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Optimasi Formulasi Emulgel Topikal Berbasis Minyak Zaitun: Peran Gelling Agent terhadap Viskositas, pH, Daya Sebar, dan Keamanan Oktavia, Lely; Yulianti, Rika; Gustaman, Firman; Indra, Indra
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 25 No 2 (2025): Jurnal Kesehatan Bakti Tunas Husada Volume 25 Nomor 2 Tahun 2025
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i2.1614

Abstract

ABSTRAKMinyak zaitun dikenal luas sebagai bahan aktif alami yang efektif dalam sediaan topikal karena sifat antioksidan, antiinflamasi, dan emoliennya. Penelitian ini bertujuan untuk mengevaluasi pengaruh tiga jenis gelling agent—Natrium Karboksimetilselulosa, Viscolam®, dan karbomer—terhadap stabilitas fisik, keamanan, dan preferensi pengguna terhadap emulgel minyak zaitun. Emulgel diformulasikan dalam tiga variasi, kemudian dievaluasi melalui uji pH, viskositas, daya sebar, organoleptik, cycling test, uji iritasi pada hewan, dan uji hedonik pada panelis manusia. Hasil menunjukkan bahwa formula dengan basis Natrium Karboksimetilselulosa memiliki viskositas tertinggi dan kestabilan pH optimal, namun daya sebarnya paling rendah. Formula dengan Viscolam® menunjukkan daya sebar terbaik, viskositas rendah, serta skor tertinggi dalam uji hedonik, menandakan kenyamanan penggunaan yang lebih baik. Formula karbomer menunjukkan stabilitas yang cukup baik secara keseluruhan. Semua formula dinyatakan aman karena tidak menimbulkan iritasi pada kulit hewan uji. Temuan ini menekankan pentingnya pemilihan gelling agent dalam pengembangan emulgel berbasis minyak zaitun yang optimal dan diterima pengguna. Studi ini memberikan kontribusi terhadap pengembangan sediaan topikal berbahan alami yang lebih efektif, stabil, dan nyaman digunakan.Kata Kunci : emulgel, minyak zaitun, gelling agent, stabilitas fisik, uji hedonik
Physicochemical Characterization and Dissolution Enhancement of Mefenamic Acid–Isonicotinamide Crystalline Solid Dispersion Indra, Indra; Apriani, Nurul; Aprillia, Ade Yeni; Wulandari, Winda Trisna; Wardani, Gatut Ari; Gustaman, Firman
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.601-607

Abstract

Poor aqueous solubility limits the bioavailability of non-steroidal anti-inflammatory drugs like mefenamic acid. This study aims to improve the solubility and dissolution of mefenamic acid through crystalline solid dispersions using solvent evaporation and co-grinding techniques with selected co-formers. Solid dispersions were formulated at different drug-to-co-former ratios (1:1, 1:2, and 2:1) and characterized using differential scanning calorimetry, Fourier-transform infrared spectroscopy, and powder X-ray diffraction. DSC results revealed reduced crystallinity, indicated by the disappearance of melting peaks and the appearance of a single glass transition temperature. FTIR analysis confirmed hydrogen bonding between the drug and co-former, while PXRD patterns showed a loss of long-range order, supporting the formation of amorphous phases. Dissolution testing demonstrated a significant increase in drug release, particularly in the 1:2 formulation, which outperformed the pure drug and other ratios. These results confirm that the choice of preparation method and co-former ratio critically influence the performance of solid dispersions. This study provides valuable insights into the design of improved oral formulations for poorly soluble drugs, contributing to the advancement of pharmaceutical technology
Physicochemical Characterization and Dissolution Enhancement of Mefenamic Acid–Isonicotinamide Crystalline Solid Dispersion Indra, Indra; Apriani, Nurul; Aprillia, Ade Yeni; Wulandari, Winda Trisna; Wardani, Gatut Ari; Gustaman, Firman
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.601-607

Abstract

Poor aqueous solubility limits the bioavailability of non-steroidal anti-inflammatory drugs like mefenamic acid. This study aims to improve the solubility and dissolution of mefenamic acid through crystalline solid dispersions using solvent evaporation and co-grinding techniques with selected co-formers. Solid dispersions were formulated at different drug-to-co-former ratios (1:1, 1:2, and 2:1) and characterized using differential scanning calorimetry, Fourier-transform infrared spectroscopy, and powder X-ray diffraction. DSC results revealed reduced crystallinity, indicated by the disappearance of melting peaks and the appearance of a single glass transition temperature. FTIR analysis confirmed hydrogen bonding between the drug and co-former, while PXRD patterns showed a loss of long-range order, supporting the formation of amorphous phases. Dissolution testing demonstrated a significant increase in drug release, particularly in the 1:2 formulation, which outperformed the pure drug and other ratios. These results confirm that the choice of preparation method and co-former ratio critically influence the performance of solid dispersions. This study provides valuable insights into the design of improved oral formulations for poorly soluble drugs, contributing to the advancement of pharmaceutical technology
Co-Authors Aceng Chotim Muwahid Ade Yeni Aprilia Ade Yeni Aprillia Ahmad Fauzi Anindita Tri Kusuma Pratita Apriani, Nurul Aprillia, Ade Yeni Aulia Nurlatifah Citra Dewi Salasanti Diana Sri Zustika, Diana Sri Estin Nofiyanti Eva Saefatuzzahro Fajar Setiawan Fajar Setiawan Firman Gustaman Firman Gustaman Gatut Ari Wardani Gatut Ari Wardhani Gustaman, Firman Gustania Intan Indriani Hanna Nurul Husna Hanna Nurul Husna Hendy Suhendy Keni Ida Cahyani Keni Idacahyati Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lusi Nurdianti, Lusi Meri, Meri Meti Kusmiati Mida Hamidah Novianti Nurmalasari Nur Rahayuningsih, Nur Nurhidah, Mia Rahmawati Rahmawati Ratih Aryani Ratih Aryani Rendi Rahman Rika Yulianti Rika Yulianti, Rika Rudiyat, Ai Saeful Amin Syahputra, Ricky Andi Taufik Hidayat Taufik Hidayat Tuslinah Lilis Vera Nurviana Vina Alvionita Wawan Rismawan Winda Trisna Wulandari Winda Trisna Wulandari Winda Trisna Wulandari, Winda Trisna Yulianti, Rika Zain, Dichy Nuryadin