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All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Bandung Dentika Dental Journal Medical Journal of Indonesia Global Medical and Health Communication BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Buletin Farmatera Indonesian Journal of Medicine SRIWIJAYA JOURNAL OF MEDICINE Jurnal Respirologi Indonesia Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL FARMASIMED (JFM) Sumatera Medical Journal KLOROFIL: Jurnal Ilmu Biologi dan Terapan Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Yahwardiah Siregar
Department Of Biochemistry, Faculty Of Medicine, Universitas Sumatera Utara, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Streptococcus mutans Antibacterial Activity of 0.1% Lysozyme Tooth Paste as an Alternative for Children Below 3 Years Old in Preventing Early Childhood Caries (ECC) (Experimental Laboratory Study): Aktivitas Antibakteri Streptococcus mutans dari Pasta Gigi Lisozim 0,1% Sebagai Alternatif Untuk Anak Di Bawah 3 Tahun Dalam Mencegah Karies Anak Usia Dini (PAUD) (Studi Laboratorium Eksperimental) Octiara, Essie; Sutadi, Heriandi; Siregar, Yahwardiah; Primasari, Ameta
Dentika: Dental Journal Vol. 24 No. 2 (2021): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v24i2.6401

Abstract

One of many possible ways of preventing Early Childhood Caries (ECC) is by removing tooth debris. Fluoride tooth paste usage by children under 3 years old must follow recommended quantity, because of its possibility of being ingested which then might cause fluorosis. Lysozyme as an active element in a toothpaste is able to mediate bacterial aggregation and inhibit bacterial adhesion and also activate bacterial autolysin by destructing bacterial cell wall. This study aimed to compared Streptococcus mutans antimicrobial activity of non-fluoride lysozyme toothpaste of various concentration such as 0.025, 0.05, 0.1, and 0.2 %. This was an experimental research with post test only design. The tested tooth paste was lysozyme-contained with 0.025, 0.05, 0.1 and 0.2% concentrations. Children tooth paste containing fluoride, enzyme tooth paste and 0.2% chlorhexidine became the positive control. Test of S. mutans antibacterial activity used 3 methods: disc diffusion, well, and microtiter plate method. Analytical test used Anova one way with Bonferoni post hoc and p<0.05 significant level. The results showed that all concentrations of lysozyme tooth paste had inhibitory effect on the growth of S. mutans (p<0.05). The highest mean of S. mutans antibacterial activity in lysozyme tooth paste were on 0.1 and 0.2% concentrations. Conclusion stated that 0.1% concentration of lysozyme tooth paste can be used as an alternative tooth paste for children under 3 years old
PENGUKURAN KADAR PIRIDOKSIN (VITAMIN B6) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD) Melvariani Syari Batubara; Yahwardiah Siregar; Herla Rusmarilin; Sri Soviani
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 2, No 1 (2018): Klorofil: Jurnal Ilmu Biologi dan Terapan
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v2i1.1801

Abstract

This research aimed to study Piridoksin (Vitamin B6) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 2 stage, namely : (1) Taken of blood sample, and (2) Analysis of Piridoksin (Vitamin B6) status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method. Data collected and assessed by once in one time. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Piridoksin (Vitamin B6) status in blood sample of ADHD children that had been was considered statistically highly significant a reduce of the assessment of Piridoksin (Vitamin B6) status in blood sample of ADHD children by 0,422 ng/ml compared with laboratory reference (control) by 0,36-1,8 ng/ml, HA<C** (p<0,001). This was considered a reduction in Piridoksin (Vitamin B6)) concentrations induces of the Hyperactivity children by 95%.
HUBUNGAN KADAR TARTRAZIN DAN SENG (ZN) DALAM DARAH PADA ANAK PENDERITA DEFISIT PERHATIAN DAN GANGGUAN HIPERAKTIVITAS (ADHD) Melvariani Syari Batubara; Yahwardiah Siregar; Herla Rusmarilin; Sri Soviani; Husnarika Febriani
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 4, No 1 (2017): Agustus
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v4i1.960

