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All Journal Public Health of Indonesia Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia World Nutrition Journal Respiratory Science Narra J Cermin Dunia Kedokteran Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) INOMED
Agustin, Heidy
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, University Of Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : respiratory science

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Immunopathogenesis of Pneumocystis Pneumonia (PCP) and Its Clinical Implications Malik, Andi Sri Suryani; Agustin, Heidy; Nurwidya, Fariz; Rozaliyani, Anna
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.172

Abstract

Pneumocystis pneumonia (PCP) is a serious lung infection caused by Pneumocystis jirovecii, primarily affecting immunocompromised individuals. It remains a major health concern, especially in HIV/AIDS patients and those undergoing immunosuppressive therapy. This review discusses how the immune system responds to P. jirovecii and why immunocompromised individuals are more vulnerable. In healthy individuals, CD4+ T cells, B cells, and macrophages help control the infection. However, in immunocompromised individuals, a weakened immune response allows fungal overgrowth, leading to severe lung damage. The review also covers symptoms, diagnosis, and treatment options. TMP-SMX is the preferred treatment, while alternative drugs are available for those who cannot tolerate it. Understanding the immune response to PCP can help improve treatment and patient care.
Co-Authors Agus Dwi Susanto Ammar Abdurrahman Hasyim Andari Perwira Putri Andari Perwira Putri Andayani, Diyah Eka Anna Rozaliyani Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Armedy Ronny Hasugian Ary Indriana Savitri Asep Purnama, Asep Astri Ayu Setianingtyas Audina, Dea Putri B Setyanto, Darmawan Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Prasetyo Budi Prasetyo Christi Giovani Anggasta Hanafi Cleopas Martin Rumende Damayanti, Triya Dewantoro, Luhur Diah Handayani Dwi Rendra Hadi Elhidsi, Mia Erick Ary Tjawanta Erlina Burhan Erna Setiawati Faisal Yunus Fanny Fachrucha Fariz, Nurwidya Ginting, Tribowo Tuahta Hanafi, Christi Giovani Anggasta Hasto, Bambang Dwi Husain, Bahtiar Isbaniah, Fathiyah Ismulat Rahmawati Mahdani, Wilda Malik, Andi Sri Suryani Marcherly Wardi Mitrasari, Surya Muhammad Nurman Ariefiansyah Murtiani, Farida Nabila Fawzia Nisyra, Mailani Novita Andayani, Novita Nur Farhanah, Nur Rabbani, Hadiati Raden Ena Sarikencana Raden Rara Diah Handayani Reisa, Tina rosamarlina, rosamarlina Samoedro, Erlang Sarif, Armaji Kamaludi Satria Pratama Satria Pratama Savitri, Ary Indriana Septauli, Kolanda Maria Siti Chandra Widjanantie Siti Chandra Widjanantie Sri Wahyudati Syah Putra Yahya, Wiendo Syam, Shaogi Taufik, Feni Fitriani Triya Damayanti Tugas Ratmono Tugas Ratmono, Tugas Utama, Made Susila Widiantari, Aninda Dinar Wiji Lestari Wiji Lestari Wiji Lestari Wiwien Heru Wiyono Yana Aurora Prathita Yohannessa Wulandari Zaini, Jamal