Wulyo Rajabto
Department Of Internal Medicine, Hematology Oncology Division, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia

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Impact of Chemotherapy on Venous Thromboembolism in Cervical Cancer: Systematic Meta-Analysis Observational Studies Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Rajabto, Wulyo; Binathara , Geraldus Sigap Gung; Mayhana, Shuffa Chilla; Faqih, Fahrayhansyah Muhammad; Wirawan, Bintang; Putra, Abdul Hafiidh Surya
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 2 (2026): April 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i2.373

Abstract

Objective: Cervical cancer is associated with an increased risk of venous thromboembolism (VTE), which may be further aggravated by chemotherapy. This study aimed to assess the impact of chemotherapy on VTE incidence in patients with cervical cancer. Methods: A systematic review was conducted according to PRISMA 2020 guidelines. PubMed, the Cochrane Library, and EMBASE were searched from inception to October 2024 for observational studies reporting VTE incidence in cervical cancer patients receiving chemotherapy. Studies including women with cervical cancer treated with chemotherapy and reporting VTE outcomes were eligible, while studies evaluating radiotherapy or surgery alone were excluded. Results: Three observational studies involving 2,292 patients met the inclusion criteria. Pooled analysis showed that chemotherapy significantly increased VTE risk (RR 2.83; 95% CI: 2.05–3.90; p < 0.001), with low statistical heterogeneity. The reported incidence of chemotherapy-associated VTE ranged from 10.0% to 18.7%. Conclusion: Chemotherapy is associated with a nearly threefold increased risk of VTE in cervical cancer patients. These findings support routine VTE risk stratification prior to chemotherapy and consideration of individualized thromboprophylaxis. Further prospective studies are needed to define optimal prevention strategies.
Co-Authors A. Harryanto Achmad Fauzi Kamal Achmad, Ibrahim Adityo Susilo, Adityo Andi Putra Kevinsyah Angkasa, Yohana Kusuma Ari F Syam Ari Fahrial Syam Bambang Setyohadi Binathara , Geraldus Sigap Gung Bintang Wirawan Birry Karim C Martin Rumende C Martin Rumende Chici - Pratiwi Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Dadang Makmun Dimas Priantono, Dimas Djumhana A Djumhana Atmakusuma Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Endang SR Hardjolukito Errol Untung Hutagalung Fachriza, Ihza Faisal, Edward Faqih, Fahrayhansyah Muhammad Fitriyadi Kusuma Gabriella, Stacy Ham, Maria Francisca Harryanto, A. Heru Sundaru Heru Widyawarman, Heru HILMAN TADJOEDIN, HILMAN Ihza Fachriza Indri Windarti Ivan Onggo S Khie Chen Kosasih, Kartika Anastasia Kuntjoro Harimurti Kurniadi Husodo, Kurniadi Laurentius A. Pramono M Usman SM Maharani, Sausan Hana Mayhana, Shuffa Chilla Muradi, Akhmadu Murdani Abdullah Murdani Abdullah Myranda Zahrah Putri Nababan, Saut Horas H. Nanang Sukmana Nicholas Wijayanto Nicholas Wijayanto Pandu Tridana Sakti Parlindungan Siregar Poespitasari, Vinandya Irvianita Putra, Abdul Hafiidh Surya Putri, Myranda Zahrah Rahmat Cahyanur Ramadan, Edwin Ti Raniah, Nida Rudi Putranto S, Ivan Onggo Sally Aman Nasution, Sally Aman Sari, Nina Kemala Sihwastuti, Sihwastuti Siti Setiati Siti Setiati Stacy Gabriella Sukamto Koesnoe Sumariyono Sumariyono Suryoadji, Kemal Akbar Suzy Maria Syahidatul Wafa Syahidatul Wafa, Syahidatul Tubagus Djumhana Atmakusuma Vito Filbert Jayalie, Vito Filbert Wijayanto, Nicholas Yohana Kusuma Angkasa Zulkifli Amin