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All Journal Microbiology Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Universa Medicina Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Human Care Journal Narra J Consilium Sanitatis: Journal of Health Science and Policy Media Penelitian dan Pengembangan Kesehatan
RAVEINAL RAVEINAL
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Determination of blaVIM and blaIMP Resistant Genes againts Meropenem of Pseudomonas aeruginosa Isolated from HCU Bronkopneumona Inpatients at Internal Medicine RSUP dr M Djamil Padang RINGGA NOVELNI; MARLINA MARLINA; RAVEINAL RAVEINAL
Microbiology Indonesia Vol. 9 No. 3 (2015): September 2015
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.993 KB) | DOI: 10.5454/mi.9.3.5

Abstract

In this research, we aimed to detect blaVIM and blaIMP the resistant genes against Meropenem in Pseudomonas aeruginosa from sample of hospitalization patients at the Internal Medicine HCU of RSUP DR. M. Djamil Padang. Firstly, bacterial isolate of P. aeruginosa were isolated from the sputum samples of patients who suffered bronkopneumonia. The isolation were started with samples cultivation to the Cetrimide Agar media which was a selective media for P. aeruginosa. To determine the species of the bacteria, the identification using Gram staining, Triple Sugar Iron Agar (TSIA) test, citric test, urease test, Methyl Red/ Voges–Proskauer (MR/VP) test, and molecular marker of 16S rRNA genes have been conducted. The isolation and identification result showed that from 20 sputum samples of the patients there were just 10 (50%) samples were positively containing P. aeruginosa. From the P. aeruginosa isolates, the resistant genes against meropenem blaVIM and blaIMP were amplified using PCR. The result showed that all these P. aeruginosa isolates have positively genes encoding for Metallo-β-Lactamase (MBLs).
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
Diagnosis dan Tatalaksana Alergi Obat Poedjijo, Yanuar Saputra; Raveinal, Raveinal; Elvira, Dwitya
Syifa'Medika Vol 15, No 1 (2024): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i1.7504

Abstract

Penggunaan obat memiliki risiko terjadinya reaksi simpang obat yang disebut dengan “Adverse Drug Reaction” (ADR). Reaksi simpang obat didefinisikan sebagai reaksi yang tidak diinginkan atau merugikan akibat penggunaan suatu obat yang terjadi pada dosis tertentu. Reaksi simpang obat dapat dibedakan menjadi tipe A dan tipe B yang dipengaruhi oleh farmakogenetik dan reaksi hipersensitivitas. Reaksi simpang obat tipe A diantaranya adalah toksisitas obat (drug overdose), efek samping umum obat, efek sekunder, dan interaksi obat. Reaksi simpang obat tipe B diantaranya adalah alergi dan hipersensitifitas. Reaksi hipersensitif dapat dibedakan menjadi reaksi tipe I, II, III, dan IVa, IVb, IVc, IVd. Penegakan diagnosis alergi obat harus dilakukan dengan anamnesis lengkap, pemeriksaan fisik dan penunjang seperti skin testing dan laboratorium. Prinsip pengobatan alergi obat yaitu dengan menghentikan segera pemberian obat yang dicurigai dapat menimbulkan gejala. Tatalaksana alergi obat dapat diberikan secara non-farmalokogis seperti desensitisasi dan secara farmakologis yang bersifat suportif dan simptomatis. sering dijumpai over diagnosis atau under diagnosis dalam kejadian alergi obat dan berdampak buruk pada kualitas hidup pasien. Berdasarkan latar belakang diatas, tinjauan kepustakaan ini ditulis untuk meningkatkan pemahaman mengenai mekanisme terjadinya alergi obat sehingga dapat menegakan diagnosis dan tatalaksana alergi obat yang tepat.
Transcriptomic analysis of profibrinolytic and fibrinolytic inhibitor genes in COVID-19 patients Febrianti, Ika K.; Putra, Andani E.; Raveinal, Raveinal; Elliyanti, Aisyah
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.843

