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The Relationship between Family's Assessment Support and MDR TB Patient's Adherence on Treatment in RSUD Dr. Soetomo Surabaya Ainiyah, Safira Nur; Soedarsono, Soedarsono; Umiastuti, Pirlina
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 2 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.779 KB) | DOI: 10.20473/juxta.V10I22019.75-78

Abstract

Introduction: Multi Drug-Resistant Tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis and has been resistant to isoniazid and rifampicin. Its treatment needs long time and causes some side effects which can make the patients non-adherent so that family support is needed. This study aims to know the relationship between family's assessment support and MDR TB patient's adherence on treatment in RSUD Dr. Soetomo Surabaya. Methods: This was an analytic observational cross-sectional study, to know the frequency distribution of family's assessment support, MDR TB patient's adherence, and the relationship between them in 24 MDR TB patients, recruited from MDR TB Clinic, RSUD Dr. Soetomo, Surabaya, from October 2017 to June 2018 and their family. The analysis was descriptive statistic and inferential statistic using Fisher Exact Test. Results: The results of this study showed that 83.3% of MDR TB patients' family give high assessment support and 58.3% of MDR TB patients in RSUD Dr. Soetomo from October 2017 to June 2018 have high adherence on treatment. There is significant (p = 0.020), moderate (c = 0.468), and direct relationship between family's assessment support and MDR TB patient's adherence on treatment in RSUD Dr. Soetomo Surabaya. Conclusion: To improve MDR TB patient's adherence on treatment, family must give high assessment support.
Analysis of IFN-gamma and IL-10 Levels as Markers of Inflammation and Response Therapy of Anti-Tuberculosis in MDR Lung TB Patients Setyawati, Herni; Soedarsono, Soedarsono; Yulistiani, Yulistiani; Fatmawati, Umi
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.191 KB) | DOI: 10.20473/fmi.v55i4.24394

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Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-γ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- γ. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an observational study using cross sectional design. There were 29 patients who received standard MDR TB OAT therapy from 1-24 months, who met the inclusion criteria. Then, the patients were divided based on duration of the therapy, which are the initial/intensive and advanced phase. The initial phase divided into 2: first one is for 1-4 months therapy's time (5 patients) and the second one is for more than 4-8 months (6 patients). Then, the advanced group divided into two groups again, which are third group with more than 8-16 months (13 patients) and fouth group with more than 16-24 months (5 patients). Then, measured serum concentration IFN-γ, IL-10 at the start of the study and 4 weeks later with the ELISA method. This research during the period July-December (6 months). IFN-γ post concentrations were decreased by 39.14 ± 139.12 pg/mL (p > 0.05). The concentration of IL-10 was decreased by 33.93 ± 109.20pg/mL (p>0.05). Based on the TB score bandim method during pre and posts results were 1 patient experienced severity change from severity class 1 to 2, 1 patient from severity class 2 to 1, 1 patient remained in severity 2 and 26 patient remained in severity 1. The results showed that serum IFN-γ and IL-10 levels in initial/intensive and advanced phase patients who received MDR TB regiment after four weeks did not changed,
Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono, Soedarsono; Semedi, Bambang Pudjo; Setiawati, Rosy; Meliana, Resti Yudhawati; Kusmiati, Tutik; Permatasari, Ariani; Bakhtiar, Arief; Syafa'ah, Irmi; Indrawanto, Dwi Wahyu
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2027.315 KB) | DOI: 10.20473/fmi.v56i3.24584

Abstract

An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.
KAJIAN PENENTUAN SEGMENTASI DAN KELAS AIR DI SUNGAI DOLOK SEBAGAI POTENSI MANFAAT UNTUK AIR BAKU Awiyati, Ian Tangguh; Wahyudi, Slamet Imam; Soedarsono, Soedarsono
Wahana Teknik Sipil: Jurnal Pengembangan Teknik Sipil Vol 29, No 2 (2024): Wahana Teknik Sipil
Publisher : Politeknik Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32497/wahanats.v29i2.6159

