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All Journal Jurnal Sain Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Enny Rohmawaty

Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran, Bandung

Author-ID : 363411

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Differences of Clinical and Laboratory Presentation in Positive and Negative Acid Fast Bacilli Pulmonary Tuberculosis Patients Amila Hanifan Muslimah; ArtoYuwono Soeroto; Enny Rohmawaty
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.195 KB)

Background: Based on bacteria status, tuberculosis is classified into positive and negative acid fast bacilli. This study was conducted to determine the differences of clinical and laboratory presentation in positive and negative acid fast bacilli pulmonary tuberculosis patients.Methods: This study was an observational analytic study with a cross-sectional approach which used 338 medical records of patients with pulmonary tuberculosis at Direct Observational Treatment Short-course(DOTS) clinic Dr. Hasan Sadikin General Hospital from January to December 2012. Data collected were clinical and laboratory presentation for analytic study. Data about comorbid were collected for descriptive data.Results: From 338 medical records, 223 were medical records of patients with pulmonary tuberculosis and 105 medical records of patients with comorbid. Twenty (18.01%) comorbid were Human Immunodeficiency Virus (HIV). Acid fast bacilli negative was more (121, 51.9%) than acid fast bacilli positive (112, 48.1%). Differences of laboratory presentation were found in hemoglobin count (p=0.037), red blood cell count (p=0.022), and erythrocyte sedimentation rate (p=0.006) and not found in white blood cell count (p=0.073), thrombocyte count (p= 0.766), serum glutamic oxaloacetic transaminase (p=0.169), and serum glutamicpyruvic transaminase (p=0.309). Difference of clinical manifestation was not found in fever (p=1), cough (p=0.608), night sweats (p=0.09), dyspnea (p=0.210), and weight loss (p=0.269).Conclusions: Differences between acid fast bacilli positive and negative are found in hemoglobin, red blood cell, and erythrocyte sedimentation rate laboratory examination. The highest comorbid of pulmonary tuberculosis patient is HIV. [AMJ.2016;3(2):286–5]DOI: 10.15850/amj.v3n2.786

Description of Treatment Outcomes among Pulmonary Tuberculosis Patients in Bandung City in 2014 Syafinaz Hamdan; Enny Rohmawaty; Bony Wiem Lestari
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.584 KB)

Background: Pulmonary Tuberculosis (pulmonary TB) is an infectious lung disease which is still a major health problem in the world. In Indonesia, pulmonary TB treatment outcomes are monitored and assessed in Directly Observed Treatment Short Course (DOTS) as an indicator of national TB control program performance. Therefore, the study was conducted to determine the treatment outcomes among pulmonary TB patients in Bandung City.Methods: This cross-sectional study was conducted using secondary data. The sample sizes were 1,598 pulmonary TB patients taken by total sampling with data collected from TB Registration database of Bandung city at Infectious Disease Control Unit, Bandung City Health Office (Unit Kontrol Penyakit Menular, Dinas Kesehatan Kota Bandung) from January to December 2014. The treatment outcomes were classified as successful (cured and treatment completed) and unsuccessful (failed, defaulted, and died).Results: Out of the 1,598 TB patients, most of the respondents were male, aged 15–24 years old and from Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas) and hospital. A total of 1,008 treatments (63.08%) were cured, 292 (18.27%) were completed, 47 (2.94%) were failed, 211 (13.21%) were defaulted, and 40 (2.50%) were died. Total of transferred outpatients were 134 and not considered as treatment outcome.Conclusions: From the results, it can be concluded that 81.35% and 18.65% were considered as successful and unsuccessful outcome respectively, thus, did not achieve WHO target of 85%. Therefore, DOTS program implemented in Bandung City should be reviewed to improve success rate of the treatment outcome.

