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All Journal Jurnal Gizi dan Pangan JURNAL GIZI INDONESIA JURNAL SISTEM INFORMASI BISNIS Journal of Nutrition College Journal of Biomedicine and Translational Research agriTECH Jurnal Media Gizi Indonesia (MGI) Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Medical Laboratory Technology Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Journal of Health and Nutrition Research Poltekita: Jurnal Ilmu Kesehatan Jurnal Info Kesehatan
Ninik Rustanti
Program Studi Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang 50275
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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The Association Between Intake of Saturated, Monounsaturated, and Polyunsaturated Fatty Acids with Bifidobacterium Abundance Among Obese Adults Without Metabolic Syndrome Rustanti, Ninik; Sinthika, Euodia; Lestari, Endang Sri
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.26630

Abstract

Background: Bifidobacterium is a key gut microbe that contributes to host metabolism, immunity, and intestinal integrity through SCFA production. Dietary fats are known to modulate gut microbiota, but evidence on the effects of specific fat types—SFA, MUFA, PUFA—on Bifidobacterium in obese adults without metabolic syndrome remains limited.Objectives: To examine the association between intake of dietary fat types and the abundance of Bifidobacterium among obese adults without metabolic syndrome.Methods: A cross-sectional study was conducted in Semarang, Indonesia, involving 60 obese adults (BMI ≥ 25 kg/m²) without metabolic syndrome. Dietary intake was assessed using a validated SQ-FFQ, and Bifidobacterium abundance was quantified using qPCR from fecal samples. Correlation and multivariate linear regression - adjusted for age, sex, and energy intake - were used to assess associations between variables.Results: Saturated fat intake was moderately and negatively correlated with Bifidobacterium levels (r = –0.464; p < 0.001), while total fat intake also showed a statistically significant, but weaker, negative correlation (r = –0.346; p = 0.007). PUFA intake showed a weak but statistically significant positive correlation (r = 0.269; p = 0.037), whereas MUFA intake was not significantly associated. Multivariate analysis identified SFA as an independent negative predictor of Bifidobacterium abundance.Conclusion: High intake of saturated fat is associated with decreased Bifidobacterium levels even in obese adults without metabolic syndrome, whereas PUFA may exert modest protective effects. These findings suggest that the type of dietary fat, rather than its quantity, plays a key role in modulating gut microbiota composition.
Risk Factors for Under-Five Children Severe Acute Malnutrition (SAM) in Grobogan Regency Nuryanto, Nuryanto; Sidhin, Syaharani; Fala, Etika Nurul; Nissa, Choirun; Candra, Aryu; Purwanti, Rachma; Fitranti, Deny Yudi; Rustanti, Ninik; Habibi, Nur Ahmad
JURNAL INFO KESEHATAN Vol 22 No 4 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss4.1494

Abstract

Severe Acute Malnutrition (SAM) is a major health risk for children under five. Various factors, such as poor food intake, infections, family size, healthcare participation, maternal nutrition knowledge, and parenting practices, contribute to SAM. However, no studies have specifically examined these factors in under-five children in Grobogan Regency. This study aims to analyze the risk factors associated with severe acute malnutrition among children under five years old in Grobogan Regency. The study employed a quantitative case-control design involving children aged 0-59 months in Grobogan Regency, with 11 children with Severe Acute Malnutrition (SAM) as the case group obtained through total sampling, and 11 well-nourished children as the control group selected via matching. Key variables examined included energy, protein, fat, and carbohydrate intake, as well as infectious diseases, family size, participation in posyandu, maternal nutrition knowledge, and parenting practices. Descriptive analysis outlined the subjects and variables, with bivariate analysis using the Chi-Square test at a 95% confidence level (α=0.05). The results study show that the statistical analysis indicated that inadequate energy intake was significantly associated with SAM (p=0.008, OR=26.667), suggesting that children under five with insufficient energy intake are 26.667 times more likely to experience severe acute malnutrition compared to those with adequate energy intake. In contrast, adequate intake of protein, fat, and carbohydrates, as well as factors such as infectious diseases, family size (p=0.080), participation in posyandu (p=1.000), maternal nutrition knowledge (p=0.476), and parenting practices (p=0.198), did not demonstrate significant associations with SAM among these children. The conclusion is adequate energy intake has been identified as a significant risk factor for SAM among under-five children in Grobogan Regency. Conversely, factors such as adequate intake of protein, fat, and carbohydrates, infectious diseases, family size, participation in posyandu, maternal nutrition knowledge, and parenting practices were not recognized as significant risk factors.
Effects of fermentation duration on α-glucosidase activity and vitamin C in temu mangga kombucha Zebua, Edarni; Maharani, Nani; Anjani, Gemala; Rustanti, Ninik; Al-Baari, Ahmad Ni’matullah
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 6, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(6).444-454