Abstract

This research aims to study Tartrazine and Zinc (Zn) status in blood sample of Attention Deficit Hyperactivity Disorder (ADHD) children. Deductive research using the descriptive method through 3 stage, namely : 1. Taken of blood sample, 2. Analysis of Tartrazine status in blood sample was performed by using High Performance Liquid Chromatograpy (HPLC) method, and 3. Analysis of Zinc (Zn) status in blood sample were measurements by using Atomic Adsorbance Spectrophotometry (AAS) method. Data were analyzed using descriptive analysis techniques and Chi Square tests (X2) by Computer programs (SPSS 15). The result of the assessment of Tartrazine status in blood sample of ADHD children that had been was considered statistically highly significant a increase of the assessment of Tartrazine status in blood sample of ADHD children by 130 mg/ml compared with laboratory reference (control) by 28 mg/ml, HA>C** (p<0,001). The result of the assessment of Zinc (Zn) status in blood sample of ADHD children that had been was showed statistically highly significant a reduce of the assessment of Zinc (Zn) status in blood sample of ADHD children by 0,37 µg/ml compared with laboratory reference (control) by 0,64-1,18 µg/ml, HA<C** (p<0,001). This was considered a reduction and increase in Tartrazine and Zinc (Zn) concentrations induces of the Hyperactivity children by 95%.
Pengaruh Pemberian Vitamin D terhadap Gambaran Foto Toraks pada Pasien Tuberkulosis Paru Beretnis Batak Debby Mirani Lubis; Yahwardiah Siregar; Bintang Y.M. Sinaga; Seri Rayani Bangun
Global Medical & Health Communication (GMHC) Vol 5, No 1 (2017)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.554 KB) | DOI: 10.29313/gmhc.v5i1.2003

Abstract

Tuberkulosis (TB) adalah penyakit menular yang sampai sekarang masih menjadi masalah kesehatan dunia. Vitamin D dapat berperan melawan bakteri Mycobacterium tuberculosis melalui mekanisme cathelicidin intraseluler. Penelitian ini bertujuan mengetahui pengaruh pemberian vitamin D terhadap perbaikan foto toraks pada pasien TB paru beretnis Batak. Sebanyak 42 pasien yang memenuhi kriteria inklusi diambil dari beberapa puskesmas di Kota Medan dan Kabupaten Deli Serdang selama bulan Januari–Juni 2016. Penelitian ini adalah penelitian analitik dengan desain eksperimental murni tersamar tunggal (single-blind randomized controlled trial). Pasien dibagi secara acak menjadi kelompok vitamin D dan kelompok plasebo. Kelompok vitamin D diberikan tablet vitamin D oral 100.000 IU (2,5 mg) sebanyak 4 kali pemberian (minggu ke-0, 2, 4, 6). Kedua kelompok diperiksa kadar vitamin D dan foto toraks sebelum dan sesudah pengobatan selama 8 minggu. Hasil penelitian menunjukkan bahwa kelompok dengan pemberian vitamin D menunjukkan kenaikan kadar vitamin D secara signifikan (p=0,00) dibanding dengan kelompok yang diberi plasebo (0,26). Tidak ada perbedaan yang bermakna pada perbaikan foto toraks (p=0,06) antara kelompok vitamin D dan plasebo, tetapi jumlah subjek yang mengalami perbaikan foto zona paru pada kelompok vitamin D lebih banyak dibanding dengan kelompok plasebo (2:1). Simpulan, pemberian vitamin D tidak memengaruhi perbaikan foto toraks pada pasien TB paru beretnis Batak.THE EFFECT OF VITAMIN D ON CHEST X-RAY PROFILE IN BATAK ETHNICITY PULMONARY TUBERCULOSIS PATIENTSTuberculosis is an infectious disease that is still a global health problem. Vitamin D may play a role in fighting the bacteria Mycobacterium tuberculosis through the mechanism of intracellular cathelicidin. This study aimed to determine the effect of vitamin D on the improvement of chest x-ray in patients with pulmonary tuberculosis from Batak ethnicity. As much as 42 patients who met the inclusion criteria taken from several clinics in Medan City and Deli Serdang District in January to June 2016. This is a analytical study using single-blind randomized controlled trial design. Patients divided into groups of vitamin D and placebo groups. Vitamin D group was given vitamin D tablet 100,000 IU (2.5 mg) orally 4 times (0, 2, 4, 6 weeks). Levels of vitamin D and chest x-ray before and after 8 weeks of treatment were examined. The results showed that group with vitamin D levels increased significantly (p=0.00) compared to the placebo group (0.26). There was no significant difference in the improvement of thoracic images (p=0.06) between group with vitamin D and placebo groups. However, the number of subjects who experienced improvement of lung zone images in the vitamin D group more than the placebo group (2:1). In conclusion, vitamin D does not affect the improvement of chest x-ray in patients with pulmonary tuberculosis from Batak ethnicity.
The Relationship between Tyr113His Epoxidized Hydrolase Enzyme Gene Polymorphisms and the Incidence of Smoking Lung Cancer Lucia Aktalina; Amira Permatasari Tarigan; Noni Novisari Soeroso; Yahwardiah Siregar; Ozar Sanuddin
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.163