Abstract

The Dolok River, which is located between Demak Regency and Semarang Regency,Central Java Province, is widely used by residents to meet their water needs in dailylife. However, as time goes by, pollution occurs which worsens the water quality ofthe Dolok River. One of the contributing factors is the existence of several factoriesand densely populated settlements along the Dolok River. Through this research,researchers intend to determine the division of segments of the Dolok River area,analyze the morphology of the Dolok River, determine the water class of the DolokRiver, predict the potential of water classes for raw water utilization and predict thepotential for raw water supply of Klambu Kudu. The methods used in this researchare the observational study method and the STORET method to determine waterclass. From the results of the analysis, Barang Dam as an upstream river has thecharacteristics of a Barbatu riverbed, relatively small discharge, river erosion andno flooding. Kebon Batur Dam is the middle part of the Dolok river which is atransportation area for erosion from upstream to downstream. Shipping channelsare areas where mud deposits occur, erosion often occurs and causes flooding.Based on the results of field surveys, the morphology of the Dolok River is a braidedtype which generally has relatively small discharge and high levels of sediment. TheDolok River water class calculated using the STORET method is classified as ClassB, namely moderately polluted. Based on the calculation results for determiningwater class by water quality category according to PP No.22 of 2021, the DolokRiver does not have potential as raw water or PDAM drinking water, because it isincluded in the class II category and can only be used as raw water for irrigation at0.52 m3. /sec. Apart from that, there was no potential for raw water supply fromKlambu Kudu to the Dolok River, because it has a different river basin.
STUDI RASIONALISASI POS CURAH HUJAN SISTEM SUNGAI SEMARANG BARAT Setyaningsih, Theresia Puji; Wahyudi, Slamet Imam; Soedarsono, Soedarsono
JMTS: Jurnal Mitra Teknik Sipil Volume 7, Nomor 2, Mei 2024
Publisher : Prodi Sarjana Teknik Sipil, FT, Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmts.v7i2.27221

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Hydrological data is basic data in the design or planning of water structures. Hydrological data was taken from hydrological stations in the study area. In catchment area with a small number of stations, this will result in a greater error rate. Meanwhile, a large number of stations will of course incur large operational and maintenance costs. Therefore, rationalization studies are needed to obtain an effective and efficient stational network. This research was conducted on the West Semarang river system. In this research, data is needed, including rainfall stations and discharge or gauged stations data, and topographic data. The methods used are WMO, isohyet, stepwise and kagan. From the results of analysis it’s known that based on WMO method, the existing rainfall station network meets the criteria issued. The stepwise method analysis produces five rainfall stations that are effective and have an influence on the Kalipancur watershed. An effective rainfall station network based on the Kagan method requires 18 stations with a distance between stations of 5.13 km. In isohyet method, it can be seen that isohyet using the IDW method is closer to field conditions. From the results of the multi-criteria analysis, it can be seen that the recommendation for the rainfall station network in West Semarang River System is to maintain 7 rainfall stations, recommending 7 rainfall stations for closed or relocated, as well as adding 12 new rainfall stations at points kagan still empty. Abstrak Data hidrologi merupakan data dasar dalam desain atau perencanaan bangunan air. Data hidrologi diambil dari pos hujan yang ada pada wilayah studi. Pada DAS dengan jumlah pos sedikit, akan menghasilkan tingkat kesalahan yang lebih besar. Sedangkan jumlah pos yang besar, akan menimbulkan biaya operasional dan pemeliharaan yang besar pula. Oleh karena itu diperlukan studi rasionalisasi untuk memperoleh jaringan pos yang efektif dan efisien. Penelitian dilakukan pada Sistem Sungai Semarang Barat. Penelitian ini memerlukan data pos hujan dan pos debit, dan data topografi. Penelitian memakai metode WMO, isohyet, stepwise dan kagan. Dari hasil analisis berdasarkan metode WMO, jaringan pos hujan existing memenuhi kriteria yang dikeluarkan. Analisis metode stepwise menghasilkan lima pos hujan yang efektif dan berpengaruh terhadap DAS Pos Duga Air Kalipancur. Jaringan pos hujan yang efektif berdasarkan metode Kagan diperlukan sebanyak 18 stasiun dengan jarak antar stasiun 5,13 km. Pada metode isohyet dapat dilihat bahwa isohyet dengan metode IDW lebih mendekati kondisi lapangan. Dari hasil analisis multi kriteria dapat diketahui bahwa rekomendasi jaringan pos hujan di Sistem Sungai Semarang Barat adalah tetap mempertahankan 7 pos hujan, merekomendasikan 7 pos hujan untuk ditutup atau dipindah serta menambah 12 pos hujan baru pada titik simpul kagan yang masih kosong.
ANALISIS MAKNA BAHASA VERBAL DAN NONVERBAL DALAM BUKU BAHASA INDONESIA KELAS XII SMA/SMK/MA: KAJIAN SEMIOTIKA Bur, Eka Yulianti; Akhiruddin, Akhiruddin; Soedarsono, Soedarsono
Arbitrer : Jurnal Pendidikan Bahasa dan Sastra Indonesia Vol 6 No 3 (2024): Arbitrer : Jurnal Pendidikan Bahasa dan Sastra Indonesia
Publisher : Program Studi Pendidikan Bahasa dan Sastra Indonesia FKIP Universitas Pattimura (Indonesia Language and Literature Education Department, The Faculty of Teacher's Training and Educational Sciences, University of Pattimura)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/arbitrervol6no3hlm1263-1276

