Priyono, Harim
Departemen Telinga Hidung Tenggorok - Bedah Kepala Leher Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Dr Cipto Mangunkusumo Jakarta

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Journal : Paediatrica Indonesiana

Association between vitamin D deficiency and otitis media with effusion in children: a systematic review and meta-analysis Restuti, Ratna Dwi; Safitri, Eka Dian; Ranakusuma, Respati Wulansari; Sriyana, Ayu Astria; Priyono, Harim; Saleh, Rangga Rayendra; Marpaung, Dora A; Lazarus, Gilbert
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.419-29

Abstract

Background Vitamin D plays a crucial role in the regulation of inflammation. However, its effect on the development of otitis media effusion (OME), an inflammatory disease of the middle ear without signs of infection, remains largely unknown. Objective To assess the association between vitamin D deficiency and OME in children by systematic review and meta-analysis of the literature. Methods Eligible studies retrieved from PubMed, ProQuest, Embase, Cochrane databases and trial registries published up to 30 October 2022 were included in this review. The risk of bias of the included articles was assessed with the JBI Critical Appraisal Checklist for observational studies. The certainty of evidence was assessed with the Grading of Recommendations Assessment, Development and Evaluation framework. Results We included eight studies (six case-control and two cross-sectional studies) involving 1,114 children, of which four studies were eligible for meta-analysis due to the significant clinical heterogeneity. We found that vitamin D deficiency (defined as vitamin D concentration of 20 ng/mL or less, i.e., ?50 nmol/L) might increase the odds of developing OME by 66.0% (n=514; OR 1.66; 95%CI 1.09 to 2.54; I2=20%), albeit with a very low certainty of evidence. Conclusion There is a very low quality of evidence indicating that vitamin D deficiency is associated with the development of OME in children. Further large, high-quality cohorts and adjusting for confounding factors are warranted to confirm our findings, ideally by exploring the dose-response relationship between vitamin D concentration and the development of OME.
Co-Authors Afrina Yanti Ahmad Sulaeman Airlangga, Tri Juda Alia, Dina Alida Harahap Aminuyati Andre Iswara Anggina Diksita Ari Prayitno, Ari Arief, Wresty Arman, Fitri Ascobat, Purwantyastuti Ayu Astria Sriyana Ayu Astria Sriyana Bernadina Chyntia Carsantiningrum Bernie Endyarni Medise Bintang Napitupulu Brastho Bramantyo Cahyono, Arie Damayanti, Heditya Dewi Sumaryani Soemarko Dewo Aksoro Dini Widiarni Dora A Marpaung Eka Dian Safitri Eka Savitri Eka Savitri Fikri Mirza Putranto Giovanni Reynaldo Harahap, Juliandi Haryuna, Tengku Siti Hajar Hidayati, Anggi Puspa Nur Hidayatul Fitria Ika Dewi Mayangsari Indra Kusuma Indra Zachreini Indra Zachreini Indrati Suroyo Jenny Bashiruddin Jenny Bashiruddin Joedo Prihartono Juliandi Harahap Juliandi Harahap Kote Noordhianta Lazarus, Gilbert Lina Lasminingrum Mariska, Tara Candida Marpaung, Dora A Mayangsari, Ika Dewi Mayangsari, Ika Dwi Natasha Supartono Natasha Supartono Nyilo Purnami Prasandhya Astagiri Yusuf Pratamisiwi, Rindy Yunita Prihartanto, Joedo Priyanto, Suko Dwi Pryambodho Pryambodho Putri, Pingkan Permata Ranakusuma, Respati Ranakusuma, Respati Wulansari Rangga Rayendra Saleh Rangga Rayendra Saleh Ratna Dwi Restuti Respati Ranakusuma Respati Ranakusuma Respati W. Ranakusuma Restuti, Ratna Dwi Rianto Setiabudy Ruth Evlin Margaretha Safitri, Eka Dian Sagung Rai Indrasari Sagung Rai Indrasari Saleh, Rangga Rayendra Sari, Anita Amalia Selfiyanti Bimantara Setyo Handryastuti Sitohang, Gortap Soetjipto, Damayanti Sriyana, Ayu Astria Supartono, Natasha Suryati, Irma Susyana Tamin Susyana Tamin Tamin, Susyana Tantri, Aida Rosita Tjandra Manukbua Tjandra Manukbua Wahyuni, Luh Kurnia Warto, Nirza Widayat Alviandi Widodo, Dini Widiarni Yussy Afriana Dewi Yussy Afriana Dewi Zachreini, Indra Zizlavsky, Semiramis Zizlavsky, Semiramis