Abstract

Background: This study aims to determine the relationship between the gene polymorphism of the enzyme Epoxid Hydrolase (EPHX) Tyr113His and the tendency of smokers to suffer from lung cancer. The EPHX Tyr113His gene polymorphism is a change in one nucleotide base of the EPHX gene to produce enzymes with decreased function by 50%. EPHX plays a role in the metabolism of chemical compounds in cigarette smoke, especially Benzo (a) Pyren (BaP), which becomes a carcinogen in the body. Methods: This study is a case-control study design conducted from October 2016 to February 2017. Venous blood was taken from 35 people with lung cancer at RSUP H Adam Malik Medan and 35 healthy smokers. The genotype examination of the EPHX gene was carried out using the PCR-RFLP method in the USU FK Integrated Laboratory. Results: The genotype frequency of heterozygous variant T/C and homozygous variant C/C in case groups was 83.3% and 16.7%, respectively. The frequency of the T allele in the case group was 41.67% and the C allele was 58.33%. Whereas in the control, the frequency was heterozygous variant T/C (80%) and homozygous variant C/C (20%). The frequency of the T allele in the control group was 40% and the C allele was 60%. There were no homozygous wildtype T/T genotypes in the two groups. There was no significant difference in the genetic distribution and allele distribution of the EPHX enzyme between case and control groups. Conclusion: There is no relationship between EPHX Tyr113His enzyme gene polymorphisms and the incidence of lung cancer in smoking. J Respir Indo 2018; 38(2): 93-9)
ANALISIS KADAR VITAMIN D PADA MAHASISWA INSTITUT KESEHATAN MEDISTRA DAN MAHASISWA FAKULTAS KEDOKTERAN GIGI UNIVERSITAS SUMATERA UTARA Miftahul Zannah; Yahwardiah Siregar; Ariyati Yosi
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 1 (2019): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.993 KB) | DOI: 10.35451/jkf.v2i1.181

