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All Journal Jurnal Sain Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Enny Rohmawaty
Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Acute Anti-Inflammatory Study by Oral Administration of Cherry Leaf (Muntingia Calabura L.) Infusion in Inflammation-induced Wistar Strain White Rats (Rattus Norvegicus) Ramadhan, Putra; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.92910

Abstract

Inflammation is a response of the body’s defense system in preparation for tissue repair. Acute inflammation is characterized by heat, redness, pain, and formation of edema. Acute inflammation involve the realese of inflammatory mediators. Muntingia calabura is a herbal plant commonly used as an anti-inflammatory medicine containing bioactive coumpounds such as flavonoids, triterpenoids, and alkaloids that can inhibit the regulation of inflammatory mediators. This study aims to determine the anti-inflammatory activity and optimal dosage of M. calabura infusion in addressing acute inflammation in rats. The research method is a laboratory experiment using Wistar strain white rats that divided into 7 treatment groups: normal, negative control, positive control (sodium diclofenac and methylprednisolone), and M. calabura infusion at doses of 150, 300, and 600 mg/kg body weight. Each rats model induced with 1% carrageenan at 0.2 ml intraplantar, the formed edema is measured using a plethysmometer every 30 minutes for the first 3 hour and every 60 minutes for the following 3 hour. The result indicate that M. calabura infusion has acute anti-inflammatory effect on white rats model induced with carrageenan, with the most optimal dose being 600 mg/kg body weight, showing a pattern of anti-inflammatory activity similar to methylprednisolone.
COVID-19 Treatment Patterns in Patients with Acute Respiratory Failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022 Rohmawaty, Enny; Sumardi, Aklila Qurrota Aini; Kulsum, Iceu Dimas
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

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Abstract

Acute respiratory failure is the most common complication and cause of death in COVID-19 patients. The COVID-19 medication has yet to be discovered. COVID-19 treatment guidelines are constantly being updated. This study aims to determine the COVID-19 treatment patterns in patients with acute respiratory failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022. This retrospective, descriptive study used systematic random sampling to examine medical records of COVID-19 patients with acute respiratory failure at Dr. Hasan Sadikin Central General Hospital between June 2021 and June 2022. Gender, age, length of stay, outcome, comorbidities, and pharmacological and non-pharmacological treatment data were analyzed by SPSS software. This study included 120 COVID-19 patients with acute respiratory failure, with the majority of patients are male (55.83%), 30–60 years old (55.83%), length of stay of 1–3 days (52.5%), and have disease severity at severe condition (43.33%) and one comorbidity (37.5%). Patients mostly received non-rebreathing oxygen mask (54.2%), antiviral remdesivir (83.3%), corticosteroid dexamethasone (76.7%), enoxaparin anticoagulants (61.7%), a combination of vitamin C, vitamin D, and multivitamins (45.8%), and two antibiotics (33.3%). Additional treatments include tocilizumab (0.8%), intravenous immunoglobulin (2.5%), and convalescent plasma (0.8%). Statistical analysis shows that patients who stay at the hospital longer, have less or no comorbidities, and are given oxygen therapy have a significant possibility of recovering. Treatments commonly prescribed to COVID-19 patients with acute respiratory failure are antivirals, corticosteroids, anticoagulants, vitamins, and antibiotics, while the administration of oxygen therapy has a significant probability of recovery. DOI: https://doi.org/10.29313/gmhc.v12i3.14073
Co-Authors Achadiyani Ade Nea Ade Zuhrotun Adyani, Kartika Amila Hanifan Muslimah Anita D. Anwar Arto Yuwono Soeroto Astrid Feinisa Khairani Bashari, Muhammad H. Bashari, Muhammad Hasan Bony Wiem Lestari Bony Wiem Lestari, Bony Wiem Cynthia Noviyanti Devani, Mochamad Dewi, Sumartini Elsa P. Pratiwi Hamdan, Syafinaz Hardisiswo Soedjana Hesti Lina Wiraswati Iceu D. Kulsum Iceu Dimas Kulsum Jose Arimathea Khairinisa, Miski A. Lazuardhi Dwipa Leni Lismayanti Muhammad Begawan Bestari Muslimah, Amila Hanifan Nenny Agustanti Nur Atik Pangastuti, Miranti Permana, Shenny S.S Putri Halleyana Adrikni Rahman Putri, Aufa A.D Rahmi Fauziah Rahmi Fauziah, Rahmi Rama Nusjirwan Ramadhan, Putra Rashmika Nambiar Rashmika Nambiar, Rashmika Resti Santika Rini Hendriani Ronny Lesmana Rosdianto, Aziiz M. Rosdianto, Aziiz Mardanarian Rudi Wisaksana Sabrina Munggarani Yusuf Sabrina Munggarani Yusuf Saragih, Winda A. M. Savira Ekawardhani Sharon Noor Alya Sudrajat, Ratu Z.A.P Sukmayani, Jasmine Y. Sumardi, Aklila Qurrota Aini Syafinaz Hamdan Usman, Hermin A. Wahyuni, Indah S. Widad Aghnia Shalannandia Wijaya, Muhammad Palar Yoga Windhu Wardhana Yunivita, Vycke Yusuf, Muchamad R.A