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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biology, Medicine, & Natural Product Chemistry Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Journal of Dentomaxillofacial Science Syntax Literate: Jurnal Ilmiah Indonesia SRIWIJAYA JOURNAL OF MEDICINE Jurnal Pengabdian Masyarakat: Humanity and Medicine Conferences of Medical Sciences Dies Natalis Eduvest - Journal of Universal Studies Media Penelitian dan Pengembangan Kesehatan Jurnal Farmasi Galenika Folia Medica Indonesiana
Larasati, Veny
Bagian Histologi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Effects of Intermittent Fasting on the Size and Number of Subcutaneus Adipocytes in Obese Mouse Models Larasati, Veny; Rasyid, Riana Sari Puspita; Fertilita, Soilia; Suciati, Tri; Farhan, Muhammad
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study helps bridge the gap between systemic effects and tissue-level changes, providing a deeper understanding of how histological analysis can be used to explore the effects of intermittent fasting on adipocytes and body weight regulation. 2. This study contributes to obesity management through lifestyle modification, specifically intermittent fasting, by focusing on histological changes in adipose tissue. Abstract The accumulation of adipose tissue can have deleterious effects and lead to obesity. Intermittent fasting (IF), an approach that involves time-restricted eating, has gained popularity as an obesity treatment option because it enhances insulin sensitivity and promotes beneficial changes in glucose metabolism. This study used a time-restricted meal intake (TRM) approach to assess the effects of IF on the histological features of obese mouse models' subcutaneous inguinal adipose tissue. The investigation employed an in vivo experimental posttest-only control group design. Twenty male mice were divided into four groups: a normal control group, an obese control group, a TRM group with a high-fat diet (TRM-HF), and a TRM group with a standard diet (TRM-S). The TRM treatment was administered for fourteen days, with a fasting window from 4 p.m. to 8 a.m. The pre- and post-treatment weight analyses were conducted using the paired t-test for normally distributed data and the Wilcoxon test for non-normally distributed data (p<0.05). One-way analysis of variance (ANOVA) was employed for unpaired data on the post-treatment weight. Per field of view, there were an average of 120,500 cells (49,700–136,200) in the normal control group, 68,380±9,194 cells in the obese control group, 70,860±11,029 cells in the TRM-HF group, and 79,360±5,112 cells in the TRM-S group. The average cell sizes (μm3) were 56,730.142±19,273.257 in the normal control group, 138,934.331±27,670.558 in the obese control group, 106,827.767±20,580.501 in the TRM-HF group, and 68,689.114±8,219.727 in the TRM-S group. The number of cells in each group did not differ significantly, but there were significant variations in cell size. The mice receiving TRM treatment did not exhibit substantial body weight changes, whereas the obese control group showed a significant body weight increase. In conclusion, TRM has an effect on cell size but does not affect the quantity of adipocytes in subcutaneous inguinal fat tissue.
Exploring The Potential of Gonggong Sea Snails (Laevistrombus Sp.) in Biotechnology as a Source of Natural Compounds for Wound Healing Fadilah, Rizka; Hafy, Zen; Larasati, Veny
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52441

Abstract

The gonggongsea snail(Laevistrombussp.) is a typical marine life of the Riau Islands that contains various bioactive compounds with potential as wound healing agents based on natural ingredients. This study aims to evaluate the potential of gonggong seasnailextract through a literature review of articles obtained from PubMed, ScienceDirect, Google Scholar, and Scopus. Analysis of 18 articles showed that gonggongsea snailscontain histone protein H2A, antimicrobial peptides, flavonoids, alkaloids, saponins, as well as essential amino acids such as arginine, proline, and glycine that work synergistically throughout the wound healing phase. The compound plays a role in suppressing inflammation through inhibition of the NF-κB pathway and increasing IL-10, supporting the proliferation phase by stimulating angiogenesis and collagen synthesis, and improving the remodeling phase through improved tissue quality and antioxidant activity. Histological assessment can use the SPOT score system to show relevant parameters to evaluate the effectiveness of natural ingredients in wound healing. The results of this study confirm that gonggongsea snailextract has great potential to be developed as an effective, safe, and sustainable wound therapy candidate, so experimental research is needed to validate molecular mechanisms and standardize formulations.
Co-Authors A, Rafdi A, Rafdi Agustiarini, Vitri Agustin, Berliana Agustin, Berliana Amanda Putri, Khairunnisa Rizqika Anak Agung Gde Budhiarta Andre Saputra Angelina N. Ricardo Argo Fauzan Athiah, Medina Ayeshah A Rosdah Berliana Agustin Bintang Arroyantri P Bintang Arroyantri Prananjaya Debby Handayati Harahap Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Handayani Dwi, Handayani Egi Nabila Eka Febri Zulissetiana Eka Febri Zulissetiana Emirzon, M Afif Baskara Emirzon, M Afif Baskara Fadilah, Rizka Fertilita, Soilia Fifa Argentina Hadani, M Hasnawi Hadani, M Hasnawi Jayawarsa, A.A. Ketut Kemas M. Yakub Laida Neti Mulyani M, Haekal M, Haekal Margiati, Asih Mayang Indah Lestari Muhammad Farhan Muhammad Irsan Saleh Mulyani, Laida Neti Nita Parisa Noer Rahmat Lubis Phey Liana Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Rafif Shidq Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Riana Sari Puspita Rasyid Riska Mareta Rizani Amran Rohan Sabloak Rohan Sabloak S, Novizar S, Novizar Soilia Fertilita Soilia Fertilita Sri Nita Stevanus E. Handrawan Susilawati Susilawati Susilawati Susilawati Susilawati Tanta, Yudhi Theodorus Tri Suciati Tri Suciati Trisnawaty Trisnawaty Trisnawaty Valentino, Albert Amadeus Wimpie I Pangkahila Yakub, Kemas M Yakub, Kemas M Zen Hafy Ziske Maritska Zulfadli, Muhammad