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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Journal of Issues in Midwifery Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Keperawatan (JKEP) Asian Journal of Health Research Jurnal Kedokteran Hewan Journal of Clinical Microbiology and Infectious Diseases
Sanarto Santoso
Fakultas Kedokteran Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Chemical Compounds and Antibacterial Activity of Thymus Vulgaris Leaves’ Ethanolic Extract Against Salmonella typhimurium: Thymus vulgaris Against Salmonella typhimurium Abousouh, Emad Khaleefah; Endharti, Agustina Tri; Santoso, Sanarto; Santosaningsih, Dewi
Journal of Tropical Life Science Vol. 14 No. 1 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.01.09

Abstract

Invasive non-typhoidal Salmonella is an important pathogen that causes life-threatening bloodstream infections. Antibiotic resistance in non-typhoidal Salmonella has emerged as a result of the increasing use of antibiotics; therefore, an alternative source of therapeutic agents is required. This study aimed to investigate the active compound and antibacterial activity of Thymus vulgaris leaves’ ethanolic extract against Salmonella typhimurium. Thin-layer chromatography was performed to identify the active compound in the ethanolic extract of T. vulgaris leaves. The antibiotic effect of the extract was carried out by agar dilution assay using the following concentrations: 0%, 2.5%, 5.0%, 7.5%, 10.0%, 12.5%, and 15.0% (w/v). Thymol and carvacrol were detected in the thin-layer chromatography. The minimum inhibitory concentration of the extract was 10.0% (w/v). In conclusion, T. vulgaris leaves’ ethanolic extract demonstrated antimicrobial activity against S. typhimurium. Further investigation is required to analyze the role of thymol and carvacrol as active compounds against S. typhimurium.
EKSPRESI PROTEIN ADHF36 STRAIN Salmonella Typhi DARI BEBERAPA DAERAH DI INDONESIA Kundera, I Nengah; A, Aulanniam; Santoso, Sanarto
Jurnal Kedokteran Hewan Vol 8, No 1 (2014): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i1.1248

Abstract

Penelitian ini bertujuan mengetahui ekspresi protein AdhF36 strain Salmonella Typhi, sebagai kajian kandidat vaksin berbasis molekul adesin. Strain yang digunakan pada penelitian ini bersumber dari Rumah Sakit Hasan Sadikin Bandung, Laboratorium Kesehatan Sulawesi Tengah, Palu, Rumah Sakit Udayana Denpasar, dan Rumah Sakit Saiful Anwar, Malang. Hasil penelitian menunjukkan bahwa sekitar 12 strain Salmonella Typhi tersebut mengekspresikan dan memiliki protein AdhF36. Hal ini memberikan gambaran umum bahwa protein AdhF36 potensial dikembangkan sebagai kandidat vaksin.
EKSPRESI PROTEIN ADHF36 PADA PERUBAHAN OSMOLARITAS SERTA pH LINGKUNGAN HIDUP SALMONELLA TYPHI SECARA IN VITRO Kundera, I Nengah; Santoso, Sanarto; a, Aulanniam; Winarsih, Sri
Jurnal Kedokteran Hewan Vol 6, No 1 (2012): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v6i1.351

Abstract

Penelitian ini bertujuan mengamati stabilitas ekspresi protein AdhF36 Salmonella typhi pada perlakuan osmolaritas dan pH dengan metodeeksperimen laboratorium-eksploratif. Hasil penelitian ini menunjukkan perbedaan ekspresi protein AdhF36 Salmonella typhi pada perlakuan osmolaritas dengan pH. Hasil SDS-PAGE menunjukkan bahwa pita protein AdhF36 tetap terekspresi pada perlakuan osmolaritas 50-350 mM, sebaliknya pita protein ini tidak terdeteksi pada perlakuan pH 4,5-6,0. Hal ini didukung oleh hasil uji Western Blot yang berhasil mendeteksi protein AdhF36 hanya pada perlakuan osmolaritas. Hasil ini membuktikan bahwa Salmonella typhi lebih toleran terhadap perubahan osmolaritas dibandingkan dengan pH.
Co-Authors A, Aulanniam A.A. Ketut Agung Cahyawan W Abousouh, Emad Khaleefah Agustina Tri Endharti Alvi Milliana Anggun Rindang Cempaka Aulanni'am, Aulanni'am Aulia Abdul Hamid Avin Ainur Fitrianingsih Bambang Rahardjo Bormasa, Pelpina Dewi Santosaningsih Dian Chusna Mufida Diyah, Nurima Erikawati, Dewi Gani, Agus A Hanifarizani, Rahma Dian I Nengah Kundera I Wayan Agung Indrawan Issiyah, Nurani Lailia Nur Rachma Laksmi Karunia Tanuwijaya M. Fendi Nur Yahya Maimun Z Arthamin, Maimun Z Mutaqin, Fadilah Ni Luh Putu HM Nur Sophia Matin Nurdiana Nurdiana Nurma Afiani Nurtjahjo Budi Santoso Nyoman Artha Megayasa, Nyoman Artha Prawiro, Sumarno Reto Regina Ayu Fristiyanti Retnoningsih, Dewi Roekistiningsih Roekistiningsih Safrina Dewi Ratnaningrum Sjoekoer M. Dzen Sri Winarsih Sumakto Sumakto Sumarno Sumarno Tina Handayani N Tinny Endang Hernowati Wahono, Cesarius Singgih Wisnu Barlianto