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Larasati, Veny
Bagian Histologi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya
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Edukasi pencegahan sindrom kelelahan (burnout) pada karyawan Pertamina MOR II Palembang veny larasati; Bintang Arroyantri P; Ziske Maritska; Nita Parisa; Diyaz Syauki Ikhsan
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 1 No 3 (2020): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V1I3.13

Abstract

Education for Preventing Burnout Syndrome to Pertamina MOR II Palembang workers. Burnout is a syndrome that occurs due to prolonged interpersonal stress due to work. Burnout can also be described as psychological fatigue caused by work. This can occur due to the high demands of the company to provide optimal work results that the employees cannot tolerate. There are three things that can trigger this syndrome, namely excessive workload, neglect of work results and feelings of underappreciation at work. Based on a survey conducted in America, the main reason of stress was due to excessive workload, 1 in 5 employees experienced burnout syndrome which is around 46%, and in Indonesia, the survey results showed that around 64% of employees experienced increased fatigue due to work, and around 20% of employees believed that psychological fatigue is the cause of the absence of employees due to illness in the company. This community service is carried out at the request of the PERTAMINA Palembang Company. Burnout syndrome is a serious problem for employees and employers. If not addressed properly, it will lead to serious psychological problems for employees such as decreased productivity, withdrawal from work, depression and even anxiety, which in turn can have a negative impact on the company. For this reason, it is necessary to have monitoring and evaluation related to the psychological condition of employees on a regular basis.
The effect of administration of siamese catfish (pangasius hypophthalmus) extract on fibroblast cells after tooth extraction in wistar rats Veny Larasati; Trisnawaty; Angelina N. Ricardo
Journal of Dentomaxillofacial Science Vol. 7 No. 1 (2022): (Available online: 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v7i1.1402

Abstract

Objective: The study aimed to determine the effect of administration of Siamese catfish extract orally on the number of fibroblast cells in wound healing after tooth extraction of Wistar rats. Material and Methods: This research was a true experimental laboratory with posttest only control group design. 24 male Wistar rat were divided into 6 groups. After the mandibular left incisor was extracted, rats in groups 1, 2, and 3 were given Siamese catfish extract and groups 4, 5, and 6 were given aquadest orally once a day. Groups 1 and 4 were treated for 3 days, groups 2 and 5 were treated for 5 days, and groups 3 and 6 were treated for 7 days, then the rats were euthanized and made histological preparations. Fibroblast cells were calculated using Image Raster software and analyzed using One Ways ANOVA and Post Hoc LSD tests. Results: The number of fibroblast cells increased on the 5th day and reached its peak on the 7th day. ANOVA test showed a significant difference in the mean of fibroblast number between the treatment and control groups (p<0,05). Conclusion: Administration of Siamese catfish extract orally can increase the number of fibroblast cells in wound healing after tooth extraction of Wistar rats.
HUBUNGAN KEBIASAAN OLAHRAGA DENGAN KADAR ANTIBODI IMMUNOGLOBULIN G SETELAH VAKSINASI COVID 19 Veny Larasati; Rohan Sabloak; Riana Sari Puspita Rasyid; Eka Febri Zulissetiana; Susilawati Susilawati; Soilia Fertilita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.19620

