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All Journal Biology, Medicine, & Natural Product Chemistry KOVALEN: Jurnal Riset Kimia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kesehatan Bakti Tunas Husada JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Pharmacopolium JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Kumawula: Jurnal Pengabdian Kepada Masyarakat Pharmacoscript Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Bakti Tunas Husada
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Optimasi Formulasi Emulgel Topikal Berbasis Minyak Zaitun: Peran Gelling Agent terhadap Viskositas, pH, Daya Sebar, dan Keamanan Oktavia, Lely; Yulianti, Rika; Gustaman, Firman; Indra, Indra
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 25 No 2 (2025)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i2.1614

Abstract

ABSTRAKMinyak zaitun dikenal luas sebagai bahan aktif alami yang efektif dalam sediaan topikal karena sifat antioksidan, antiinflamasi, dan emoliennya. Penelitian ini bertujuan untuk mengevaluasi pengaruh tiga jenis gelling agent—Natrium Karboksimetilselulosa, Viscolam®, dan karbomer—terhadap stabilitas fisik, keamanan, dan preferensi pengguna terhadap emulgel minyak zaitun. Emulgel diformulasikan dalam tiga variasi, kemudian dievaluasi melalui uji pH, viskositas, daya sebar, organoleptik, cycling test, uji iritasi pada hewan, dan uji hedonik pada panelis manusia. Hasil menunjukkan bahwa formula dengan basis Natrium Karboksimetilselulosa memiliki viskositas tertinggi dan kestabilan pH optimal, namun daya sebarnya paling rendah. Formula dengan Viscolam® menunjukkan daya sebar terbaik, viskositas rendah, serta skor tertinggi dalam uji hedonik, menandakan kenyamanan penggunaan yang lebih baik. Formula karbomer menunjukkan stabilitas yang cukup baik secara keseluruhan. Semua formula dinyatakan aman karena tidak menimbulkan iritasi pada kulit hewan uji. Temuan ini menekankan pentingnya pemilihan gelling agent dalam pengembangan emulgel berbasis minyak zaitun yang optimal dan diterima pengguna. Studi ini memberikan kontribusi terhadap pengembangan sediaan topikal berbahan alami yang lebih efektif, stabil, dan nyaman digunakan.Kata Kunci : emulgel, minyak zaitun, gelling agent, stabilitas fisik, uji hedonik
DEVELOPMENT AND EVALUATION OF PEPEROMIA PELLUCIDA L. PEEL-OFF GEL MASK AS ANTI-ACNE AGENT Indra, Indra; Yadi Aditya, Prawira; Fajar, Setiawan
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.1981

Abstract

This study investigates the development of a peel-off gel mask formulated with Peperomia pellucida L. extract as a natural treatment for acne. Peperomia pellucida L., traditionally valued for its medicinal properties, was characterized microscopically and macroscopically to confirm the plant’s identity and quality. Ethanol extraction yielded 16.54% bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory activities. The research utilized a concentration-dependent approach, formulating three gel variants with 5% (F1), 10% (F2), and 15% (F3) extract concentrations. Antibacterial testing against Propionibacterium acnes showed that F3 exhibited the largest inhibition zone (10.72 mm), significantly outperforming the positive control (4.6 mm). Stability testing revealed that the formulations maintained consistent color, odor, and pH but faced challenges in viscosity and homogeneity at extreme temperatures. Hedonic testing indicated that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. Despite stability challenges, the formulations, mainly F3, demonstrated promising antibacterial efficacy. In conclusion, the peel-off gel mask containing Peperomia pellucida L. extract (F3) shows significant potential as a natural alternative to synthetic acne treatments. Further refinement is needed to enhance stability and user experience while maintaining its high antibacterial activity. study explores the development of a peel-off gel mask formulated with Peperomia pellucida L. extract for acne treatment. Peperomia pellucida L., traditionally known for its medicinal properties, was characterized microscopically and macroscopically, confirming the plant’s identity and quality. The ethanol extraction process yielded 16.54% of bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, known for their antibacterial and anti-inflammatory properties. Phytochemical screening confirmed these compounds’ presence, and antibacterial testing against Propionibacterium acnes revealed concentration-dependent inhibition, with the highest inhibition zone observed in the 15% extract formulation (F3). The gel formulations were evaluated for physical properties, stability, and user acceptance. Stability testing demonstrated consistency in colour, odour, and pH but revealed challenges in inhomogeneity and viscosity at extreme temperatures. Despite these issues, the formulations maintained antibacterial efficacy, mainly F3. Hedonic testing showed that participants favored F2 (10% extract) for its balanced aroma, color, and ease of application, although F1 and F3 were preferred for texture. In conclusion, the peel-off gel mask containing Peperomia pellucida L. shows significant potential as a natural, effective treatment for acne. However, further refinement is needed to optimize stability and user-friendliness while maintaining high antibacterial efficacy. These findings suggest that the extract could be a valuable addition to topical acne treatments, offering a natural alternative to synthetic products
Development and Characterization of Effervescent Granules Containing Cinnamomum burmanii Ethanolic Extract with Potent Antioxidant Activity Rahmawati, Rima; Yulianti, Rika; Indra, Indra
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1805

