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THE RISK FACTORS FOR DRUG INDUCED HEPATITIS IN PULMONARY TUBERCULOSIS PATIENTS IN DR. SOETOMO HOSPITAL Soedarsono, Soedarsono; Mandayani, Sari; Prayuni, Kinasih; Yuliwulandari, Rika
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 3 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.097 KB) | DOI: 10.20473/ijtid.v7i3.8689

Abstract

Tuberculosis (TB) is still a major public health problem in Indonesia. Anti-tuberculosis drug-induced hepatotoxicity (DIH) is common side effect leading to changes in treatment regimens, and the less effective second-line treatments. Several risk factors such as age, sex, body mass index (BMI) and acetylization status for hepatotoxicity were suggested in previous studies but in the fact, those are often not related to DIH incidence after receiving standard TB treatment regimen. The aim of this study was to asses the role of risk factors in the DIH incidence in pulmonary TB patients receiving standard TB treatment regimen in Dr. Soetomo Hospital, Surabaya. Study design was analytic observational with case control. The subjects were 30 TB DIH patients and 31 TB non-DIH patients receiving standard national TB program therapy. DIH severity was divided based on International DIH Expert Working Group. Demographic data and BMI status were taken from medical records. The age classification are ≥35 years old and <35 years old as one of the risk factors studied. DNA sequencing was used to assess single-nucleotide polymorphisms in NAT2 coding region to evaluate acetylator status from blood samples. The risk factors were evaluated using chi-square test and Mantel-Haenszel test. Significant association between low BMI and DIH in general was identified (OR=3.017; 95% CI=1.029-8.845) and more significant association between low BMI and moderate DIH (OR=15.833; 95% CI=1.792-139.922). Age, sex, and acetylization status has no significant correlation with DIH incidence in general. Significant association between slow acetylator phenotype and incidence of moderate DIH was identified (OR=7.125; 95% CI= 1.309-38.711). In conclusion, some risk factors were correlated to DIH incidence in pulmonary TB patientsreceiving standart TB treatment regimen.
FIRST LINE ANTI-TUBERCULOSIS DRUG RESISTANCE PATTERN IN MULTIDRUG-RESISTANT PULMONARY TUBERCULOSIS PATIENTS CORRELATE WITH ACID FAST BACILLI MICROSCOPY GRADING Soedarsono, Soedarsono; Mertaniasih, Ni Made; Sulistyowati, Titiek
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 2 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i2.14294

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a global public health crisis. Acid-fast bacilli (AFB) gradation in sputum examination is an important component in Pulmonary Tuberculosis (PTB) diagnosis and treatment outcome monitoring. Previously treated pulmonary TB patients with a higher AFB smear gradation may have higher rates of acquired resistance. Patients with a higher AFB grade indicate a higher bacillary load and had higher rates of acquired resistance. This study aims to evaluate the correlation between AFB gradation and first-line anti-TB drug resistance patterns in MDR pulmonary TB patients. This was a retrospective study conducted from August 2009 to April 2018 in Dr. Soetomo Hospital. Sputum samples were taken from MDR PTB patients. Sputum smear examination was done using Ziehl–Neelsen staining and gradation was measured according to IUATLD criteria. Samples with positive smear were evaluated for resistance patterns based on culture and resistance tests using the MGIT 960 BACTEC System. There were 433 sputum samples with AFB positive collected from MDR PTB patients. Resistance to RHES was found in 22 (14%) AFB +1, 19 (15%) AFB +2, and 29 (20%) AFB +3. Resistance to RHS was found in 22 (14%) AFB +1, 12 (9%) AFB +2, and 13 (9%) AFB +3. Resistance to RHE was found in 39 (25%) AFB +1, 38 (29%) AFB +2, and 35 (24%) AFB +3. Resistance to RH was found in 74 (47%) AFB +1, 61 (47%) AFB +2, and 69 (47%) AFB +3. Statistic analysis by Spearman test showed that there was no significant correlation between AFB gradation and first-line anti-TB drug resistance patterns. Acquired resistance to RHES can also found in lower bacillary load AFB +1.
Validity of Method for MTBC and NTM Detection in FNAB Specimens from Tuberculous Lymphadenitis Using Microscopy, XPERT MTB / RIF and Culture Method Junus, Herisa Nataliana; Mertaniasih, Ni Made; Soedarsono, Soedarsono
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.16043