Abstract

Vitamin D levels influenced by many factors like formation, nutritions, malabsorbtion and degradation of 25(OH)D. Formation factors is one of important for metabolism vitamin D. Vitamin D is the main hormone regulating calcium phosphate homeostasis and mineral bone metabolism. Loss of muscle mass and fraity are prevalent in many chronic disease. The study group consisted of 31 samples from Institut Kesehatan Medistra (n=12) and Fakultas Kedokteran Gigi USU (n=19). Vitamin D levels were measure with ELISA (Diagnostic Biochem Canada). Most age for student Institut Kesehatan Medistra is 21 years old and student Fakultas Kedokteran Gigi USU is 22 years old. Frequency of Vitamin D level student Institut Kesehatan Medistra is 91,7% (deficiency) and student Fakultas Kedokteran Gigi USU 84,2%(deficiency). There was significant difference in vitamin D levels between two group with significant (p=0,018).
PENGARUH PEMBERIAN D-GALAKTOSA TERHADAP PERUBAHAN BERAT BADAN MENCIT JANTAN Indah Permata Sari; Muhammad Ichwan; Yahwardiah Siregar
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 2 No 2 (2020): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.105 KB) | DOI: 10.35451/jkf.v2i2.336

Abstract

D-galactose is aldohexose which occurs naturally in the body, including in the brain which is found in lactose disaccharides in honey, beets and milk products. Needed in the body for lactose formation during the process of lactogenesis. Provision of large amounts of D-galactose can cause oxidative damage to various tissues and organs. The purpose was to see changes in body weight in male rats after being given a D-galactose injection. Samples using male mice aged 8 weeks with a weight of ± 30 grams, the number of samples was 6 mice swiss webster strain. intra-peritoneal injection of D-galactose is given for 6 weeks every day (150 mg / kg / bb). The results of this study indicate that the statistical analysis is significant p <0.05 (p = 0.016). The conclusion after being given injection of D-galactose for 6 weeks every day intra peritoneally was found D-galactose had an effect on the weight gain of male mice.
PERAN POLIMORFISME GEN MATRIKS METALLOPROTEINASE-9 DENGAN KEJADIAN PENYAKIT PARU OBSTRUKTIF KRONIK Wilson Arthur Zein; Yahwardiah Siregar; Amira P Tarigan
JURNAL KEPERAWATAN DAN FISIOTERAPI (JKF) Vol 3 No 1 (2020): Jurnal Keperawatan dan Fisioterapi (JKF)
Publisher : Fakultas Keperawatan dan Fisioterapi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkf.v3i1.427

Abstract

Excessive secretion of MMP-9 is one of the cause of COPD is which can cause undesirable lung tissue degradation. Increased expression of MMP-9 is associated with increased gene promoter activity. The purpose of this study was to determine the role of mettaloproteinase-9 matrix gene polymorphisms with COPD events. This was a case-control study. With a total sample of 60 patients consisting of 30 COPD patients and 30 non-COPD patients. Samples were amplified by PCR (Polymerase Chain Reaction) The results of DNA amplification were digested with SphI restriction enzyme to see the allele variant of MMP-9 C-1562T. Visualization of restriction results with 2% agarose gel electrophoresis will show 2 bands on the T allele (188bp, 247bp), 1 band on the C allele (435bp). The results obtained were homozygous CC variants in COPD 20 (66.67%) and non-COPD 21 (70%). Heterozygous variant of CT 10 (33.33%) in COPD and 9 (30%) in non-COPD. TT variant is not found at all. Based on the results obtained by the most CC homozygous variants in COPD (66.67%) and non-COPD (70%) and no association was found between MMP-9 polymorphism and COPD events (p> 0.05). Based on the results of this study, there is no significant relationship that we can conclude.
EFEK LATIHAN FISIK TERHADAP KADAR MALONDIALDEHID PADA HEWAN MODEL PENUAAN Indah Permata Sari1; Muhammad Ichwan; Yahwardiah Siregar
Jurnal Endurance Vol. 6 No. 1 (2021): Jurnal Endurance : Kajian Ilmiah Problema Kesehatan
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.772 KB) | DOI: 10.22216/jen.v6i1.134