Hypertension Treatment and Control in Older Adult at Tanjung Sari Primary Health Care Rahmi Fauziah; Enny Rohmawaty; Lazuardhi Dwipa
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Background: Hypertension is considered as a major health problem in Indonesia, especially in older adult population because of its prevalence increases by age. Treatment strategy and control management of hypertension in Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas) as primary health care should be enhanced to overcome this issue. This study aimed to describe the pattern of antihypertensive agent in older adults.Methods: This was a descriptive study with total sampling method for data collection. Data were collected from medical record of older adult patients with diagnosis of hypertension at Puskesmas Tanjung Sari from January to December 2013. The variables observed were gender, number of visits, the degree of hypertension, types of antihypertensive drug, combinations of antihypertensive drugs, and blood pressure control.Results: The number of older adults with hypertension was 180 people. Some of which, 120 women (66.7%) participated, 152 (84.4%) had hypertension stage 2, 100 (55.6%) had just one visit, and 80 (44.4%) had more than one visit. Among 80 participants with more than one visit, 8 had achieved target blood pressure. There were 166 participants (92.2%) who received single antihypertensive agent (captopril was given the most), and 14 participants (7.8%) who received the combination of two antihypertensive agent (combination of captopril and HCT (hydrochlorothiazide)) were given the most).Conclusions: More than 75% of older adult with hypertension have stage 2 hypertension and are treated by single antihypertensive agent. Ninety percent of the patient have uncontrolled blood pressure. [AMJ.2016;3(1):17–21] DOI: 10.15850/amj.v3n1.699

Efek Samping Obat Antituberkulosis Kategori I dan II Pasien Tuberkolosis Paru Dewasa di Rumah Sakit Hasan Sadikin Elsa P. Pratiwi; Enny Rohmawaty; Iceu D. Kulsum
Indonesian Journal of Clinical Pharmacy Vol 7, No 4 (2018)
Publisher : Universitas Padjadjaran

Terapi tuberkulosis (TB) menggunakan beberapa antibiotik yang sering diberikan dalam Kombinasi Dosis Tetap (KDT) kategori I dan II berdasarkan Directly Observed Treatment Short-course (DOTS). Kombinasi berbagai jenis obat antituberkulosis (OAT) dan durasi terapi yang lama bisa menimbulkan efek samping. Tujuan penelitian ini adalah untuk mengetahui gambaran dan frekuensi efek samping OAT kategori I dan II. Penelitian cross-sectional ini mengambil data dari rekam medis pasien TB paru dewasa di Klinik DOTS Rumah Sakit Dr. Hasan Sadikin Bandung, Indonesia, pada periode Juli 2015–Juni 2016. Data yang diambil adalah jenis TB, jenis OAT, efek samping dan waktu kemunculan efek samping. Dari 178 pasien, 27 pasien (15,2%) mengalami efek samping. Jumlah pasien dengan OAT kategori I yang mengalami efek samping sebanyak 22 pasien, sedangkan OAT kategori II sebanyak 5 pasien. Efek samping terbanyak adalah hepatotoksisitas. Efek samping di kategori I paling banyak adalah hepatotoksisitas (52%) sedangkan di kategori II frekuensinya sama yaitu 20% yang terdiri dari hepatotoksisitas, gangguan gastrointestinal, ruam dan gatal, gangguan neurologi dan gagal ginjal. Efek samping pada kategori I banyak terjadi di bulan pertama (48%), sedangkan kategori II banyak terjadi di bulan pertama dan kedua yang masing-masing adalah 40%. Efek samping tidak berhubungan dengan usia dan jenis kelamin (nilai p>0,05). Kesimpulan penelitian ini adalah kejadian efek samping OAT kategori I dan II bervariasi dan terdapat 27 pasien yang mengalami satu atau lebih efek samping dengan efek samping terbanyak adalah hepatotoksisitas.Kata Kunci: Efek samping, obat antituberkulosis, tuberkulosis paru Adverse Reactions of Category I and II Regimens of Anti-tuberculosis Drugs among Adult Pulmonary Tuberculosis Patients in Hasan Sadikin General HospitalAbstractAnti-tuberculosis therapy (ATT) with multiple antibiotics, administered as category I and II regimens fixed dose combination (FDC) which based on Directly Observed Treatment Short-course (DOTS) is commonly used. Since the process of this treatment is long-term and consists of multidrug, adverse reaction may occur. The aim of this study was to find the description and frequency of adverse reactions during the therapy of category I and II regimens of ATT. This cross-sectional study used data which was taken from adult pulmonary TB medical record at DOTS clinic of Hasan Sadikin General Hospital, Bandung, Indonesia, in the period of July 2015–June 2016. The data consisted of type of TB, drug choice, adverse effect and the time of emergence. Among 178 patients, 27 patients (15.2%) experienced adverse effects which consisted of 22 patients in category I regimens and 5 patients in category II regimens. The majority of adverse effects is hepatotoxicity. Adverse effects occurred in category I regimens mostly was hepatotoxicity (52%) and in category II regimens were hepatotoxicity, gastrointestinal disorder, skin reactions, neurological disorder and renal failure, with each frequency was 20%. Adverse effects in category I regimens mostly occurred in first month (48%) and in category II regimens mostly occurred in first and second month, with both frequencies were 40%. Side effects were not related to age and sex (p-value >0.05). The conclusion of this study is there were various pattern of adverse reactions of category I and II regimens of ATT. A total of 27 patients experienced one or more adverse reactions, the most frequent reaction was hepatotoxicity.Keywords: Adverse effects, anti-tuberculosis drugs, pulmonary tuberculosis