Abstract

Mycobacterium tuberculosis and Nontuberculous Mycobacteria usually cause infection in tuberculous lymphadenitis. To improve accuracy of the detection MTB and NTM bacteria it is necessary to select valid methods. This study aims to compare validity of diagnostic methods from FNAB specimens for determining tuberculous lymphadenitis patients. a descriptive observational laboratory study involved 35 samples were obtained from tuberculous lymphadenitis patients in Dr. Soetomo Hospital Surabaya East Java. All specimens examined Ziehl-Neelsen staining microscopy, Xpert MTB/RIF , culture method Middlebrook7H10 solid media and  MGIT as Gold standard. Identification of MTB dan NTM with SD Bioline TB Ag MPT64 and niacin paper strip BD . Used diagnostic test 2x2 to analyze sensitivity, specificity, negative predictive value and positive predictive value. Ziehl-Neelsen staining microscopy Sensitivity 83,33 %  and Specificity 95,65% of  , PPV  90,91%and NPV 91,67%, Diagnostic Accuracy 91,43 % . Xpert MTB/RIF Sensitivity 75% and Specificity 95,65% , PPV  90 % and NPV 88 %, Diagnostic Accuracy 88,57 % with 95% CI (Confidence Interval ) . Characteristics female dominated 23/35 (65.7%) while Male numbered 12/35 (34.3%), age range distribution of TB lymphadenitis patients is highest in young adults 17 years to 25 years as many as 15/35 (42.9%) the second highest is the age group of 36 years to 45 years by 8/35 (22.9%), Clinicial presentation are mostly lymph node enlargement in cervical  37% patients other locations supraclavicular ,mamae. Clinical symptoms mostly lymphadenopathy 31,5% and other lymphadenopathy with fever. Microscopy method still have the good validity shoul be conjunction with the  molecular rapid tests and culture as gold standard in determining the diagnosis of TB lymphadenitis.
Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis Mertaniasih, Ni Made; Ananda, I Gede Yogi Prema; Soedarsono, Soedarsono; Kusumaningrum, Deby
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22160

Abstract

Tuberculosis diagnosis is an important component in decreasing TB incidence and prevalence. Because of the difficulty to collect sputum in some cases, urine specimens are used as it is easier to garner. One of the biomarkers in urine that can be used to diagnose pulmonary TB is IP-10, which can be represented by the CXCL10 gene. The study aims to determine the accuracy of diagnosis based on detection of the CXCL10 gene in urine as a biomarker for the patients with suspected pulmonary TB in Dr. Soetomo Hospital in Surabaya from November 2019 until March 2020. Thus, this is an observative laboratory research with a cross-sectional study. CXCL10 gene was examined using PCR for 36 urine samples, and then, the data, together with the medical records of clinical manifestations of pulmonary TB, GeneXpert MTB /RIF, blood count, and thorax radiograph, were processed using IBM SPSS Statistics 26. The results of the GeneXpert MTB/RIF and thorax radiograph criteria show positive results of pulmonary TB, which were 44.4% and 69.4% respectively. CXCL10 gene was not found in all urine of healthy people (negative), while 2.8% (1/36 samples) positive CXCL10 gene was found in a patient with positive GeneXpert, also with negative clinical manifestations and urine culture. In this study, the accuracy of diagnosis based on detection of the CXCL10 gene in urine for diagnosis of active pulmonary TB was 2.8%. Future research is needed to improve the methods, among them are bigger size of urine samples and clearer medical history of patients. 
An Initiative Report on Hospitalized Pulmonary TB Patients Co-Infected by SARS-CoV-2 during the COVID-19 Pandemic from Tertiary Referral Hospitals in Surabaya Effendy, Lyndia; Mertaniasih, Ni Made; Soedarsono, Soedarsono; Endraswari, Pepy
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.38940

