with the observation results closest to the negative control for each parameter.
Co-Authors Aisyah Agustina Aria, Mimi Asra, Ridho B.A Martinus Boy Chandra Desi Ratnasari Fendri, Sandra Tri Juli Festires Kurnia Harefa I Gusti Bagus Wiksuana Ifmaily Ilona, Sandra Laksono Trisnantoro M Husni Mukhtar Melzy Putri Sani Misfadhila, Sestry Mutmaina , Iim Nize Ria Azni Noni Rahayu Putri Putri , Noni Rahayu R. Rusdi Rahmat Kartija Ringga Novelni Selly Audina Silfa Oktarina Siska Ferilda Sofia Nofianti Sufi Auliya Muztika Tobat, Sanubari Rela Tri Kurnia, Nelia Wahyu Lestari Wahyu Putri, Sri Widyastuti Widyastuti Yetti, Rina Desni Yoga Ramadhana Yumna Athifah Zikra Azizah Zulharmita Zulharmita Zulkarni R