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Penelitian ini bertujuan untuk mendeskripsikan makna bahasa verbal dan nonverbal dalam Buku Bahasa Indonesia Kelas XII SMA/SMK/MA dengan menggunakan kajian semiiotika Charles Sander Pierce. Penelitian ini termasuk penelitian kualitatif dengan pemaparan data secara deskripstif. Sumber data dalam penelitian ini, yaitu Buku Bahasa Indonesia Kelas XII SMA/SMK/MA dengan spesifikasi data adalah BAB I s.d. BAB III. Kajian dalam penelitian ini adalah penggunaan komponen semiotika dalam buku teks Bahasa Indonesia Kelas XII SMA/SMK/MA dengan fokus pada pembahasan topik H.B. Jassin, kewirausahaan, dan kecerdasan buatan (AI). Analisis berdasarkan teori semiotika Peirce menelusuri tiga komponen utama: representamen, objek, dan interpretan. Temuan menunjukkan bahwa representamen berupa infografik, teks naratif, dan diagram visual membantu siswa memahami konsep-konsep kompleks. H.B. Jassin dihadirkan sebagai simbol dedikasi dalam sastra melalui infografik dan narasi historis, sedangkan pada materi kewirausahaan, teks dan visualisasi diagram memperkenalkan prosedur bisnis secara sistematis. Pada topik AI, diagram dan ilustrasi robot, seperti Deep Blue menggambarkan dampak teknologi AI terhadap pekerjaan manusia. Analisis ini menyoroti ikon, indeks, dan simbol yang berperan dalam memperkuat pemahaman siswa terhadap materi, memperdalam makna melalui visualisasi, dan contoh nyata yang kontekstual. Pendekatan semiotika dalam materi pendidikan ini berpotensi meningkatkan kualitas pembelajaran dengan memberikan siswa pemahaman yang lebih komprehensif terhadap topik yang kompleks
Analisis Parkir dan Manajemen Rekayasa Lalu Lintas pada Pasar Mranggen Kab. Demak untuk Mengatasi Kemacetan di Ruas Jalan Semarang-Godong Pradhana, Agung; Mudiyono, Rachmat; Soedarsono, Soedarsono
Teknika Vol. 20 No. 1 (2025): Maret
Publisher : Universitas Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26623/8ctk2489