Abstract

The enduring effect of SARS-CoV-2 pandemic has been experienced throughout the past and ongoing three years. Incidences of SARS-CoV-2 co-infected tuberculosis patients were reported globally, including in Italy and several European countries and resulted in a more complicated disease with severe clinical features and poorer clinical outcomes. To effectively manage this co-infection, it is important to be informed of the prevalence and characteristics of an acute SARS-CoV-2 co-infection on TB and determining factors of severity. Therefore, early warning signs can be recognized, monitored closely and managed. This retrospective study, carried out on hospitalized TB patients in Dr. Soetomo Hospital and Universitas Airlangga Hospital, Surabaya, Indonesia, used medical records from March 2020 to December 2022. Samples were from inpatients with a molecularly-Gene Xpert MTB/Rif-confirmed tuberculosis, and currently experienced respiratory and fever symptoms that resembles the symptoms of SARS-CoV-2 infection or exacerbation of tuberculosis. They are then screened and examined using a molecular diagnostic test, with real-time RT-PCR for SARS-CoV-2. A total of 54 (0.7%) patients had TB-SARS-CoV-2 co-infection among 7,786 suspected to have TB, of which 35 had Rifampicin Sensitive (TB-RS), while 19 had TB Rifampicin Resistant (TB-RR) co-infected with SARS-CoV-2. The remaining 2,586 suspected TB patients had only MTB, based on the detection methods of X-pert MTB/RIF, but with negative RT-PCR of SARS-CoV-2. The clinical severity and mortality of TB-SARS-CoV2 co-infected patients were significantly associated with the number of co-morbidities (p=0.0156), and serum haemoglobin levels (p=0.0672), in which p value < 0.05 is considered significant.
PENGARUH KOORDINASI SIMPANG BERSINYAL TERHADAP WAKTU TEMPUH PENGGUNA JALAN (STUDI KASUS SIMPANG PEGADAIAN DAN SIMPANG ALUN-ALUN LAMA UNGARAN) Bimantara, Firmandhi Sahid; rachmat, rachmat; soedarsono, soedarsono
Pondasi Vol 28, No 2 (2023): Desember
Publisher : UNISSULA Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/pondasi.v28i2.33125

Abstract

The increasing volume of vehicles creates a traffic problem that often occurs in urban areas, long time of travel time delays experienced by road users, therefore the government's role is needed to overcome these problems. The problems that occur make road users experience twice the red time which makes the travel time longer. This research was focused on evaluating the existing cycle time settings at the Alun-alun lama and Pegadaian intersections in Semarang Regency with the aim of obtaining optimal cycle times. The main objectives of this study include evaluating the existing cycle timing, analyzing intersection control using the greenwave method, evaluating the effectiveness of intersection coordination, and determining the benefits of intersection coordination. The recommendations put forward include implementing various and coordinated cycle timings at the intersection of Pegadaian and Alun-alun Lama by utilizing the greenwave method. Based on literature analysis, research, and field observations it is known that the coordination of signalized intersections can reduce travel time for road users. The research findings show that setting the current cycle time requires longer time than the proposed new cycle time. The results of controlling the intersection using the greenwave method managed to reduce travel time by up to 27.9% of the total time required. This shows the importance of varying timing to achieve optimal performance.
EFFECTIVENESS AND EFFICIENCY OF PUBLIC TRANSPORTATION ON THE PENGGARON-KALIBANTENG ROUTE (TRANS SEMARANG CORRIDOR 1) Setyobudi, Nurul Ilmiyati; Mudiyono, Rachmad; Soedarsono, Soedarsono
Pondasi Vol 29, No 1 (2024): June
Publisher : UNISSULA Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/pondasi.v29i1.32953

Abstract

Semarang is one of the major cities in Indonesia with a population that continues to increase every year. The policy on urban density is not a transportation policy, but this policy has an impact, directly and indirectly, on the city's transportation system. The existence of public transportation facilities serving various urban areas is currently of poor quality, causing various impacts on the community. As a result, many people underutilize these modes and prefer to use private vehicles. The research method that will be used in this research is descriptive quantitative method with a rationalistic approach. The ratio used is a simple statistical method. The data used for the assessment of effectiveness and efficiency is seen from the ratio of Accessibility, Capacity, Punctuality, Ticket Prices, Organizational Characteristics, Environmental Characteristics, Worker Characteristics and Management Practices. The results of this study can be concluded that the pattern of movement of public transport users in the Penggaron-Kalibanteng route area of Semarang City (Trans Semarang Corridor 1) falls into the category of evenly accessible to public transport users easily and effectively by meeting all indicators of the effectiveness and efficiency of public transportation. The effectiveness level of the Penggaron-Kalibanteng route in Semarang City (Trans Semarang Corridor 1) has an average percentage value of 96.23% and is classified as very effective. Easy accessibility, bus capacity is in accordance with the number of passengers, and ticket prices are in accordance with the facilities. SPSS calculation of the effectiveness of public transportation services where what is considered effective is from the assessment characteristics of the elements of Capacity, Ticket prices, Organizational characteristics, Environmental characteristics, Worker characteristics and Management characteristics. Meanwhile, the efficiency level has an average percentage value of 94.50% (Vehicle Utility and Load Factor) which is classified as good and efficient. The results of the SPSS calculation of the efficiency of public transportation services where what is considered efficient consists of assessing accessibility, ticket prices, environmental characteristics and management characteristics.
Analisis Penataan Sistem Drainase Sebagai Pengembangan Edu-Tourism Khaira Ummah di Kampus Unissula Semarang Ashari, Mochamad Hisam; Mudiyono, Rachmat; Soedarsono, Soedarsono
Pondasi Vol 28, No 1 (2023): Juni 2023
Publisher : UNISSULA Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/pondasi.v28i1.30389