Abstract

Aging is a natural process that is characterized by decreased function. In the aging process a decline in the ability of reactive oxygen species. This causes damage to the membrane lipids that cause a decrease in function of the body's organs. Lipid oxidation process in the membrane because free radicals produce lipid peroxidation such as malondialdehyde which is used as a marker of oxidative stress. Regular physical exercise can overcome the negative effects of oxidative stress. To conduct studies on aging, animal models are used. One of the animal models used is the aging induction model by giving D-galactose. Metabolites from d-galactose can induce aging by causing oxidative stress. The purpose of this study was to determine the effect of physical exercise on reducing malondialdehyde levels in an aging animal model induced by D-galactose. This research was experimental in-vivo with a post test only research design. The research sample of 8 weeks old swiss webster mice, consisted of 10 treatment groups. The results of studies on animal models of aging induced D-galactose on malondialdehyde levels after being treated for 6 weeks from the statistical results obtained p value ≥ 0.05 was not significant. However, there was a significant decrease in MDA levels in the D-galactose + physical exercise group
STUDI PRELIMINARI TENTANG PENGARUH D-GALAKTOSA DALAM MENGINDUKSI STRES OKSIDATIF PADA MENCIT JANTAN GALUR OUTBRED FK USU Bintang, Siti Sarah Bintang Sarah; Siregar, Yahwardiah; Ichwan, Muhammad
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.922 KB) | DOI: 10.35451/jfm.v2i1.191

Abstract

Abstract Oxidative stress occurs due to imbalance of free radicals over antioxidant level in the body. This condition causes lipid peroxidation and DNA damage. D-Galaktosa is The mechanism of oxidative stress induced by d-galactose occurs in the subcellular, especially in the brain's mitochondria. Increasing the concentration of d-galaktosa is oxidized by galaktosa oxidase to form hydrogen peroxide (H202) which causes a decrease in superoxide dismutase (SOD). H202 reacts with reduced iron and forms hydroxide ions (OH-). Objective: The aim of this study was to determine the effect of d-galaktosa induction on oxidative stress levels (MDA) in male mice. Methods: Methods of samples of mice given d-galaktosa and blood collection from the heart were carried out at the Pharmacology Laboratory of the Faculty of Medicine, University of North Sumatra. Results: The results showed that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, had an effect on the levels of oxidative stress in male mice. Conclusion: The results of this study indicate that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, has an effect on levels of oxidative stress in male mice.
Co-Authors Ameta Primasari Amira P Tarigan Amira Permatasari Tarigan Ariyati Yosi Bahagia Loebis, Bahagia Bintang Y.M. Sinaga Bintang Y.M. Sinaga, Bintang Y.M. Bintang, Siti Sarah Bintang Sarah Blondina Marpaung Chandra, Vincent Alexander Cut Aria Arina Debby Mirani Lubis Donny Nauphar Elmeida Effendy Essie Octiara Febriani, Husnarika Hadyanto Lim Henny Erina Saurmauli Ompusunggu Heriandi Sutadi Herla Rusmarilin Herla Rusmarilin Herla Rusmarilin Husnarika Febriani Indah Permata Sari Indah Permata Sari1 Isra Thristy Jaminsen Sinaga Juwita -, Juwita Lucia Aktalina Melvariani Syari Batubara Miftahul Zannah Muhammad Amin Muhammad Ichwan Muhammad Ichwan Noni Novisari Soeroso Nurmiati Amir Oentari, Widyaningsih Ompusunggu, Henny E.S. Ozar Sanuddin Pardede, Sumondang M. Pratiwi, Astrid Siska Pratiwi, Astrid Siska Putri Chairani Eyanoer, Putri Chairani Rahmiwita, Rahmiwita Roesyanto-Mahadi, Irma D Sarah, Dewi Maya Seri Rayani Bangun Siregar, Kamal B. Sori M Sarumpaet, Sori M Soviani, Sri Sri Soviani Sri Soviani Syarifah, Siti Umar Zein Wilson Arthur Zein