Abstract

Kebiasaan olahraga identik dengan konsep FITT (Frequency, Intensity, Type, Time) untuk menentukan efektifitas dari olahraga yang dilakukan. Sistem imun tubuh responsif terhadap kebiasaan berolahraga sehingga mampu meningkatkan respon imun terhadap antigen penyusun yang terdapat di dalam vaksin. Tujuan dari penelitian ini yaitu mengetahui hubungan antara kebiasaan olahraga dengan respon imun pasca vaksinasi COVID-19 di Kota Palembang. Penelitian ini menggunakan pendekatan cross sectional terhadap individu yang mendapatkan inactivated vaccine COVID-19 dosis kedua, dengan pengambilan sampel secara consecutive sampling dengan 78 sampel. Data pada penelitian diambil dengan wawancara mengenai kebiasaan olahraga 1 bulan sebelum vaksinasi, serta dilakukan pengambilan sampel darah vena sebanyak 5 cc pada ±28-30 hari setelah vaksinasi kedua. Darah diproses menjadi serum untuk pemeriksaan kadar IgG anti s1 RBD SARS-CoV-2 menggunakan kit produksi Abbott dengan metode CMIA. Analisis data pada penelitian ini menggunakan uji Pearson’s Chi-squared atau uji Fisher’s Exact dan/atau uji penggabungan sel sebagai alternatif. Pada penelitian ini distribusi frekuensi sampel dominan pada usia dewasa muda (56,4%), jenis kelamin perempuan (52,6%) dan kadar IgG rendah (52,6%). Interval kadar IgG pada sampel adalah 42,1 – 12971,3 AU/mL, dengan rata-rata kadar IgG 1494,95 AU/mL dan median 794,35 AU/mL. Sebaran data dominan pada kelompok dengan kebiasaan olahraga (64,1%), frekuensi olahraga kurang ideal (33,3%), jenis olahraga aerobik (59%), intensitas olahraga ringan (46,2%), dan durasi olahraga sangat lama (20,5%). Tidak diperoleh hubungan yang signifikan antara kebiasaan olahraga olahraga (frekuensi, jenis, intensitas dan durasi olahraga) dengan respon imun pasca vaksinasi (P value > 0,05). Kata kunci: Kebiasaan olahraga, latihan fisik, frekuensi, jenis, intensitas, durasi, Respon Imun, COVID-19, IgG, dan vaksin inaktif.
The Association Between Clinical Characteristics and Histopathology of Nasopharyngeal Carcinoma At Dr. Mohammad Hoesin General Hospital, In 2019-2020 Argo Fauzan; Susilawati Susilawati; Veny Larasati
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.133

Abstract

Introduction. Nasopharyngeal carcinoma is a cancer originating from the nasopharyngeal epithelium. Clinical characteristics such as age, gender, and risk factors are believed to influence the incidence of this cancer. Patients suffering from nasopharyngeal cancer may have certain clinical symptoms and provide certain histopathological features. Methods. The method used in this research were analytic observational with a cross sectional design using secondary data in the form of medical records from the Department of Anatomical Pathology section and the Central Medical Record section of RSUP Dr. Mohammad Hoesin Palembang as the research subject. Samples obtained 64 samples, then managed using the SPSS application. Results. The highest age group was 35-55 years old, which amounted to 44 people (68.8%). According to gender, the most common were males with 53 people (82,8%). According to clinical symptom, the most common were non-epistaxis with 33 people (51.6%). According to risk factors, the most were smokers with 36 people (56.3%).  According to histopathology, the most common features were differentiated non-keratinized squamous cell carcinoma with 40 people (62,5%). From the statistical test, it resulted that p > 0,05 for all variables (age, gender, clinical symptoms, and risk factors) that associated with histopathology of nasopharyngeal carcinoma. Conclusion. There was no significant association found between clinical characteristics and histopathology of nasopharyngeal carcinoma.
HUBUNGAN KEBIASAAN OLAHRAGA DENGAN KADAR ANTIBODI IMMUNOGLOBULIN G SETELAH VAKSINASI COVID 19 Veny Larasati; Rohan Sabloak; Riana Sari Puspita Rasyid; Eka Febri Zulissetiana; Susilawati; Soilia Fertilita
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 1 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i1.329