Abstract

ABSTRAKLatar Belakang: Diabetes Mellitus Tipe 2 (DMT2) merupakan gangguan metabolik yang semakin meningkat di Indonesia, ditandai dengan tingginya kadar gula darah akibat gangguan fungsi sel β pankreas. Pangan fungsional yang memiliki sifat antioksidan dan kemampuan menghambat enzim pencernaan karbohidrat, seperti kombucha, berpotensi mendukung pengelolaan DMT2.  Tujuan: Menganalisis aktivitas inhibisi enzim α-glukosidase dan kadar vitamin C pada kombucha temu mangga.  Metode: Penelitian eksperimental dilakukan di UPT Laboratorium Terpadu, Universitas Diponegoro, Semarang, mulai Agustus sampai November 2024, menggunakan rancangan acak lengkap dengan empat lama fermentasi (5, 7, 10, dan 14 hari), masing-masing diulang tiga kali. Aktivitas penghambatan enzim α-glukosidase dan kadar vitamin C dianalisis menggunakan spektrofotometri UV-Vis pada panjang gelombang 540 nm dan 265 nm. Data aktivitas inhibisi α-glukosidase dan kadar vitamin C dianalisis dengan ANOVA, jika hasil uji menunjukkan perbedaan signifikan (p<0,05) dilanjutkan uji Post Hoc Tukey untuk menentukan kelompok yang berbeda dan Kruskal Wallis digunakan jika data tidak berdistribusi normal.Hasil: Aktivitas penghambatan enzim α-glukosidase tertinggi diperoleh pada hari ke-14 fermentasi (75,84 ± 1,46%), menunjukkan penurunan signifikan dibandingkan kontrol (87,42 ± 0,96%). Kandungan vitamin C tertinggi ditemukan pada hari ke-5 fermentasi (2,06 ± 0,06 mg/100 mL), kemudian menurun seiring waktu fermentasi. Kesimpulan: Kombucha temu mangga menunjukkan potensi sebagai minuman fungsional yang mampu menghambat enzim α-glukosidase secara in vitro dan mengandung antioksidan yang relevan. Penelitian lanjutan diperlukan untuk menguji efektivitas dan keamanannya secara klinis pada manusia. KATA KUNCI : diabetes melitus; enzim α-glukosidase; kombucha; temu mangga (curcuma mangga); vitamin c  ABSTRACTBackground: Type 2 Diabetes Mellitus (T2DM) is a growing metabolic disorder in Indonesia, associated with impaired pancreatic β-cell function and elevated blood glucose levels. Functional foods with antioxidant and enzyme-inhibitory properties, like kombucha, may support T2DM management.Objective: To analyze the inhibition activity of the α-glucosidase enzyme and the vitamin C content in temu mangga kombucha.Methods: An experimental study was conducted in UPT Laboratory, Diponegoro University, Semarang, from August to November 2024., using a completely randomized design with four fermentation durations (5, 7, 10, and 14 days), each in triplicate. α-Glucosidase inhibition and vitamin C levels were assessed using UV-Vis spectrophotometry at wavelengths of 540 nm and 265 nm. The inhibition activity data of α-glucosidase and vitamin C levels were analyzed using ANOVA. If the test results showed significant differences (p<0.05), a Tukey Post Hoc test was conducted to determine the different groups, and Kruskal-Wallis was used if the data were not normally distributed.Results: The highest α-glucosidase inhibitory activity was observed on day 14 (75.84 ± 1.46%), showing a significant reduction compared to the control (87.42 ± 0.96%). The highest vitamin C content (2.06 ± 0.06 mg/100 mL) was detected on day 5, followed by a gradual decline with prolonged fermentation.Conclusion: Temu mangga kombucha exhibits promising in vitro α-glucosidase inhibitory potential and relevant antioxidant content. These findings suggest its potential as a dietary adjunct for T2DM management. However, in vivo studies are warranted to confirm its efficacy and safety in human subjects. KEYWORDS : α-glucosidase enzyme; diabetes mellitus; kombucha; temu mangga (curcuma mangga); vitamin cArticle submitted on January 31, 2025; Articles revised on February 20, 2025; Articles received on June 12, 2025; Articles available online on November 28, 2025
Co-Authors Adriyan Pramono Agung Dwi Prasetyo Agung Dwi Prasetyo, Agung Dwi Al-Baari, Ahmad Ni’matullah Andriana Murdi Hastuti Ani Margawati Anjani, Gemala Annisa Istiqomah, Annisa Aryu Candra Aulia, Salma Shafrina Avisha, Rosita Nur Ayu Rahadiyanti Ayu, Azzahra Mutiara Ayudya Luthfia Nintami Christanto, Monica Lemuela Deny Yudi Fitranti Dewi Marfu’ah Kurniawati Dewi, Sonia Kurnia Dhiyas, Ardhanareswari Dian Estiningtyas Dian Isti Cahyani, Dian Isti Diana Nur Afifah, Diana Nur Edarni Zebua Elvizahro Leiyla Endang Sri Lestari Endang Sri Lestari Etika Ratna Noer Fadhila, Farah Rosyihana Fala, Etika Nurul Firdha Ayu Trianie Fitri Wulandari Fitriyono Ayustaningwarno Hajar Surya Wardani Hardaning Ausiea Marantha Hartanti Sandi Wijayanti Hestin Rahmawati Ina Susanti Indah Mega Astuti Indriyanti, Risa Latifah Nur Aisiyah Magfirah, Ariel Maria Annisa Primawestri Marsella Temala Dewi Mukarromah, Tsamaroh Azzah Muthia Fauzan Nafsih, Vifin Zakiahtin Nani Maharani Nissa, Choirun Nur Afifah, Diana Nur Ahmad Habibi Nur Ilaika Zulfa Nurul Alam Sayekti Nuryanto Nuryanto . Nuryanto Nuryanto Oky Dwi Nurhayati Puspadani, Nurlina Rachma Purwanti Ramayani, Gita Ratih Paramastuti Ratna Ratna Rayyani Zaena Dini Resmi Unggul Pratiwi, Resmi Unggul Rozanah, Ishmah Safitri, Ulan Sidhin, Syaharani Sinthika, Euodia Sugiharto Suryaningrum, Trisna Ulil Albab Utami Harjantini, Utami Velicia, Velicia Yustitie, Normasari