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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Folia Medica Indonesiana Biology, Medicine, & Natural Product Chemistry Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Journal of Dentomaxillofacial Science Syntax Literate: Jurnal Ilmiah Indonesia SRIWIJAYA JOURNAL OF MEDICINE Jurnal Pengabdian Masyarakat: Humanity and Medicine Conferences of Medical Sciences Dies Natalis Media Penelitian dan Pengembangan Kesehatan Jurnal Farmasi Galenika
Larasati, Veny
Bagian Histologi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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TINJAUAN SISTEMATIS HISPATOLOGI GOUT ARTRITIS: PERAN SEL IMUN DALAM PROSES INFLAMASI DAN KERUSAKAN JARINGAN Larasati, Veny; Parisa, Nita; Valentino, Albert Amadeus; Diba, Msy. Farah
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2210

Abstract

Gout arthritis is a joint inflammation caused by increased uric acid levels, leading to the formation of monosodium urate (MSU) crystals. The study aimed to deepen the understanding of the role of MSU crystals in triggering both acute and chronic inflammatory responses, as well as the formation of tophi, which damage joint and bone tissues. The method used is the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The reviewed articles were obtained from the Science Direct, Semantic Scholar, and PubMed databases using the keywords “Gout Arthritis,” “Histopathology,” “Inflammation,” and “Tophus.” The publication period was limited to 2019-2024. Out of 745 articles found, 12 were selected based on inclusion criteria, which included experimental, observational, and case study reports. The results show that MSU crystals induce inflammation through the infiltration of inflammatory cells such as neutrophils and macrophages. In chronic Gout, the formation of tophi, granulomatous lesions with a crystalline core, leads to bone and joint destruction. Understanding the histopathological aspects is crucial for more accurate diagnosis and more effective management of Gout arthritis. The progression of the disease is related to acute and chronic inflammation, as well as the destructive effects of tophi on joints and bones. In conclusion, MSU crystals play a significant role in triggering inflammation and tissue damage in Gout arthritis, and understanding histopathology can improve diagnostic accuracy and therapeutic efficacy.
Co-Authors A, Rafdi A, Rafdi Agustiarini, Vitri Agustin, Berliana Agustin, Berliana Amanda Putri, Khairunnisa Rizqika Anak Agung Gde Budhiarta Andre Saputra Angelina N. Ricardo Argo Fauzan Athiah, Medina Ayeshah A Rosdah Berliana Agustin Bintang Arroyantri P Bintang Arroyantri Prananjaya Debby Handayati Harahap Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Handayani Dwi, Handayani Egi Nabila Eka Febri Zulissetiana Eka Febri Zulissetiana Emirzon, M Afif Baskara Emirzon, M Afif Baskara Fadilah, Rizka Fertilita, Soilia Fifa Argentina Hadani, M Hasnawi Hadani, M Hasnawi Jayawarsa, A.A. Ketut Kemas M. Yakub Laida Neti Mulyani M, Haekal M, Haekal Margiati, Asih Mayang Indah Lestari Muhammad Farhan Muhammad Irsan Saleh Mulyani, Laida Neti Nita Parisa Noer Rahmat Lubis Phey Liana Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Rafif Shidq Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Riana Sari Puspita Rasyid Riska Mareta Rizani Amran Rohan Sabloak Rohan Sabloak S, Novizar S, Novizar Soilia Fertilita Soilia Fertilita Sri Nita Stevanus E. Handrawan Susilawati Susilawati Susilawati Susilawati Susilawati Tanta, Yudhi Theodorus Tri Suciati Trisnawaty Trisnawaty Trisnawaty Valentino, Albert Amadeus Wimpie I Pangkahila Yakub, Kemas M Yakub, Kemas M Zen Hafy Ziske Maritska Zulfadli, Muhammad