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Kawasan Pasar Mranggen, Kab. Demak merupakan salah satu daerah yang berada pada salah satu ruas jalan provinsi dengan kepadatan arus lalu lintas yang cukup tinggi. Kemacetan yang terjadi pada kawasan tersebut juga diakibatkan karena aktifitas pasar dan kendaraan yang berhenti di sekitar kawasan pasar. Penelitian ini bertujuan untuk mengetahui karakteristik lalu lintas yang ada di kawasan Pasar Mranggen, mengetahui sirkulasi simpang, dan mengetahui karakteristik parkir eksisting serta kebutuhan lahan parkir. Penelitian ini menggunakan metode MKJ1 1997 dan Pedoman Teknis Penyelenggaraan Fasilitas Parkir 1996. Dari hasil analisa didapat hasil untuk ruas Jl. Semarang-Godong volume lalu lintas tertinggi pada hari Senin dengan 3013 smp/jam dan Derajat Kejenuhan 1,85 dengan tingkat pelayanan F yang berarti arus yang terhambat,kecepatan rendah,dan sering terjadi kemacetan. Untuk kinerja simpang di kawasan Pasar Mranggen volume tertinggi pada hari Kamis dengan 1228 smp/jam dan Derajat Kejenuhan 1,56 dengan tingkat pelayanan F yang berarti berkecepatan lambat, hambatan besar dan kemacetan arus. Untuk lahan parkir off street untuk mobil (3 SRP < 20 SRP), untuk motor (102 SRP
PHILOSOPHICAL VALIDITY, THEORETICAL, NORMATIVE AND EMPIRICAL PARADIGM OF GENERAL PRINCIPLES OF GOOD GOVERNANCE (AUPB) AS A REVIEW OF PRESIDENTIAL IMPEACHMENT Nadir, Nadir; Soedarsono, Soedarsono; Hamidi, Jazim; Syafaat, Muchamad Ali
Brawijaya Law Journal Vol. 4 No. 1 (2017): Constitutional Issues and Indigenous Rights
Publisher : Faculty of Law, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.blj.2017.004.01.05

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Philosophical validity showed of the Principles of Good Governance (AUPB) as A review to Presidential impeachment, is a principle of AUPB that contains ethical normative values used as the foundation of good governance, clean and respectable, moreover to complement the shortcomings and ambiguities in law. Technically, the application of AUPB by the judges of the Constitutional Court (MK-RI) can be approached through induction and deduction legal reasoning. The method of implementing AUPB by the judges of the Constitutional Court (MK-RI) is accomplished by deductive at first, meaning that the special rules is focused more to the certain field of law, then these are deducted based on its basic rules and deducted again into the rules of substantive, and deducted again into the rules of cases. After that, it starts to applicate the rules of case based on the concrete case by the judge, because of the nature of the judges of the Constitutional Court (MK-RI) is kholifah fil'ardi as the representative of God on earth to uphold the law and justice. While theoretically AUPB is valid, the judge ius curia Novit as a verdict maker to perform legal discovery (rechtsvinding). Empirically AUPB is valid, it can be seen from the cases of impeachment against the President of the United States William Jefferson Clinton, on suspicion of "abominably act" (misdemeanors). Additionally, AUPB empirically has been tested through jurisprudence since Amtenarenwet 1929 officially applied on March 1, 1933. Centrale Raad van Beroep, in his verdict on June 22, 1933, and the jurisprudence verdict of Hoge Raad on November 13, 1936, and the jurisprudence verdict of Hoge Raad 1919. While the normative validity is based on the leading legal doctrine, that AUPB is positioned as the unwritten laws that must be obeyed by the government, and AUPB considered as a part of positive law. Moreover, in Indonesia AUPB incarnates in various legislations even though his name is remained as principal.
Pengaruh Linezolid terhadap Timbulnya Neuropati Optik pada Tuberkulosis Paru Multidrug Resistance: Laporan Kasus Aryanti, Yuni; Herawati, Fauna; Fatmawati, Umi; Soedarsono, Soedarsono; Agustini, Lukisiari
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.58296

