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All Journal Journal of Food and Pharmaceutical Science Natural Science: Journal of Science and Technology Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY YARSI Medical Journal Majalah Farmasetika Journal of Comprehensive Science Biosaintifika: Journal of Biology & Biology Education Jurnal Kefarmasian Indonesia
Ediati Sasmito
Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health

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Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity Anwar, La Ode Muhammad; Sasmito, Ediati; Rasydy, La Ode Akbar; Ismoyowati, Tri Wahyuni; Hashim, Salma Hilmy Rusydi; Siregar, Rohani; Hutagaol, Emmelia Kristina; Bratajaya, Cicilia Nony Ayuningsih; Sartika, Aprilina; Sanjaya, Dandi; Rohmah, Hajar Nur Fathur; Ximenes, Joao Manuel Correia
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.26258

Abstract

Noni fruit containing polysaccharides, has the potential to be developed into pharmaceutical products such as SPF syrup. The content of noni fruit polysaccharides is known to increase the proliferation of T lymphocyte cells, the regulation of the immune system molecularly, especially with regard to antibodies (IgG), CD4+, and CD8+, is still not widely studied. The aim of this study was to assess the impact of SPF syrup on the modulation of immunoglobulin G (IgG) and T lymphocytes. The study was conducted on female Wistar rats aged 8-9 months, which were given SPF syrup orally at doses of 25, 50, and 100 mg/kgBB for 31 days. Mice were vaccinated against hepatitis B every week. Blood samples were taken on day 31 to measure IgG levels by the ELISA method and T cells (CD4+ and CD8+) by flow cytometry. The results showed that SPF administration had a significant effect on IgG levels (p<0.05), and there were no significant changes in T lymphocyte cells (CD4+, CD8+) (p>0.05). Histopathological examination showed that long-term induction of hepatitis B caused damage to the liver and kidney, but SPF did not affect the condition of these organs. SPF that contains polysaccharides can be an innovative component in immunostimulant formulations.
Morinda citrifolia Linn. Ethanolic-extract Improve Inflammation Condition in Acetic Acid-induced Colitis Ulcerative Mice Models Utami, Tri Fitri Yana; Sahid, Muhammad Novrizal Abdi; Sari, Ika Puspita; Sasmito, Ediati
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95065

Abstract

Ulcerative Colitis (UC) is a chronic inflammatory disorder affecting the colon, characterized by recurrent episodes and involving multifaceted etiological factors in its pathogenesis. This study aims to explore the pharmacological effect of Morinda citrifolia Linn. fruit ethanolic-extract (MFE) in UC. The UC mice model was induced using 2% acetic acid administered per-rectal. Subsequently, mice were categorized into six groups, comprising a normal control, negative control, positive control, and three MFE treatment groups (100mg/kgBW; 200mg/kgBW; 400mg/kgBW). Colitis severity was assessed by scoring system to obtain the Disease Activity Index (DAI) and Hematoxylin-Eosin (HE) staining. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was employed to determine the free radical scavenging activity. MFE exhibited notable antioxidant activity, with an IC50 value of 0,553 mg/ml. Notably, MFE administration led to a discernible reduction in DAI scores, with MFE treatment demonstrating improved inflammation condition compared to the negative control from day 6 through day 11. Furthermore, immune cell infiltration within colonic tissue was markedly attenuated in the MFE-treated group compared to the negative control group. Evaluation of colon tissue damage revealed scores of 5.7, 4.2, and 3 for MFE doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg, respectively, whereas the positive control group exhibited a score of 3, indicating superior tissue preservation. Notably, these scores contrasted starkly with the negative control group, which registered a damage score of 11.8. These findings exhibit the MFE potential as a therapeutic intervention for UC owing to its pharmacological properties, underscoring its potential as a natural remedy in UC management.
Aktivitas Antioksidan Ekstrak Etanol 50% dan 70% Daun Kenikir (Cosmos Caudatus Kunth) Dengan Metode DPPH (2,2 Diphenyl-1 Picrylhydrazyl) Astuti, Syafira Wiji; Sasmito, Ediati
Journal of Comprehensive Science Vol. 3 No. 9 (2024): Journal of Comprehensive Science (JCS)
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v3i9.978

Abstract

Antioxidants are molecules that work by warding off free radicals thereby reducing the damaging effects of free radicals. Coronary heart disease is a disease caused by free radicals. Kenikir leaves contain quite high flavonoid metabolite compounds, namely 12.197 mg QE/g. Flavonoids are among the largest natural phenolic compounds in plants that have bioactivity as medicines. The benefits of flavonoids are as anticancer, antifungal, anti-inflammatory, antimicrobial and antioxidant. The aim of this research was to determine the antioxidant activity of 50% and 70% ethanol extract of kenikir leaves (Cosmos caudatus Kunth.) using the DPPH method. This type of research is analytic cross sectional. The results of this study indicate that there is antioxidant activity of 50% and 70% ethanol extract of kenikir leaves (Cosmos caudatus Kunth.) using the DPPH method. The lowest IC50 value was 70% ethanol extract of kenikir leaves, namely 45.573 ± 0.241 ppm. The highest potential antioxidant activity is 70% ethanol extract of kenikir leaves with an IC50 value of 45.573 ± 0.241 ppm. The highest total flavonoid content was 70% ethanol extract of kenikir leaves, namely 17.209 ± 0.297%. The conclusion of this research is that 70% ethanol extract of kenikir leaves (Cosmos caudatus Kunth.) has the highest antioxidant activity with an IC50 value of 45.573 ± 0.241 ppm.
Co-Authors Adam Hermawan Agung Endro Nugroho Aini S., Aini Akhmad Khumaidi Annisa Novarina Astuti, Syafira Wiji Cicilia Nony Ayuningsih Bratajaya Dandi Sanjaya Emmelia Kristina Hutagaol ERMAWATI, DIAN EKA Esha ND., Pramitha Evie Andriyani, Evie H., Muchammad Ika Puspita Sari Ikawati, Muthi' Ismoyowati, Tri Wahyuni Joko Santoso KD, Anggi Khairunnisa Sy La Ode Muhammad Anwar Maria Ulfah Meirizky Zulharini S Merlindasari, Dita Alfina Muchammad H., Muchammad mufrod mufrod ND., Pramitha Esha Nirmalasari Nirmalasari Putu UA., Ni Rasydy, La Ode Akbar Rikat Raksamiharja Rochmy Istikharah Rohmah, Hajar Nur Fathur Rumiyati, Rumiyati S., Aini Sahid, Muhammad Novrizal Abdi Salma Hilmy Rusydi Hashim Sartika, Aprilina Siregar, Rohani Sri Rahayu W., Sri Rahayu Susi Ari Kristina Triana Hertiani UA., Ni Putu Utami, Tri Fitri Yana W., Windhartono Ximenes, Joao Manuel Correia Yose V. Sagala, Yose Zainul Kamal