Abstract

Kebiasaan olahraga identik dengan konsep FITT (Frequency, Intensity, Type, Time) untuk menentukan efektifitas dari olahraga yang dilakukan. Sistem imun tubuh responsif terhadap kebiasaan berolahraga sehingga mampu meningkatkan respon imun terhadap antigen penyusun yang terdapat di dalam vaksin. Tujuan dari penelitian ini yaitu mengetahui hubungan antara kebiasaan olahraga dengan respon imun pasca vaksinasi COVID-19 di Kota Palembang. Penelitian ini menggunakan pendekatan cross sectional terhadap individu yang mendapatkan inactivated vaccine COVID-19 dosis kedua, dengan pengambilan sampel secara consecutive sampling dengan 78 sampel. Data pada penelitian diambil dengan wawancara mengenai kebiasaan olahraga 1 bulan sebelum vaksinasi, serta dilakukan pengambilan sampel darah vena sebanyak 5 cc pada ±28-30 hari setelah vaksinasi kedua. Darah diproses menjadi serum untuk pemeriksaan kadar IgG anti s1 RBD SARS-CoV-2 menggunakan kit produksi Abbott dengan metode CMIA. Analisis data pada penelitian ini menggunakan uji Pearson’s Chi-squared atau uji Fisher’s Exact dan/atau uji penggabungan sel sebagai alternatif. Pada penelitian ini distribusi frekuensi sampel dominan pada usia dewasa muda (56,4%), jenis kelamin perempuan (52,6%) dan kadar IgG rendah (52,6%). Interval kadar IgG pada sampel adalah 42,1 – 12971,3 AU/mL, dengan rata- rata kadar IgG 1494,95 AU/mL dan median 794,35 AU/mL. Sebaran data dominan pada kelompok dengan kebiasaan olahraga (64,1%), frekuensi olahraga kurang ideal (33,3%), jenis olahraga aerobik (59%), intensitas olahraga ringan (46,2%), dan durasi olahraga sangat lama (20,5%). Tidak diperoleh hubungan yang signifikan antara kebiasaan olahraga (frekuensi, jenis, intensitas dan durasi olahraga) dengan respon imun pasca vaksinasi.
EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW Amanda Putri, Khairunnisa Rizqika; Lusiana, Evi; Theodorus; Rosdah, Ayeshah Augusta; Harahap, Debby Handayati; Larasati, Veny
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.453

Abstract

Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms.
Effectiveness of Cherry Tomato Extract in Gel Form to Accelerate the Healing Process of Excision Wounds in Wistar White Rats Fertilita, Soilia; Zulfadli, Muhammad; Larasati, Veny; Rasyid, Riana Sari Puspita; Argentina, Fifa; Tanta, Yudhi; Athiah, Medina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.427-434

Abstract

Cherry tomatoes (Solanum lycopersicum L. var. cerasiforme) are rich in antioxidants, particularly flavonoids and lycopene, which help reduce free radicals and promote wound healing. Flavonoids exhibit anti-inflammatory, antioxidant, antibacterial, and antidiabetic properties. They enhance wound contraction, collagen deposition, granulation tissue formation, and epithelialization in wound healing. This study evaluates the efficacy of cherry tomato extract gel in accelerating excision wound healing in Wistar rats. This in vivo experimental study used a post-test control group design. Twenty-five 2–3-month-old Wistar rats with excision wounds were treated with cherry tomato extract gel or controls. The five groups included a positive control (NaCl), a negative control (CMC-Na gel), and treatment groups receiving 8%, 12%, or 16% extract gel. Wound size was measured on days 3, 5, 7, and 9, with data analyzed using One-Way ANOVA and post hoc tests. The extract-treated groups exhibited nearly complete wound closure by day 9. The wound size of the treatment groups significantly differed from the control groups (p<0.05). Cherry tomato extract gel significantly accelerates wound closure at 8%, 12%, and 16% concentrations, with the best results observed at 16% (p<0.05), surpassing even the positive control. The 16% extract gel group demonstrated the most effective wound healing. Cherry tomato extract gel significantly enhances wound healing, with the 16% concentration demonstrating the most effective acceleration of wound closure. These findings suggest that cherry tomato extract gel, particularly at 16%, holds promise as a potent wound-healing agent.
Pengembangan Bahan Alam Dari Siput Gonggong (Laevistrombus Sp.) Untuk Penyembuhan Luka: Tinjauan Histologis Fadilah, Rizka; Hafy, Zen; Larasati, Veny
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62261

