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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Panrita Abdi - Jurnal Pengabdian pada Masyarakat Chimica et Natura Acta Indonesian Journal of Chemistry Scientific Journal of Reflection : Economic, Accounting, Management and Business Jurnal Sinergitas PkM & CSR Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Unri Conference Series: Community Engagement FORTE JOURNAL
Yuli Haryani
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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UJI AKTIVITAS ENZIM PROTEASE DARI ISOLAT Bacillus sp. ENDOFIT TANAMAN KELAPA SAWIT (Elaeis quinensis) Atika Marnolia; Yuli Haryani; Fifi Puspita
Sistem Informasi Vol 6 No 02 (2016): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v6i02.429

Abstract

Proteolytic bacteria are able to hydrolyze proteins into amino acid and smaller peptides. The objective of this study to determine the abilty of three Bacillus sp. isolated from leaf (BD), root (BA), and stem (BP) of palm oil to produce protease. The proteolytic activity was determine based on the amount of tyrosin liberated in Unit/mL, while the specific activity was indicated by activity per unit weight of proteins. Protein concentration of enzymes extracts was determined by Lowry method. The results showed that all isolates were able to produce protease. Protease activity of Bacillus sp. BD, BA and BP was (711,260 ± 0,735) x 10-3 U/mL, (708,536 ± 0,918) x 10-3 U/mL and (710,027 ± 0,091) x 10-3 U/mL in optimal production times of 24 hours, repectively.
PENAPISAN DAN KARAKTERISASI BAKTERI SELULOLITIK TERMOFILIK Lilik Septiana; Emma Susanti; Yuli Haryani; Zulmai Rani; Robiatun Rambe
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.974

Abstract

Bakteri selulolitik adalah bakteri yang mampu menghidrolisis kompleks selulosa menjadi oligosakarida yang lebih kecil dan akhirnya menjadi glukosaPenelitian penapisan dan karakterisasi bakteri selulolitik termofilik dari sumber air panas ini dilakukan untuk mendapatkan bakteri termofilik yang berpotensi sebagai penghasil selulase termostabil dan karakteristik bakteri tersebut. Penelitian ini menggunakan sampel dari sumber air panas Desa Sungai Pinang, Kabupaten Kuantan Singingi, dengan 4 titik pengambilan yang berbeda. Sebanyak 24 bakteri selulolitik diisolasi menggunakan medium spesifik yang mengandung carboxy methyl cellulose (CMC). Aktivitas selulolitik dari isolat yang diperoleh kemudian ditentukan berdasarkan kemampuan bakteri dalam menghidrolisis substrat CMC dengan mengukur zona bening yang terbentuk di sekitar koloni pada medium CMC-congo red. Hasil penelitian menunjukkan bahwa 15 dari 24 isolat (62,5%) mampu mendegradasi selulosa dengan indeks selulolitik (IS) yang beragam. Isolat SPT (III)7 memiliki aktivitas selulolitik tertinggi dengan nilai indeks selulolitik sebesar 4,80. Hasil karakterisasi morfologi dan fisiologi dari semua isolat yang diidentifikasi memperlihatkan bahwa isolat tersebut berupa bakteri Bacillus sp1 dan Bacillus sp2.
Design, Synthesis, and Antifungal Analysis of Pyrazoline Derivatives Against Candida Species: A Comprehensive In Vitro and In Silico Approach Rohim, Muhammad; Haryani, Yuli; Frimayanti, Neni; Muttaqin, Fauzan Zein; Teruna, Hilwan Yuda; Hendra, Rudi
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.105255

Abstract

This study utilized in vitro and in silico methods to assess the antifungal efficacy of synthesized pyrazoline derivatives (4a–e) against Candida species. The compounds were produced by a one-pot process and structurally analyzed using spectroscopic methods. The antifungal efficacy was evaluated against C. albicans, C. glabrata, and C. krusei using minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) assays. Among the derivatives, compound 4e exhibited potent antifungal action, displaying MIC values similar to ketoconazole. Molecular docking and pharmacophore modeling have shown that 4e interacts efficiently with critical residues of lanosterol 14α-demethylase (CYP51). The density functional theory (DFT) study indicated advantageous electrical characteristics, while molecular dynamics simulations validated the structural stability of the 4e–CYP51 complex, evidenced by low RMSD and RMSF values, along with an MM/GBSA binding energy comparable to that of ketoconazole. A robust association between binding energy and MIC substantiates the predictive use of computational data. The results suggest that compound 4e replicates the binding characteristics of ketoconazole and may be a viable candidate for antifungal medication development. This integrative strategy reinforces the justification for additional optimization and preclinical assessment of pyrazoline-based antifungal drugs aimed at CYP51.
Transfer Teknologi Pengolahan Bunga Telang (Clitoria ternatea) menjadi Teh Celup Herbal di Desa Dayang Suri Kecamatan Bunga Raya Kabupaten Siak Perdana, Fitra; Dahliaty, Andi; Nurulita, Yuana; Fawrin, Heralda; Yanti, Selfi; Haryani, Yuli
Unri Conference Series: Community Engagement Vol 7 (2025): Seminar Nasional Pemberdayaan Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/unricsce.7.507-512

Abstract

Butterfly pea (Clitoria ternatea) is a plant that provides various health benefits due to its pharmacologically active compounds. Nevertheless, the community’s limited knowledge and skills in utilizing and processing butterfly pea into herbal tea bags underline the importance of this community service activity. Processing butterfly pea into herbal tea serves as an effective approach to make its health benefits more accessible for daily use. This program aimed to enhance community knowledge about the health properties of butterfly pea, improve their skills in producing herbal tea bags, and encourage its development as a household-scale product with market potential, given its simple and low-cost processing method. The target beneficiaries were residents of Dayang Suri Village, Bunga Raya Subdistrict, Siak Regency with 55 participants. Program achievements were measured by determining the increased knowledge and skills in processing butterfly pea into herbal tea bags, as well as growing interest in its commercialization. Pre- and post-test results demonstrated a significant improvement in participants’ average scores from 45% to 87%, with a statistically significant paired t-test result (α=0.05).
Co-Authors Alchalish, Dhia Tijani Andi Dahliaty Ariani Gusti Rahayu Atika Marnolia Christine Jose Christine Jose Dhia Tijani Alchalish Dian Permata Sari Eka Marissa Putri Fawrin, Heralda Fifi Puspita Fifi Puspita Fitra Perdana Fitri Rahayu Franka Hendra Sukma Ganis F. Kartika Ganis Fia Kartika Ganis Fia Kartika Hendra, Rudi Hexsha Rizki Amelia Hilwan Yuda Teruna Iswatun Nabella Jasmadi ' Jisman Hutasoit Kartika, Ganis F. Kiki Apriani Kurniawan Agung Lilik Septiana Marnolia, Atika Melanie, Yonatha Muttaqin, Fauzan Zein Nabella, Iswatun Neni Frimayanti Putri, Eka Marissa Retno Indriyati K Robiatun Rambe Rohim, Muhammad Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Rosidah ' Rudi Hendra Rudi Hendra Rudi Hendra Sarlly Deviani Saryono Sikumbang Silvera Devi Siti Muthmainah Usna Juwita Yanti, Selfi Yonatha Melanie Yuana Nurulita Yuharmen - Yuharmen Yuharmen Yuharmen, Yuharmen Yuharmen, Yuharmen Yum Eryanti Yum Eryanti Zulmai Rani