Abstract

Floods and Rob floods are natural disasters that often occur in Indonesia. The UNISSULA campus area is in the Pantura road area. UNISSULA is one of the campuses affected by floods and robs. Extreme weather conditions and rising sea levels have exacerbated the condition of the north coast road. Thus causing traffic jams and activities of the surrounding community to falter.The purpose of this study was to analyze the drainage system of the UNISSULA campus area by utilizing the potential of a storage pond by disposing of water directly into the estuary. With this research, it is hoped that it can be used as data and material for consideration for the development of a drainage system in the campus area and to become a pilot campus to control flooding. The method used is a simulation of the rainfall-runoff model using EPA SWMM Version 5.1.This study carried out two scenarios in carrying out flood control efforts, namely the first scenario, the existing west, and east retention ponds will be connected to pond 1, for the pond in the north, will be connected from pool 4 to the engineering pool, channeled to pool 3, to pool 2 and connected with pool 1 equipped with a pump with a capacity of 1 m3/sec with additional long storage from pool 2 to pool 1 along 184 meters. The second scenario is to break the direction of the front and rear drainage flows. For drainage, it will be pulled into pond 4, then a technical pond until it is connected to pool 2 and discharged directly into the sea with a flood pump with a capacity of 0.5 m3/sec. This makes the flood travel time short and is expected to reduce inundation. With this scenario, it can also be developed as Khairu Ummah Edu-tourism Khaira Ummah in the campus area.
Effect of Different Levofloxacin Doses on QTc Interval Prolongation in Multidrug-Resistant Tuberculosis Patients Treated with the 9-Month All-Oral Regimen Soedarsono, Soedarsono; Rampengan, Vicky Reinold Christofel; Agustiyanto, Catur; Cho, Yong-Soon
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.203-208

Abstract

Introduction: The World Health Organization (WHO) has recommended the 9-month all-oral regimen for multidrug-resistant tuberculosis (MDR-TB) treatment. This regimen is expected to increase the treatment success rate. Bedaquiline, levofloxacin, and clofazimine are QT-prolonging drugs included in the 9-month all-oral regimen. Bedaquiline and clofazimine are given at the same dose for all patients, while levofloxacine dose is given in 750 mg and 1,000 mg based on the body weight. This study analyzed the correlation between different levofloxacin doses and certain factors on QTc interval prolongation. Methods: This observational retrospective study used the medical records of MDR-TB patients who underwent the 9-month all-oral regimen. Electrocardiography (ECG) for QTc interval measurement was recorded at the baseline before and 2 weeks after treatment. The measured variables included patient demographic data, body mass index (BMI), electrolyte levels, and comorbidities. Results: Thirty MDR-TB patients were included in this study. Gender, diabetes mellitus (DM), and levofloxacin dose did not correlate with QTc interval prolongation at 2 weeks after drug administration (p-values of 0.558, 0.197, and 0.134, respectively). Age, potassium level, magnesium level, calcium level, and baseline QTc interval also did not correlate with QTc interval prolongation at 2 weeks after drug administration (p-values of 0.433, 0.479, 0.705, 0.746, and 0.333, respectively). Multivariate analysis showed that the risk factor associated with QTc interval prolongation at 2 weeks after drug administration was a BMI of 0.013. Conclusion: Different levofloxacin doses did not correlate with QTc interval prolongation in MDR-TB patients treated with the 9-month all-oral regimen. The incidence of QTc interval prolongation was significantly associated with the lower BMI level.
ANALISIS PELAKSANAAN KONSTRUKSI DAN PERCEPATAN PENJADWALAN PROYEK DENGAN INOVASI PRECAST DI SALURAN INDUK GLAPAN BARAT Nugroho, Antonius Novan Setyo; Wahyudi, Slamet Imam; Soedarsono, Soedarsono
Rang Teknik Journal Vol 8, No 1 (2025): Vol. 8 No. 1 Januari 2025
Publisher : Fakultas Teknik Universitas Muhammadiyah Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/rtj.v8i1.5336