Snakebites and the Effect of Serum Anti Bisa Ular (SABU) Antivenom at Dr. Hasan Sadikin General Hospital Bandung, Indonesia: an Overview Period 2015–2019 Sharon Noor Alya; Enny Rohmawaty; Achadiyani Achadiyani; Muhammad Hasan Bashari; Hardisiswo Soedjana
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2392

Background: Snakebite is considered a global health issue, especially in the Southeast Asian region. However, data regarding snakebite cases in Indonesia are still very limited. This study aimed to explore the venomous snakebite cases and the serum anti bisa ular (SABU) antivenom effect in treating venomous snakebite caused by other than the snake species indicated in currently available SABU antivenom formulas.Methods: The analytical descriptive method with a cross-sectional study design was conducted in 2021 using a total sampling from the medical records of 63 patients diagnosed with snakebite at Dr. Hasan Sadikin General Hospital Bandung from 2015 to 2019. Characteristics of patients, clinical manifestation, and correlation between snakes species and outcomes after treatment with or without administration of SABU antivenom were collected.Results: Out of 63 patients, males (79%) were predominant with an average age of 39 years. Fifty-six patients arrived at the Emergency Room less than 24 hours after the occurrence (89%). Most cases were categorized as grade 2 (41.%) where the upper extremities were commonly bitten the body area (64%). Edema (83%) was the most common manifestation. There was no correlation between snake antivenom administered to a specific snake species and the stated outcome (p=0.053), meaning that SABU antivenom might be an effective alternative to treat more types of snakebites.Conclusions: Snakebites are most common in males, attack the upper extremities, categorized as grade 2 with edema. Administration of SABU antivenom provides the similar outcome compared to the group caused by the Javan spitting cobra, Banded krait, and Malayan pit viper.

Purple Sweet Potato Yogurt Affects Lipid Metabolism and Reduces Systemic Inflammation and Oxidative Stress in High Fat Diet Mice Astrid Feinisa Khairani; Nur Atik; Putri Halleyana Adrikni Rahman; Enny Rohmawaty; Cynthia Noviyanti; Resti Santika; Jose Arimathea; Widad Aghnia Shalannandia
The Indonesian Biomedical Journal Vol 14, No 3 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i3.1921

