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All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Bandung Dentika Dental Journal Medical Journal of Indonesia Global Medical and Health Communication BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Buletin Farmatera Indonesian Journal of Medicine SRIWIJAYA JOURNAL OF MEDICINE Jurnal Respirologi Indonesia Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL FARMASIMED (JFM) Sumatera Medical Journal KLOROFIL: Jurnal Ilmu Biologi dan Terapan Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Yahwardiah Siregar
Department Of Biochemistry, Faculty Of Medicine, Universitas Sumatera Utara, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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ApaI Vitamin D Receptor Gene Polymorphisms in Psoriasis Oentari, Widyaningsih; Roesyanto-Mahadi, Irma D; Siregar, Yahwardiah
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.6528

Abstract

Psoriasis is a chronic autoimmune skin disorder that is an autoimmune disease and still considers a global problem. This condition is suspected to be contributed by genetic and environmental factors. Several studies have shown an association between vitamin D gene receptor polymorphisms and the risk of psoriasis. This study was an observational study, which involved 64 research subjects, who were psoriasis patients. Each subject was interviewed and went through physical examination, also Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) examination to determine ApaI (rs7975232) vitamin D receptor gene polymorphism. After the tabulation of the data, we found that the age of psoriasis onset in this study was 21 to 40 years old with an average of 34.40 14.98 years old. The majority of our subjects ApaI VDR gene polymorphism genotype was aa (53.1%). This is consistent with the results of several studies conducted in Asia.
Distribusi Polimorfisme Gen Transforming Growth Factor Beta-1 (T869C) Pada Pasien Psoriasis Di Kota Medan, Sumatera Utara Rahmiwita, Rahmiwita; Siregar, Yahwardiah; Ichwan, Muhammad
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.3981

Abstract

Psoriasis is a chronic inflammatory skin disease with a prevalence in the world around 2-3%. TGF-?1 is a growth factor that has a polymorphism in its genes. The TGF-?1 gene polymorphism plays a role in the pathogenesis of psoriasis. This is a descriptive study with a simple random sampling technique. This study was conducted on the strored of DNA specimens collected from 62 psoriasis patients comprising 33 women and 29 men. This study aims to determine the frequency distribution of the TGF-?1 gene polymorphism (T869C) in patients with psoriasis. The TGF-?1 gene polymorphism (T869C) was determined using PCR-based restricted fragment length polymorphism (PCR-RFLP). TC genotype was the most prevalent (50%) of TGF-?1 (T869C) gene polymorphism in psoriasis patients, followed by TT genotype (6.5%) and CC (43.5%). TC variant is the most variant of TGF-?1 (T869C) gene polymorphism in psoriasis sufferers in Medan
Co-Authors Ameta Primasari Amira P Tarigan Amira Permatasari Tarigan Ariyati Yosi Bahagia Loebis, Bahagia Bintang Y.M. Sinaga Bintang Y.M. Sinaga, Bintang Y.M. Bintang, Siti Sarah Bintang Sarah Blondina Marpaung Chandra, Vincent Alexander Cut Aria Arina Debby Mirani Lubis Donny Nauphar Elmeida Effendy Essie Octiara Febriani, Husnarika Hadyanto Lim Henny Erina Saurmauli Ompusunggu Heriandi Sutadi Herla Rusmarilin Herla Rusmarilin Herla Rusmarilin Husnarika Febriani Indah Permata Sari Indah Permata Sari1 Isra Thristy Jaminsen Sinaga Juwita -, Juwita Lucia Aktalina Melvariani Syari Batubara Miftahul Zannah Muhammad Amin Muhammad Ichwan Muhammad Ichwan Noni Novisari Soeroso Nurmiati Amir Oentari, Widyaningsih Ompusunggu, Henny E.S. Ozar Sanuddin Pardede, Sumondang M. Pratiwi, Astrid Siska Pratiwi, Astrid Siska Putri Chairani Eyanoer, Putri Chairani Rahmiwita, Rahmiwita Roesyanto-Mahadi, Irma D Sarah, Dewi Maya Seri Rayani Bangun Siregar, Kamal B. Sori M Sarumpaet, Sori M Soviani, Sri Sri Soviani Sri Soviani Syarifah, Siti Umar Zein Wilson Arthur Zein