Abstract

Penyembuhan luka merupakan proses biologis kompleks yang melibatkan fase inflamasi, proliferasi, dan remodeling jaringan. Pemanfaatan bahan alami dari laut, seperti siput gonggong (Laevistrombus sp.), menawarkan potensi besar sebagai agen penyembuh luka karena kandungan senyawa bioaktifnya yang memiliki aktivitas antimikroba, antiinflamasi, dan antioksidan. Penelitian ini bertujuan untuk meninjau potensi ekstrak siput gonggong dalam mempercepat penyembuhan luka melalui analisis terhadap kandungan bioaktif, mekanisme kerja, dan bukti histologis. Kajian dilakukan secara sistematis terhadap literatur dari PubMed, ScienceDirect, Google Scholar, dan Scopus dalam lima tahun terakhir hingga April 2025, dengan fokus pada aktivitas biologis moluska laut dan aplikasinya pada regenerasi jaringan kulit. Hasil tinjauan menunjukkan bahwa siput gonggong mengandung protein histon H2A, peptida antimikroba (AMPs), flavonoid, alkaloid, dan saponin yang berperan dalam menekan sitokin proinflamasi (TNF-α, IL-6), meningkatkan sitokin antiinflamasi (IL-10), serta menstimulasi proliferasi fibroblas, angiogenesis, dan sintesis kolagen melalui jalur NF-κB, PPAR-γ, dan TGF-β/Smad. Secara histologis, senyawa ini mempercepat reepitelisasi dan meningkatkan deposisi kolagen pada jaringan luka. Dengan demikian, ekstrak siput gonggong memiliki potensi besar sebagai bahan dasar alami untuk pengembangan produk dermatologis dan farmasi yang aman, efektif, serta berkelanjutan.
Formulasi Masker Peel Off Nano Dari Ekstrak Teh Hijau (Camelia sinensis) Pagar Alam Dengan Aktivitas Anti Aging Mulyani, Laida Neti; Dwi, Handayani; Larasati, Veny; Agustiarini, Vitri; Margiati, Asih
JURNAL FARMASI GALENIKA Vol 9 No 3 (2022): Jurnal Farmasi Galenika Vol 9 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i3.240

Abstract

Pagar Alam merupakan salah satu daerah produsen teh dengan kualitas ekspor salah satunya adalah Teh Hijau. Tanaman ini dapat dimanfaatkan sebagai sumber antioksidan karena kandungan senyawa polifenol golongan katekin yang tinggi. Seperti penelitian yang dilakukan oleh Tita (2013) menunjukkan bahwa kandungan antioksidan dalam ekstrak Teh Hijau 3,17μg/mL. Berdasarkan hal tersebut ekstrak teh hijau sangat potensial untuk dikembangkan menjadi suatu sediaan kosmetika dengan aktivitas anti aging. Bentuk sediaan kosmetika yang dapat dikembangkan adalah masker gel peel off. Nanoteknologi pada produk kosmetika akan memberika kelebihan seperti kemampuan penetrasi ke kulit lebih efektif, pelepasan senyawa aktif dalam kosmetika yang lebih terkontrol, stabilitas yang tinggi, penargetan yang spesifik serta beberapa penelitian menunjukkan bahwa teknologi in mampu memperbaiki tekstur kulit dan merangsang pertumbuhan kolagen dengan menangkal radikal bebas. Oleh karna itu pada penelitian ini akan dilakukan enkapsulasi dan karakterisasi ekstrak etanol teh hijau (Camellia sinensis) serta formulasi serta evaluasi sebagai masker gel peel off dengan aktivitas anti-aging melalui uji aktivitas antioksidan dengan metode peredaman DPPH. Tahapan dan Metode yang dilakukan untuk mencapai tujuan pada penelitian ini antara lain esktraksi dengan UAE, identifiksi dan skrining fitokimia ekstrak, uji aktivitas antioksida ekstrak secara invitro dengan metode DPPH. Selanjutnya ekstrak di enkapsulasi dan dikarakterisasi ukuran partikel, PDI, transmitan, zeta potensialnya. Nano-ekstrak the hijau ditentukan aktivitas antioksidannya dan selanjutnya dilakukan formulasi pada nano-ekstrak serta dilakukan evaluasi dari sediaan yang dibuat. Berdasarkan hasil ekstraksi teh hijau (Camellia sinensis) Pagar Alam dengan pelarut ethanol dan metode UAE diperoleh rendemen sebesar 10,26% dengan kandungan senywa flavonoid, alkaloid, steroid, tannin yang menunjukkan aktivitas anitoksidan dengan nilai IC50 sebesar 98,6 µg/mL. Hasil enkapsulasi ekstrak menggunakan metode gelasi ionik dengan matriks Kitosan-TPP menunjukkan ekstrak nano-The Hijau memilik ukuran partikel 831,2 nm dengan nilai PDI 0,72 dan zeta Potensial 24,9 mV. Nano ekstrak Teh Hijau yang telah dienkapsuli menunjukkan peningkatan aktivitas antioksidan dengan nilai IC50 sebesar 6,51 µg/mL. Formulasi dan evaluasi masker Gel peel off nano-ekstrak teh hijau menunjukkan masker gel peel off memenuhi persyaratan dengan parameter sifat organoleptis, viskositas, daya sebar, waktu kering, pH yang masuk dalam rentang. Berdasarkan hal tersebut diatas dapat disimpulkan bahwa nano ekstra dengan aktivitas antioksidan telah berhasil dienkapsulasi dan diformulasikan sebagai sediaan Masker pel peel off yang berpotensi untuk dikembangkan sebagai suatu masker sebagai Anti aging.
TINJAUAN SISTEMATIS HISPATOLOGI GOUT ARTRITIS: PERAN SEL IMUN DALAM PROSES INFLAMASI DAN KERUSAKAN JARINGAN Larasati, Veny; Parisa, Nita; Valentino, Albert Amadeus; Diba, Msy. Farah
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 4 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i4.2210