Abstract

The immunopathogenesis of COVID-19 infection is initiated by the entry of the SARS-CoV-2 virus into the human body through droplets, entering the lungs and binding to the ACE-2 receptor. Activated macrophages stimulate an immune and inflammatory response, leading to the activation of the coagulation cascade, including profibrinolytic and fibrinolytic inhibitor processes. One of the proteins involved in profibrinolytic is encoded by the PLAUR gene, while fibrinolytic inhibitor proteins are encoded by the A2M and SERPINE1 genes. This research aims to assess the transcriptomic analysis of genetic expression data of profibrinolytic genes, fibrinolytic inhibitor genes and their correlation with serum D-dimer levels, which describe the clinical condition of coagulation in COVID-19 patients. This cross-sectional study included 25 patients each for mild and moderate-to-severe COVID-19 at Dr. M. Djamil Padang General Hospital, Padang, Indonesia. Inter-group gene expression comparisons will be analyzed using log2 folds change, and bivariate tests will be analyzed using correlation. The results show that the PLAUR gene has higher expression in moderate-to-severe compared to mild cases. Similarly, the SERPINE1 and A2M genes expressions are higher in moderate-to-severe compared to mild cases. Furthermore, there is a significant correlation between serum D-dimer levels and profibrinolytic factor (PLAUR gene) expression in COVID-19 patients. The correlation between serum D-dimer levels with fibrinolytic inhibitor factor (SERPINE1 and A2M genes) expression was found. These conclude that there is a significant difference in the expression of the profibrinolytic and fibrinolytic inhibitor genes between mild and moderate-to-severe cases in COVID-19, demonstrating COVID-19 infection affects coagulation activities.
Talaromycosis Marneffei pada Pasien HIV Ihsani, Aulia; Raveinal, Raveinal
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1331

Abstract

Talaromycosis marneffei adalah infeksi jamur yang disebabkan Talaromyces marneffei. Talaromikosis adalah salah satu infeksi oportunistik yang sering mengenai orang dengan infeksi Human Immunodeficiency Virus (HIV) stadium akhir di Asia Tenggara, India timur laut, Cina Selatan, Hongkong, dan Taiwan. Gejala klinis talaromikosis tidak spesifik, seperti demam, anemia, penurunan berat badan, hepatomegali, splenomegali, gangguan pernapasan dan manifestasi kulit. Diagnosis ditegakkan berdasarkan kecurigaan klinis dengan konfirmasi pemeriksaan histopatologi. Dilaporkan pasien laki-laki berusia 29 tahun, dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang, dengan keluhan utama muncul bintil-bintil berwarna kehitaman hampir diseluruh wajah sejak 3 bulan yang lalu. Pasien sudah dikenal menderita HIV sejak 4 bulan yang lalu dan sudah mendapat terapi antiretroviral (ARV). Didapatkan plak hiperpigmentasi pada wajah dan hepatomegali. Laboratorium didapatkan kadar hemoglobin 8,9 gr/dl, CD4 8 sel/uL dan pemeriksaan histopatologi yang menunjukkan massa sporis eosinofilik di intraseluler dan diantara stroma jaringan ikat. Pemberian ARV dilanjutkan dan juga diberikan antijamur.Kata kunci: human immunodeficiency virus, talaromycosis, talaromyces marneffei
Analysis of serum levels of B cell activating factor and soluble B cell activating factor receptor with disease activity in systemic lupus erythematosus Raveinal, Raveinal; Elvira, Dwitya; Delfin, Muhamad
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.181-189

Abstract

Background Systemic lupus erythematosus (SLE) is caused by B-cell hyperactivity, which stimulates the production of autoantibodies, leading to the formation of immune complexes and resulting in tissue damage. Increased B-cell activation is associated with disease activity in SLE. The cytokine B-cell Activating Factor (BAFF) and its soluble BAFF receptor (sBAFF-R) play a crucial role in B-cell activation and survival. Their serum levels may serve as potential biomarkers for SLE severity. This study aimed to compare serum levels of BAFF and sBAFF-R between SLE patients with mild, moderate, and severe disease activity. Methods A cross-sectional study was conducted involving 33 female SLE patients. Subjects were divided into mild, moderate, and severe disease activity groups. Disease activity was assessed using Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) scores. Serum BAFF and sBAFF-R levels were measured using ELISA. Data were analyzed using the Kruskal–Wallis and Mann-Whitney tests. A p-value < 0.05 was considered statistically significant. Results The median serum BAFF level in SLE patients was 0.51 ng/mL, and 4.66 ng/mL in sBAFF-R level.There was a statistically significant difference in serum BAFF and sBAFF-R levels between mild, moderate, and severe disease activity among SLE patients (p<0.0001). Conclusion Increased serum levels of BAFF and sBAFF-R may influence disease activity in SLE. Serum concentrations of BAFF and sBAFF-R were found to be associated with disease severity, including mild, moderate, and severe categories. These findings suggest that serum BAFF and sBAFF-R levels may serve as potential biomarkers for assessing SLE activity.
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Febrianti, Ika Kurnia; Putra, Andani Eka; Raveinal, Raveinal; Elliyanti, Aisyah
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p139-147.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
HIV-1 drug resistance-associated mutations in relation to viral load among HIV/AIDS patients at Dr. M. Djamil-Hospital Padang Nadia, Rizka; Elvira, Dwitya; Raveinal, Raveinal
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.38-43