BACKGROUND: Purple sweet potato yogurt (PSPY) is a funtional food which is rich in anthocyanin and probiotics. However, the currently available data on its potentially protective effect on anthropometry, lipid metabolism, oxidative stress, and pro-inflammatory markers is very minimal, especially in mice. This study was performed to investigate those effects on balb/c mice models (Mus musculus) given a high-fat diet (HFD).METHOD: Balb/c mice were treated with or without standard diet, HFD, ethanol extract, yogurt, and PSPY according to the group. The changes of anthropometry were analyzed using Lee Index. After three months, the interscapular brown adipose tissue (iBAT) was morphologically observed with hematoxylin and eosin (H&E) staining. The blood serum was used for evaluation using cholesterol oxidase-peroxidase aminoantypirin (CHOD-PAP) for lipid profile, enzyme-linked immunoassay (ELISA) for tumor necrosis factor (TNF)-α and interleukin (IL)-6, and thiobarbituric acid reactive substance (TBARS) procedure for malondialdehyde (MDA).RESULT: Lee Index revealed a decrease in time (p<0.0001). The PSPY group showed a decrease in iBAT weight (p<0.05), lipid profiles including LDL (p<0.05) and total cholesterol (p>0.05), TNF-α and IL-6 (p>0.05), and MDA (p>0.05). Adipocytes’ density showed a significant increase (p=0.001). CONCLUSION: This research finding indicates that PSPY affects lipid metabolism and has a potential protective effect of reducing systemic inflammation and oxidative stress.KEYWORDS: anthocyanin, high-fat diet, lee index, lipid metabolism, oxidative stress, purple sweet potato yogurt, systemic inflammation

Prospect Study of Anti-inflammatory Activity by Identification of Muntingia calabura Leaf Infusion Permana, Shenny S.S; Yusuf, Muchamad R.A; Putri, Aufa A.D; Sukmayani, Jasmine Y.; Sudrajat, Ratu Z.A.P; Khairinisa, Miski A.; Wahyuni, Indah S.; Rohmawaty, Enny; Bashari, Muhammad H.; Lesmana, Ronny; Rosdianto, Aziiz M.
Pharmacology and Clinical Pharmacy Research Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i1.49774

Many diseases occur due to inflammation that is not handled properly. One of the feature of inflammation is swelling or edema. Inflammation can be handled with traditional medicine, such as Muntingia calabura L. (M. calabura L.) Pharmacologically, this plant extract is reported to have antipyretic, analgesic, anti-inflammatory, antioxidant, and antibacterial. Metabolite compound contained in M. calabura L. has the potential as an anti-inflammatory agent. The objective of this study is to ascertain the secondary metabolites contained in M. calabura L. leaves infusion. This experimental research method includes the simplicia making and infusion of M. calabura L. leaves by cold infusion and phytochemical screening. This study also showed that the infusion of M. calabura L. leaves contained flavonoids, alkaloids, and triterpenoids. Overall, the findings indicate potential as an anti-inflammatory agent that requires further investigation, specifically in preclinical testing.

Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.

COVID-19 Treatment Patterns in Patients with Acute Respiratory Failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022 Rohmawaty, Enny; Sumardi, Aklila Qurrota Aini; Kulsum, Iceu Dimas
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14073

Acute respiratory failure is the most common complication and cause of death in COVID-19 patients. The COVID-19 medication has yet to be discovered. COVID-19 treatment guidelines are constantly being updated. This study aims to determine the COVID-19 treatment patterns in patients with acute respiratory failure at Dr. Hasan Sadikin General Hospital Bandung in 2021–2022. This retrospective, descriptive study used systematic random sampling to examine medical records of COVID-19 patients with acute respiratory failure at Dr. Hasan Sadikin Central General Hospital between June 2021 and June 2022. Gender, age, length of stay, outcome, comorbidities, and pharmacological and non-pharmacological treatment data were analyzed by SPSS software. This study included 120 COVID-19 patients with acute respiratory failure, with the majority of patients are male (55.83%), 30–60 years old (55.83%), length of stay of 1–3 days (52.5%), and have disease severity at severe condition (43.33%) and one comorbidity (37.5%). Patients mostly received non-rebreathing oxygen mask (54.2%), antiviral remdesivir (83.3%), corticosteroid dexamethasone (76.7%), enoxaparin anticoagulants (61.7%), a combination of vitamin C, vitamin D, and multivitamins (45.8%), and two antibiotics (33.3%). Additional treatments include tocilizumab (0.8%), intravenous immunoglobulin (2.5%), and convalescent plasma (0.8%). Statistical analysis shows that patients who stay at the hospital longer, have less or no comorbidities, and are given oxygen therapy have a significant possibility of recovering. Treatments commonly prescribed to COVID-19 patients with acute respiratory failure are antivirals, corticosteroids, anticoagulants, vitamins, and antibiotics, while the administration of oxygen therapy has a significant probability of recovery.

