Article Per Year (5 Year)
p-Index From 2021 - 2026
0.882
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) Majalah Kedokteran Bandung Dentika Dental Journal Global Medical and Health Communication BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Buletin Farmatera Indonesian Journal of Medicine Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Jurnal Respirologi Indonesia Jurnal Keperawatan dan Fisioterapi (JKF) JURNAL FARMASIMED (JFM) Sumatera Medical Journal KLOROFIL: Jurnal Ilmu Biologi dan Terapan Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Yahwardiah Siregar
Department Of Biochemistry, Faculty Of Medicine, Universitas Sumatera Utara, Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Association between vitamin D receptor FokI polymorphism and hypertension in Indonesian ischemic stroke patients: a cross-sectional study Arrizal, Rizki; Arina, Cut Aria; Siregar, Yahwardiah
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.237

Abstract

Background: Vitamin D receptor (VDR) FokI polymorphism (rs2228570) affects VDR protein transcriptional activity and may influence hypertension risk through renin-angiotensin system modulation. However, evidence in Southeast Asian stroke populations remains limited. Objective: To investigate the association between VDR FokI polymorphism and hypertension in Indonesian ischemic stroke patients. Methods: This cross-sectional study enrolled 85 ischemic stroke patients (50 hypertensive, 35 normotensive) from Medan, Indonesia. VDR FokI genotypes (CC, CT, TT) were determined using PCR-RFLP. Association with hypertension was analyzed using chi-square test. Results: Genotype distribution showed CC and CT at equal frequency (44.7% each) and TT at 10.6%, with corresponding C and T allele frequencies of 67.1% and 32.9%, respectively. Among hypertensive stroke patients, CT genotype predominated (52.0%), whereas CC genotype was most prevalent in normotensive patients (57.1%). Despite these distributional differences, no significant association was observed between VDR FokI polymorphism and hypertension (χ² = 3.732, p = 0.155). Conclusion: VDR FokI polymorphism was not significantly associated with hypertension in Indonesian ischemic stroke patients, suggesting that genetic predisposition via this single polymorphism may be overshadowed by established stroke pathophysiology or complex gene-environment interactions in this specific clinical context.
Co-Authors Ameta Primasari Ariyati Yosi Arrizal, Rizki Bahagia Loebis, Bahagia Bintang Y.M. Sinaga Bintang Y.M. Sinaga, Bintang Y.M. Bintang, Siti Sarah Bintang Sarah Blondina Marpaung Chandra, Vincent Alexander Cut Aria Arina Debby Mirani Lubis Donny Nauphar Elmeida Effendy Essie Octiara Febriani, Husnarika Hadyanto Lim Henny Erina Saurmauli Ompusunggu Heriandi Sutadi Herla Rusmarilin Herla Rusmarilin Herla Rusmarilin Husnarika Febriani Indah Permata Sari Indah Permata Sari1 Isra Thristy Jaminsen Sinaga Juwita -, Juwita Lucia Aktalina Melvariani Syari Batubara Miftahul Zannah Muhammad Amin Muhammad Ichwan Muhammad Ichwan Noni Novisari Soeroso Nurmiati Amir Oentari, Widyaningsih Ompusunggu, Henny E.S. Ozar Sanuddin Pardede, Sumondang M. Pratiwi, Astrid Siska Pratiwi, Astrid Siska Putri Chairani Eyanoer, Putri Chairani Rahmiwita, Rahmiwita Roesyanto-Mahadi, Irma D Sarah, Dewi Maya Seri Rayani Bangun Siregar, Kamal B. Sori M Sarumpaet, Sori M Soviani, Sri Sri Soviani Sri Soviani Syarifah, Siti Tarigan, Amira Permatasari Umar Zein Wilson Arthur Zein