Abstract

The study aimed to develop effervescent granules containing Cinnamomum burmanii extract with strong antioxidant activity, good physicochemical stability, and consumer acceptability. Ethanolic extraction was employed to maximize the recovery of phenolic and flavonoid compounds, followed by formulation through controlled wet granulation using citric acid, tartaric acid, sodium bicarbonate, polyvinylpyrrolidone, and aspartame. The resulting extract showed potent antioxidant capacity with an IC₅₀ of 7.82 ppm, indicating high radical-scavenging activity. Three formulations (F1–F3) were evaluated for physical properties, dissolution, pH, and sensory characteristics. The optimized formulation (F3) demonstrated rapid effervescence (<3 minutes), suitable acidity (pH 3.7–4.2), low moisture content (<5%), and strong consumer acceptance. Although antioxidant activity slightly decreased after granulation (IC₅₀ ≈ 69 ppm), the product maintained significant efficacy and stability. These results confirm that ethanol extraction combined with optimized wet granulation effectively produces a stable, functional, and palatable herbal effervescent formulation. The study establishes a scientific basis for converting C. burmanii into a modern nutraceutical product and supports its potential application in antioxidant beverages. Future work should explore bioavailability enhancement and synergistic formulations with other botanical extracts to maximize therapeutic value and product performance.
Physicochemical Characterization and Dissolution Enhancement of Mefenamic Acid–Isonicotinamide Crystalline Solid Dispersion Indra Indra; Nurul Apriani; Ade Yeni Aprillia; Winda Trisna Wulandari; Gatut Ari Wardani; Firman Gustaman
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.601-607

Abstract

Poor aqueous solubility limits the bioavailability of non-steroidal anti-inflammatory drugs like mefenamic acid. This study aims to improve the solubility and dissolution of mefenamic acid through crystalline solid dispersions using solvent evaporation and co-grinding techniques with selected co-formers. Solid dispersions were formulated at different drug-to-co-former ratios (1:1, 1:2, and 2:1) and characterized using differential scanning calorimetry, Fourier-transform infrared spectroscopy, and powder X-ray diffraction. DSC results revealed reduced crystallinity, indicated by the disappearance of melting peaks and the appearance of a single glass transition temperature. FTIR analysis confirmed hydrogen bonding between the drug and co-former, while PXRD patterns showed a loss of long-range order, supporting the formation of amorphous phases. Dissolution testing demonstrated a significant increase in drug release, particularly in the 1:2 formulation, which outperformed the pure drug and other ratios. These results confirm that the choice of preparation method and co-former ratio critically influence the performance of solid dispersions. This study provides valuable insights into the design of improved oral formulations for poorly soluble drugs, contributing to the advancement of pharmaceutical technology
Application of Quasi-Emulsion Solvent Diffusion for Spherical Crystallization of Atorvastatin with HPMC E50 Indra Indra; Ria Marliana Tika; Winda Trisna Wulandari
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.475-481

Abstract

Poor solubility and inadequate flowability of active pharmaceutical ingredients are significant challenges in developing solid oral dosage forms, particularly for BCS Class II drugs such as atorvastatin calcium. This study aimed to improve the micromeritic and dissolution properties of atorvastatin through spherical crystallization using quasi-emulsion solvent diffusion. Methanol was used as a good solvent, dichloromethane as a bridging liquid, water as a poor solvent, and HPMC E50 as a polymeric stabilizer. Spherical agglomerates were prepared and characterized for morphology (SEM); crystallinity (DSC and PXRD); chemical compatibility (FTIR); micromeritic parameters; and dissolution performance. The crystallization process transformed irregular atorvastatin crystals into smooth spherical agglomerates with significantly enhanced flow properties, as evidenced by increased flow rate and improved angle of repose, bulk density, and compressibility index. FTIR analysis confirmed no chemical interaction with HPMC, while PXRD and DSC indicated reduced crystallinity. Dissolution studies showed spherical atorvastatin exhibited superior release, reaching over 80% in 30 minutes, compared with 51% for raw atorvastatin. In conclusion, spherical crystallization effectively improved the physicochemical and micromeritic properties of atorvastatin calcium, offering a promising approach for enhancing its manufacturability and oral bioavailability.
Co-Authors Aceng Chotim Muwahid Ade Yeni Aprilia Ade Yeni Aprillia Ahmad Fauzi Anindita Tri Kusuma Pratita Aulia Nurlatifah Citra Dewi Salasanti Diana Sri Zustika, Diana Sri Estin Nofiyanti Eva Saefatuzzahro Fajar Setiawan Fajar Setiawan Fajar Setiawan Firman Gustaman Firman Gustaman Gatut Ari Wardani Gatut Ari Wardhani Gustaman, Firman Gustania Intan Indriani Hanna Nurul Husna Hanna Nurul Husna Hendy Suhendy Keni Ida Cahyani Keni Idacahyati Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lusi Nurdianti, Lusi Meri, Meri Meti Kusmiati Mida Hamidah Novianti Nurmalasari Nur Rahayuningsih, Nur Nurhidah, Mia Nurul Apriani Rahmawati Rahmawati Rahmawati, Rima Ratih Aryani Ratih Aryani Rendi Rahman Ria Marliana Tika Rika Yulianti Rika Yulianti, Rika Rudiyat, Ai Saeful Amin Syahputra, Ricky Andi Taufik Hidayat Taufik Hidayat Tuslinah Lilis Vera Nurviana Vina Alvionita Wawan Rismawan Winda Trisna Wulandari, Winda Trisna Yadi Aditya, Prawira Yulianti, Rika Zain, Dichy Nuryadin