Abstract

Pendekatan PERT digunakan dalam penelitian ini, dan dengan menggunakannya, proyek Rehabilitasi Saluran Induk Glapan Barat dapat menghemat uang dengan mengurangi durasi awal 214 hari menjadi hanya 210 hari. Dengan percepatan waktu pelaksanaan pekerjaan menjadi 30 minggu (210 hari) dengan biaya tambahan sebesar Rp. 26.406.307,49, analisis metode PERT pada pekerjaan Rehabilitasi Saluran Induk Glapan Barat (Lining Precast Condition) menghasilkan durasi 210 hari, yang lebih cepat dari jadwal yang direncanakan selama 214 hari. Dengan 210 hari tersisa, ada kemungkinan 93,29% untuk memenuhi tujuan penyelesaian proyek, dan kemungkinan kegagalan 6,71%. Analisis metode PERT dari pekerjaan Rehabilitasi Saluran Induk Glapan Barat (Kondisi Lining Insitu) menghasilkan durasi 217 hari, yang lebih lama dari 214 hari yang dijadwalkan. Probabilitas kegagalan sebesar 87,77%, dan waktu pelaksanaan pekerjaan dipercepat menjadi 31 minggu (217 hari) dengan biaya tambahan sebesar Rp. 28.877.073,11. Probabilitas peluang pencapaian target penyelesaian proyek selama 217 hari sebesar 12,23%.
Co-Authors Abd. Rasyid Syamsuri Adnyana , I Made Dwi Mertha Agustini, Lukisiari Agustiyanto, Catur Ainiyah, Safira Nur Akhiruddin Akhiruddin Amaliah, Lia Ananda, I Gede Yogi Prema Aryanti, Yuni Ashari, Mochamad Hisam Awiyati, Ian Tangguh Bakhtiar, Arief Bambang Hariyanto Bimantara, Firmandhi Sahid Bur, Eka Yulianti Cho, Yong-Soon Deby Kusumaningrum Deddy Susanto Endraswari, Pepy Hartanto, Azis Herawati, Fauna Herni Setyawati Imam Wahyudi Indrawan, Imam Wahyudi Indrawanto, Dwi Wahyu Jazim Hamidi Joko Sutrisno Junus, Herisa Nataliana Jusak Nugraha Kartono Wibowo, Kartono Kasih, Shindya Kinasih Prayuni, Kinasih Kusmiati, Tutik Kusuma Dewi, Anindya Zalfaa Lyndia Effendy M. Dikman, Irmawati Mahardika, Vera Makhfudli Makhfudli Mandayani, Sari Mudiyono, Rachmad Nadir Nadir, Nadir Najimuddin, Didin Ni Made Mertaniasih Ni'am, M. Faiqun Nono Carsono Nugroho, Antonius Novan Setyo Nugroho, Eko Pudjo Pangeran Paita Yunus Panuwun, Rizky Tulus Permatasari, Ariani Poedjiastuti, Hermin Pradhana, Agung Pratama A., Ronald Pratiwi Adi, Henny Rachmat Mudiyono, Rachmat RACHMAT RACHMAT Rampengan, Vicky Reinold Christofel Resti Yudhawati Rika Yuliwulandari, Rika Ronald Pratama Adiwinoto Rudi Hariyono, Rudi S Imam Wahyudi Safitri, Adam Semedi, Bambang Pudjo Setiawati, Rosy Setyaningsih, Theresia Puji Setyobudi, Nurul Ilmiyati Slamet Imam Wahyudi, Slamet Imam SP Gustami Suhaemi Suhaemi, Suhaemi Sulistyowati, Titiek Syafa'ah, Irmi Syafaat, Muchamad Ali Syafaat, Muchamad Ali TARUNA, DODY Tasalina Yohana Parameswari Gustam UMI FATMAWATI Umiastuti, Pirlina Wajdi*, Bina Arumbinang Wajdi, Bina Arumbinang Wicaksana, Bayu Septiaji Wulandari, Dian Novita Yelvi Levani Yulistiani Yulistiani, Yulistiani