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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Kedokteran Bandung Althea Medical Journal The Journal of Pure and Applied Chemistry Research Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Journal of Maternal and Child Health The International Journal of Tropical Veterinary and Biomedical Research Unnes Journal of Public Health
Budi Setiabudiawan
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Journal : The Indonesian Biomedical Journal

 1 
Correlation of Maternal Serum Hepcidin, Soluble Transferrin Receptor (sTfR) and Cholecalciferol with Third Trimester Anemia: Findings from A Nested Case-control Study on A Pregnancy Cohort Raden Tina Dewi Judistiani; Sefty Mariany Samosir; Setyorini Irianti; Benny Hasan Purwara; Budi Setiabudiawan; Johannes Cornelius Mose; Budi Handono
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1252

Abstract

BACKGROUND: Cholecalciferol, hepcidin, and soluble transferrin receptor (sTfR) interaction play an essential role in iron hemostasis. Anemia in pregnancy contributes to morbidity and mortality both for the mother and baby. In this study, we assessed the correlation between hepcidin, sTfR and cholecalciferol in third trimester maternal anemia. We aimed to find the cut-off for hepcidin and sTfR.METHODS: A case-control study involving 56 pregnant women in each anemia and healthy group was nested on a previous larger cohort study in Indonesia. Serum hepcidin, sTfR and cholecalciferol level were measured by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: Serum hepcidin and sTfR level were significantly higher in case group, while serum cholecalciferol level has no difference between the two groups. New cut-off points were found for hepcidin (<15.93 ng/mL) and sTfR level (>2234.45 ng/mL). Low level of hepcidin (OR=5.32) and high level of sTfR (OR=8.28) increase the risk of anemia. High level of sTfR (adjusted OR=4.725; CI 95%=1.730-12.904; p=0.02) was the most important factor contributes to anemia, followed by the low level of hepcidin (adjusted OR=3.677; CI 95%=1.363-9917; p=0.01).CONCLUSION: The high level of sTfR is the most important factor related to anemia in the third trimester, followed by the low level of hepcidin. Low cholecalciferol level tends to favor the incident of anemia. The new cut-off point of third trimester sTfR and third trimester hepcidin were established in this study and may be useful for risk assessment and treatment monitoring for anemia in pregnancy.KEYWORDS: anemia, cholecalciferol, hepcidin, pregnancy, soluble transferrin receptor
N-Acetyltransferase 2 (NAT2) Acetylator Status among Systemic Lupus Erythematosus Patients from A Tuberculosis Endemic Area in Bandung, Indonesia Laniyati Hamijoyo; Sasfia Candrianita; Ika Agus Rini; Endang Sutedja; Budi Setiabudiawan; Edhyana Sahiratmadja
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.553

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) patients living in Indonesia are prone to tuberculosis (TB) infection, since this country ranks second globally for TB prevalence. Isoniazid, an anti-tuberculosis (TB) drug, is metabolized by enzyme N-acetyltransferase 2 (NAT2) that is encoded by NAT2 gene. NAT2 haplotype, referring as acetylator status, may predispose as genetic factor in SLE development or complicate SLE therapy. This study explored the NAT2 haplotypes and acetylator status among SLE patients living in a TB endemic area.METHODS: Genomic DNA of 260 registered SLE patients at The Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia were isolated. NAT2 gene was amplified and sequenced, then NAT2 haplotypes and the acetylator status among SLE patients with or without TB history were determined and presented.RESULTS: Most of SLE patients registered were female (n=250; 96.2%). The median age of patients when SLE was diagnosed for the first time was 27 years old (8-69 years), with organ involvement predominantly in musculoskeletal (80.8%) and mucocutaneous (73.1%). TB history, mostly pulmonary TB, was present in 23.1% of SLE patients of whom TB was diagnosed before SLE (10.4%) or after SLE (10.7%) or both before and after SLE (2%). The acetylator status was mostly intermediate (61.5%) with the NAT2*4/*6B was the most prevalent haplotype (25.8%).CONCLUSION: There is a high number of intermediate and low acetylator status among SLE patients. Since these SLE patients live in TB endemic area, the NAT2 acetylator status determination among SLE patients before starting TB therapy may have clinical benefit to decrease a possible drug induced liver injury, and this warrants further study.KEYWORDS: NAT2, acetylator, systemic lupus erythematosus, tuberculosis
Co-Authors Abdurachman Sukadi Abdurachman Sukadi Ahmad Zaeni Syafii Alex Chairulfatah Ambrosius Purba Anang Endaryanto Andhika T. Hutapea Andri Firdaus Ani Melani Maskoen Arini Setiawati Asep Aziz Asopari Asri Arum Sari Atu Purnama Dewi Ayu Alia Aziz, Muhammad Alamsyah Bakhtiar Bakhtiar Basrowi, Ray Wagiu Benny Hasan Purwara Budi Handono Cissy B. Kartasasmita Cissy B. Kartasasmita Citra Amelinda Dedi Rachmadi Diana Rosifah Diet Sadiah Rustama Dikdik Kurnia Dilantika, Charisma Dina Muktiarti, Dina Dita Lasendra Djatnika Setiabudi Dwi Prasetyo Edhyana Sahiratmadja Edhyana Sahiratmadja Elza Noviani Endang Sutedja Erny Rachmawati Triwardhani Fedri Ruluwedrata Rinawan Gaga Irawan Nugraha Gartika Sapartini Harold Eka Atmaja Harry Raspati Hendra Dian Adhita Henni Djuhaeni Herry Garna Hesti Puspasari Ida Parwati Ika Agus Rini Irma Ruslina Defi Irman Permana Irna Sufiawati Isabella Riandani Johanes C. Mose Johanes C. Mose Johannes Cornelius Mose Johannes Hudyono Juandy Jo Jusuf Sulaeman Effendi Kartjito, Melissa Stephanie Keri Lestari Ketut Dewi Kumara Wati Kuswandewi Mutyara Laniyati Hamijoyo, Laniyati Lelani Reniarti M. Thaufiq S. Boesoirie, M. Thaufiq S. Mahesa Suryanagara Melati Sudiro Melva Louisa Mieke H. Satari Minerva Riani Kadir Mohamad Yanuar Anggara Myrna Soepriadi Nur Melani Sari Perdana, Nanan Surya Putria Rayani Putria Rayani Apandi Raden Tina Dewi Judistiani Rahmat Gunadi Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani DM Riana Novy RINI SUNDARI RINI SUNDARI, RINI Rovina Ruslami, Rovina Saputri, R. Ayu Hardianti Sasfia Candrianita Sefty Mariany Samosir Setyorini Irianti Sheba, Shiane Hanako Sinta Boesoerie Sitorus, Nova Sjarif Hidayat Effendi Sofie R. Krisnadi Sumadiono Sumadiono Sunjaya, Deni K. Surapsari, Juwalita Susy P. Wihadi Sylvia Rachmayati Teti Madiadipoera Tetty Yuniati Tetty Yuniati Thaufiq S. Boesoirie Tisnasari Hafsah Triana Nurul Meirina Triatmaja, Dendy Vitriana Vitriana Vycke Yunivita Kusumah Dewi Weninggalih, Endah Yulia Yulia Zakiudin Munasir Zulfan M. Alibasyah