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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Panrita Abdi - Jurnal Pengabdian pada Masyarakat Chimica et Natura Acta Indonesian Journal of Chemistry Scientific Journal of Reflection : Economic, Accounting, Management and Business Jurnal Sinergitas PkM & CSR Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Acta Chimica Asiana Unri Conference Series: Community Engagement FORTE JOURNAL Jurnal Farmasi Indonesia
Yuli Haryani
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Riau University, Pekanbaru, Riau, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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UJI AKTIVITAS ENZIM PROTEASE DARI ISOLAT Bacillus sp. ENDOFIT TANAMAN KELAPA SAWIT (Elaeis quinensis) Atika Marnolia; Yuli Haryani; Fifi Puspita
Sistem Informasi Vol 6 No 02 (2016): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v6i02.429

Abstract

Proteolytic bacteria are able to hydrolyze proteins into amino acid and smaller peptides. The objective of this study to determine the abilty of three Bacillus sp. isolated from leaf (BD), root (BA), and stem (BP) of palm oil to produce protease. The proteolytic activity was determine based on the amount of tyrosin liberated in Unit/mL, while the specific activity was indicated by activity per unit weight of proteins. Protein concentration of enzymes extracts was determined by Lowry method. The results showed that all isolates were able to produce protease. Protease activity of Bacillus sp. BD, BA and BP was (711,260 ± 0,735) x 10-3 U/mL, (708,536 ± 0,918) x 10-3 U/mL and (710,027 ± 0,091) x 10-3 U/mL in optimal production times of 24 hours, repectively.
PENAPISAN DAN KARAKTERISASI BAKTERI SELULOLITIK TERMOFILIK Lilik Septiana; Emma Susanti; Yuli Haryani; Zulmai Rani; Robiatun Rambe
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.974

Abstract

Bakteri selulolitik adalah bakteri yang mampu menghidrolisis kompleks selulosa menjadi oligosakarida yang lebih kecil dan akhirnya menjadi glukosaPenelitian penapisan dan karakterisasi bakteri selulolitik termofilik dari sumber air panas ini dilakukan untuk mendapatkan bakteri termofilik yang berpotensi sebagai penghasil selulase termostabil dan karakteristik bakteri tersebut. Penelitian ini menggunakan sampel dari sumber air panas Desa Sungai Pinang, Kabupaten Kuantan Singingi, dengan 4 titik pengambilan yang berbeda. Sebanyak 24 bakteri selulolitik diisolasi menggunakan medium spesifik yang mengandung carboxy methyl cellulose (CMC). Aktivitas selulolitik dari isolat yang diperoleh kemudian ditentukan berdasarkan kemampuan bakteri dalam menghidrolisis substrat CMC dengan mengukur zona bening yang terbentuk di sekitar koloni pada medium CMC-congo red. Hasil penelitian menunjukkan bahwa 15 dari 24 isolat (62,5%) mampu mendegradasi selulosa dengan indeks selulolitik (IS) yang beragam. Isolat SPT (III)7 memiliki aktivitas selulolitik tertinggi dengan nilai indeks selulolitik sebesar 4,80. Hasil karakterisasi morfologi dan fisiologi dari semua isolat yang diidentifikasi memperlihatkan bahwa isolat tersebut berupa bakteri Bacillus sp1 dan Bacillus sp2.
Design, Synthesis, and Antifungal Analysis of Pyrazoline Derivatives Against Candida Species: A Comprehensive In Vitro and In Silico Approach Rohim, Muhammad; Haryani, Yuli; Frimayanti, Neni; Muttaqin, Fauzan Zein; Teruna, Hilwan Yuda; Hendra, Rudi
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.105255

Abstract

This study utilized in vitro and in silico methods to assess the antifungal efficacy of synthesized pyrazoline derivatives (4a–e) against Candida species. The compounds were produced by a one-pot process and structurally analyzed using spectroscopic methods. The antifungal efficacy was evaluated against C. albicans, C. glabrata, and C. krusei using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) assays. Among the derivatives, compound 4e exhibited potent antifungal action, displaying MIC values similar to ketoconazole. Molecular docking and pharmacophore modeling have shown that 4e interacts efficiently with critical residues of lanosterol 14α-demethylase (CYP51). The density functional theory (DFT) study indicated advantageous electrical characteristics, while molecular dynamics simulations validated the structural stability of the 4e–CYP51 complex, evidenced by low RMSD and RMSF values, along with an MM/GBSA binding energy comparable to that of ketoconazole. A robust association between binding energy and MIC substantiates the predictive use of computational data. The results suggest that compound 4e replicates the binding characteristics of ketoconazole and may be a viable candidate for antifungal medication development. This integrative strategy reinforces the justification for additional optimization and preclinical assessment of pyrazoline-based antifungal drugs aimed at CYP51.
Biological degradation of aflatoxin by microbe and enzyme: a review Musyirna Nasution; Suryono Suryono; Amir Awaluddin; Yuli Haryani
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.230