Abstract

Penemuan kasus tuberkulosis (TB) resisten obat (RO) di Indonesia adalah sebesar 12.531 dengan cakupan 51% di tahun 2022. Linezolid merupakan antibiotik dari kelompok oksazolidinon, dan merupakan salah satu obat dalam terapi TB RO. Linezolid memiliki farmakokinetika nonlinier, distribusi di mata 40%, ikatan obat protein 15%, diperlukan penyesuaian dosis dan frekuensi pemberian secara individual. Kasus neuropati optik akibat linezolid di Indonesia hingga kini masih jarang ditemukan, sehingga menjadi nilai lebih bagi laporan kasus di Dr. Soetomo General Academic Hospital ini. Pasien wanita 46 tahun dengan berat badan 40 kg dan tinggi badan 157 cm (underweight), didiagnosis TB multidrug resistance (MDR) primer dan hipotiroid. Pasien menjalani pemeriksaan awal mata, dinyatakan normal fundus dan tidak ada kelainan. Pasien memulai terapi TB regimen individual (pengobatan jangka panjang) sejak 25 Mei 2023 dengan fase intensif enam bulan, yaitu kombinasi bedakuinin 400 mg, levofloksasin 750 mg, linezolid 450 mg, clofazimin 100 mg, sikloserin 500 mg, dan vitamin B6 100 mg. Neuropati optik muncul setelah penggunaan linezolid selama enam bulan yang ditandai dengan skotoma sentral. Linezolid dihentikan tanggal 18 Januari 2024, dan setelah 5 bulan kondisi mata pasien mengalami perbaikan. Neuropati optik akibat linezolid adalah proses reversibel, dan memiliki kemungkinan 2,6 kali lebih besar pada BMI <18,5 kg/m2 sehingga dosis linezolid 300 mg tiap 24 jam dapat disarankan pada pasien underweight. Pemantauan awal dan berkala setiap bulan efek neuropati optik akibat linezolid selama pengobatan sangat diperlukan, terutama pada pasien underweight.
Selection of Sediment Retention Structure Type in Coastal Reservoir (Case Study of Terboyo Retention Pond, Semarang) Susanto, Deddy; Wahyudi, Slamet Imam; Soedarsono, Soedarsono
ASTONJADRO Vol. 14 No. 3 (2025): ASTONJADRO
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/astonjadro.v14i3.18176

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To overcome the problem of flooding and tidal flooding in the city of Semarang, especially in the eastern part of Semarang, the Semarang-Demak Toll Road was built which is integrated with the sea wall. The sea wall is planned to prevent sea water from entering the land area, however, the sea wall will also block the direct flow of several rivers to the sea so that a fairly large coastal reservoir is needed. As in general, coastal reservoirs and retention ponds often experience sedimentation problems which have an impact on the economic value of the reservoir concerned, while in the planning of coastal reservoirs and retention ponds in general they are not equipped with sediment retaining structures. From this study, the results of the selection of the right type of sediment retaining structure to be applied in coastal reservoirs were obtained. The selection of the type of sediment retaining structure in this study used the AHP (Analytical Hierarchy Process) method, which is a decision support model that involves experts who have knowledge and experience in planning or implementing retention ponds or sedimentation in river estuaries. From the results of the global priority analysis above, the weight of each alternative sediment retaining structure is obtained, namely a fixed dam of 33.21%, a vertical movable dam with an upper opening of 31.35%, without a sediment retaining structure of 19.61%, a vertical movable dam with a lower opening of 15.84%. From the results of the AHP analysis above, the highest weight was obtained, which was then used as a decision maker to choose the type of building with the highest value, namely a sediment retaining structure in the form of a permanent dam.