Abstract

BackgroundAccording to the WHO, 38 million people suffer from HIV worldwide and according to the HIV Drug Resistance Report, the prevalence of antiretroviral therapy (ART) resistance is 3-29%. Drug resistance-associated mutations (DRAMs) are the presence of one or more HIV mutations that reduce the ability of certain drugs to inhibit viral replication and that will increase viral replication and HIV RNA, which can lead to therapeutic failure. The objective of this study was to determine the prevalence of HIV-1 DRAMs among patients with chronic HIV-1 infections and to compare HIV RNA viral load between M184V and K103N mutations. Methods A cross-sectional was conducted involving 80 patients with HIV who met the inclusion criteria. The study subjects were examined for genotype and HIV RNA viral load, both using the polymerase chain reaction (PCR). Data were analyzed with the Kruskal-Wallis test. Results The overall drug resistance mutation prevalence was 10.0%. The most common mutations were M184V and K103N. There was a significant difference between the median HIV RNA viral load counts in patients with either M184V or K103N, and with both M184V and K103N mutations, the values being 45.420, 13.207, and 97.517 copies/mL, respectively (p<0.001). Conclusion The HIV RNA viral load count was higher in the mutation group than in the group without mutation. Long-term and ongoing surveillance of HIV DRAMs among these patients is necessary, which will help us to adjust the treatment regimen.
Profil Pasien Lupus Eritematosus Sistemik di RSUP Dr. M. Djamil Padang Tahun 2020-2021 Akmal, Elfi Fauzana; Dwitya Elvira; Noverika Windasari; Malinda Meinapuri; Raveinal, Raveinal; Yulistini, Yulistini
Consilium Sanitatis: Journal of Health Science and Policy Vol. 2 No. 2 (2024)
Publisher : EDUPEDIA Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56855/jhsp.v2i2.1867

Abstract

Objective: To understand the profile of SLE patients at RSUP.Dr.M.Djamil Padang period of 2020-2021. Methods: The research is a descriptive type with a retrospective approach. Medical record data were collected using total sampling technique,189 samples met the inclusion criteria. Data analysis using Microsoft Excel. Results: The study found that the majority of characteristics include female patients (95.8%), age group 17-25 years (33.9%), housewives (41.8%), medium-level education (66.1%), and of Minangkabau ethnicity (86.8%). Most patients had a disease duration of ≥ 2 years (78.8%), mild disease activity (36%), the most common clinical manifestation being mucocutaneous involvement (82%). ANA Profile results, the most prevalent finding was positive dsDNA (25.4%). Patients meeting ACR 1997 criteria were 57.1%, SLICC 2012 35.4%, and EULAR 2019 10.6%. The most frequently therapy was a combination of HCQ and glucocorticoids (45%), while the most common patient outcome was survival (96.8%). Conclusion: Majority of SLE patients at RSUP Dr.M.Djamil Padang are in the productive age group with mild disease activity. The majority of patients have good outcome, indicating a favorable prognosis for SLE at RSUP Dr. M. Djamil Padang.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

Abstract

Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
Co-Authors Aisyah Elliyanti Akmal, Elfi Fauzana Alexander Kam Andani Eka Putra Arina Widya Murni Asir, Taufik Rizkian Delfin, Muhamad Deswinar Darwin Dwitya Elvira, Dwitya Eka Kurniawan Fadrian, Fadrian Fandi Triansyah Fauzar Fauzar Febrianti, Ika K. Febrianti, Ika Kurnia Harun Harnavi Helmi Arifin Ihsani, Aulia Ika Kurnia Febrianti Lia Dwi Lestari Malinda Meinapuri Marlina Marlina Nadia, Rizka Noverika Windasari Poedjijo, Yanuar Saputra Putra, Andani E. Ringga Novelni Ririn Anjelin Rose Dinda Martini Roza Kurniati Roza Mulyana Rudi Erwin Kurniawan Saptino Miro Selly Cintya Gusman Siti Nurhajjah Suci Maulida Yugo Berri Putra Rio Yuliana Arsil Yulistini, Yulistini Zikry Aulia Hidayat Zulkarnain Arsyad