Abstract

Aflatoxins, produced by fungi like Aspergillus flavus and Aspergillus parasiticus, pose significant threats to food safety, impacting human and animal health while causing economic losses. Detoxifying aflatoxins is crucial to reducing contamination in food and feed. Enzymes and microorganisms present an eco-friendly and efficient solution for this purpose. This review highlights their roles in detoxification, focusing on bacteria, yeasts, and fungi that can degrade or bind aflatoxins, thereby lowering toxicity. Enzymes such as laccase, peroxidase, and reductase facilitate detoxification through oxidative and hydrolytic degradation. The efficiency of these methods depends on factors like pH, substrate availability, and temperature. Understanding the interactions between enzymes, microorganisms, and aflatoxins is essential for optimizing detoxification strategies. While promising, further research is needed to enhance their application in food safety.
Asam HidroksiAsam Hidroksisinamat dari Drynaria sparsisora ​​sebagai Agen Anti-Vibrio: Bukti Terintegrasi In Vitro dan In Silicosinamat dari Drynaria sparsisora sebagai Agen Anti-Vibrio: Bukti Terpadu Secara In Vitro dan In Silico Hesti Marliza; Fitra Perdana; Yuli Haryani; Hilwan Yuda Teruna; Rudi Hendra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.974

Abstract

Drynaria sparsisora is a fern species long utilized in ethnomedicine and recognized as a source of phenolic compounds. This study aims to isolate antibacterial ingredients from D. sparsisora, evaluate their efficacy against Vibrio species, and investigate potential molecular interactions by in silico docking analysis. Dried plant material was extracted with methanol and separated by liquid–liquid partitioning followed by chromatographic purification. Two main compounds were identified and structurally characterized using UV–Vis, FTIR, and ¹H/¹³C NMR spectroscopy. Spectroscopic measurements established the identification of the substances as ferulic acid (1) and caffeic acid (2). In vitro antibacterial activity was investigated against Vibrio alginolyticus, Vibrio parahaemolyticus, and Vibrio cholerae using a broth microdilution method to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Both isolated compounds displayed MIC values of 20 µg/mL and MBC values of 40 µg/mL against all tested strains, leading to an MBC/MIC ratio of 2, confirming bactericidal activity. Although chloramphenicol revealed higher efficacy (MIC 12.5 µg/mL), the separated phenylpropanoids showed consistent and repeatable suppression across all Vibrio species tested. To give mechanistic insight, molecular docking simulations were performed against three bacterial protein targets (PDB IDs: 2ZDQ, 1HNJ, and 3IL7). Both ferulic acid and caffeic acid displayed favorable binding energies and persistent interaction patterns inside the active regions of these proteins, involving hydrogen bonding and hydrophobic interactions. In selected models, docking affinities neared those of chloramphenicol, confirming the likelihood of target engagement. The multi-target binding behavior found suggests possible interference with important bacterial functions, including cell wall function, protein synthesis, and fatty acid production. Overall, the data reveal that D. sparsisora contains hydroxycinnamic acids with considerable bactericidal activity against Vibrio spp., backed by computational evidence of protein interaction. Further investigations are necessary to validate molecular targets and clarify antibacterial processes.
Transfer Teknologi Pengolahan Bunga Telang (Clitoria ternatea) menjadi Teh Celup Herbal di Desa Dayang Suri Kecamatan Bunga Raya Kabupaten Siak Fitra Perdana; Andi Dahliaty; Yuana Nurulita; Heralda Fawrin; Selfi Yanti; Yuli Haryani
Unri Conference Series: Community Engagement Vol 7 (2025): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.7.507-512

Abstract

Butterfly pea (Clitoria ternatea) is a plant that provides various health benefits due to its pharmacologically active compounds. Nevertheless, the community’s limited knowledge and skills in utilizing and processing butterfly pea into herbal tea bags underline the importance of this community service activity. Processing butterfly pea into herbal tea serves as an effective approach to make its health benefits more accessible for daily use. This program aimed to enhance community knowledge about the health properties of butterfly pea, improve their skills in producing herbal tea bags, and encourage its development as a household-scale product with market potential, given its simple and low-cost processing method. The target beneficiaries were residents of Dayang Suri Village, Bunga Raya Subdistrict, Siak Regency with 55 participants. Program achievements were measured by determining the increased knowledge and skills in processing butterfly pea into herbal tea bags, as well as growing interest in its commercialization. Pre- and post-test results demonstrated a significant improvement in participants’ average scores from 45% to 87%, with a statistically significant paired t-test result (α=0.05).
Co-Authors Alchalish, Dhia Tijani Amir Awaluddin Andi Dahliaty Ariani Gusti Rahayu Atika Marnolia Christine Jose Christine Jose Dhia Tijani Alchalish Dian Permata Sari Eka Marissa Putri Fifi Puspita Fifi Puspita Fitra Perdana Fitri Rahayu Franka Hendra Sukma Ganis F. Kartika Ganis Fia Kartika Ganis Fia Kartika Hendra, Rudi Heralda Fawrin Hesti Marliza Hexsha Rizki Amelia Hilwan Yuda Teruna Hilwan Yuda Teruna Iswatun Nabella Jasmadi ' Jisman Hutasoit Kartika, Ganis F. Kiki Apriani Kurniawan Agung Lilik Septiana Marnolia, Atika Melanie, Yonatha Musyirna Nasution Musyirna Rahmah Nst Muttaqin, Fauzan Zein Nabella, Iswatun Neni Frimayanti Putri, Eka Marissa Retno Indriyati K Robiatun Rambe Rohim, Muhammad Rosidah ' Rudi Hendra Rudi Hendra Rudi Hendra Rudi Hendra Sarlly Deviani Saryono Sikumbang Selfi Yanti Silvera Devi Siti Muthmainah Suryono Suryono Usna Juwita Yonatha Melanie Yuana Nurulita Yuharmen - Yuharmen Yuharmen Yuharmen, Yuharmen Yuharmen, Yuharmen Yum Eryanti Yum Eryanti Zulmai Rani