Clinical Features of Drug Eruption in An Indonesian Tertiary Hospital Rohmawaty, Enny; Devani, Mochamad; Pangastuti, Miranti
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3839

Drug eruption is a response to drugs undergoing sensitization, which is mediated by the immune system. Clinical features of drug eruptions, such as maculopapular drug eruption, Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are known as common drug reactions. This study aimed to explore the characteristics and clinical features of patients with drug eruptions at the Department of Dermatology and Venereology of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This retrospective descriptive study used data from the department from patients treated between January 1, 2014 and December 31, 2018. Data were analyzed using Excel and SPSS software. In this study, 200 subjects were included, mainly consisting of female subjects (50.5%) and aged between 19 and 65 (89%). Maculopapular drug eruption (45%) was the most typical clinical presentation, followed by SJS/TEN (37.5%), and DRESS (3%). The analgesics and non-steroidal anti-inflammatory drugs (NSAID) group was the most commonly suspected causative drug (36.91%), with paracetamol (29.18% of total drugs consumed) as the most frequent NSAID causing the eruption. This was followed by the antibiotic-type drugs group (36.48%), with cotrimoxazole (9.87% of total drugs consumed) as the most common one. So, maculopapular drug eruption is the most common clinical presentation of drug eruption, with analgesics and non-steroidal anti-inflammatory drugs (NSAID) class as the most suspected causative drug. Further investigations are needed to get the accurate result.

Co-Authors Achadiyani Ade Nea Ade Zuhrotun Adyani, Kartika Amila Hanifan Muslimah Anita D. Anwar Arto Yuwono Soeroto Astrid Feinisa Khairani Bashari, Muhammad H. Bashari, Muhammad Hasan Bony Wiem Lestari Bony Wiem Lestari, Bony Wiem Cynthia Noviyanti Devani, Mochamad Dewi, Sumartini Elsa P. Pratiwi Hamdan, Syafinaz Hardisiswo Soedjana Hesti Lina Wiraswati Iceu D. Kulsum Iceu Dimas Kulsum Jose Arimathea Khairinisa, Miski A. Lazuardhi Dwipa Leni Lismayanti Muhammad Begawan Bestari Muslimah, Amila Hanifan Nenny Agustanti Nur Atik Pangastuti, Miranti Permana, Shenny S.S Putri Halleyana Adrikni Rahman Putri, Aufa A.D Rahmi Fauziah Rahmi Fauziah, Rahmi Rama Nusjirwan Ramadhan, Putra Rashmika Nambiar Rashmika Nambiar, Rashmika Resti Santika Rini Hendriani Ronny Lesmana Rosdianto, Aziiz M. Rosdianto, Aziiz Mardanarian Rudi Wisaksana Sabrina Munggarani Yusuf Sabrina Munggarani Yusuf Saragih, Winda A. M. Savira Ekawardhani Sharon Noor Alya Sudrajat, Ratu Z.A.P Sukmayani, Jasmine Y. Sumardi, Aklila Qurrota Aini Syafinaz Hamdan Usman, Hermin A. Wahyuni, Indah S. Widad Aghnia Shalannandia Wijaya, Muhammad Palar Yoga Windhu Wardhana Yunivita, Vycke Yusuf, Muchamad R.A

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