Abstract

Gout arthritis is a joint inflammation caused by increased uric acid levels, leading to the formation of monosodium urate (MSU) crystals. The study aimed to deepen the understanding of the role of MSU crystals in triggering both acute and chronic inflammatory responses, as well as the formation of tophi, which damage joint and bone tissues. The method used is the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The reviewed articles were obtained from the Science Direct, Semantic Scholar, and PubMed databases using the keywords “Gout Arthritis,” “Histopathology,” “Inflammation,” and “Tophus.” The publication period was limited to 2019-2024. Out of 745 articles found, 12 were selected based on inclusion criteria, which included experimental, observational, and case study reports. The results show that MSU crystals induce inflammation through the infiltration of inflammatory cells such as neutrophils and macrophages. In chronic Gout, the formation of tophi, granulomatous lesions with a crystalline core, leads to bone and joint destruction. Understanding the histopathological aspects is crucial for more accurate diagnosis and more effective management of Gout arthritis. The progression of the disease is related to acute and chronic inflammation, as well as the destructive effects of tophi on joints and bones. In conclusion, MSU crystals play a significant role in triggering inflammation and tissue damage in Gout arthritis, and understanding histopathology can improve diagnostic accuracy and therapeutic efficacy.
Co-Authors A, Rafdi A, Rafdi Agustiarini, Vitri Agustin, Berliana Agustin, Berliana Ali, Defa Agripratama Amanda Putri, Khairunnisa Rizqika Anak Agung Gde Budhiarta Andre Saputra Angelina N. Ricardo Argo Fauzan Athiah, Medina Ayeshah A Rosdah Berliana Agustin Bintang Arroyantri P Bintang Arroyantri Prananjaya Debby Handayati Harahap Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Handayani Dwi, Handayani Egi Nabila Eka Febri Zulissetiana Eka Febri Zulissetiana Emirzon, M Afif Baskara Emirzon, M Afif Baskara Fadilah, Rizka Fertilita, Soilia Fifa Argentina Hadani, M Hasnawi Hadani, M Hasnawi Jayawarsa, A.A. Ketut Kemas M. Yakub Laida Neti Mulyani M, Haekal M, Haekal Margiati, Asih Mayang Indah Lestari Muhammad Farhan Muhammad Irsan Saleh Mulyani, Laida Neti Nita Parisa Noer Rahmat Lubis Phey Liana Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Rafif Shidq Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Riana Sari Puspita Rasyid Riska Mareta Rizani Amran Rohan Sabloak Rohan Sabloak S, Novizar S, Novizar Soilia Fertilita Soilia Fertilita Sri Nita Stevanus E. Handrawan Susilawati Susilawati Susilawati Susilawati Susilawati Tanta, Yudhi Theodorus Tri Suciati Tri Suciati Trisnawaty Trisnawaty Trisnawaty Valentino, Albert Amadeus Wimpie I Pangkahila Yakub, Kemas M Yakub, Kemas M Zen Hafy Ziske Maritska Zulfadli, Muhammad