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All Journal Journal of Food and Pharmaceutical Science Natural Science: Journal of Science and Technology Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY YARSI Medical Journal Majalah Farmasetika Biosaintifika: Journal of Biology & Biology Education Jurnal Kefarmasian Indonesia
Ediati Sasmito
Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity Anwar, La Ode Muhammad; Sasmito, Ediati; Rasydy, La Ode Akbar; Ismoyowati, Tri Wahyuni; Hashim, Salma Hilmy Rusydi; Siregar, Rohani; Hutagaol, Emmelia Kristina; Bratajaya, Cicilia Nony Ayuningsih; Sartika, Aprilina; Sanjaya, Dandi; Rohmah, Hajar Nur Fathur; Ximenes, Joao Manuel Correia
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.26258

Abstract

Noni fruit containing polysaccharides, has the potential to be developed into pharmaceutical products such as SPF syrup. The content of noni fruit polysaccharides is known to increase the proliferation of T lymphocyte cells, the regulation of the immune system molecularly, especially with regard to antibodies (IgG), CD4+, and CD8+, is still not widely studied. The aim of this study was to assess the impact of SPF syrup on the modulation of immunoglobulin G (IgG) and T lymphocytes. The study was conducted on female Wistar rats aged 8-9 months, which were given SPF syrup orally at doses of 25, 50, and 100 mg/kgBB for 31 days. Mice were vaccinated against hepatitis B every week. Blood samples were taken on day 31 to measure IgG levels by the ELISA method and T cells (CD4+ and CD8+) by flow cytometry. The results showed that SPF administration had a significant effect on IgG levels (p<0.05), and there were no significant changes in T lymphocyte cells (CD4+, CD8+) (p>0.05). Histopathological examination showed that long-term induction of hepatitis B caused damage to the liver and kidney, but SPF did not affect the condition of these organs. SPF that contains polysaccharides can be an innovative component in immunostimulant formulations.
Morinda citrifolia Linn. Ethanolic-extract Improve Inflammation Condition in Acetic Acid-induced Colitis Ulcerative Mice Models Utami, Tri Fitri Yana; Sahid, Muhammad Novrizal Abdi; Sari, Ika Puspita; Sasmito, Ediati
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95065

Abstract

Ulcerative Colitis (UC) is a chronic inflammatory disorder affecting the colon, characterized by recurrent episodes and involving multifaceted etiological factors in its pathogenesis. This study aims to explore the pharmacological effect of Morinda citrifolia Linn. fruit ethanolic-extract (MFE) in UC. The UC mice model was induced using 2% acetic acid administered per-rectal. Subsequently, mice were categorized into six groups, comprising a normal control, negative control, positive control, and three MFE treatment groups (100mg/kgBW; 200mg/kgBW; 400mg/kgBW). Colitis severity was assessed by scoring system to obtain the Disease Activity Index (DAI) and Hematoxylin-Eosin (HE) staining. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was employed to determine the free radical scavenging activity. MFE exhibited notable antioxidant activity, with an IC50 value of 0,553 mg/ml. Notably, MFE administration led to a discernible reduction in DAI scores, with MFE treatment demonstrating improved inflammation condition compared to the negative control from day 6 through day 11. Furthermore, immune cell infiltration within colonic tissue was markedly attenuated in the MFE-treated group compared to the negative control group. Evaluation of colon tissue damage revealed scores of 5.7, 4.2, and 3 for MFE doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg, respectively, whereas the positive control group exhibited a score of 3, indicating superior tissue preservation. Notably, these scores contrasted starkly with the negative control group, which registered a damage score of 11.8. These findings exhibit the MFE potential as a therapeutic intervention for UC owing to its pharmacological properties, underscoring its potential as a natural remedy in UC management.
Co-Authors Adam Hermawan Agung Endro Nugroho Aini S., Aini Akhmad Khumaidi Annisa Novarina Cicilia Nony Ayuningsih Bratajaya Dandi Sanjaya Emmelia Kristina Hutagaol ERMAWATI, DIAN EKA Esha ND., Pramitha Evie Andriyani, Evie H., Muchammad Ika Puspita Sari Ikawati, Muthi' Ismoyowati, Tri Wahyuni Joko Santoso KD, Anggi Khairunnisa Sy La Ode Muhammad Anwar Maria Ulfah Meirizky Zulharini S Merlindasari, Dita Alfina Muchammad H., Muchammad mufrod mufrod ND., Pramitha Esha Nirmalasari Nirmalasari Putu UA., Ni Rasydy, La Ode Akbar Rikat Raksamiharja Rochmy Istikharah Rohmah, Hajar Nur Fathur Rumiyati, Rumiyati S., Aini Sahid, Muhammad Novrizal Abdi Salma Hilmy Rusydi Hashim Sartika, Aprilina Siregar, Rohani Sri Rahayu W., Sri Rahayu Susi Ari Kristina Triana Hertiani UA., Ni Putu Utami, Tri Fitri Yana W., Windhartono Ximenes, Joao Manuel Correia Yose V. Sagala, Yose Zainul Kamal