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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi Pharmacoscript Journal of Pharmaceutical and Health Research JUKESHUM: Jurnal Pengabdian Masyarakat Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Kedokteran Hewan
Vivi Sofia
Unknown Affiliation
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Ekstrak Etanol Kulit Buah Jeruk Baby (Citrus sinensis L. Osbeck) Selama 28 hari terhadap Kadar SGOT dan SGPT Sofia, Vivi; Widyaningsih, Wahyu; Yuliani, Sapto; Bachri, Moch Saiful
Jurnal Sain Veteriner Vol 42, No 2 (2024): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.71513

Abstract

One of the plants used as natural medicine is baby orange (Citrus sinensis L. Osbeck). Baby oranges contain hesperidin, hesperetin, narirutin and nobiletin compounds. The purpose of this study was to determine the effect of giving ethanol extract of baby orange peel for 28 days on liver function as seen from the increase in SGOT and SGPT levels. This research is a pure experimental study with a completely randomized design (CRD) with a unidirectional pattern, namely the method used to observe the relationship of independent variables (including: normal control, negative control, ethanol extract of baby orange peel (EEKBJB) doses of 50, 100, 200 and 400 mg/kg BW) with the dependent variable (SGOT and SGPT levels). The test animals used in this study were 30 male Wistar rats which were divided into 6 treatment groups which were treated for 28 consecutive days. On day 29, blood samples were taken from the orbital sinus of the eye and the levels of SGOT and SGPT were measured. There was a significant difference in the levels of SGOT and SGPT as indicated by the results of the One Way ANOVA test (p<0.05). The results of the Post Hoc-Tukey test for SGOT levels showed a significant difference between the control group and the 50 mg/kg BW dose group, while the 100, 200 and 400 mg/kg BW doses did not show a significant difference. The results of the Post Hoc-Tukey, s-HSD test for SGPT levels did not show a significant difference between the control group and the 50, 100, 200 and 400 mg/kg BW dose groups. Significant differences were shown by doses of 50 and 400 mg/kg BW. Giving EEKBJB for 28 days did not cause toxic effects on liver function, seen from the absence of an increase in SGOT and SGPT levels.
Analysis of bioactive compounds, antioxidant activity, and acute toxicity test of black garlic (Allium sativum L.) Moch. Saiful Bachri; Muhammad Ma'ruf; Hasna Tsamarah; Daru Estiningsih; Prasasti, Dian; Danang Prasetyaning Amukti; Sapto Yuliani; Vivi Sofia
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.31393

Abstract

Black garlic is obtained through a controlled fermentation process that alters its color, aroma, and flavor while enhancing its concentration of bioactive compounds. This product is rich in phenolics, flavonoids, alkaloids, and organosulfur compounds such as S-allyl cysteine, which are known to exhibit antioxidant, anti-inflammatory, and antimicrobial properties. This study aimed to determine the total alkaloid, flavonoid, and phenolic content, antioxidant activity, and acute toxicity profile of black garlic. Black garlic samples were prepared by fermenting Solo garlic for 12 days at 60–70 °C. Alkaloid content was analyzed spectrophotometrically using Bromocresol Green reagent with quinine as the standard, flavonoid content was determined using quercetin, and total phenolic content was measured using the Folin–Ciocalteu method with gallic acid as the standard. Antioxidant activity was assessed using the DPPH method, while acute toxicity testing was conducted on male BALB/c mice at doses of 500–5.000 mg/kg BW following OECD/GHS guidelines. The results showed that black garlic contained 301.65 ± 3.436 mg QE/kg alkaloids, 2.190 ± 0.051 mg QE/g flavonoids, and 81.976 ± 1.179 mg GAE/g phenolics. Antioxidant activity was categorized as very strong with an IC₅₀ value of 9.94 ± 0.012 ppm, comparable to Vitamin C (9.92 ± 0.005 ppm). Acute toxicity tests revealed no toxic symptoms or mortality up to 5.000 mg/kg BW, classifying black garlic as practically non-toxic. In conclusion, black garlic is rich in bioactive compounds, demonstrates strong antioxidant activity, and is safe for consumption, making it a potential functional food and health supplement.
Co-Authors Aji, Abisyahdan Satria Akrom, Akrom Antri Andra Lubis, Dello Aulia Putri, Melati Cipta Khairunnisa Daan Khambri Danang Prasetyaning Amukti Dandy Annas Muttaqien Daru Estiningsih Dea Anggraini Deddi Prima Putra Desi Iswahyuni Dian Prasasti Dwi Ari Nugrahani Fatma Sri Wahyuni Firdaus, Tya Novita Fitratul, Wahyuni Frengki Frengki, Frengki Fujiko, Muflihah Galuh Rista Putri Hasna Tsamarah Henni Vanda Intan Dwi Rahmita Julianty, Siti Muliani Kanne Dachi Karima, Nurul Khozanatul Ulwy Laela Hayu Nurani M Sandila Okta Mariany Razali Mauliza, Indah Meutia Indriana Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Ma'ruf Nadia Selvia Nadia, Syarifah Natasya E.Purba, Nazwa Nugrahani, Dwi Ari Okta, M Sandila Rahma Yulia Rahmawanti, Salsabila Rahmi Ningrum, Siti Reka Rukmiati Salman Salman Sapto Yuliani Sapto Yuliani Saputri, Muharni Shabrina Arwi Laily Siahaan, Desy Natalia Sofina Rahmadita Suci Kurniati Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widya, Kardela Wiki Yuli Anita